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Effects of mind–body exercise on knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

BMC Musculoskeletal Disorders volume 25, Article number: 229 (2024) Cite this article

Abstract

Objective

To evaluate the effect of mind–body exercise on improving knee osteoarthritis (KOA) and thereby informing osteoarthritis exercise rehabilitation.

Methods

The China National Knowledge Infrastructure (CNKI), Wanfang, PubMed/Medline, Cochrane Library, Web of Science, EBSCO, Embase, Scopus, and ProQuest databases were searched to identify randomized controlled trials (RCTs) that involved tai chi, yoga, and baduanjin interventions for KOA. The search period ranged from inception to October 25, 2022. The methodological quality of the included studies was evaluated by the Cochrane risk of bias assessment tool, and the included data were statistically analyzed and plotted using Review Manager 5.3 and Stata 14.0 software.

Results

We included 17 articles with a total of 1122 patients. Compared with the control group, mind–body exercise significantly improved patient pain (standardized mean difference (SMD) = -0.65, 95% confidence interval (CI) [-0.87, -0.42], p < 0.00001), stiffness (SMD = -0.75, 95% CI [-1.05, -0.45], p < 0.00001), physical function (SMD = -0.82, 95% CI [-1.03, -0.62], p < 0.00001), mental health (SMD = 0.31, 95% CI [0.11, 0.51], p = 0.002), and depression (SMD = -0.32, 95% CI [-0.50, -0.15], p = 0.0003). In terms of motor ability, mind–body exercise significantly increased the 6-min walking distance (SMD = 18.45, 95% CI [5.80, 31.10], p = 0.004) and decreased timed up and go test time (SMD = -1.15, 95% CI [-1.71, -0.59], p < 0.0001).

Conclusions

The current study showed that mind–body exercise is safe and effective for KOA patients. However, given the methodological limitations of the included studies, additional high-quality evidence is needed to support the conclusions of this study.

Peer Review reports

Background

Knee osteoarthritis (KOA) is a common progressive joint disease involving tissues such as cartilage and subchondral bone; this disease can induce physical disability and functional impairment in elderly individuals [1]. Different factors cause KOA, such as aging, obesity, trauma, and genetics, which ultimately lead to problems such as joint pain, stiffness, and loss of joint function. The global incidence of (radiologically diagnosed) KOA is 3.8%, but among people older than 60 years, the incidence exceeds 10% [2]. At present, the clinical treatment goals are mostly limited to analgesia and improvement of function [3]. Except for surgical treatment (in cases when conservative treatment is ineffective), KOA can be treated by both drug and nondrug means [4]. While pharmacological interventions can reduce pain and improve physical function, accumulating evidence suggests that long-term use of drugs and intra-articular injections may cause adverse effects such as gastrointestinal reactions, multiple-organ failure, pain, and swelling [5]. Therefore, identification of simple and effective nondrug treatment methods is urgently needed.

In recent decades, complementary and alternative medicine has become popular among patients with various types of diseases [6]. Mind–body exercise has been incorporated into treatment and has been shown to improve neuromuscular activity and physical health [7]. Tai chi, yoga, and baduanjin are the three most popular forms of mind–body exercise; researchers have examined their effects on biological processes and responses such as inflammation [8]. Tai chi and baduanjin are traditional Chinese medicine (TCM) fitness exercises involving specific movements or postures, breathing coordination, and mental focus. Yoga originated in ancient India and usually includes specific body postures, breathing control, meditation, and relaxation. Accumulating evidence indicates that mind–body exercise can improve depressive symptoms [9], help in treating chronic obstructive pulmonary disease [10, 11], relieve chronic pain in middle-aged and elderly people [12], improve cognitive function in elderly individuals with mild cognitive impairment [13,14,15], and improve symptoms of posttraumatic stress disorder [16].

According to our review of KOA, few studies have integrated findings focused on different types of mind–body exercise as a whole. In the present study, we aimed to systematically evaluate and quantify the effects of mind–body exercise on pain, stiffness, physical function, mental health, depression, and motor ability in patients with KOA.

Methods

Registration and search strategy

This review was registered in the Prospective Register of Systematic Reviews (PROSPERO, ID: CRD42022367434). Articles were retrieved from nine electronic databases: China National Knowledge Infrastructure (CNKI), Wanfang, PubMed/Medline, Cochrane Library, Web of Science, EBSCO, Embase, Scopus, and ProQuest. In each database, we combined the following groups of terms for the search: (1) "Taichi" OR "Baduanjin" OR "Yoga"; (2) "osteoarthritis, knee" OR "KOA" OR "osteoarthritis of the knee". The period of the search ranged from database inception to October 25, 2022; relevant studies were added retrospectively.

Study inclusion criteria

The included studies were all randomized controlled trials (RCTs) published in Chinese or English. The subjects were patients with confirmed KOA. The interventions conducted in the experimental group included tai chi, yoga, or baduanjin, and the intervention duration was at least 8 weeks. The control group interventions involved health education, physical therapy, attentional control, or no intervention. The outcome indicators were pain, stiffness, physical function, mental health, depression, timed up and go (TUG) test time, and 6-min walk test (6-MWT) time.

Study exclusion criteria

The exclusion criteria for studies were as follows: 1) the experimental group underwent mind–body exercise combined with other interventions, 2) the study lacked a control group or had a control group involving another exercise intervention, 3) data related to outcome indicators could not be extracted, 4) duplicate publications, or 5) the full text could not be obtained.

Study screening and data extraction

The data extraction form was designed in advance, and information extraction was completed independently by two authors. The extracted information included the following: 1) basic study information (first author, publication year, country, and research design), 2) characteristics of the research subjects (age, sex, diagnostic method, and sample size), 3) experimental intervention (exercise form, exercise frequency, and exercise cycle), 4) control conditions, 5) outcome indicators, 6) adverse reactions, and 7) relevant information regarding study quality. The above two authors resolved any disagreements through discussion, and the third author provided suggestions when the disagreement could still not be resolved.

We compared the differences in the changes between the intervention and control groups to determine the effects of mind–body exercise. The data are expressed as the means and standard deviations (SDs), and the data in other formats (such as 95% confidence intervals (CIs)) were translated to the means ± SDs as described in the Cochrane Handbook [17].

Evaluation of study quality

The methodological quality of the included studies was assessed using the Cochrane risk of bias assessment tool. The assessed items included random sequence generation, allocation sequence concealment, blinding of subjects and investigators, blinding of outcome measurers, outcome data incompleteness, selective reporting, and other potential sources of bias. According to the risk of bias assessment criteria, a judgment of "low risk of bias", "high risk of bias", or "unclear" was issued for each item.

Statistical analysis

This study used Review Manager 5.3 statistical software for study quality evaluation, data merging, heterogeneity testing, and forest plot generation. The extracted outcome indicators were all continuous variables. If the measurement tools used were the same among the studies, the weighted mean difference (WMD) and 95% CI were selected as the effect magnitude for analysis; if the measurement tools were different, the standard mean difference (SMD) and its 95% CI were used as the effect magnitude for analysis.

Heterogeneity was evaluated with I2 values: I2 ≤ 25% indicated mild heterogeneity; 25% < I2 < 50% indicated moderate heterogeneity; 50% < I2 < 75% indicated substantial heterogeneity; and I2 ≥ 75% indicated high heterogeneity. When I2 < 50% and p ≥ 0.1, a fixed-effects model was used for meta-analysis; otherwise, a random-effects model was used for analysis. When the merged data included more than 10 items and the heterogeneity was substantial, subgroup analysis, Egger's test and sensitivity analysis were performed with Review Manager 5.3 and Stata 14.0.

Results

Literature search results

The preliminary search yielded 569 articles in the searched databases, including the CNKI (8 articles), Wanfang (36 articles), PubMed/Medline (18 articles), Cochrane Library (55 articles), Web of Science (93 articles), EBSCO (46 articles), Embase (160 articles), Scopus (136 articles), and ProQuest databases (17 articles). Eight supplementary articles were retrospectively added, for a total of 577 articles. The bibliographies was imported into EndNote X7, and 330 articles remained after duplicates were eliminated. After screening, 17 articles were ultimately included in the quantitative analysis (Fig. 1).

Fig. 1
figure 1

PRISMA flow chart of articles screening procedure

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Study characteristics

The basic characteristics of the included studies are shown in Table 1 and 2. A total of 17 articles (18 studies) were included in this study, including two studies extracted from the paper of Liu et al. [18], with a total sample of 1122 people. The studies were published from 2008 to 2022 and were conducted in China (n = 7), Australia (n = 1), the USA (n = 7), Canada (n = 1), or Korea (n = 1). Participants were diagnosed with KOA by the American College of Rheumatology (ACR) classification criteria, the diagnostic criteria of the American Rheumatism Association (ARA), the Kellgren-Lawrence Scale (KL), the National Institute for Health and Care Excellence (NICE) osteoarthritis clinical criteria, X-ray imaging, or physician confirmation.

Table 1 Basic information of the included studies
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Table 2 Mind–body exercise Intervention and Outcome Index of the Included Studies
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Of the 18 included studies, 10 studies [18, 20, 22, 25, 27,28,29,30,31, 34] involved tai chi as the intervention, four involved yoga [21, 23, 24, 26], and four involved baduanjin [18, 19, 32, 33]. The duration of the mind–body exercises ranged from 8 to 24 weeks, with 2–5 exercise sessions per week. There were almost no reports of adverse events related to mind–body exercises.

Risk of bias assessment

Of the 17 articles included, 15 [18, 20,21,22,23,24,25,26,27,28,29,30, 32,33,34] described the process of generating random sequences, seven [21, 22, 24, 26, 27, 30, 33] reported allocation concealment, and 12 [20, 22,23,24,25,26,27, 29, 30, 32,33,34] reported the blinding of outcome assessors. Among the included articles, 5 [18, 19, 21, 28, 31] had a high risk of performance bias because they failed to blind the participants and personnel. One article [21] reported the outcomes by using online questionnaires (self-reported) and thus was considered to have a high risk of detection bias. Three articles [18, 26, 34] did not report all outcomes and so were categorized as having a high risk of reporting bias. The risk assessment results of all included studies are shown in Figs. 2 and 3.

Fig. 2
figure 2

Risk of bias graph

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Fig. 3
figure 3

Risk of bias summary

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Data synthesis analysis

Effects of mind–body exercise on pain, stiffness, and physical function indicators

In the included studies, pain, stiffness, and physical function were measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) or the Knee Injury and Osteoarthritis Outcome Score (KOOS). Due to the use of different measurement tools, we calculated the SMDs and their 95% CIs to determine the effect sizes of the interventions.

Pain: Seventeen articles [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34] (18 studies) were included in the pain analysis, for a total sample of 1122 people. The results indicated (Fig. 4) that mind–body exercise was significantly better than was the control intervention at improving pain (random-effects model, SMD = -0.65; 95% CI = -0.87, -0.42; p < 0.00001).

Fig. 4
figure 4

Forest plots showing standardized mean difference of change on the pain between Mind–body exercise group and a control/comparison group

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The meta-analysis showed that there was substantial heterogeneity between studies (I2 = 66%, p < 0.0001). Subgroup analysis was performed to explore the possible sources of heterogeneity and showed that duration, frequency, and sex were significant factors influencing the heterogeneity of studies on pain (Table 3).

Table 3 Results of subgroup analysis affecting pain heterogeneity
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Stiffness: Sixteen articles [18,19,20,21,22,23,24,25, 27,28,29,30,31,32,33,34] (17 studies) were included in the stiffness analysis, for a total sample of 1102 people. The results indicated (Fig. 5) that mind–body exercise was significantly better than was the control condition at improving stiffness (random-effects model, SMD = -0.75; 95% CI: -1.05, -0.45; p < 0.00001).

Fig. 5
figure 5

Forest plots showing standardized mean difference of change on the stiffness between Mind–body exercise group and a control/comparison group

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The meta-analysis showed that there was high heterogeneity among the studies (I2 = 81%, p < 0.00001). The subgroup analysis showed that duration and frequency were significant factors influencing the heterogeneity of studies on stiffness (Table 4).

Table 4 Results of subgroup analysis affecting stiffness heterogeneity
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Physical function: Seventeen articles [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34] (18 studies) were included in the physical function analysis, for a total sample of 1122 people. The results suggested (Fig. 6) that mind–body exercise was significantly better than was the control condition at improving physical function (random-effects model, SMD = -0.82; 95% CI: -1.03, -0.62; p < 0.00001).

Fig. 6
figure 6

Forest plots showing standardized mean difference of change on the physical function between Mind–body exercise group and a control/comparison group

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The meta-analysis showed that there was substantial heterogeneity among the studies (I2 = 58%, p = 0.001). The subgroup analysis showed that exercise type, duration, frequency, sex, and region were significant factors influencing the heterogeneity of studies on physical function (Table 5).

Table 5 Results of subgroup analysis affecting physical function heterogeneity
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Effect of mind–body exercise on mental health and depression indicators

In the included studies, the 12-item Short Form Survey (SF-12) and SF-36 were used to assess mental health. Depression was measured with scales such as the Beck Depression Inventory, Hospital Anxiety and Depression Scale, and Center for Epidemiologic Studies Depression Scale. Due to the differences in the measurement tools used, the effect sizes of the included studies were calculated according to the SMDs and 95% CIs.

Mental Health: Six studies [19, 22,23,24, 27, 30] were included in the analysis, for a total sample of 400 people. The meta-analysis indicated moderate heterogeneity among the studies (I2 = 28%, p = 0.22). The results indicated (Fig. 7) that mind–body exercise was significantly better than was the control condition at improving mental health (fixed-effects model, SMD = 0.31; 95% CI = 0.11, 0.51; p = 0.002).

Fig. 7
figure 7

Forest plots showing standardized mean difference of change on the mental health between Mind–body exercise group and a control/comparison group

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Depression: Four studies [21, 22, 24, 30] were included in the depression analysis, for a total sample of 511 people. The meta-analysis indicated substantial heterogeneity among the studies (I2 = 63%, p = 0.04). The results indicated (Fig. 8) that mind–body exercise was significantly better than was the control condition at improving depression (fixed-effects model, SMD = -0.32; 95% CI: -0.50, -0.15; p = 0.0003).

Fig. 8
figure 8

Forest plots showing standardized mean difference of change on the depression between Mind–body exercise group and a control/comparison group

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Effect of mind–body exercise on 6-MWT and TUG times

The 6-MWT and TUG times were measured using the same methods in all the included studies, with meters (of distance) and stopwatches, respectively. The WMDs and 95% CIs were calculated to determine the effect size.

6-MWT: Six studies [19, 22, 26, 28, 30, 31] were included in the 6-MWT analysis, for a total sample of 364 people. The meta-analysis indicated substantial heterogeneity among the studies (I2 = 62%, p = 0.02). The results indicated (Fig. 9) that mind–body exercise was significantly better than was the control condition at increasing 6-MWT time (fixed-effects model, WMD = 18.45; 95% CI: 5.8, 31.1; p = 0.004).

Fig. 9
figure 9

Forest plots showing standardized mean difference of change on the 6-MWT between Mind–body exercise group and a control/comparison group

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TUG time: Three studies [26, 28, 31] were included in the TUG analysis, for a total sample of 99 people. The meta-analysis indicated no heterogeneity among the studies (I2 = 0%, p = 0.71). The results indicated (Fig. 10) that mind–body exercise was significantly better than was the control condition at reducing TUG time (fixed-effects model, WMD = -1.15; 95% CI: -1.71, -0.59; p < 0.0001).

Fig. 10
figure 10

Forest plots showing standardized mean difference of change on the TUG between Mind–body exercise group and a control/comparison group

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Sensitivity analysis

Sensitivity analysis was performed for variables with substantial heterogeneity using Stata 14.0. The results are shown in Figs. 11, 12 and 13. The included pain, stiffness and physical function variables had good sensitivity, as exclusion of any individual experiment did not lead to significant changes in the total effect size. According to the sensitivity analysis, the pooled effect of mind–body exercise on improving pain, stiffness and physical function was robust.

Fig. 11
figure 11

Sensitivity Analysis Plot of Pain

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Fig. 12
figure 12

Sensitivity Analysis Plot of Stiffness

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Fig. 13
figure 13

Sensitivity Analysis Plot of Physical function

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Evaluation of publication bias

Egger's test was used to detect publication bias in experiments with substantial heterogeneity. The test result for the effect of mind–body exercise on pain was t = -2.69 (95% CI: -4.634, -0.552; P = 0.016). Egger’s test of the effect of mind–body exercise on stiffness yielded a t = -2.93 (95% CI = -6.417, -1.01; P = 0.01). Egger’s test of the effect of mind–body exercise on physical function intervention yielded a t = -2.59 (95% CI: -4.133, -0.415; P = 0.023). The results suggest that there was publication bias in the intervention effects of mind–body exercise on pain, stiffness, and physical function.

Discussion

Overall findings

Mind–body exercise, described as low-intensity exercise that enhances body–mind coordination and awareness through exercise, such as by controlling movement and concentration [35] and focusing on interactions among the mind, brain, behavior, and body [36], has been used to treat a variety of chronic pain disorders [37,38,39]. This form of exercise is considered suitable for middle-aged and elderly individuals [40, 41]. There are many advantages to using mind–body exercise as an adjunctive treatment for patients with KOA compared with first-line treatments (medications, physical therapy, intra-articular injections). There are few known adverse events associated with this type of exercise, which is particularly important for older patients who are prone to drug side effects and potential drug‒drug interactions. Compared to traditional exercises, which target muscle strength and the cardiovascular and respiratory systems, mind–body exercise has additional physiological, psychological, and clinical effects [42]. Fogaca LZ et al. [43] suggested mind–body exercises for different disease fields based on an evidence map, providing a reference for patients and researchers. The present meta-analysis combined data from three types of mind–body exercises: tai chi, yoga, and baduanjin. Eighteen RCTs (17 articles) with a sample size of 1,122 people were included. The results showed that mind–body exercise can effectively improve pain, stiffness, physical function, mental health, depression, and motor ability.

Selfe TK et al. [44] conducted a systematic review of the effects of tai chi, yoga, and baduanjin on pain and physical function in patients with KOA; however, they did not perform a meta-analysis. Our study analyzed additional outcome indicators (pain, physical function, stiffness, mental health, depression, 6-MWT time, and TUG time) and included additional RCTs (18). Our meta-analysis showed that, compared with the control group, mind–body exercise significantly improved pain (SMD = -0.65; 95% CI: -0.87, -0.42; p < 0.00001), stiffness (SMD = -0.75; 95% CI: -1.05, -0.45; p < 0.00001), and physical function (SMD = -0.82; 95% CI: -1.03, -0.62; p < 0.00001). Goh et al. [45] compared the effects of different exercise interventions on the physical function, pain, and quality of life of patients with knee and hip osteoarthritis. Mind–body exercise and aerobic exercise seemed to yield the greatest improvements in pain and physical function. They found that mind–body exercise and aerobic exercise were equally effective at reducing pain.

Because of the high heterogeneity, subgroup analyses based on exercise type, duration, frequency, sex, and region were conducted. In terms of improving pain, stiffness, and physical function, the source of heterogeneity might be attributed to the duration and frequency of mind–body exercises. In the included studies, the duration of mind–body exercises ranged from 8 to 24 weeks, and the frequency was 2–5 times per week. Mind–body exercise twice a week did not significantly improve stiffness. With a duration of more than 12 weeks, the effects of mind–body exercise on pain, stiffness and physical function were more significant.

In addition, the subgroup analysis showed that tai chi, yoga, and baduanjin had consistent beneficial effects on stiffness and physical function. These findings are consistent with previous meta-analyses involving one or two types of mind–body exercises [5, 46,47,48,49]. In terms of pain, the present study showed that the effects of tai chi and yoga on pain improvement were significant, while the effect of baduanjin was not significant, which is consistent with the subgroup analysis of Li et al. [5]. A review of the included data revealed some inconsistent results; specifically, Ye et al. [32, 33] reported that a 12-week baduanjin intervention did not significantly improve pain, which is inconsistent with the results of Liu et al. [18]. Differences in interventions (such as in the frequency and duration of exercise) and in assessment scales among the studies may have affected the research findings. Few studies have evaluated the use of a baduanjin intervention in KOA patients, and additional RCTs are needed for further evaluation.

Depression is associated with pain, worse physical function, and structural disease progression in patients with osteoarthritis [50]. One-fifth of adults with osteoarthritis suffer from depression in addition to chronic pain [51]. Available evidence [52, 53] suggests a bidirectional relationship between pain and depression; that is, each affects the severity of the other. However, depression is often overlooked—in particular, overt osteoarthritis symptoms mask less apparent depression symptoms—limiting its diagnosis [54]. Future treatments should focus on both pain and depression in KOA patients. Kroenke et al. [55] confirmed that simultaneous treatment of depression and pain can improve pain and physical function in patients. Rathbun et al. [56] explained why a single treatment strategy is not effective for osteoarthritis patients with depression. Among KOA patients, depressive symptoms have been associated with poorer future physical function, but the relationship is partly mediated by pain (approximately one-fifth), and the magnitude of the effect decreases with increasing depressive symptoms. The results of the present study showed that in addition to reducing pain, mind–body exercise also significantly improved depression in patients, which may explain why mind–body exercise yields substantial benefits.

Another notable effect of mind–body exercise is the improved motor ability of KOA patients. The meta-analysis showed that, compared with the control condition, mind–body exercise significantly increased the 6-MWT time (18.45; 95% CI: 5.80, 31.10; p = 0.004) and significantly decreased the TUG time (-1.15; 95% CI: -1.71, -0.59; p < 0.0001). These findings are consistent with those of the meta-analysis on tai chi by Hu et al. [46]. Shimizu H et al. reported that patients with early KOA took longer to complete the TUG test [57]. In a separate study on knee osteoarthritis, ALGHADIR et al. reported minimal detectable change (MDC) values for the TUG test of 1.14 s [58].

At present, the specific mechanism underlying the effect of mind–body exercise on KOA patients has not been fully elucidated. Preliminary evidence suggests that mind–body exercise may exert therapeutic effects by improving joint proprioception and inducing central nervous system plasticity. Proprioception is necessary for preventing excessive movement and maintaining postural stability and motor coordination, which are potentially important for preventing joint injury. KOA patients exhibit impaired proprioceptive (positional and motor sense) accuracy, but this appears to be the result of structural degeneration rather than an early risk factor for KOA onset [59]. Multiple RCTs have shown that mind–body exercise positively affects knee proprioception [32, 60, 61].

The dorsolateral prefrontal cortex (DLPFC) plays an important role in pain regulation. After a 12-week intervention consisting of tai chi and baduanjin, KOA patients showed decreased resting-state functional connectivity between the DLPFC and supplementary motor areas as well as enhanced resting-state functional connectivity between the DLPFC and anterior cingulate cortex [62]. In addition, tai chi significantly increased the gray matter volume in the auxiliary motor areas. Shen et al. explored the relationships of brain functional connectivity with pain and physical function in postmenopausal women with KOA after an 8-week tai chi intervention [63]. The study revealed a moderate-to-high correlation between postintervention changes in connectivity between the amygdala and medial prefrontal cortex and improvements in pain and physical function, suggesting that mind–body exercise may modulate pain and physical function by directly affecting the cerebral cortex.

Limitations

This study has several limitations. First, the included studies were limited to those published in English or Chinese, which may have led to incompleteness bias. Second, this study analyzed only data collected immediately after the intervention; thus, it lacked analysis of long-term effects. Third, there are obvious shortcomings in the methods used in these studies. For example, more than 70% of the studies had a sample size of less than 30, most studies were single-blinded (evaluator), and some studies lacked allocation concealment, which may have affected the study results. Finally, mind–body exercise intervention programs vary greatly, and this paper does not provide suggestions on the optimal exercise scheme (such as exercise frequency, exercise timing, or exercise duration).

Conclusions

Mind–body exercise can effectively improve pain, stiffness, physical function, mental health, depression, and motor ability in KOA patients. After combining these results with the low risk of adverse events in the included studies, we concluded that mind–body exercise is a safe and effective KOA intervention. Given the methodological limitations of the included studies, additional high-quality evidence is needed to support the conclusions of this study.

Availability of data and materials

The data are available in this published article and can be procured from the corresponding author upon request.

Abbreviations

KOA:

Knee osteoarthritis

RCTs:

Randomized controlled trials

KOOS:

Knee Injury and Osteoarthritis Outcome Score

6-MWT:

Six-minute walk test

WOMAC:

Western Ontario and McMaster Universities Osteoarthritis Index

TUG:

Timed up and go

DLPFC:

Dorsolateral prefrontal cortex

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  1. School of Physical Education, Soochow University, Suzhou, 215021, China

    Hujun Qiao & Guoxiang Wang

  2. Changzhi University, Changzhi, 046000, China

    Hujun Qiao & Xin Hao

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GXW conceived and designed the study. HJQ carried out the literature searches. HJQ and XH selected the studies, extracted the data, assessed the study quality, and wrote the manuscript. HJQ performed the statistical analyses. GXW, XH and HJQ revised the manuscript. All the authors have read and approved the final manuscript.

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Qiao, H., Hao, X. & Wang, G. Effects of mind–body exercise on knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. BMC Musculoskelet Disord 25, 229 (2024). https://doi.org/10.1186/s12891-024-07278-4

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Keywords

BMC Musculoskeletal Disorders

ISSN: 1471-2474

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