Articles

Does breaking up prolonged sitting improve cognitive functions in sedentary adults? A mapping review and hypothesis formulation on the potential physiological mechanisms

Prolonged (excessive) sitting is detrimentally associated with cardiovascular, metabolic and mental health. Moreover, prolonged sitting has been associated with poor executive function, memory, attention and v...

Authors: Baskaran Chandrasekaran, Arto J. Pesola, Chythra R. Rao and Ashokan Arumugam

Pentosan polysulfate sodium for Ross River virus-induced arthralgia: a phase 2a, randomized, double-blind, placebo-controlled study

Alphaviruses, such as Ross River (RRV) and chikungunya virus (CHIKV), cause significant global morbidity, with outbreaks of crippling joint inflammation and pain, leaving patients incapacitated for months to y...

Authors: Ravi Krishnan, Melanie Duiker, Penny A. Rudd, Donna Skerrett, James G. D. Pollard, Carolyn Siddel, Rifat Rifat, Jennifer H. K. Ng, Peter Georgius, Lara J. Hererro and Paul Griffin

Isolated thoracic intramedullary Erdheim-Chester disease presenting with paraplegia: a case report and literature review

Erdheim-Chester disease (ECD) is a rare, idiopathic, systemic non-Langerhans cell histiocytosis involving long bone and visceral organs. Central nervous system (CNS) involvement is uncommon and most cases deve...

Authors: Ikchan Jeon and Joon Hyuk Choi

Locking plate combined with titanium cable for Neer type II distal clavicle fractures

There is controversy about the optimal strategy treatment of unstable distal clavicle fractures. We explored use of a surgical strategy: combination of a distal clavicle locking plate and a titanium cable. The...

Authors: Fan Zhang, Qiang Fu, Yongchuan Li, Nan Lu, Aimin Chen and Liangyu Zhao

Is the contralateral lesser trochanter a reliable reference for planning of total hip arthroplasty – a 3-dimensional analysis

Preoperative templating in total hip arthroplasty (THA) is mandatory to achieve appropriate offset and leg length equality. However, templating methods using the contralateral hip might be susceptible to error...

Authors: Julian Hasler, Armando Hoch, Philipp Fürnstahl, Jakob Ackermann, Patrick O. Zingg and Lazaros Vlachopoulos

Management of acute Achilles tendon ruptures: a survey of Army orthopaedic surgeons

Despite the literature on acute Achilles tendon ruptures, there remains a lack of consensus regarding the optimal treatment. The purpose of this survey study was to investigate treatment preferences among Army...

Authors: Nischal Nadig, Thomas Dowd and Jeannie Huh

Operatively treated ankle fractures in Switzerland, 2002–2012: epidemiology and associations between baseline characteristics and fracture types

Ankle fractures are common, and their incidence has been increasing. Previous epidemiological studies have been conducted in the US, Scandinavia, and Scotland. Our objectives were to provide a current epidemio...

Authors: Diogo Vieira Cardoso, Victor Dubois-Ferrière, Axel Gamulin, Christophe Baréa, Pablo Rodriguez, Didier Hannouche and Anne Lübbeke

Transcranial direct current stimulation (a-tCDS) after subacromial injections in patients with subacromial pain syndrome: a randomized controlled pilot study

Subacromial pain syndrome (SAPS) is a common complaint in orthopaedics. Subacromial corticosteroid injections (CSI) can relieve pain in the short term. Anodal transcranial direct current stimulation (a-tDCS) h...

Authors: Samuel Larrivée, Frédéric Balg, Guillaume Léonard, Sonia Bédard, Michel Tousignant and Patrick Boissy

Preoperative deep venous thrombosis (DVT) after femoral neck fracture in the elderly, the incidence, timing, location and related risk factors

To investigate the epidemiologic characteristics of deep venous thrombosis (DVT) in elderly patients with femoral neck fracture.

Authors: Shuai Niu, Juan Li, Yan Zhao, Dianzhu Ding, Guangwei Jiang and Zhaohui Song

Correction to: Patterns of pain location in music students: a cluster analysis

An amendment to this paper has been published and can be accessed via the original article.

Authors: Cinzia Cruder, Marco Barbero, Emiliano Soldini and Nigel Gleeson

Longitudinal study of MRI and functional outcome measures in facioscapulohumeral muscular dystrophy

Facioscapulohumeral muscular dystrophy (FSHD) is a patchy and slowly progressive disease of skeletal muscle. For MRI to be a useful biomarker in an FSHD clinical trial, it should reliably detect changes over r...

Authors: Leo H. Wang, Dennis W. W. Shaw, Anna Faino, Christopher B. Budech, Leann M. Lewis, Jeffrey Statland, Katy Eichinger, Stephen J. Tapscott, Rabi N. Tawil and Seth D. Friedman

Association of circulating B-type natriuretic peptide with osteoporosis in a Chinese type 2 diabetic population

Altered circulating levels and genetic variation of B-type natriuretic peptide (BNP), has been associated with lower bone mineral density (BMD) values and incidence of osteoporosis in peritoneal dialysis patie...

Authors: Pan Chen, Pijun Yan, Qin Wan, Zhihong Zhang, Yong Xu, Ying Miao and Jun Yang

Fear-of-falling and associated risk factors in persons with rheumatoid arthritis: a 1 year prospective study

Falls, associated injuries and fear-of-falling are common in adults with RA. Fear-of-falling can be a major consequence of, and as debilitating as falling, resulting in a cycle of activity restriction, reduced...

Authors: Emma K. Stanmore, Jackie Oldham, Dawn A. Skelton, Terence O’Neill, Mark Pilling and Chris Todd

Low muscle mass affect hip fracture treatment outcomes in older individuals: a single-institution case-control study

Although sarcopenia has been known as a risk factor for hip fracture, only a few reports have described the impact of muscle mass on hip fracture treatment outcomes. The current study aimed to investigate the ...

Authors: Hiroki Iida, Taisuke Seki, Yoshihito Sakai, Tsuyoshi Watanabe, Norimitsu Wakao, Hiroki Matsui and Shiro Imagama

Incidence and predictors of surgical site infection after distal femur fractures treated by open reduction and internal fixation: a prospective single‐center study

There remain limited data on the epidemiological characteristics and related predictors of surgical site infection (SSI) after open reduction and internal fixation (ORIF) for distal femur fractures (DFFs). We ...

Authors: Chao Zhu, Junzhe Zhang, Junyong Li, Kuo Zhao, Hongyu Meng, Yanbin Zhu and Yingze Zhang

A case of Schnitzler’s syndrome without monoclonal gammopathy successfully treated with canakinumab

Schnitzler’s syndrome (SchS) is a rare autoinflammatory syndrome with diagnostic challenge and be characterized by chronic urticaria, a monoclonal gammopath, periodic fever and bone pain. In addition to the mo...

Authors: Yuya Fujita, Tomoyuki Asano, Akira Sakai, Natsumi Norikawa, Toshiyuki Yamamoto, Haruki Matsumoto, Shuzo Sato, Jumpei Temmoku, Makiko Yashiro-Furuya, Naoki Matsuoka, Hiroshi Watanabe and Kiyoshi Migita

Invited reply to the letter to the editor by McNally et al., 2021

Authors: Christian Morgenstern, Nora Renz, Sabrina Cabric, Elena Maiolo, Carsten Perka and Andrej Trampuz

The importance of appropriate diagnostics in prosthetic joint infection: letter to the editor of BMC musculoskeletal disorders

Assessment of a new diagnostic test must be performed against an acceptable and validated standard to allow comparison with other studies. We are concerned that the adoption of lower diagnostic criteria in thi...

Authors: Martin McNally, Marjan Wouthuyzen-Bakker, Ricardo Sousa, Bridget Atkins and Alex Soriano

The risk factors of postoperative delirium in patients with hip fracture: implication for clinical management

Delirium is a common complication of hip surgery patients. It is necessary to investigate the epidemiological characteristics and related risk factors of delirium after hip fracture surgery, to provide evidenc...

Authors: Weifang Xu, Haiping Ma, Wang Li and Chen Zhang

Hypertension is associated with osteoporosis: a case-control study in Chinese postmenopausal women

Osteoporosis and cardiovascular disease (CVD) are age-related diseases. It is reported that patients with CVD have a higher risk of bone loss. This retrospective study sought to reveal the association between ...

Authors: Hao Chai, Jirong Ge, Li Li, Jianyang Li and Yunjin Ye

Diagnostic value of next-generation sequencing to detect periprosthetic joint infection

We herein compared the diagnostic value of next-generation sequencing (NGS), bacterial culture, and serological biomarkers to detect periprosthetic joint infection (PJI) after joint replacement.

Authors: Han Yin, Duliang Xu and Dawei Wang

Multidisciplinary programme for rehabilitation of chronic low back pain – factors predicting successful return to work

There are no clear indicators for predicting return to work for patients with chronic low back pain (LBP). We aim to report the outcomes of a 14-week multidisciplinary programme targeting patients with chronic...

Authors: Gabriel Ching Ngai Leung, Prudence Wing Hang Cheung, Gareth Lau, Sin Ting Lau, Keith Dip Kei Luk, Yat Wa Wong, Kenneth Man Chee Cheung, Paul Aarne Koljonen and Jason Pui Yin Cheung

Evaluation of an occipito-cervico fusion with a new implant design: a biomechanical study

A novel implant for occipitocervical fusion consisting of a median plate with an additional hook inserting in the foramen magnum was tested. Aim of this study was to test the stability of a new implant for occ...

Authors: Filippo Migliorini, Alice Baroncini, Yasser El Mansy, Valentin Quack, Andreas Prescher, Max Mischer, Johannes Greven, Markus Tingart and Jörg Eschweiler

Major ceRNA regulation and key metabolic signature analysis of intervertebral disc degeneration

Intervertebral disc degeneration (IDD) is a complex multifactorial and irreversible pathological process. In IDD, multiple competing endogenous RNAs (ceRNA, including mRNA, lncRNA, and pseudogenes) can compete...

Authors: Shuai Cao, Jie Li, Kai Yang and Haopeng Li

Physiotherapy utilisation and costs before lumbar spine surgery: a retrospective analysis of workers compensation claims in Australia

Understanding how much physiotherapy people receive before lumbar spine surgery could give insight into what people and clinicians consider an adequate trial of non-operative management. The aim of this study ...

Authors: Joshua R. Zadro, Adriane M. Lewin, Priti Kharel, Justine Naylor, Christopher G. Maher and Ian A. Harris

Characterization of hyaluronan-coated extracellular vesicles in synovial fluid of patients with osteoarthritis and rheumatoid arthritis

Hyaluronic acid (HA) is the major extracellular matrix glycosaminoglycan with a reduced synovial fluid (SF) concentration in arthropathies. Cell-derived extracellular vesicles (EV) have also been proposed to c...

Authors: Anne-Mari Mustonen, Janne Capra, Kirsi Rilla, Petri Lehenkari, Sanna Oikari, Tommi Kääriäinen, Antti Joukainen, Heikki Kröger, Tommi Paakkonen, Johanna Matilainen and Petteri Nieminen

Plasma interleukin-21 levels and genetic variants are associated with susceptibility to rheumatoid arthritis

Rheumatoid Arthritis (RA) is a chronic inflammatory condition characterized by autoantibodies development and an elevated spectrum of pro-inflammatory cytokines. Previous reports highlighted a relationship bet...

Authors: Youguo Hao, Lijun Xie, Jing Xia, Zhen Liu, Baoxiu Yang and Minqin Zhang

A mixed-methods survey to explore issues with virtual consultations for musculoskeletal care during the COVID-19 pandemic

To explore orthopaedic and musculoskeletal clinicians’ views and experiences of legal, safety, safeguarding and security issues regarding the use of virtual consultations (VC) during the COVID-19 pandemic. A s...

Authors: Anthony W Gilbert, Gregory Booth, Tony Betts and Andy Goldberg

Predictors of a placebo response in patients with hand osteoarthritis: post-hoc analysis of two randomized controlled trials

Placebo can have a significant therapeutic effect in patients with hand osteoarthritis (OA). This aim of the study is to identify factors associated with a clinically meaningful placebo response in patients wi...

Authors: Jin Kyun Park, Se Han Ahn, Kichul Shin, Yun Jong Lee, Yeong Wook Song and Eun Bong Lee

Effectiveness of Mulligan manual therapy over exercise on headache frequency, intensity and disability for patients with migraine, tension-type headache and cervicogenic headache – a protocol of a pragmatic randomized controlled trial

Non - pharmacological management of migraine, tension-type headache (TTH), and cervicogenic headache (CGH) may include spinal manual therapy and exercise. Mulligan Manual Therapy (MMT) utilizes a protocol of h...

Authors: Kiran Satpute, Nilima Bedekar and Toby Hall

Independent and sensitive gait parameters for objective evaluation in knee and hip osteoarthritis using wearable sensors

Although it is well-established that osteoarthritis (OA) impairs daily-life gait, objective gait assessments are not part of routine clinical evaluation. Wearable inertial sensors provide an easily accessible ...

Authors: Ramon J. Boekesteijn, José M. H. Smolders, Vincent J. J. F. Busch, Alexander C. H. Geurts and Katrijn Smulders

Three-year clinical and radiological results of a cruciate-retaining type of the knee prosthesis with anatomical geometry developed in Japan

The FINE total knee was developed in Japan and clinical use began in 2001. It has unique design features, including an oblique 3^o femorotibial joint line that reproduces anatomical geometry. Although 20 years hav...

Authors: Arata Nakajima, Manabu Yamada, Masato Sonobe, Yorikazu Akatsu, Masahiko Saito, Keiichiro Yamamoto, Junya Saito, Masaki Norimoto, Keita Koyama, Hiroshi Takahashi, Yasuchika Aoki, Toru Suguro and Koichi Nakagawa

Effects of body mass index and range of motion on intraoperative change in pelvic tilt during total hip arthroplasty using the direct anterior approach

Intraoperative pelvic tilt changes that occurs during total hip arthroplasty (THA) in the supine position affects cup placement and sometimes causes malalignment. The relationship between body mass index (BMI)...

Authors: Masanori Okamoto, Masashi Kawasaki, Toshiaki Okura, Taisuke Seki and Shiro Imagama

Exercise-induced muscle damage: multi-parametric MRI quantitative assessment

To explore the value of magnetic resonance quantitative analysis using diffusion tensor imaging, T2 mapping, and intravoxel incoherent motion in the evaluation of eccentric exercise-induced muscle damage and t...

Authors: Xiaohong Lyu, Yue Gao, Qiang Liu, Heng Zhao, Huadong Zhou and Shinong Pan

Compressive mechanical stress enhances susceptibility to interleukin-1 by increasing interleukin-1 receptor expression in 3D-cultured ATDC5 cells

Mechanical overload applied on the articular cartilage may play an important role in the pathogenesis of osteoarthritis. However, the mechanism of chondrocyte mechanotransduction is not fully understood. The p...

Authors: Yuki Takeda, Yasuo Niki, Yusuke Fukuhara, Yoshitsugu Fukuda, Kazuhiko Udagawa, Masayuki Shimoda, Toshiyuki Kikuchi, Shu Kobayashi, Kengo Harato, Takeshi Miyamoto, Morio Matsumoto and Masaya Nakamura

Validation of self-administered tests for screening for chronic pregnancy-related pelvic girdle pain

Many women develop pelvic girdle pain (PGP) during pregnancy and about 10% have chronic pain several years after delivery. Self-administered pain provocation tests are one way to diagnose and evaluate this pai...

Authors: Monika Fagevik Olsén, Paulina Körnung, Sophie Kallin, Helen Elden, Gunilla Kjellby Wendt and Annelie Gutke

Percutaneous spinal endoscopy with unilateral interlaminar approach to perform bilateral decompression for central lumbar spinal stenosis: radiographic and clinical assessment

Recently, a percutaneous spinal endoscopy unilateral posterior interlaminar approach to perform bilateral decompression has been proposed for use in treatment of lumbar spinal stenosis, As a development and su...

Authors: Jingbo Xue, Haoxiang Chen, Bin Zhu, Xuelin Li, Zhihua Ouyang, Shan Li, Zhun Xu, Yong Xie and Yiguo Yan

Characterization of the distributions of collagen and PGs content in the decellularized book-shaped enthesis scaffolds by SR-FTIR

Bone-tendon interface (enthesis) plays a pivotal role in relaxing load transfer between otherwise structurally and functionally distinct tissue types. Currently, decellularized extracellular matrix (DEM) from ...

Authors: Qiang Shi, Can Chen, Muzhi Li, Yang Chen, Yan Xu, Jianzhong Hu, Jun Liu and Hongbin Lu

Outcomes of intra-articular calcaneal fractures: surgical treatment of 114 consecutive cases at a maximum care trauma center

The aim of this retrospective monocentric study was to investigate the outcomes of surgically treated intra-articular calcaneus fractures in a maximum care trauma center.

Authors: Christin Schindler, Andreas Schirm, Vilijam Zdravkovic, Primoz Potocnik, Bernhard Jost and Andreas Toepfer

Open-label phase 3 study of diclofenac conjugated to hyaluronate (diclofenac etalhyaluronate: ONO-5704/SI-613) for treatment of osteoarthritis: 1-year follow-up

We evaluated the 1-year safety and efficacy of diclofenac etalhyaluronate (DF-HA), a diclofenac-conjugated hyaluronate, in patients with osteoarthritis (OA).

Authors: Yoshihiro Nishida, Kazuyuki Kano, Taiki Osato and Takayuki Seo

Surgical outcomes of transverse acetabular fractures and risk factors for poor outcomes

Transverse acetabular fractures, although classified as elementary, have worse outcomes than other types of acetabular fractures. Prognostic factors for this fracture type are not clearly established. This stu...

Authors: Jae Hoon Jang, Nam Hoon Moon, Seung Joon Rhee, Seok Jin Jung and Tae Young Ahn

Is open bone graft always necessary when treating aseptic subtrochanteric nonunion with a reamed intramedullary nail?

This study aimed to compare the radiological results between closed nailing without bone graft (BG) and open nailing with BG for aseptic subtrochanteric nonunion and to determine when an open procedure with BG...

Authors: Won Chul Shin, Jae Hoon Jang, Nam Hoon Moon and Se Bin Jun

Advancing frontiers in rheumatic and musculoskeletal imaging

In recent years, technological improvements allowed imaging modalities to become increasingly essential in achieving early and precise diagnoses in the field of rheumatic and musculoskeletal diseases (RMDs). T...

Authors: Domenico Albano and Francesco Carubbi

Criterion validity of The International Physical Activity Questionnaire-Short Form (IPAQ-SF) for use in clinical practice in patients with osteoarthritis

To tailor physical activity treatment programs for patients with osteoarthritis, clinicians need valid and feasible measurement tools to evaluate habitual physical activity. The widely used International Physi...

Authors: Kenth Louis Joseph, Hanne Dagfinrud, Anne Christie, Kåre Birger Hagen and Anne Therese Tveter

The attenuation of insulin-like growth factor signaling may be responsible for relative reduction in matrix synthesis in degenerated areas of osteoarthritic cartilage

In osteoarthritis (OA), cartilage matrix is lost gradually despite enhanced matrix synthesis by chondrocytes. This paradox may be explained, at least partly, by reduced chondrocyte anabolism in degenerated are...

Authors: Nobuho Tanaka, Hirotaka Tsuno, Satoru Ohashi, Mitsuyasu Iwasawa, Hiroshi Furukawa, Tomohiro Kato and Naoshi Fukui

Persisting inter‐limb differences in patients following total hip arthroplasty four to five years after surgery? A preliminary cross‐sectional study

Total hip arthroplasty (THA) is an effective procedure for patients with end-stage hip osteoarthritis. However, whether or not pre-operatively existing functional deficits are persisting several years post-sur...

Authors: Stefanie John, David Weizel, Anna S. Heumann, Anja Fischer, Katja Orlowski, Kai-Uwe Mrkor, Jürgen Edelmann-Nusser and Kerstin Witte

A comparative analysis of NLRP3-related inflammatory mediators in synovial fluid in temporomandibular joint osteoarthritis and internal derangement

The nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome signaling pathway is a highlighted topic in the field of inflammation. However, there is little resear...

Authors: Mengying Jia, Yaoguang Lv, Yingjie Xu and Zhongcheng Gong

Cryoneurolysis for the management of chronic pain in patients with knee osteoarthritis; a double-blinded randomized controlled sham trial

Pain is the principal symptom in knee osteoarthritis (OA). Current non-operative treatment options have only moderate effects and often patients experience persistent pain or side-effects. Novel advances in th...

Authors: Niels-Peter Brøchner Nygaard, Carsten Koch-Jensen, Henrik Bjarke Vægter, Niels Wedderkopp, Morten Blichfeldt-Eckhardt and Bibi Gram

Prevalence of musculoskeletal disorders among perioperative nurses: a systematic review and META-analysis

To evaluate the prevalence of work-related musculoskeletal disorders (WRMSDs) in perioperative nurses and to explore their association with personal characteristics.

Authors: Marco Clari, Alessandro Godono, Giacomo Garzaro, Gianluca Voglino, Maria Rosaria Gualano, Giuseppe Migliaretti, Attilia Gullino, Catalina Ciocan and Valerio Dimonte

Predictive factors for intraoperative blood loss in surgery for adolescent idiopathic scoliosis

Adolescent idiopathic scoliosis (AIS) is a common spinal deformity. Posterior spinal fusion remains an important surgical treatment for AIS. This study aims to determine the predictive factors for intraoperati...

Authors: Chris Yuk Kwan Tang, Vijay H. D. Kamath, Prudence Wing Hang Cheung and Jason Pui Yin Cheung