Fig. 4
From: Intervertebral disc degeneration in mice with type II diabetes induced by leptin receptor deficiency
Incresed cell apoptosis in intervertebral disc cells of db/db mice indcued by leptin receptor knock out. a, b, c Representative TUNEL assay shows cell death for the intervertebral disc in WT, IGF treated and db/db group. d Quantitative analysis of the percentage of TUNEL-positive cells to the total cells per view in (a, b, c). (N = 5, triplicates per group). All data are reported as the mean ± s.d. Statistical significance was determined by three-way ANOVA and Student’s t-test. *P < 0.05(IGF-1 treated group compare to WT). #P < 0.05(db/db group compare to WT). aP < 0.05(IGF-1 treated compare to db/db group)