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  1. Research article

    Rheumatoid factors do not predict cardiovascular disease and mortality in the general population in the Busselton Health Survey

    Rheumatoid Factors (RF) are antibodies directed against the Fc portion of IgG and are involved in clearance of immune complexes. While RF can develop in a wide range of conditions, higher RF levels indicate a ...

    Johannes Nossent, Warren Raymond, Mark Divitini and Matthew Knuiman

    BMC Musculoskeletal Disorders 2017 18:221

    Published on: 26 May 2017

  2. Research article

    Efficacy and safety of single injection of cross-linked sodium hyaluronate vs. three injections of high molecular weight sodium hyaluronate for osteoarthritis of the knee: a double-blind, randomized, multi-center, non-inferiority study

    This randomized, double-blind, multi-center, non-inferiority trial was conducted to assess the efficacy and safety of a cross-linked hyaluronate (XLHA, single injection form) compared with a linear high molecu...

    Chul-Won Ha, Yong-Beom Park, Chong-Hyuk Choi, Hee-Soo Kyung, Ju-Hong Lee, Jae Doo Yoo, Ju-Hyung Yoo, Choong-Hyeok Choi, Chang-Wan Kim, Hee-Chun Kim, Kwang-Jun Oh, Seong-Il Bin and Myung Chul Lee

    BMC Musculoskeletal Disorders 2017 18:223

    Published on: 26 May 2017

  3. Research article

    Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind Trial

    Viscosupplementation is a symptomatic treatment of the knee osteoarthritis based on the intra-articular injection of hyaluronic acid (IAHA). Although many studies have investigated its effect on symptoms, few ...

    Yves Henrotin, Francis Berenbaum, Xavier Chevalier, Marc Marty, Pascal Richette and François Rannou

    BMC Musculoskeletal Disorders 2017 18:222

    Published on: 26 May 2017

  4. Research article

    Influences of lumbar disc herniation on the kinematics in multi-segmental spine, pelvis, and lower extremities during five activities of daily living

    Low back pain (LBP) is a common problem that can contribute to motor dysfunction. Previous studies reporting the changes in kinematic characteristics caused by LBP present conflicting results. This study aimed...

    Shengzheng Kuai, Wenyu Zhou, Zhenhua Liao, Run Ji, Daiqi Guo, Rui Zhang and Weiqiang Liu

    BMC Musculoskeletal Disorders 2017 18:216

    Published on: 25 May 2017

  5. Research article

    Chronic musculoskeletal ankle disorders in Sri Lanka

    Musculoskeletal disorders of the lower extremities are commonly affected by chronicity and disability. One of the most commonly affected areas is the ankle. Epidemiological information is limited for chronic m...

    Ishanka Weerasekara and Claire E. Hiller

    BMC Musculoskeletal Disorders 2017 18:219

    Published on: 25 May 2017

  6. Research article

    Cervical kyphosis in patients with Lenke type 1 adolescent idiopathic scoliosis: the prediction of thoracic inlet angle

    Several studies have explored cervical kyphosis (CK) in adolescent idiopathic scoliosis (AIS) patients. However, few studies have evaluated the cervical alignment in these patients according to their coronal c...

    Ce Zhu, Xi Yang, Bangjian Zhou, Lei Wang, Chunguang Zhou, Tingxian Ling, Limin Liu and Yueming Song

    BMC Musculoskeletal Disorders 2017 18:220

    Published on: 25 May 2017

  7. Research article

    Rotational alignment of femoral component with different methods in total knee arthroplasty: a randomized, controlled trial

    Femoral component rotation (FCR) is one of the most important factors in total knee arthroplasty. In this prospective study, we used three different techniques for FCR and analyzed their accuracy with postoper...

    Joon Kyu Lee, Sahnghoon Lee, Sae Hyung Chun, Ki Tae Kim and Myung Chul Lee

    BMC Musculoskeletal Disorders 2017 18:217

    Published on: 25 May 2017

  8. Research article

    No correlation between radiolucency and biomechanical stability of keeled and pegged glenoid components

    The purpose of this study was to examine biomechanical properties and the degree of radiolucency of two cemented basic glenoid designs for total shoulder arthroplasty. Our hypothesis was that a component with ...

    Andreas Voss, Knut Beitzel, Elifho Obopilwe, Stefan Buchmann, John Apostolakos, Jessica Di Venere, Michael Nowak, Mark P. Cote, Anthony A. Romeo and Augustus D. Mazzocca

    BMC Musculoskeletal Disorders 2017 18:213

    Published on: 25 May 2017

  9. Research article

    Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells

    A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and...

    Christoph Spang, Ludvig J. Backman, Sandrine Le Roux, Jialin Chen and Patrik Danielson

    BMC Musculoskeletal Disorders 2017 18:218

    Published on: 25 May 2017

  10. Research article

    Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients

    Rheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune syst...

    Francesca Romana Spinelli, Arbi Pecani, Francesco Ciciarello, Tania Colasanti, Manuela Di Franco, Francesca Miranda, Fabrizio Conti, Guido Valesini and Cristiano Alessandri

    BMC Musculoskeletal Disorders 2017 18:214

    Published on: 25 May 2017

  11. Study protocol

    Treatment of acute sciatica with transforaminal epidural corticosteroids and local anesthetic: design of a randomized controlled trial

    Transforaminal epidural injections with steroids (TESI) are used increasingly for patients with sciatica. However there is much debate about their safety and effectiveness. It is important to identify patients...

    Bastiaan C. ter Meulen, Esther T. Maas, Amrita Vyas, Marinus van der Vegt, Koo de Priester, Michiel R. de Boer, Maurits W. van Tulder, Henry C. Weinstein and Raymond W. J. G. Ostelo

    BMC Musculoskeletal Disorders 2017 18:215

    Published on: 25 May 2017

  12. Research article

    Analysis of change in gait in the ovine stifle: normal, injured, and anterior cruciate ligament reconstructed

    Many patients who undergo anterior cruciate ligament (ACL) reconstructive surgery develop post-traumatic osteoarthritis (PTOA). ACL reconstructive surgery may not fully restore pre-injury joint biomechanics, t...

    B. J. Heard, J. E. Beveridge, M. Atarod, E. J. O’Brien, C. Rolian, C. B. Frank, D. A. Hart and N. G. Shrive

    BMC Musculoskeletal Disorders 2017 18:212

    Published on: 23 May 2017

  13. Research article

    Usefulness of clinical predictors for preoperative screening of deep vein thrombosis in hip fractures

    Recent studies showed that preoperative deep vein thrombosis (DVT) was common after hip fracture (HF), and preoperative DVT screening has been recommended for preventing the fatal DVT-related complications, es...

    Kitchai Luksameearunothai, Paphon Sa-ngasoongsong, Noratep Kulachote, Sorawut Thamyongkit, Praman Fuangfa, Pongsthorn Chanplakorn, Patarawan Woratanarat and Chanyut Suphachatwong

    BMC Musculoskeletal Disorders 2017 18:208

    Published on: 22 May 2017

  14. Research article

    Distal femoral replacement with the MML system: a single center experience with an average follow-up of 86 months

    The aim of this study was to compare the functional outcomes and complication rates after distal femoral replacement (DFR) performed with the modular Munich-Luebeck (MML) modular prosthesis (ESKA/Orthodynamics...

    Andreas Toepfer, Norbert Harrasser, Paul-Ruben Schwarz, Florian Pohlig, Ulrich Lenze, Heinrich M. L. Mühlhofer, Ludger Gerdesmeyer, Ruediger von Eisenhart-Rothe and Christian Suren

    BMC Musculoskeletal Disorders 2017 18:206

    Published on: 22 May 2017

  15. Research article

    Variation in Prosthetic Joint Infection and treatment strategies during 4.5 years of follow-up after primary joint arthroplasty using administrative data of 41397 patients across Australian, European and United States hospitals

    To identify best practices and quality improvement initiatives, we aimed to assess whether the incidence of Periprosthetic Joint Infection (PJI) and treatment strategies differed across patients treated in Aus...

    Perla J. Marang-van de Mheen, Ellie Bragan Turner, Susan Liew, Nora Mutalima, Ton Tran, Sten Rasmussen, Rob G. H. H. Nelissen and Andrew Gordon

    BMC Musculoskeletal Disorders 2017 18:207

    Published on: 22 May 2017

  16. Research article

    Cross-cultural adaptation and validation of the Spanish version of the Oxford Hip Score in patients with hip osteoarthritis

    Osteoarthritis (OA) of the hip is a disease that entails a major burden for patients and the society as a whole. One way of measuring this burden for the patient is through impact on Health-related Quality of ...

    Jesús Martín-Fernández, Pedro Gray-Laymón, Antonio Molina-Siguero, Javier Martínez-Martín, Roberto García-Maroto, Isidoro García-Sánchez, Lidia García-Pérez, Vanesa Ramos-García, Olga Castro-Casas and Amaia Bilbao

    BMC Musculoskeletal Disorders 2017 18:205

    Published on: 22 May 2017

  17. Research article

    Effects of osteochondral defect size on cartilage regeneration using a double-network hydrogel

    There has been increased interest in one-step cell-free procedures to avoid the problems related to cell manipulation and its inherent disadvantages. We have studied the chondrogenic induction ability of a PAM...

    Kotaro Higa, Nobuto Kitamura, Keiko Goto, Takayuki Kurokawa, Jian Ping Gong, Fuminori Kanaya and Kazunori Yasuda

    BMC Musculoskeletal Disorders 2017 18:210

    Published on: 22 May 2017

  18. Study protocol

    Study protocol: a double blind randomised control trial of high volume image guided injections in Achilles and patellar tendinopathy in a young active population

    Chronic tendinopathy is a significant problem particularly in active populations limiting sporting and occupational performance. The prevalence of patellar tendinopathy in some sports is near 50% and the incid...

    Robert M. Barker-Davies, Alastair Nicol, I. McCurdie, James Watson, Polly Baker, Patrick Wheeler, Daniel Fong, Mark Lewis and Alexander N. Bennett

    BMC Musculoskeletal Disorders 2017 18:204

    Published on: 22 May 2017

  19. Research article

    Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritis

    There have been no previous report of hand joint destruction prevalence in Chinese rheumatoid arthritis (RA) patients. Therefore, the aim of this study was to investigate the prevalence and potential factors o...

    Lijuan Zhang, Jing Wang, Qiuxiang Zhang, Ting Fu, Rulan Yin, Ze Wang, Liren Li, Xianhua Wu and Zhifeng Gu

    BMC Musculoskeletal Disorders 2017 18:211

    Published on: 22 May 2017

  20. Research article

    Bone turnover and periprosthetic bone loss after cementless total hip arthroplasty can be restored by zoledronic acid: a prospective, randomized, open-label, controlled trial

    Although the loss of bone mineral density (BMD) after total hip arthroplasty (THA) is a known problem, it remains unresolved. This study prospectively examined the effect of zoledronic acid (ZA) on bone turnov...

    Tsan-Wen Huang, Chao-Jan Wang, Hsin-Nung Shih, Yuhan Chang, Kuo-Chin Huang, Kuo-Ti Peng and Mel S. Lee

    BMC Musculoskeletal Disorders 2017 18:209

    Published on: 22 May 2017

  21. Research article

    High incidence of periprosthetic joint infection with propionibacterium acnes after the use of a stemless shoulder prosthesis with metaphyseal screw fixation - a retrospective cohort study of 241 patients propionibacter infections after eclipse TSA

    A stemless shoulder prosthesis with humeral metaphyseal screw fixation was introduced in order to save bone-stock and to facilitate reconstruction of biomechanics (Eclipse®). The aim of this study was to analy...

    Lisa Johansson, Nils P Hailer and Hans Rahme

    BMC Musculoskeletal Disorders 2017 18:203

    Published on: 19 May 2017

  22. Research article

    T1rho and T2 relaxation times of the normal adult knee meniscus at 3T: analysis of zonal differences

    Prior studies describe histological and immunohistochemical differences in collagen and proteoglycan content in different meniscal zones. The aim of this study is to evaluate horizontal and vertical zonal diff...

    Shoichiro Takao, Tan B. Nguyen, Hon J. Yu, Shigeo Hagiwara, Yasuhito Kaneko, Taiki Nozaki, Seiji Iwamoto, Maki Otomo, Ran Schwarzkopf and Hiroshi Yoshioka

    BMC Musculoskeletal Disorders 2017 18:202

    Published on: 18 May 2017

  23. Research article

    Immunogenicity and immunomodulatory effects of the human chondrocytes, hChonJ

    Invossa™ (TissueGene-C) is a cell and gene therapy for osteoarthritis. It is composed of primary human chondrocytes (hChonJ cells) and irradiated human chondrocytes modified to express TGF-β1 (hChonJb#7 cells)...

    Chae-Lyul Lim, Yeon-Ju Lee, Jong-Ho Cho, Heonsik Choi, Bumsup Lee, Myung Chul Lee and Sujeong Kim

    BMC Musculoskeletal Disorders 2017 18:199

    Published on: 18 May 2017

  24. Research article

    A multimedia campaign to improve back beliefs in patients with non-specific low back pain: a process evaluation

    Low back pain (LBP) is one of the most prevalent and costly disorders worldwide. To reduce its burden in the Netherlands, implementation of a multidisciplinary guideline for LBP was supported by a multifaceted...

    Arnela Suman, Frederieke G. Schaafsma, Jiman Bamarni, Maurits W. van Tulder and Johannes R. Anema

    BMC Musculoskeletal Disorders 2017 18:200

    Published on: 18 May 2017

  25. Research article

    Multidimensional daily diary of fatigue-fibromyalgia-17 items (MDF-fibro-17): part 2 psychometric evaluation in fibromyalgia patients

    The Multidimensional Daily Diary of Fatigue-Fibromyalgia-17 instrument (MDF-Fibro-17) has been developed for use in fibromyalgia (FM) clinical studies and includes 5 domains: Global Fatigue Experience, Cogniti...

    Y. Li, S. Morris, J. Cole, S. Dube’, J. A. M. Smith, C. Burbridge, T. Symonds, S. Hudgens and W. Wang

    BMC Musculoskeletal Disorders 2017 18:198

    Published on: 18 May 2017

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