Articles

HEMGN and SLC2A1 might be potential diagnostic biomarkers of steroid-induced osteonecrosis of femoral head: study based on WGCNA and DEGs screening

Steroid-induced osteonecrosis of the femoral head (SONFH) is a chronic and crippling bone disease. This study aims to reveal novel diagnostic biomarkers of SONFH.

Authors: Zhixin Wu, Yinxian Wen, Guanlan Fan, Hangyuan He, Siqi Zhou and Liaobin Chen

ACTION trial: a prospective study on diagnostic Accuracy of 4D CT for diagnosing Instable ScaphOlunate DissociatioN

Early detection of scapholunate ligament (SLL) tears is essential after minor and major trauma to the wrist. The differentiation between stable and instable injuries determines therapeutic measures which aim t...

Authors: Leonie Goelz, Simon Kim, Claas Güthoff, Frank Eichenauer, Andreas Eisenschenk, Sven Mutze and Ariane Asmus

Osteoporotic vertebral fracture misdiagnosed as “normal postoperative phenomenon” in post decompression surgery: a case report

Previous research and published literature indicate that some patients with spinal diseases who underwent percutaneous transforaminal endoscopic decompression (PTED) still suffer some discomfort in the early r...

Authors: Li-sheng Hou, Dong Zhang, Feng Ge, Hai-feng Li and Tian-jun Gao

Cervical sagittal alignment after Prestige LP cervical disc replacement: radiological results and clinical impacts from a single-center experience

Cervical disc replacement (CDR) has been widely used to treat one- and two-level cervical degenerative disc disease. Studies have shown the effectiveness of CDR in preserving range of motion (ROM) and delaying...

Authors: Xiaofei Wang, Yang Meng, Hao Liu, Hua Chen, Beiyu Wang and Ying Hong

Comparison between velocity‐specific exercise and isometric exercise on neck muscle functions and performance: a randomised clinical trial

Evidence has shown that velocity-specific exercise results in additional benefits for peripheral joint muscles by promoting their functions, however, its effects on spinal muscles are yet to be investigated. T...

Authors: Sharon MH Tsang, Kenneth TK Chan, Parco LT Ho, Jacky CY Kwok, Daniel HT Tse and Henry HT Tsoi

Short-term effectiveness of precise safety decompression via double percutaneous lumbar foraminoplasty and percutaneous endoscopic lumbar decompression for lateral lumbar spinal canal stenosis: a prospective cohort study

This prospective cohort study reports on a modified technique, namely precise safety decompression via double percutaneous lumbar foraminoplasty (DPLF) and percutaneous endoscopic lumbar decompression (PELD) f...

Authors: Yu Wang, Mingyan Deng, Hao Wu, Ye Wu, Chuan Guo, Dongfeng Zhang and Qingquan Kong

Improving osteoarthritis management in primary healthcare: results from a quasi-experimental study

To improve quality of care for patients with hip and knee osteoarthritis (OA), general practitioners (GPs) and physiotherapists (PTs) in a Norwegian municipality initiated an intervention. The intervention aim...

Authors: Nina Østerås, Irma Brandeggen Blaker, Tore Hjortland, Elizabeth Cottrell, Jonathan G. Quicke, Krysia S. Dziedzic, Steven Blackburn and Aksel Paulsen

Total spine magnetic resonance imaging for detection of multifocal infection in pyogenic spondylodiscitis: a retrospective observational study

Due to the unspecific symptoms of spondylodiscitis (SpD), an early radiological examination is necessary. However, controversially discussed is the need for magnetic resonance imaging of the entire spine to ex...

Authors: Jeanette Henkelmann, Timm Denecke, Philipp Pieroh, Stephanie Einhorn, Nicolas H. von der Hoeh, Christoph-Eckhard Heyde and Anna Voelker

Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) is a primary cause of degenerative disc diseases; however, the mechanisms underlying the degeneration remain unclear. The immunoinflammatory response plays an important ...

Authors: Zhu Guo, Chensheng Qiu, Christina Mecca, Yang Zhang, Jiang Bian, Yan Wang, Xiaolin Wu, Tianrui Wang, Weiliang Su, Xianglin Li, Wei Zhang, Bohua Chen and Hongfei Xiang

Height and volume restoration in osteoporotic vertebral compression fractures: a biomechanical comparison of standard balloon kyphoplasty versus Tektona® in a cadaveric fracture model

Standard balloon kyphoplasty represents a well-established treatment option for osteoporotic vertebral compression fractures. Aim of the present study was to evaluate two different methods of percutaneous augm...

Authors: Antonio Krüger, Martin Bäumlein, Tom Knauf, Hugues Pascal-Moussellard, Steffen Ruchholtz and Ludwig Oberkircher

Factors associated with failure of bony union after conservative treatment of acute cases of unilateral lumbar spondylolysis

If bone union is expected, conservative treatment is generally selected for lumbar spondylolysis. However, sometimes conservative treatments are unsuccessful. We sought to determine the factors associated with...

Authors: Masaki Tatsumura, Hisanori Gamada, Shun Okuwaki, Fumihiko Eto, Katsuya Nagashima, Takeshi Ogawa, Takeo Mammoto, Atsushi Hirano, Masao Koda and Masashi Yamazaki

Preliminary clinical outcomes of the double-row anchor suture-bridge technique for the fixation of tibial intercondylar eminence fractures in adults: a 12-months minimal follow-up

Tibial intercondylar eminence avulsion fractures occur primarily in adolescents and young adults. However, the incidence of such fractures is increasing in adults, concurrent with an increase in sports injurie...

Authors: Yupeng Chu, Ting Hu, Mangmang Chen, Chendi Jiang, Zhuqi Wu and Junwu Shi

Comparison of three treatment methods for simple bone cyst in children

The unicameral bone cyst (UBC) is a kind of benign tumor whose clinical treatments and efficacy are controversial. The purpose of this study was to evaluate the efficacy of the elastic stable intramedullary na...

Authors: Ke-Xue Zhang, Wei Chai, Jia-Jia Zhao, Jun-Hao Deng, Zhan Peng and Ji-Ying Chen

Proper positioning of mice for Cobb angle radiographic measurements

There is no recommended standard for positioning of a mouse for radiographic assessment of the spine. This is necessary to have reproducible radiographic data and avoid false positive results. The objective of...

Authors: Zhe Yi Chen, Keith Dip Kei Luk, You Qiang Song, Bo Gao and Jason Pui Yin Cheung

Neglect of relevant treatment recommendations in the conduct and reporting of a laser therapy knee osteoarthritis trial: letter to the editor

We read with interest the article by Gomes et al. entitled: “Exercise program combined with electrophysical modalities in subjects with knee osteoarthritis: A randomised, placebo-controlled clinical trial”. Gomes...

Authors: Martin Bjørn Stausholm and Jan Magnus Bjordal

Characterization of bone metabolism in hungarian psoriatic arthritis patients: a case–control study

Skeletal manifestations are predominant in psoriatic arthritis (PsA). The aim of this cross-sectional, case-control study is the complex assessment of areal and volumetric bone mineral density (BMD), fracture ...

Authors: Zsófia Pethő, Edit Kalina, Zoltán Pap, Katalin Hodosi, Rebeka Falcsik, Ádám Balogh, Zoltán Szekanecz and Harjit Pal Bhattoa

Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density

Primary hyperparathyroidism (PHPT) is a common endocrinopathy that may increase fracture risk and decrease bone mineral density (BMD). Some patients develop distal renal tubular acidification dysfunction under...

Authors: Wangna Tang, Hongwei Jia, Baoping Wang, Yun Chai, Tong Liu, Hao Wang and Chenlin Dai

A cluster-randomized trial of workplace ergonomics and neck-specific exercise versus ergonomics and health promotion for office workers to manage neck pain – a secondary outcome analysis

Neck pain is prevalent among office workers. This study evaluated the impact of an ergonomic and exercise training (EET) intervention and an ergonomic and health promotion (EHP) intervention on neck pain inten...

Authors: Venerina Johnston, Xiaoqi Chen, Alyssa Welch, Gisela Sjøgaard, Tracy A. Comans, Megan McStea, Leon Straker, Markus Melloh, Michelle Pereira and Shaun O’Leary

LncRNA HOTTIP leads to osteoarthritis progression via regulating miR-663a/ Fyn-related kinase axis

Long non-coding RNA (lncRNA) has been implicated in the progression of osteoarthritis (OA). This study was aimed to explore the role and molecular mechanism of lncRNA HOXA terminal transcriptional RNA (HOTTIP)...

Authors: Xianwei He, Kun Gao, Shuaihua Lu and Rongbo Wu

The predictive factors that are associated with the number of sutures used during meniscal repair

To investigate factors associated with the consumption of a large number of sutures during arthroscopic meniscus repair procedures.

Authors: Xiaoxiao Song, Dongyang Chen, Xinsheng Qi, Qing Jiang and Caiwei Xia

Evaluation of efficacy and safety of percutaneous transforaminal endoscopic surgery (PTES) for surgical treatment of calcified lumbar disc herniation: a retrospective cohort study of 101 patients

Percutaneous transforaminal endoscopy has been widely used to treat lumbar disc herniation (LDH), but the steep learning curve and difficulties in removing the calcified disc hinders the application of convent...

Authors: Hao Wang, Tianyao Zhou, Yutong Gu and Zuoqin Yan

Exercise-therapy and education for individuals one year after anterior cruciate ligament reconstruction: a pilot randomised controlled trial

Guided rehabilitation beyond 6-months is rare following anterior cruciate ligament reconstruction (ACLR), despite high prevalence of unacceptable symptoms and quality of life (QoL). Our primary aim was to dete...

Authors: Brooke E. Patterson, Christian J. Barton, Adam G. Culvenor, Randall L. Cooper and Kay M. Crossley

The IlluminOss® photodynamic bone stabilization system for pathological osteolyses and fractures of the humerus: indications, advantages and limits in a series of 12 patients at 24 months of minimum follow‐up

Locked titanium nails are considered the reference treatment for metastatic bone lesions of the humerus in patients with aggressive histotypes, high risk of fracture or when estimated survival is lower than 6 ...

Authors: Carmine Zoccali, Dario Attala, Mattia Pugliese, Alessandra Scotto di Uccio and Jacopo Baldi

Association of cardiotrophin-like cytokine factor 1 levels in peripheral blood mononuclear cells with bone mineral density and osteoporosis in postmenopausal women

Recent research has suggested that cardiotrophin-like cytokine factor 1 (CLCF1) may be an important regulator of bone homeostasis. Furthermore, a whole gene chip analysis suggested that the expression levels o...

Authors: Xuan Chen, Jianyang Li, Yunjin Ye, Jingwen Huang, Lihua Xie, Juan Chen, Shengqiang Li, Sainan Chen and Jirong Ge

Positive airway pressure therapy for obstructive sleep apnea in patients with Osteogenesis imperfecta: a prospective pilot study

Obstructive sleep apnea (OSA) is prevalent in individuals with Osteogenesis imperfecta (OI). To date, no study has investigated treatment of OSA in adult individuals with OI using positive airway pressure (PAP...

Authors: Heidi Arponen, Adel Bachour, Leif Bäck, Helena Valta, Antti Mäkitie, Outi Mäkitie and Janna Waltimo-Sirén

A retrospective cohort study on prevalence of postoperative complications in comminuted patellar fractures: comparisons among stabilized with Cannulated-Screw, Kirschner-Wire, or Ring-Pin Tension Bands

Displaced patellar fractures are commonly treated with open reduction and fixation with several different types of tension-band (TB) constructs. The main objective of this study was to compare the prevalence o...

Authors: Xiao-zhong Zhu, Teng-li Huang, Hong-yi Zhu, Bing-bo Bao, Tao Gao, Xing-wei Li, Jun-qing Lin and Xian-You Zheng

Photobiomodulation therapy and the clinical reality in Brazil: response to the letter to the editor

Authors: Cid André Fidelis de Paula Gomes, Almir Vieira Dibai-Filho, Fabiano Politti, Adriano Rodrigues de Oliveira, Cheila de Souza Bacelar Pereira, Aron Charles Barbosa da Silva and Daniela Aparecida Biasotto-Gonzalez

Functional outcomes of full-endoscopic spine surgery for high-grade migrated lumbar disc herniation: a prospective registry-based cohort study with more than 5 years of follow-up

Full-endoscopic lumbar discectomy (FELD) is an alternative to posterior open surgery to treat a high-grade migrated herniated disc. However, because of the complexity of the surgery, success is dependent on th...

Authors: Christopher Wu, Ching-Yu Lee, Sheng Chi Chen, Shao-Keh Hsu and Meng-Huang Wu

Fracture-related outcome study for operatively treated tibia shaft fractures (F.R.O.S.T.): registry rationale and design

Tibial shaft fractures (TSFs) are among the most common long bone injuries often resulting from high-energy trauma. To date, musculoskeletal complications such as fracture-related infection (FRI) and compromis...

Authors: Willem-Jan Metsemakers, Kirsten Kortram, Nando Ferreira, Mario Morgenstern, Alexander Joeris, Hans-Christoph Pape, Christian Kammerlander, Sanjit Konda, Jong-Keon Oh, Peter V. Giannoudis, Kenneth A. Egol, William T. Obremskey, Michael H. J. Verhofstad and Michael Raschke

Adapting MRI as a clinical outcome measure for a facioscapulohumeral muscular dystrophy trial of prednisone and tacrolimus: case report

Facioscapulohumeral muscular dystrophy (FSHD) is a patchy and slowly progressive disease of skeletal muscle. MRI short tau inversion recovery (STIR) sequences of patient muscles often show increased hyperinten...

Authors: Leo H. Wang, Laura M. Johnstone, Michael Bindschadler, Stephen J. Tapscott and Seth D. Friedman

Comparative analysis of clinical factors associated with pedicle screw pull‐out during or immediately after surgery between intraoperative cone‐beam computed tomography and postoperative computed tomography

No studies to date have elucidated the clinical factors associated with pedicle screw pull-out during or immediately after surgery. The aim of this study was to assess the frequency of pedicle screw pull-out b...

Authors: Satoshi Sumiya, Kazuyuki Fukushima, Yoshiro Kurosa, Takashi Hirai, Hiroyuki Inose, Toshitaka Yoshii and Atsushi Okawa

Predictive ability of pharyngeal inlet angle for the occurrence of postoperative dysphagia after occipitocervical fusion

PIA has been proven to be a predictor for postoperative dysphagia in patients who undergo occipitospinal fusion. However, its predictive effect for postoperative dysphagia in patients who undergo OCF is unknow...

Authors: Lin-nan Wang, Bo-wen Hu, Yue-ming Song, Li-min Liu, Chun-guang Zhou, Lei Wang and Xi Yang

Temporary hemiepiphysiodesis using an eight‐plate implant for coronal angular deformity around the knee in children aged less than 10 years: efficacy, complications, occurrence of rebound and risk factors

Temporary hemiepiphysiodesis (TH) using an eight-Plate implant is one of the most common surgeries used for the correction of coronal angular deformities around the knee in adolescents. However, few studies ha...

Authors: Zhen-Zhen Dai, Zhen-Peng Liang, Hao Li, Jing Ding, Zhen-Kai Wu, Zi-Ming Zhang and Hai Li

Defining the role of TT-TG and TT-PCL in the diagnosis of lateralization of the Tibial tubercle in recurrent patellar dislocation

The radiological indicators can help doctors determine whether to make tibial tubercle transfer. But which indicator is better is still in question.

Authors: Peng Su, Nengri Jian, Beini Mao, Zhong Zhang, Jian Li and Weili Fu

Musculoskeletal pathology as an early warning sign of systemic amyloidosis: a systematic review of amyloid deposition and orthopedic surgery

Transthyretin and immunoglobulin light-chain amyloidoses cause amyloid deposition throughout various organ systems. Recent evidence suggests that soft tissue amyloid deposits may lead to orthopedic conditions ...

Authors: Austin E. Wininger, Brian M. Phelps, Jessica T. Le, Joshua D. Harris, Barry H. Trachtenberg and Shari R. Liberman

Conservative versus surgical management for patients with rotator cuff tears: a systematic review and META-analysis

This study aims to compare conservative versus surgical management for patients with full-thickness RC tear in terms of clinical and structural outcomes at 1 and 2 years of follow-up.

Authors: Umile Giuseppe Longo, Laura Risi Ambrogioni, Vincenzo Candela, Alessandra Berton, Arianna Carnevale, Emiliano Schena and Vincenzo Denaro

Is preoperative glenoid bone mineral density associated with aseptic glenoid implant loosening in anatomic total shoulder arthroplasty?

Aseptic loosening of glenoid implants is the primary revision cause in anatomic total shoulder arthroplasty (aTSA). While supported by biomechanical studies, the impact of glenoid bone quality, more specifical...

Authors: Sandrine Mariaux, Raphaël Obrist, Alain Farron, Fabio Becce and Alexandre Terrier

Effectiveness of reverse total shoulder arthroplasty for primary and secondary fracture care: mid-term outcomes in a single-centre experience

The introduction of reverse total shoulder arthroplasty (RSA) as a treatment option in complex proximal humeral fractures, has significantly extended the surgical armamentarium.

Authors: AM Schwarz, GM Hohenberger, M Sauerschnig, M Niks, G Lipnik, G Mattiassich, M Zacherl, FJ Seibert and M Plecko

Clinical and cost effectiveness of arthritis gloves in rheumatoid arthritis (A-GLOVES): randomised controlled trial with economic analysis

Arthritis (or compression) gloves are widely prescribed to people with rheumatoid arthritis and other forms of hand arthritis. They are prescribed for daytime wear to reduce hand pain and improve hand function...

Authors: Alison Hammond, Yeliz Prior, Sarah Cotterill, Chris Sutton, Elizabeth Camacho, Calvin Heal, Jo Adams, Yvonne Hough, Terence W. O’Neill and Jill Firth

Effects of unweighting on gait kinematics during walking on a lower-body positive-pressure treadmill in patients with hip osteoarthritis

Hip osteoarthritis (OA) is a musculoskeletal condition that makes walking difficult due to pain induced by weight-bearing activities. Treadmills that support the body weight (BW) reduce the load on the lower l...

Authors: Yoshiaki Kataoka, Tomohiro Shimizu, Ryo Takeda, Shigeru Tadano, Yuki Saito, Satoshi Osuka, Tomoya Ishida, Mina Samukawa, Tohru Irie, Daisuke Takahashi, Norimasa Iwasaki and Harukazu Tohyama

Hyperalgesia affects muscle activity and knee range of motion during a single-limb mini squat in individuals with knee osteoarthritis: a cross-sectional study

The effect of hyperalgesia on functionality remains uncertain for individuals with knee osteoarthritis (KOA). This study aimed examine the clinical measures and hyperalgesia’s effect on muscle activity, knee r...

Authors: Jéssica Garcia Jorge, Ana Luiza Costa e Silva Cabral, Vanessa Martins Pereira Silva Moreira, Wallisen Tadashi Hattori and Valdeci Carlos Dionisio

Patterns of coronal and sagittal deformities in adolescent idiopathic scoliosis

Thoracic scoliosis has been shown to be associated with hypokyphosis in adolescent idiopathic scoliosis (AIS). However, the relationship of sagittal spino-pelvic parameters with different coronal curve pattern...

Authors: Trixie Mak, Prudence Wing Hang Cheung, Teng Zhang and Jason Pui Yin Cheung

Associations of objectively measured total duration and maximum bout length of standing at work with lower-extremity pain intensity: a 2-year follow-up of construction and healthcare workers

Musculoskeletal disorders are among the major reasons for years lived with disability. Approximately one third of the European working population report lower-extremity discomfort and many attribute these disc...

Authors: Lars-Kristian Lunde, Suzanne Merkus, Markus Koch, Stein Knardahl, Morten Wærsted and Kaj Bo Veiersted

Patient-reported outcomes in young adults with osteonecrosis secondary to developmental dysplasia of the hip - a longitudinal and cross-sectional evaluation

Osteonecrosis of the femoral head is a common complication in the treatment of developmental dysplasia of the hip (DDH). While functional outcomes of affected patients are good in childhood, it is not clear ho...

Authors: Avi Marks, Mario Cortina-Borja, Dror Maor, Aresh Hashemi-Nejad and Andreas Roposch

Open synovectomy treatment for intra- and extraarticular localized pigmented villonodular synovitis of the knee: a case report

Pigmented villonodular synovitis (PVNS) is a rare, benign, proliferative neoplastic process that commonly affects synovial-lined anatomic spaces. The diffuse type (DPVNS) is characterized by invasion of the en...

Authors: Daoliang Xu, Jianxia Wen, Shisi Zhang and Xiaoyun Pan

The association between keloid and osteoporosis: real-world evidence

Keloids are characterized by disturbance of fibroblast proliferation and apoptosis, deposition of collagen, and upregulation of dermal inflammation cells. This benign dermal fibro-proliferative scarring condit...

Authors: Chun-Ching Lu, Hao Qin, Zi-Hao Zhang, Cong-Liang Zhang, Ying-Yi Lu and Chieh-Hsin Wu

Clinical study of anatomical ACL reconstruction using a rounded rectangular dilator

The aim of this study was that to compare clinical results between the rounded rectangular femoral tunnel ACL reconstruction (RFTR) and the conventional round femoral tunnel ACL reconstruction using a hamstrin...

Authors: Junsuke Nakase, Yasushi Takata, Kengo Shimozaki, Kazuki Asai, Rikuto Yoshimizu, Mitsuhiro Kimura and Hiroyuki Tsuchiya

Treatment of diaphyseal forearm defects caused by infection using Ilizarov segmental bone transport technique

The Ilizarov segmental bone transport technique can be applied in the reconstruction of the bone defects with less invasive fashion and more versatility compared to other methods, while most studies were focus...

Authors: Yanshi Liu, Maimaiaili Yushan, Zhenhui Liu, Jialin Liu, Chuang Ma and Aihemaitijiang Yusufu

Polyglucosan body myopathy 1 may cause cognitive impairment: a case report from China

Polyglucosan body myopathy 1 (PGBM1) is a type of glycogen storage disease that can cause skeletal muscle myopathy and cardiomyopathy with or without immunodeficiency due to a pathogenic mutation in the RBCK1 ...

Authors: Lin Chen, Nan Wang, Wenbin Hu, Xuen Yu, Renming Yang, Yongzhu Han, Yan Yan, Na Nian and Congbo Sha

Reconstruction of massive tibial bone and soft tissue defects by trifocal bone transport combined with soft tissue distraction: experience from 31 cases

Large post-traumatic tibial bone defects combined with soft tissue defects are a common orthopedic clinical problem associated with poor outcomes when treated using traditional surgical methods. The study was ...

Authors: Yong-Qing Xu, Xin-Yu Fan, Xiao-Qing He and Hong-Jie Wen