Li X, Hu Z, Cui J, Han Y, Pan J, Yang M, et al. Percutaneous endoscopic lumbar discectomy for recurrent lumbar disc herniation. Int J Surg. 2016;27:8–16.
Article
CAS
PubMed
Google Scholar
Mizrahi O, Sheyn D, Tawackoli W, Ben-David S, Su S, Li N, et al. Nucleus pulposus degeneration alters properties of resident progenitor cells. Spine J. 2013;13(7):803–14.
Article
PubMed
PubMed Central
Google Scholar
Li X, Wang X, Hu Z, Chen Z, Li H, Liu X, et al. Possible involvement of the oxLDL/LOX-1 system in the pathogenesis and progression of human intervertebral disc degeneration or herniation. Sci Rep. 2017;7(1):7403.
Article
PubMed
PubMed Central
CAS
Google Scholar
Koerner JD, Markova DZ, Yadla S, Mendelis J, Hilibrand A, Vaccaro AR, et al. Differential gene expression in anterior and posterior annulus fibrosus. Spine (Phila Pa 1976). 2014;39(23):1917–23.
Article
Google Scholar
Lee JM, Song JY, Baek M, Jung HY, Kang H, Han IB, et al. Interleukin-1beta induces angiogenesis and innervation in human intervertebral disc degeneration. J Orthop Res. 2011;29(2):265–9.
Article
CAS
PubMed
Google Scholar
Sheng B, Feng C, Zhang D, Spitler H, Shi L. Associations between obesity and spinal diseases: A medical expenditure panel study analysis. Int J Environ Res Public Health. 2017;14(2):183.
Article
PubMed Central
Google Scholar
Jakoi AM, Pannu G, D'Oro A, Buser Z, Pham MH, Patel NN, et al. The clinical correlations between diabetes, cigarette smoking and obesity on intervertebral degenerative disc disease of the lumbar spine. Asian Spine J. 2017;11(3):337–47.
Article
PubMed
PubMed Central
Google Scholar
Zhao CQ, Liu D, Li H, Jiang LS, Dai LY. Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation. Spine (Phila Pa 1976). 2008;33(23):E858–64.
Article
Google Scholar
Griffin TM, Huebner JL, Kraus VB, Guilak F. Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis Rheum. 2009;60(10):2935–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell. 2000;100(2):197–207.
Article
CAS
PubMed
Google Scholar
Sasaki T, Kuroko M, Sekine S, Matsui S, Kikuchi O, Susanti VY, et al. Overexpression of insulin receptor partially improves obese and diabetic phenotypes in db/db mice. Endocr J. 2015;62(9):787–96.
Article
CAS
PubMed
Google Scholar
Hummel KP, Dickie MM, Coleman DL. Diabetes, a new mutation in the mouse. Science. 1966;153(3740):1127–8.
Article
CAS
PubMed
Google Scholar
Ernst A, Sharma AN, Elased KM, Guest PC, Rahmoune H, Bahn S. Diabetic db/db mice exhibit central nervous system and peripheral molecular alterations as seen in neurological disorders. Transl Psychiatry. 2013;3:e263.
Article
CAS
PubMed
PubMed Central
Google Scholar
Poloni M, Nappi G, Arrigo A, Savoldi F. Cerebrospinal fluid 5-hydroxyindoleacetic acid level in migrainous patients during spontaneous attacks, during headache-free periods and following treatment with L-tryptophan. Experientia. 1974;30(6):640–1.
Article
CAS
PubMed
Google Scholar
Calorini L, Fallani A, Tombaccini D, Mugnai G, Ruggieri S. Lipid composition of cultured B16 melanoma cell variants with different lung-colonizing potential. Lipids. 1987;22(9):651–6.
Article
CAS
PubMed
Google Scholar
Huang L, You YK, Zhu TY, Zheng LZ, Huang XR, Chen HY, et al. Validity of leptin receptor-deficiency (db/db) type 2 diabetes mellitus mice as a model of secondary osteoporosis. Sci Rep. 2016;6:27745.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ribeiro M, Lopez de Figueroa P, Nogueira-Recalde U, Centeno A, Mendes AF, Blanco FJ, et al. Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation. Osteoarthr Cartil. 2016;24(12):2116–25.
Article
CAS
Google Scholar
Aguirre GA, De Ita JR, de la Garza RG, Castilla-Cortazar I. Insulin-like growth factor-1 deficiency and metabolic syndrome. J Transl Med. 2016;14:3.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ranke MB. Insulin-like growth factor-I treatment of growth disorders, diabetes mellitus and insulin resistance. Trends Endocrinol Metab. 2005;16(4):190–7.
Article
CAS
PubMed
Google Scholar
Pratipanawatr T, Pratipanawatr W, Rosen C, Berria R, Bajaj M, Cusi K, et al. Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects. Am J Physiol Endocrinol Metab. 2002;282(6):E1360–8.
Article
CAS
PubMed
Google Scholar
Fraenkel M, Caloyeras J, Ren SG, Melmed S. Sex-steroid milieu determines diabetes rescue in pttg-null mice. J Endocrinol. 2006;189(3):519–28.
Article
CAS
PubMed
Google Scholar
Leiter EH, Chapman HD. Obesity-induced diabetes (diabesity) in C57BL/KsJ mice produces aberrant trans-regulation of sex steroid sulfotransferase genes. J Clin Invest. 1994;93(5):2007–13.
Article
CAS
PubMed
PubMed Central
Google Scholar
D'Souza AM, Johnson JD, Clee SM, Kieffer TJ. Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lep (Ob/Ob) mice. Mol Metab. 2016;5(11):1103–12.
Article
CAS
PubMed
PubMed Central
Google Scholar
Saukkonen T, Shojaee-Moradie F, Williams RM, Amin R, Yuen KC, Watts A, et al. Effects of recombinant human IGF-I/IGF-binding protein-3 complex on glucose and glycerol metabolism in type 1 diabetes. Diabetes. 2006;55(8):2365–70.
Article
CAS
PubMed
Google Scholar
Williams GA, Callon KE, Watson M, Costa JL, Ding Y, Dickinson M, et al. Skeletal phenotype of the leptin receptor-deficient db/db mouse. J Bone Miner Res. 2011;26(8):1698–709.
Article
CAS
PubMed
Google Scholar
Burkemper KM, Garris DR. Influences of obese (Ob/Ob) and diabetes (db/db) genotype mutations on lumber vertebral radiological and morphometric indices: skeletal deformation associated with dysregulated systemic glucometabolism. BMC Musculoskelet Disord. 2006;7:10.
Article
PubMed
PubMed Central
CAS
Google Scholar
Ealey KN, Fonseca D, Archer MC, Ward WE. Bone abnormalities in adolescent leptin-deficient mice. Regul Pept. 2006;136(1–3):9–13.
Article
CAS
PubMed
Google Scholar
Hamrick MW, Pennington C, Newton D, Xie D, Isales C. Leptin deficiency produces contrasting phenotypes in bones of the limb and spine. Bone. 2004;34(3):376–83.
Article
CAS
PubMed
Google Scholar
Chen J, Liang L, Zhan L, Zhou Y, Zheng L, Sun X, et al. ZiBuPiYin recipe protects db/db mice from diabetes-associated cognitive decline through improving multiple pathological changes. PLoS One. 2014;9(3):e91680.
Article
PubMed
PubMed Central
CAS
Google Scholar
Maor G, Rochwerger M, Segev Y, Phillip M. Leptin acts as a growth factor on the chondrocytes of skeletal growth centers. J Bone Miner Res. 2002;17(6):1034–43.
Article
CAS
PubMed
Google Scholar
Cornish J, Callon KE, Bava U, Lin C, Naot D, Hill BL, et al. Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol. 2002;175(2):405–15.
Article
CAS
PubMed
Google Scholar
Gordeladze JO, Drevon CA, Syversen U, Reseland JE. Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: impact on differentiation markers, apoptosis, and osteoclastic signaling. J Cell Biochem. 2002;85(4):825–36.
Article
CAS
PubMed
Google Scholar
Holloway WR, Collier FM, Aitken CJ, Myers DE, Hodge JM, Malakellis M, et al. Leptin inhibits osteoclast generation. J Bone Miner Res. 2002;17(2):200–9.
Article
CAS
PubMed
Google Scholar
Steppan CM, Crawford DT, Chidsey-Frink KL, Ke H, Swick AG. Leptin is a potent stimulator of bone growth in Ob/Ob mice. Regul Pept. 2000;92(1–3):73–8.
Article
CAS
PubMed
Google Scholar
Song Y, Wang Y, Zhang Y, Geng W, Liu W, Gao Y, et al. Advanced glycation end products regulate anabolic and catabolic activities via NLRP3-inflammasome activation in human nucleus pulposus cells. J Cell Mol Med. 2017;21(7):1373–87.
Article
CAS
PubMed
PubMed Central
Google Scholar
Joseph JR, Farooqui Z, Smith BW, Kahn EN, Liu X, La Marca F, et al. Does clinical improvement of symptomatic degenerative lumbar disease impact obesity? J Neurosurg Spine. 2017;26(6):705–8.
Article
PubMed
Google Scholar
Tsarouhas A, Soufla G, Tsarouhas K, Katonis P, Pasku D, Vakis A, et al. Molecular profile of major growth factors in lumbar intervertebral disc herniation: correlation with patient clinical and epidemiological characteristics. Mol Med Rep. 2017;15(4):2195–203.
Article
CAS
PubMed
PubMed Central
Google Scholar
Han C, Kuang MJ, Ma JX, Ma XL. Prevalence of Modic changes in the lumbar vertebrae and their associations with workload, smoking and weight in northern China. Sci Rep. 2017;7:46341.
Article
CAS
PubMed
PubMed Central
Google Scholar
Illien-Junger S, Lu Y, Qureshi SA, Hecht AC, Cai W, Vlassara H, et al. Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice. PLoS One. 2015;10(2):e0116625.
Article
PubMed
PubMed Central
CAS
Google Scholar
Illien-Junger S, Grosjean F, Laudier DM, Vlassara H, Striker GE, Iatridis JC. Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes. PLoS One. 2013;8(5):e64302.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ahsan R, Tajima N, Chosa E, Sugamata M, Sumida M, Hamada M. Biochemical and morphological changes in herniated human intervertebral disc. J Orthop Sci. 2001;6(6):510–8.
Article
CAS
PubMed
Google Scholar
Alini M, Li W, Markovic P, Aebi M, Spiro RC, Roughley PJ. The potential and limitations of a cell-seeded collagen/hyaluronan scaffold to engineer an intervertebral disc-like matrix. Spine (Phila Pa 1976). 2003;28(5):446–54 discussion 453.
Google Scholar
Urano T, Narusawa K, Shiraki M, Usui T, Sasaki N, Hosoi T, et al. Association of a single nucleotide polymorphism in the insulin-like growth factor-1 receptor gene with spinal disc degeneration in postmenopausal Japanese women. Spine (Phila Pa 1976). 2008;33(11):1256–61.
Article
Google Scholar
Seki S, Kawaguchi Y, Chiba K, Mikami Y, Kizawa H, Oya T, et al. A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nat Genet. 2005;37(6):607–12.
Article
CAS
PubMed
Google Scholar
An JL, Zhang W, Zhang J, Lian LC, Shen Y, Ding WY. Vitamin D improves the content of TGF-beta and IGF-1 in intervertebral disc of diabetic rats. Exp Biol Med (Maywood). 2017;242(12):1254–61.
Article
CAS
Google Scholar