Skip to main content

Artificial intelligence improves the accuracy of residents in the diagnosis of hip fractures: a multicenter study



Less experienced clinicians sometimes make misdiagnosis of hip fractures. We developed computer-aided diagnosis (CAD) system for hip fractures on plain X-rays using a deep learning model trained on a large dataset. In this study, we examined whether the accuracy of the diagnosis of hip fracture of the residents could be improved by using this system.


A deep convolutional neural network approach was used for machine learning. Pytorch 1.3 and 1.0 were applied as frameworks, and an EfficientNet-B4 model (a pre-trained ImageNet model) was used. We handled the 5295 X-rays from the patients with femoral neck fracture or femoral trochanteric fracture from 2009 to 2019. We excluded cases in which the bilateral hips were not included within an image range, and cases of femoral shaft fracture and periprosthetic fracture. Finally, we included 5242 AP pelvic X-rays from 4851 cases. We divided these 5242 images into two images per image, and prepared 5242 images including fracture site and 5242 images without fracture site. Thus, a total of 10,484 images were used for machine learning. The accuracy, sensitivity, specificity, F-value, and area under the curve (AUC) were assessed. Gradient-weighted class activation mapping (Grad-CAM) was used to conceptualize the basis for the diagnosis of the fracture by the deep learning algorithm. Secondly, we conducted a controlled experiment with clinicians. Thirty-one residents;young doctors within 2 years of graduation from medical school who rotate through various specialties, were tested using 300 hip fracture images that were randomly extracted from the dataset. We evaluated the diagnostic accuracy with and without the use of the CAD system for each of the 300 images.


The accuracy, sensitivity, specificity, F-value, and AUC were 96.1, 95.2, 96.9%, 0.961, and 0.99, respectively, with the correct diagnostic basis generated by Grad-CAM. In the controlled experiment, the diagnostic accuracy of the residents significantly improved when they used the CAD system.


We developed a newly CAD system with a deep learning algorithm from a relatively large dataset from multiple institutions. Our system achieved high diagnostic performance. Our system improved the diagnostic accuracy of residents for hip fractures.

Level of evidence

Level III, Foundational evidence, before-after study. Clinical relevance: high

Peer Review reports


In Japan, as many as 13 million elderly people have osteoporosis [1, 2]. Fragility fractures, such as hip fractures and spinal fractures are also increasing, with 200,000 patients suffering from hip fractures annually [3]. Patients with hip fractures require admission to hospital as soon as possible, because the longer the patients delay getting treatment, the worse their walking ability and prognosis will be [4, 5].

Most hip fracture patients visit the emergency department because they have difficulty walking due to pain. In the emergency department, clinicians are exposed to excessive time and mental stress, which can cause fatigue and misdiagnosis [6, 7]. This tendency is particularly pronounced among residents [8]. In previous studies, the misdiagnosis rate at the initial diagnosis for hip fractures was estimated to be 2–10% [9].

A delay in the diagnosis and treatment worsens the prognosis [10], and a misdiagnosis may lead to medical litigation [6]. To prevent a misdiagnosis, radionuclide bone scans, computed tomography (CT), and magnetic resonance imaging (MRI), as well as plain X-rays, are recommended as additional diagnostic imaging [11, 12]. However, these additional tests are not always available in all institutions.

In recent years, deep learning, a method of machine learning using multi-layered neural networks, has emerged and improved the accuracy of image recognition [13]. In the field of medicine, many previous studies have reported the application of deep learning to imaging analysis and demonstrated its high diagnostic accuracy [14]. Several studies have applied a deep learning algorithm to the diagnosis of fractures [15]. Olczak first demonstrated that artificial intelligence (AI) with the use of a deep learning approach for the diagnosis of ankle and wrist fracture on plain X-rays [16]. There have been some papers on the use of a deep learning algorithm to diagnose hip fractures. Some of these studies diagnose from antero-posterior images only [17,18,19,20], one from both antero-posterior and lateral images [21], one can predict not only presence of fractures but also fracture type [22], and one of the same algorithms can be used to diagnose both proximal femur and pelvic fractures [23] . Additionally, a previous study reported that deep learning algorithm improved the diagnostic accuracy of fracture detection by clinicians [20, 22, 24]. However, these studies were conducted in a single center. The dataset was relatively small and the image processing method was uniform. Few studies have described the improvement of clinicians’ diagnostic accuracy for hip fractures with the aid of deep learning algorithms and no studies have reported differences in outcomes according to years of clinical experience.

Thus, we planned to train a deep learning model using a large dataset with images obtained by various protocols in a multi-institutional setting. We newly developed the computer-aided diagnosis (CAD) system using a model that could visualize the diagnostic method of the AI. In the present study, we hypothesized that the CAD system would improve the diagnostic accuracy of clinicians, including residents.



All research contents were performed in accordance with the ethical standards of the amended Declaration of Helsinki. This study was conducted with the approval of the ethics committee of each hospital (Gamagori City Hospital: approval No. 368–1, Tsushima City Hospital: Approval No. 2019–3, Nagoya Daini Red Cross Hospital: approval No. 1360).

We collected images from 3 hospitals (Gamagori City Hospital, Tsushima City Hospital, Nagoya Daini Red Cross Hospital) in Aichi Prefecture, Japan. The Nagoya Daini Red Cross Hospital provided tertiary care in an urban area with a population of 2.3 million. The other two hospitals—Gamagori City Hospital and Tsushima City Hospital—are primary care hospitals in a rural area in Japan. Table 1 shows the background factors of each institution.

Table 1 Information about the participating medical institutions

We collected 5295 cases of femoral neck fractures or femoral trochanteric fractures that were diagnosed by orthopedic surgeons using plain X-ray, CT or MRI between 2009 and 2019. Patients aged 20 years and older were included in the study. Among these 5295 cases, 391 cases subsequently suffered a hip fracture on the opposite side during the study period. We also included hip implants on the opposite side (n = 452), complicated pubic or sciatic fracture (n = 93), cases with osteoarthritis of the hip (Kellgren–Lawrence Grade III or IV: 84 cases) [25], including spine implants (n = 46), and pathologic fractures of the proximal femur due to metastatic cancer (n = 12). We excluded images for the following reasons: periprosthetic fractures (n = 32), bilateral hips were not included within an image range (n = 14), and femoral shaft fracture (n = 7). Finally, we utilized 5242 AP pelvic X-rays in 4851 cases (Sex: male, n = 1193; female, n = 3658, mean age at injury: 81.1 years) (Fig. 1). Of these, we diagnosed 5024 (95.8%) from frontal simple hip radiographs, 97 (1.9%) with radiographic lateral views as well, and 121 (2.3%) with CT or MRI for definitive or exclusionary diagnosis.

Fig. 1
figure 1

Patient flow

Evaluation of fractures

Two orthopedic surgeons (YS, TA) assessed the presence or absence and the type of fracture. The Kappa statistic of inter-observer correlation for the presence or absence of these fractures was 0.91. If the results differed, it was decided after a discussion. To classify the fracture type, we used the Garden classification (Garden classification stage I, II, III, IV: G/S I-IV) for femoral neck fractures [26] and the AO/OTA classification for femoral trochanteric fractures (AO/OTA 31-A1, A2, A3) [27]. We defined a great trochanteric fracture as one in which the fracture line did not extend to the medial cortex [28]. A total of 5024 cases (95.8%) were diagnosed from AP pelvic X-rays alone. Other patients were diagnosed by lateral X-ray (n = 97; 1.9%) and CT or MRI (n = 121; 2.3%). All of these images were incorporated into the dataset without any specific labeling, and were being trained equally. Table 2 shows the classifications of fracture types.

Table 2 Patient background and the classification of fracture type

Image capturing environment and image data extraction

X-rays were taken with the patient in the supine position with internal rotation of their hip. The central beam in the AP view was directed to the midpoint between the upper border of the pubic symphysis and a horizontal line connecting both anterior iliac spines. The imaging conditions were as follows: 70 kV, 200 mA, 0.4 s, and tube-to-film distance, 100 cm. The X-ray generator and CR or DR image processor. We used a Digital Imaging and Communications in Medicine (DICOM) image display (Toshiba Medical Systems Corporation, Tokyo) as the image reference software program. The image file format and the size of the original image varied from each institution. (Table 1).

Image preprocessing and development of the algorithm

We described the details image processing and the algorithm in Supplemental method. We used uncompressed data. Images extracted from the DICOM server were converted into 3 channels and 8-bit JPEG images, and both were resized to 380 × 380 pixels. For each image, the window level was not adjusted. All images were given a rectangle that included the entire fracture site. To extract larger images, we placed a vertical dividing line at a position with a 50-pixel margin for the rectangle and adopted the images without the rectangle as the non-fractured side data and generated 5242 images that did not contain the fracture site. We also adopted the image of the side containing the rectangle of the same size as the non-fractured site data as the fracture side data and generated 5242 images containing the fracture site. In total, 10,484 images were prepared for machine learning (Supplementary Figure 1).

We randomly divided the dataset into three sets: a training dataset (non-fracture sides, n = 4242; fracture side, n = 4242; total, 8484 images), a validation dataset (non-fracture side, n = 500; fracture side, n = 500; for a total of 1000 images), and a test dataset (non-fracture side, n = 500; fracture side, n = 500; for a total of 1000 images) (Fig. 1).

We used gradient-weighted class activation mapping (Grad-CAM) [29] to conceptualize the basis for the deep learning algorithm’s diagnosis of a fracture. We used the show-heatmap-function of Fast.AI ( on the deep learning algorithm to obtain the heatmap. Through this process, we have developed a CAD system based on a deep learning algorithm that provides diagnosis and visualization of basis.

We determined the calculation time for the whole process of the inference and the generation of heat maps for one image of the test dataset. The calculation method is the average time per image of the test dataset divided by the calculation time, which was deduced from 1000 images of test data.

Controlled experiment with clinicians

To investigate the application of the CAD system and verify its effectiveness in a clinical setting, we conducted a controlled experiment with clinicians. There were 65 residents;young doctors within 2 years of graduation from medical school without speciality, in the three institutions included in the study. Thirty-one of these residents agreed to participate in the study (10 in their first year of residency, and 21 in their second year of residency). Each of these participants provided their informed consent at their respective institutions.

We randomly extracted 300 images (133 on the non-fractured side and 167 on the fractured side) from 1000 test image datasets described as a previous study [24]. The 300 images included 136 right femur images and 164 left femur images. First, we checked the performance of the deep learning algorithm for the 300 images.

Then, clinicians undertook the diagnostic test. Before conducting the test, we presented the accuracy of the CAD to the clinicians. The outline of the diagnostic test was as follows: 1) the clinicians diagnosed the presence or absence of fracture by themselves; 2) after the clinician answered, the CAD system added the visualization of the fracture to the same image; 3) as a second test, the clinician responded again based on the hint. (Supplemental Figure 4) This sequence was repeated 300 times.


Performance of the deep learning algorithm

We evaluated the performance of the trained deep learning algorithm using the test image dataset. We also calculated the accuracy, sensitivity, specificity, F-value, receiver operating characteristic (ROC) curve and measured the area under the curve (AUC), as described in the STARD 2015 guidelines [30].

Evaluation of the heatmap generated by the CAD system

We performed accuracy validation of Grad-CAM in accordance with the previous research [18]. We used a total of 40 images, 20 with and 20 without fractures, randomly selected from images that the algorithm was able to correctly diagnose in the test data set, for accuracy validation. For accuracy validation, we used the area with the highest signal intensity in the Heat map as the basis for determining “with fracture” if it was located directly above the femur between the femoral head and just above the popliteus. The assessor (YS) evaluated the consistency between the high signal intensity region on the heat map and the actual fracture site on the X-ray using sensitivity and specificity. The kappa value for intra-observer correlation between two-week intervals was 1.0.

The diagnostic accuracy of clinicians with or without the use of the CAD system

We compared the accuracy, sensitivity, and specificity with/without the aid of the CAD system among residents. We also compared the diagnostic accuracy of the first-year residents to that of second-year residents.

Statistical analysis

The EZR software program was used to perform the statistical analyses [16]. We used Fisher’s exact test were used to analyze categorical variables. The normality of the distribution of diagnostic accuracy was tested for using the Shapiro-Wilk test. As a result, the value did not show a normal distribution. Thus, we used the Wilcoxon signed-rank test. P values of < 0.05 were considered to indicate statistical significance. Scikit-Learn ( was used to analyze the performance of the deep learning algorithm.


Performance of the deep learning algorithm

The performance of the deep learning algorithm was as follows: accuracy, 96.1% (95% CI: 94.9, 97.3); sensitivity, 95.2% (95% CI: 93.9, 96.5); specificity, 96.9% (95% CI: 95.8, 98.0), and F-value, 0.961 (95% CI: 0.950, 0.972). The ROC curve is shown in Fig. 2; the AUC was 0.99 (95% CI, 0.98, 1.00).

Fig. 2
figure 2

ROC Curves. This is the ROC curve for the EfficientNet-B4 model, which showed an AUC of 0.992. Class 0 indicates cases without fracture, and Class 1 indicates cases with fracture. Each ROC curve was calculated. The micro-average ROC sums contributions by class, while the macro-average ROC shows the average results for all classes (AUC = 0.992)

On the other hand, the deep learning algorithm misdiagnosed 39 of the 1000 images. A total of 24 images with fractures were diagnosed as “without fracture” (false negative). These included slightly displaced fractures (n = 21); fractures located at the greater trochanter of the femur (n = 9), non-displaced femoral neck fractures (n = 8), femoral trochanteric fractures (n = 8; AO31 - A1). The others included relatively displaced fractures (n = 3); femoral trochanteric fracture (n = 2; AO31 - A2, 3), and displaced femoral neck fracture (n = 1; G/S 3, 4). A total of 15 images without fracture were diagnosed as “with fracture” (false-positive). These included 13 cases with normal images, a case with deformity after conservative treatment and a case after nail removal (Fig. 3).

Fig. 3
figure 3

Images that were misdiagnosed by the CAD system. a-c Incorrectly diagnosed by the CAD system (false-negative). a A case that even orthopedic surgeons could not decide. b A case in which a non-orthopedic surgeon could be wrong. c A case in which even non-orthopedic surgeons were not confused by the diagnosis. d-f Images that were incorrectly diagnosed by the CAD system (false-positive). d Normal image. e A case after implant removal. f A case in which deformity healed after conservative treatment

Evaluation of the heatmap generated by the CAD system

For images diagnosed by the algorithm as “with fracture”, Grad-CAM showed a high-signal region consistent with the fracture site. For images diagnosed as “without fracture”, Grad-CAM showed high-signal areas in the region other than femoral neck and trochanteric. (Fig. 4) For the 20 “with Fracture” images, all 20 images had the same high-signal region on the heat map as the fracture site. On the other hand, 19 of the 20 “without fracture” images had high signal areas except from the femoral head to just above the trochanter in the 19 images, but one image had a high signal area in the greater trochanter. (Supplemental Figure 5) The accuracy of Grad-CAM was thus calculated to be 100% sensitivity and 95% specificity. The average inference time per image, including Grad-CAM, was 1.17 s.

Fig. 4
figure 4

Visualization of the area of fracture detection using Grad-CAM. a For images diagnosed by the algorithm as “with fracture”, Grad-CAM showed a high-signal region consistent with the fracture site . b For images diagnosed as “no fracture”, Grad-CAM showed high-signal areas in the region other than femoral neck and trochanteric. From red to green, the diagnostic basis of the CAD system was strongly evident

The diagnostic accuracy of clinicians with or without the aid of the CAD system

The residents’ mean diagnostic accuracy was significantly improved with the aid of the CAD system. (accuracy of 84.7% (95% CI: 82.2, 87.2) without aid to 91.2% (95% CI: 89.6, 92.8) with aid; p < 0.01, sensitivity of 83.4% (95% CI: 83.4, 90.6) with aid to 90.6% (95% CI: 83.9, 97.3) with aid p < 0.01, specificity of 88.7% (95% CI: 82.1, 95.3) without aid to 93.4% (95% CI: 89.5, 97.3) with ai p < 0.01).

The results of the diagnostic accuracy of residents in both the first and second years are presented in Table 3. The accuracy, sensitivity, and specificity of the residents were improved with the CAD system, irrespective of their year of residency.

Table 3 Results of the controlled experiment in which clinicians diagnosed 300 test images


We developed a newly CAD system based on a deep learning algorithm for hip fracture. This system provided high accuracy, sensitivity, and specificity. The areas activated on the heat map all corresponded to the areas pointed out by the orthopedic surgeon. Inexperienced residents’ diagnostic accuracy, sensitivity, and specificity in the diagnosis of hip fracture improved when they used the CAD system.

Our CAD system, based on a deep learning algorithm, had some advantages over other studies. We conducted a literature review that demonstrated the application of AI-based systems for the diagnosis of hip fracture in Table 4 [17,18,19,20,21,22]. We used the largest amount of learning data from multiple institutions. In this study, almost all of the images of hip fractures obtained from multiple institutions were used, and approximately 10,000 images of machine learning data were generated from approximately 5000 cases. Large datasets are the key to success in machine learning [31]. The majority of published studies on AI to date were conducted in a single institution; only 6% of these studies used data from multiple institutions [32]. Our multiple-center dataset provides 1) a large amount of data, and 2) images with different imaging formats. In this study, the deep learning algorithm achieved high accuracy at multiple institutions, despite the use of different radiographic equipment and image file formats. The high performance of the multi-center data may help in the practical application of this system.

Table 4 Literature review

The performance of our deep learning algorithm was as good as that described in previous reports. On the other hand, the deep learning algorithm failed to diagnose 3.9% of images (39 out of 1000 test data) correctly. Twenty-four images with fractures were diagnosed as “without fracture” and 15 images without fracture were diagnosed as “with fracture”.

Second, our CAD system, which was based on a deep learning algorithm, was able to provide a heat map of the fracture site, which provided evidence about where the AI recognized the fracture. In all cases, the fracture site indicated on the heat map was located in the area indicated by the orthopedic surgeon. AI-based diagnostics has classically been associated with a “black box problem” [33], in that cannot explicitly express the feature quantity, the reasons for the judgment are not clear, and humans cannot understand or interpret the reasons. In this study, we used Grad-CAM to visualize class-discriminative regions on the X-rays. This could reveal the location of the diagnosis. However, the Grad-CAM could show the fracture as a rough area, but cannot show the fracture line itself. Besides, the image information that the deep learning algorithm based its decision on (e.g., the fracture line, bone marrow edema, or soft-tissue contrast) is still unclear.

Third, in this study, the diagnostic accuracy, sensitivity, and specificity of residents improved when they used the CAD system. Moreover, the CAD system improved their diagnostic accuracy regardless of the year of residency. There have been many studies in which deep learning algorithms showed high diagnostic performance at the basic research level [14]. However, they did not provide comparisons with health-care professionals (i.e., human vs. machine), and few of the studies reported comparisons with healthcare professionals using the same test dataset. As shown in Table 4, in previous studies on deep learning algorithms for hip fractures, few assessments were made as to how deep learning algorithms affect clinicians’ diagnostic abilities [17,18,19,20,21,22]. Our study showed that the CAD system would be useful for aiding residents in the diagnosis of hip fracture.

The present study was associated with several limitations. First, the present dataset included cases of pathological fractures caused by metastatic bone tumors but did not include cases of osteomyelitis without fracture. It is desirable to consult a specialist as soon as possible in such cases; however, the CAD system developed in this study may not be able to point this out. Second, the image needs to be divided by preprocessing. A CAD system that can diagnose hip fractures without preprocessing from X-rays of both hips should be developed using the deep learning algorithm obtained in this study. Third, the diagnostic imaging test was not conducted in an actual clinical setting. This study was retrospective study conducted via a PACS-like web interface used by clinicians for medical imaging. Unlike the high-resolution monitors used in clinical practice, the reading of the images is done on a home personal computer, and therefore the diagnostic rate for clinicians may be underestimated. It is also possible that the incidence of “with fracture” images in clinical practice is different from the frequency of diagnosis in clinical practice. In this regard, future prospective studies in actual clinical settings using an actual PACS system are needed. Fourth, we have not been able to assess whether clinicians have fundamentally improved their diagnostic abilities in the diagnostic imaging test. In the diagnostic imaging test, clinicians read images without diagnostic aid and images with diagnostic aid consecutively. Because clinicians didn’t read the images at regular time intervals, the effect in terms of education is not known. In addition, the correctness criteria for the diagnostic imaging test was whether the clinician was able to answer the fracture site correctly on the basis of the presence or absence of a fracture. Grad-CAM presented the heat map as an indication of the fracture site, but it is unclear how much the heat map contributed to the clinician’s ability to read it.


We developed a newly CAD system for the diagnosis of hip fracture based on a deep learning algorithm. This system provided high accuracy, sensitivity, and specificity. The areas activated on the heat map all corresponded to the areas pointed out by the orthopedic surgeon. The accuracy, sensitivity, and specificity of residents in the diagnosis of hip fracture improved when they used this CAD system. This system may aid residents in the diagnosis of hip fractures.

Availability of data and materials

The datasets analyzed during the current study available from the corresponding author on reasonable request.



Artificial Intelligence


Area Under the Curve


Computer-Aided Diagnosis


Confidence Interval


Computed Tomography


Deep Convolutional Neural Network


Digital Imaging and COmmunications in Medicine


Gradient-weighted Class Activation Napping


Magnetic Resonance Imaging


Picture Archiving and Communication Systems


Receiver Operating Characteristic


  1. Yoshimura N, Muraki S, Oka H, Mabuchi A, En-Yo Y, Yoshida M, et al. Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study. J Bone Miner Metab. 2009;27:620–8.

    Google Scholar 

  2. Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T. Cohort profile: research on osteoarthritis/osteoporosis against disability study. Int J Epidemiol. 2009;39:988–95.

    Google Scholar 

  3. Orimo H, Yaegashi Y, Onoda T, Fukushima Y, Hosoi T, Sakata K. Hip fracture incidence in Japan: estimates of new patients in 2007 and 20-year trends. Arch Osteoporos. 2009;4:71–7.

    Google Scholar 

  4. Boonen S, Autier P, Barette M, Vanderschueren D, Lips P, Haentjens P. Functional outcome and quality of life following hip fracture in elderly women: a prospective controlled study. Osteoporos Int. 2004;15:87–94.

    Google Scholar 

  5. Grimes JP, Gregory PM, Noveck H, Butler MS, Carson JL. The effects of time-to-surgery on mortality and morbidity in patients following hip fracture. Am J Med. 2002;112:702–9.

    Google Scholar 

  6. Berlin L. Malpractice issues in radio: defending the “missed” radiographic diagnosis. Am J Roentgenol. 2001;176:317–22.

    Google Scholar 

  7. Hallas P, Ellingsen T. Errors in fracture diagnoses in the emergency deparment - characteristics of patients and diurnal variation. BMC Emerg Med. 2006;6:3–7.

    Google Scholar 

  8. Leeper WR, Leeper TJ, Vogt KN, Charyk-Stewart T, Gray DK, Parry NG. The role of trauma team leaders in missed injuries: does specialty matter? J Trauma Acute Care Surg. 2013;75:387–90.

    Google Scholar 

  9. Cannon J, Silvestri S, Munro M. Imaging choices in occult hip fracture. J Emerg Med. 2009;37:144–52.

    Google Scholar 

  10. Tarrant SM, Hardy BM, Byth PL, Brown TL, Attia J, Balogh ZJ. Preventable mortality in geriatric hip fracture inpatients. J Bone Jt Surg. 2014;96 B(9):1178–84.

    Google Scholar 

  11. Hakkarinen DK, Banh KV, Hendey GW. Magnetic resonance imaging identifies occult hip fractures missed by 64-slice computed tomography. J Emerg Med. 2012;43:303–7.

    Google Scholar 

  12. Rehman H, Clement RGE, Perks F, White TO. Imaging of occult hip fractures: CT or MRI? Injury. 2016;47:1297–301.

    Google Scholar 

  13. He K, Zhang X, Ren S, Sun J. Delving deep into rectifiers: surpassing human-level performance on imagenet classification. Proc IEEE Int Conf Comput Vis. 2015;2015 Inter:1026–34.

    Google Scholar 

  14. Liu X, Faes L, Kale AU, Wagner SK, Fu DJ, Bruynseels A, et al. A comparison of deep learning performance against health-care professionals in detecting diseases from medical imaging: a systematic review and meta-analysis. Lancet Digit Heal. 2019;1:e271–97.

    Google Scholar 

  15. Kalmet PHS, Sanduleanu S, Primakov S, Wu G, Jochems A, Refaee T, et al. Deep learning in fracture detection: a narrative review. Acta Orthop. 2020;91:215–20.

    Google Scholar 

  16. Olczak J, Fahlberg N, Maki A, Razavian AS, Jilert A, Stark A, et al. Artificial intelligence for analyzing orthopedic trauma radiographs: deep learning algorithms—are they on par with humans for diagnosing fractures? Acta Orthop. 2017;88:581–6.

    Google Scholar 

  17. Adams M, Chen W, Holcdorf D, McCusker MW, Howe PDL, Gaillard F. Computer vs human: deep learning versus perceptual training for the detection of neck of femur fractures. J Med Imaging Radiat Oncol. 2019;63:27–32.

    Google Scholar 

  18. Cheng CT, Ho TY, Lee TY, Chang CC, Chou CC, Chen CC, et al. Application of a deep learning algorithm for detection and visualization of hip fractures on plain pelvic radiographs. Eur Radiol. 2019;29:5469–77.

    Google Scholar 

  19. Urakawa T, Tanaka Y, Goto S, Matsuzawa H, Watanabe K, Endo N. Detecting intertrochanteric hip fractures with orthopedist-level accuracy using a deep convolutional neural network. Skelet Radiol. 2019;48:239–44.

    Google Scholar 

  20. Cheng CT, Chen CC, Cheng FJ, Chen HW, Su YS, Yeh CN, et al. A human-algorithm integration system for hip fracture detection on plain radiography: system development and validation study. JMIR Med Informatics. 2020;8:1–13.

    Google Scholar 

  21. Yamada Y, Maki S, Kishida S, Nagai H, Arima J, Yamakawa N, et al. Automated classification of hip fractures using deep convolutional neural networks with orthopedic surgeon-level accuracy: ensemble decision-making with antero-posterior and lateral radiographs. Acta Orthop. 2020;91:699–704.

    Google Scholar 

  22. Krogue JD, Cheng K, Hwang KM, Toogood P, Meinberg EG, Geiger EJ, et al. Automatic hip fracture identification and functional subclassification with deep learning. Radiol Intell. 2020;2:1–12.

    Google Scholar 

  23. Cheng CT, Wang Y, Chen HW, Hsiao PM, Yeh CN, Hsieh CH, et al. A scalable physician-level deep learning algorithm detects universal trauma on pelvic Radiographs. Nat Commun. 2021;12:1-10.

  24. Lindsey R, Daluiski A, Chopra S, Lachapelle A, Mozer M, Sicular S, et al. Deep neural network improves fracture detection by clinicians. Proc Natl Acad Sci U S A. 2018;115:11591–6.

    Google Scholar 

  25. Inoue K. Prevalence of hip osteoarthritis and acetabular dysplasia in French and Japanese adults. Rheumatology. 2000;39:745–8.

    Google Scholar 

  26. Bjørgul K, Reikerås O. Low interobserver reliability of radiographic signs predicting healing disturbance in displaced intracapsular fracture of the femoral neck. Acta Orthop Scand. 2002;73:307–10.

    Google Scholar 

  27. Jin WJ, Dai LY, Cui YM, Zhou Q, Jiang LS, Lu H. Reliability of classification systems for intertrochanteric fractures of the proximal femur in experienced orthopaedic surgeons. Injury. 2005;36:858–61.

    Google Scholar 

  28. Moon NH, Shin WC, Do MU, Woo SH, Son SM, Suh KT. Diagnostic strategy for elderly patients with isolated greater trochanter fractures on plain radiographs. BMC Musculoskelet Disord. 2018;19:1–9.

    Google Scholar 

  29. Selvaraju RR, Cogswell M, Das A, Vedantam R, Parikh D, Batra D. Grad-CAM: visual explanations from deep networks via gradient-based localization. Int J Comput Vis. 2020;128:336–59.

    Google Scholar 

  30. Cohen JF, Korevaar DA, Altman DG, Bruns DE, Gatsonis CA, Hooft L, et al. STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration. BMJ Open. 2016;6:1–17.

    Google Scholar 

  31. Giger ML. Machine learning in medical imaging. J Am Coll Radiol. 2018;15:512–20.

    Google Scholar 

  32. Kim DW, Jang HY, Kim KW, Shin Y, Park SH. Design characteristics of studies reporting the performance of artificial intelligence algorithms for diagnostic analysis of medical images: results from recently published papers. Korean J Radiol. 2019;20:405–10.

    Google Scholar 

  33. Fogel AL, Kvedar JC. Artificial intelligence powers digital medicine. NPJ Digit Med. 2018;1:3–6.

    Google Scholar 

  34. Shin HC, Roth HR, Gao M, Lu L, Xu Z, Nogues I, et al. Deep convolutional neural networks for computer-aided detection: CNN architectures, dataset characteristics and transfer learning. IEEE Trans Med Imaging. 2016;35:1285–98.

    Google Scholar 

  35. Tan M, Le QV. EfficientNet: rethinking model scaling for convolutional neural networks. In: 36th Int Conf Mach Learn ICML 2019; 2019. 2019-June:10691–700.

    Google Scholar 

Download references


Not applicable.


Not applicable.

Author information

Authors and Affiliations



YS carried out the studies and drafted the manuscript. YT participated in its design and helped to draft the manuscript. RG, AK and SH developed the computer-aided diagnosis system using a deep learning model. TA, YO and HT recruited the participants and developed the image dataset. YS and TA analyzed the X-ray data. SH coordinated the team. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yoichi Sato.

Ethics declarations

Ethics approval and consent to participate

This study was approved by each institutional review board and all experiments were performed in accordance with the ethical standards laid down in the amended Declaration of Helsinki. This study was conducted with the approval of the ethics committee of each hospital (Gamagori City Hospital: approval No. 368-1, Tsushima City Hospital: approval No. 2019-3, Nagoya Daini Red Cross Hospital: approval No. 1360). At each site, the chair of the ethics committee gave administrative permission for access to the raw data.

In this study, we adopted an opt-out method for obtaining patient consent, and obtained permission from the ethics committee of each institution. This research falls into the category of “research that does not use samples obtained from human subjects” in the “Ethical Guidelines for Medical Research Involving Human Subjects” under “research using existing samples and information held at the institution”. In accordance with the guidance, we published the disclosure document of this research on each hospital’s website for 30 days from the date of hospital director’s approval, notifying the research subjects and guaranteeing them the opportunity to refuse the research.

Consent for publication

Not applicable.

Competing interests

The authors, RG and AK, are employees of Search Space Co. Ltd., a startup company, the eventual products and services of which will be related to the subject matter of the article. No authors own shares in the above companies. SH, the last author, represents the AI research division in the nonprofit organization (NPO) Nagoya Orthopedic Regional Healthcare Support Center, ( NPO Nagoya Orthopedic Regional Healthcare Support Center, AI Research Division is a research division established for multi-center collaborative research. With the exception of two Search Space Co. Ltd. employees and one NPO employee, no authors received compensation from these organizations.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Additional file 1

: Supplemental methods. Supplemental Figure 1. Image preprocessing. Supplemental Figure 2. Configuration diagram of the EfficientNet-B4 model. Supplemental Figure 3. The machine learning process. Supplemental Figure 4. The diagnostic test for clinicians. Supplemental Figure 5. Validation of the accuracy of heat maps generated by Grad-CAM [34, 35].

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sato, Y., Takegami, Y., Asamoto, T. et al. Artificial intelligence improves the accuracy of residents in the diagnosis of hip fractures: a multicenter study. BMC Musculoskelet Disord 22, 407 (2021).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: