van Staa TP, Dennison EM, Leufkens HG, Cooper C. Epidemiology of fractures in England and Wales. Bone. 2001;29(6):517–22.
Article
PubMed
Google Scholar
Calori GM, Albisetti W, Agus A, Iori S, Tagliabue L. Risk factors contributing to fracture non-unions. Injury. 2007;38(Suppl 2):S11–8.
Article
PubMed
Google Scholar
Bliuc D, Nguyen TV, Eisman JA, Center JR. The impact of nonhip nonvertebral fractures in elderly women and men. J Clin Endocrinol Metab. 2014;99(2):415–23.
Article
CAS
PubMed
Google Scholar
Minns Lowe CJ, Toye F, Barker KL. Men’s experiences of having osteoporosis vertebral fractures: a qualitative study using interpretative phenomenological analyses. Osteoporos Int. 2019;30(7):1403–12.
Article
CAS
PubMed
Google Scholar
Dovjak P. Diagnostics and treatment of osteoporosis in patients over 65 years old : Current status and future perspectives. Z Gerontol Geriatr. 2019;52(5):421–7.
Article
PubMed
Google Scholar
Araujo AB, Travison TG, Harris SS, Holick MF, Turner AK, McKinlay JB. Race/ethnic differences in bone mineral density in men. Osteoporos Int. 2007;18(7):943–53.
Article
CAS
PubMed
Google Scholar
Cauley JA, Fullman RL, Stone KL, Zmuda JM, Bauer DC, Barrett-Connor E, Ensrud K, Lau EM, Orwoll ES. Factors associated with the lumbar spine and proximal femur bone mineral density in older men. Osteoporos Int. 2005;16(12):1525–37.
Article
PubMed
Google Scholar
Makitie RE, Niinimaki T, Nieminen MT, Schalin-Jantti C, Niinimaki J, Makitie O. Impaired WNT signaling and the spine-heterozygous WNT1 mutation causes severe age-related spinal pathology. Bone. 2017;101:3–9.
Article
CAS
PubMed
Google Scholar
Dimitriou R, Jones E, McGonagle D, Giannoudis PV. Bone regeneration: current concepts and future directions. BMC Med. 2011;9:66.
Article
PubMed
PubMed Central
Google Scholar
Liedert A, Rontgen V, Schinke T, Benisch P, Ebert R, Jakob F, Klein-Hitpass L, Lennerz JK, Amling M, Ignatius A. Osteoblast-specific Krm2 overexpression and Lrp5 deficiency have different effects on fracture healing in mice. PLoS One. 2014;9(7):e103250.
Article
PubMed
PubMed Central
CAS
Google Scholar
Skripitz R, Aspenberg P. Early effect of parathyroid hormone (1-34) on implant fixation. Clin Orthop Relat Res. 2001;392(392):427–32.
Article
Google Scholar
Skripitz R, Aspenberg P. Implant fixation enhanced by intermittent treatment with parathyroid hormone. J Bone Joint Surg. 2001;83(3):437–40.
Article
CAS
Google Scholar
Agholme F, Macias B, Hamang M, Lucchesi J, Adrian MD, Kuhstoss S, Harvey A, Sato M, Aspenberg P. Efficacy of a sclerostin antibody compared to a low dose of PTH on metaphyseal bone healing. J Orthop Res. 2013;32(3):471–6.
Article
PubMed
CAS
Google Scholar
Sandberg O, Macias BR, Aspenberg P. Low dose PTH improves metaphyseal bone healing more when muscles are paralyzed. Bone. 2014;63(3):15–9.
Article
CAS
PubMed
Google Scholar
Nakajima A, Shimoji N, Shiomi K, Shimizu S, Moriya H, Einhorn TA. Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1–34). J Bone Mineral Res. 2002;17(11):2038–47.
Article
CAS
Google Scholar
Xie Y, Yi L, Weng T, Huang J, Luo F, Jiang W, Xian CJ, Du X, Chen L. Fibroblast growth factor receptor 3 deficiency does not impair the Osteoanabolic action of parathyroid hormone on mice. Int J Biol Sci. 2016;12:990–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen H, Sun X, Yin L, Chen S, Zhu Y, Huang J, Jiang W, Chen B, Zhang R, Chen L. PTH 1-34 ameliorates the osteopenia and delayed healing of stabilized tibia fracture in mice with Achondroplasia resulting from gain-of-function mutation of FGFR3. Int J Biol Sci. 2017;13(10):1254–65.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li J, Bao Q, Chen S, Liu H, Feng J, Qin H, Li A, Liu D, Shen Y, Zhao Y. Different bone remodeling levels of trabecular and cortical bone in response to changes in Wnt/β-catenin signaling in mice. J Orthop Res. 2016;35(4):812–9.
Article
PubMed
CAS
Google Scholar
Bao Q, Chen S, Qin H, Feng J, Liu H, Liu D, Li A, Shen Y, Zhong X, Li J. Constitutive β-catenin activation in osteoblasts impairs terminal osteoblast differentiation and bone quality. Exp Cell Res. 2016;350(1):123–31.
Article
PubMed
CAS
Google Scholar
Kim JB, Leucht P, Lam K, Luppen C, Ten BD, Nusse R, Helms JA. Bone regeneration is regulated by wnt signaling. J Bone Miner Res. 2007;22(12):1913–23.
Article
CAS
PubMed
Google Scholar
Agholme F, Li XH, Ke HZ, Aspenberg P. Sclerostin antibody treatment enhances metaphyseal bone healing in rats. J Bone Miner Res. 2010;25(11):2412–8.
Article
CAS
PubMed
Google Scholar
Mcgeelawrence ME, Ryan ZC, Carpio LR, Kakar S, Westendorf JJ, Kumar R. Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification. Biochemical Biophysical Res Communications. 2013;441(4):886–90.
Article
CAS
Google Scholar
Bernhardsson M, Aspenberg P. Osteoblast precursors and inflammatory cells arrive simultaneously to sites of a trabecular-bone injury. Acta Orthop. 2018;89(4):457–61.
Article
PubMed
PubMed Central
Google Scholar
Xie C, Liang B, Xue M, Lin AS, Loiselle A, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X. Rescue of impaired fracture healing in COX-2−/− mice via activation of prostaglandin E2 receptor subtype 4. Am J Pathol. 2009;175(2):772–85.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gao F, Lv TR, Zhou JC, Qin XD. Effects of obesity on the healing of bone fracture in mice. J Orthop Surg Res. 2018;13(1):145.
Article
PubMed
PubMed Central
Google Scholar
Gaur T, Lengner CJ, Hovhannisyan H, Bhat RA, Bodine PV, Komm BS, Javed A, van Wijnen AJ, Stein JL, Stein GS, et al. Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J Biol Chem. 2005;280(39):33132–40.
Article
CAS
PubMed
Google Scholar
Chen S, Feng J, Bao Q, Li A, Zhang B, Shen Y, Zhao Y, Guo Q, Jing J, Lin S. Adverse effects of osteocytic constitutive activation of ß-catenin on bone strength and bone growth. J Bone Min Res. 2015;30(7):1184–94.
Article
CAS
Google Scholar
Chen T, Li J, Cordova LA, Liu B, Mouraret S, Sun Q, Salmon B, Helms J. A WNT protein therapeutic improves the bone-forming capacity of autografts from aged animals. Sci Rep. 2018;8(1):119.
Article
PubMed
PubMed Central
CAS
Google Scholar
McKibbin B. The biology of fracture healing in long bones. J Bone Joint Surg Br. 1978;60-b(2):150–62.
Article
CAS
PubMed
Google Scholar
Marsell R, Einhorn TA. The biology of fracture healing. Injury. 2011;42(6):551–5.
Article
PubMed
PubMed Central
Google Scholar
Li X, Quigg RJ, Zhou J, Ryaby JT, Wang H. Early signals for fracture healing. J Cell Biochem. 2005;95(1):189–205.
Article
CAS
PubMed
Google Scholar
Lombardo F, Komatsu D, Hadjiargyrou M. Molecular cloning and characterization of mustang, a novel nuclear protein expressed during skeletal development and regeneration. FASEB J. 2004;18(1):52–61.
Article
CAS
PubMed
Google Scholar
Carano RA, Filvaroff EH. Angiogenesis and bone repair. Drug Discov Today. 2003;8(21):980–9.
Article
CAS
PubMed
Google Scholar
Saran U, Gemini Piperni S, Chatterjee S. Role of angiogenesis in bone repair. Arch Biochem Biophys. 2014;561:109–17.
Article
CAS
PubMed
Google Scholar
Olsen JJ, Pohl SO, Deshmukh A, Visweswaran M, Ward NC, Arfuso F, Agostino M, Dharmarajan A. The role of Wnt Signalling in angiogenesis. Clin Biochem Rev. 2017;38(3):131–42.
PubMed
PubMed Central
Google Scholar
Choi SH, Kim H, Lee HG, Kim BK, Park JY, Kim DY, Ahn SH, Han KH, Kim SU. Dickkopf-1 induces angiogenesis via VEGF receptor 2 regulation independent of the Wnt signaling pathway. Oncotarget. 2017;8(35):58974–84.
Article
PubMed
PubMed Central
Google Scholar
Hu K, Olsen BR. The roles of vascular endothelial growth factor in bone repair and regeneration. Bone. 2016;91:30–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Karki S, Ngo DTM, Farb MG, Park SY, Saggese SM, Hamburg NM, Carmine B, Hess DT, Walsh K, Gokce N. WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-A165b in obese humans. Am J Physiol Heart Circ Physiol. 2017;313(1):H200–6.
Article
PubMed
PubMed Central
Google Scholar
Haxaire C, Hay E, Geoffroy V. Runx2 controls bone Resorption through the Down-regulation of the Wnt pathway in osteoblasts. Am J Pathol. 2016;186(6):1598–609.
Article
CAS
PubMed
Google Scholar
Rudnicki MA, Williams BO. Wnt signaling in bone and muscle. Bone. 2015;80:60–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ryan ZC, Craig TA, Salisbury JL, Carpio LR, McGee-Lawrence M, Westendorf JJ, Kumar R. Enhanced prostacyclin formation and Wnt signaling in sclerostin deficient osteocytes and bone. Biochem Biophys Res Commun. 2014;448(1):83–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pietrogrande L, Raimondo E. Teriparatide in the treatment of non-unions: scientific and clinical evidences. Injury. 2013;44(Suppl 1):S54–7.
Article
PubMed
Google Scholar
Milstrey A, Wieskoetter B, Hinze D, Grueneweller N, Stange R, Pap T, Raschke M, Garcia P. Dose-dependent effect of parathyroid hormone on fracture healing and bone formation in mice. J Surg Res. 2017;220:327–35.
Article
CAS
PubMed
Google Scholar
Huang TW, Chuang PY, Lin SJ, Lee CY, Huang KC, Shih HN, Lee MS, Hsu RW, Shen WJ. Teriparatide improves fracture healing and early functional recovery in treatment of osteoporotic intertrochanteric fractures. Medicine (Baltimore). 2016;95(19):e3626.
Article
CAS
Google Scholar
Barnes GL, Einhorn TA. Enhancement of fracture healing with parathyroid hormone. Clin Rev Bone Min Metab. 2006;4(4):269–75.
Article
CAS
Google Scholar
Yu B, Zhao X, Yang C, Crane J, Xian L, Lu W, Wan M, Cao X. Parathyroid hormone induces differentiation of mesenchymal stromal/stem cells by enhancing bone morphogenetic protein signaling. J Bone Miner Res. 2012;27(9):2001–14.
Article
CAS
PubMed
Google Scholar
Zanotti S, Canalis E. Parathyroid hormone inhibits notch signaling in osteoblasts and osteocytes. Bone. 2017;103:159–67.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lombardi G, Di Somma C, Rubino M, Faggiano A, Vuolo L, Guerra E, Contaldi P, Savastano S, Colao A. The roles of parathyroid hormone in bone remodeling: prospects for novel therapeutics. J Endocrinol Investig. 2011;34(7 Suppl):18–22.
CAS
Google Scholar
Beresford JN, Bennett JH, Devlin C, Leboy PS, Owen ME. Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci. 1992;102(Pt 2):341–51.
Article
CAS
PubMed
Google Scholar
Burkhardt R, Kettner G, Bohm W, Schmidmeier M, Schlag R, Frisch B, Mallmann B, Eisenmenger W, Gilg T. Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone. 1987;8(3):157–64.
Article
CAS
PubMed
Google Scholar
Bergman RJ, Gazit D, Kahn AJ, Gruber H, McDougall S, Hahn TJ. Age-related changes in osteogenic stem cells in mice. J Bone Miner Res. 1996;11(5):568–77.
Article
CAS
PubMed
Google Scholar
Gruber R, Koch H, Doll BA, Tegtmeier F, Einhorn TA, Hollinger JO. Fracture healing in the elderly patient. Exp Gerontol. 2006;41(11):1080–93.
Article
PubMed
Google Scholar
Ekeland A, Engesoeter LB, Langeland N. Influence of age on mechanical properties of healing fractures and intact bones in rats. Acta Orthop Scand. 1982;53(4):527–34.
Article
CAS
PubMed
Google Scholar
Bak B, Andreassen TT. The effect of aging on fracture healing in the rat. Calcif Tissue Int. 1989;45(5):292–7.
Article
CAS
PubMed
Google Scholar
Strube P, Sentuerk U, Riha T, Kaspar K, Mueller M, Kasper G, Matziolis G, Duda GN, Perka C. Influence of age and mechanical stability on bone defect healing: age reverses mechanical effects. Bone. 2008;42(4):758–64.
Article
PubMed
Google Scholar
Bailey AJ, Sims TJ, Ebbesen EN, Mansell JP, Thomsen JS, Mosekilde L. Age-related changes in the biochemical properties of human cancellous bone collagen: relationship to bone strength. Calcif Tissue Int. 1999;65(3):203–10.
Article
CAS
PubMed
Google Scholar
Mosekilde L. Age-related changes in bone mass, structure, and strength--effects of loading. Z Rheumatol. 2000;59(Suppl 1):1–9.
Article
PubMed
Google Scholar
Giannoudis P, Tzioupis C, Almalki T, Buckley R. Fracture healing in osteoporotic fractures: is it really different? A basic science perspective. Injury. 2007;38(Suppl 1):S90–9.
Article
PubMed
Google Scholar
Villareal DT, Morley JE. Trophic factors in aging. Should older people receive hormonal replacement therapy? Drugs Aging. 1994;4(6):492–509.
Article
CAS
PubMed
Google Scholar