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Fig. 1 | BMC Musculoskeletal Disorders

Fig. 1

From: Intervertebral disc degeneration in mice with type II diabetes induced by leptin receptor deficiency

Fig. 1

Bone mass decreased in vertebral bone of db/db mice indcued by leptin receptor knock out. (A) Representative μCT scans of the fifth lumbar spine showing the 3D reconstructed trabecular bones. (B) (a) Quantitative analysis of the percentage of bone marrow density (BMD). (b) Quantitative analysis of the percentage of bone volume (BV/TV) (c) Quantitative analysis of trabecular thickness (Tb.Th). (d) Quantitative analysis of trabecular spacing (Tb.Sp). (e) Quantitative analysis of trabecular number (BV/TV). All analyses were performed with 5 mice per group. All data are reported as the mean ± s.d. Statistical significance was determined by three-way ANOVA and Student’s t-test. NS = not significant. *P < 0.05 (IGF-1 group compare to WT). #P < 0.05(db/db group compare to WT)

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