- Research article
- Open Access
Assessment of success of the Ponseti method of clubfoot management in sub-Saharan Africa: a systematic review
BMC Musculoskeletal Disorders volume 18, Article number: 453 (2017)
Clubfoot is one of the most common congenital deformities affecting mobility. It leads to pain and disability if untreated. The Ponseti method is widely used for the correction of clubfoot. There is variation in how the result of clubfoot management is measured and reported. This review aims to determine and evaluate how success with the Ponseti method is reported in sub-Saharan Africa.
Five databases were examined in August 2017 for studies that met the inclusion criteria of: (1) evaluation of the effect of clubfoot management; (2) use of the Ponseti method; (3) original study undertaken in sub-Saharan Africa; (4) published between 2000 and 2017. We used the PRISMA statement to report the scope of studies. The included studies were categorised according to a hierarchy of study methodologies and a 27-item quality measure identified methodological strengths and weaknesses. The definition of success was based on the primary outcome reported.
Seventy-seven articles were identified by the search. Twenty-two articles met the inclusion criteria, of which 14 (64%) reported a primary outcome. Outcomes were predominantly reported though case series and the quality of evidence was low. Clinical assessment was the most commonly reported outcome measure and few studies reported long-term outcome. The literature available to assess success of clubfoot management is characterised by a lack of standardisation of outcomes, with different measures reporting success in 68% to 98% of cases.
We found variation in the criteria used to define success resulting in a wide range of results. There is need for an agreed definition of good outcome (successful management) following both the correction and the bracing phases of the Ponseti method to establish standards to monitor and evaluate service delivery.
Clubfoot, or congenital talipes equinovarus (CTEV), is one of the most common congenital musculoskeletal deformities. Within the Africa region, clubfoot birth prevalence is estimated as 1.11 (95%CI 0.96–1.26) per 1000 live births . Untreated clubfoot results in pain, physical impairment and can ultimately cause disability . The Ponseti method is widely used for the management of clubfoot . It consists of two distinct phases, the correction phase and the maintenance phase . The correction phase involves precise manipulation of the foot around the talus to correct the cavus, adductus and varus of the deformity. The manipulation position is held in a long leg plaster of paris cast and the cast is typically changed weekly. A percutaneous tenotomy of the Achilles tendon is usually performed to correct the residual equinus. The maintenance phase involves the use of a foot abduction brace (FAB) for 23 h a day for three months, followed by nightly use until four to five years of age .
Many classification systems have been proposed to assess the severity of the clubfoot deformity and to measure the impact of treatment . Ponseti and Smoley  based their classification on clinical assessment of ankle dorsiflexion, heel varus, forefoot supination and tibial torsion after treatment. Feet were classified as good, acceptable or poor. Harrold and Walker  considered the extent of deformity correction. The Pirani score  and the Dimeglio score  are two of the most widely used classification systems for clubfoot deformity . The Pirani score is from 0 to 6 where zero is a normal foot and six is the most severe deformity. It is reliable when used by non-specialist health workers . The Dimeglio score has a maximum of 20 points and the deformity is graded as benign, moderate, severe or very severe.
Tools that have been developed to assess function include: assessment of patient satisfaction and pain, gait, heel position and range of motion [12, 13]; a questionnaire designed to measure overall satisfaction, foot appearance, pain and physical limitations ; and a detailed assessment of movement quality that requires mobility testing with a goniometer and muscle testing , but does not include parent reported outcomes.
There is a need for a standardised approach to report clubfoot treatment outcomes [16,17,18]. To address this gap, this review aims to investigate the literature and to determine and evaluate how success with the Ponseti method is reported in sub-Saharan Africa.
A systematic literature search was conducted in August 2017 for peer-reviewed articles presenting original research findings on the effect of treatment of clubfoot in children in sub-Saharan Africa. Studies were limited to outcomes of the Ponseti method as this technique is widely accepted as best practice . There was no language restriction. Results are presented according to the PRISMA guidelines .
Excerpta Medica Database (EMBASE), Global Health, Medline, Africa Wide Information and African Journals Online were examined for studies meeting the following inclusion criteria:  evaluation of the effect of clubfoot management,  use of the Ponseti method,  original study undertaken in sub-Saharan Africa, and  published between 1st January 2000 and 1st August 2017. Concepts were expanded to include related terms and synonyms. A study was excluded if there was no evaluation of treatment, however there was no restriction on type of study to allow a quality assessment review. There was no limitation on age of children and the search was restricted by date (2000–2017) to capture current best practice. Full search terms are presented in Table 1 and the search terms for the country names are outlined in detail in Additional file 1.
All titles and abstracts were screened independently by two authors (TS and DM). The full paper was reviewed if selected by either author or if the abstract was absent. In addition, the reference lists of the included articles were screened. Consensus was reached through discussion where there was disagreement on eligibility.
A pilot-tested spread-sheet was used for data extraction from articles that met the inclusion criteria. All characteristics recorded by one author (TS) were reviewed for accuracy by another author (DM). Data extracted included authors, year of publication, type of study, sample size, age of participants, duration of follow up and reported measurement of treatment outcome. Two authors [20, 21] were contacted to provide missing information. Where other forms of treatment were detailed or where a paper included a country outside of sub-Saharan Africa, only data regarding the Ponseti method and from the sub-Saharan African country were extracted.
Assessment of study quality
Full articles that met the eligibility criteria were categorised according to a hierarchy of study methodologies  developed to assess intervention strategies used with children with developmental disabilities. Quality of evidence was ranked as:
Systematic review of randomised controlled trials (RCTs); RCT with N > 100
RCT with N < 100; Systematic review of cohort studies
Cohort studies with concurrent control group; Systematic reviews of case control studies
Case series; Cohort study without concurrent control group; Case-control study
Expert opinion; Case study or report; Anecdotal Evidence.
In addition to the levels of evidence, we used a quality measure proposed by Downs and Black  to identify methodological strengths and weaknesses of the included studies as there was no limitation on type of study. The quality index is a 27-item checklist designed for use with both observational studies and randomised controlled trials. The index is comprised of five subscales: reporting (ten questions), external validity (three questions), internal validity (bias and confounding) (13 questions), and power (one question). Items are checked as ‘yes’, ‘partially’, ‘no’ or ‘unable to determine’ depending on the subscale and higher scores indicating higher quality. The maximum score is 32.
The definition of success was determined by the primary outcome reported in the studies or if explicitly stated. There were no studies that were sufficiently homogenous in terms of participants and outcomes to include in a meta-analysis and data were not combined due to methodological and clinical heterogeneity. An integrative review method  that included problem identification, data presentation and analysis was used to incorporate results. Summary statistics for the quality measure were calculated and include the mean and range (minimum and maximum).
A total of seventy-seven articles were identified. Twenty-two studies met the inclusion criteria. The search strategy and reasons for excluding articles are presented in Fig. 1.
The quality of evidence that reported outcomes of the Ponseti method in sub-Saharan Africa was low. Studies were included from ten countries in sub-Saharan Africa; studies undertaken in Nigeria and Malawi contributed five papers each. There were three RCTs, all with small sample sizes of less than 100 children. The majority of studies were classed as level IV  due to their observational nature.
Definition of success – Primary outcome
All authors described a form of clinical assessment to assess outcome of treatment. Only 14 studies (64%) gave a clear definition of success. The Pirani score was defined as the primary outcome measure to assess the deformity correction in 14 studies. Change in the mean Dimeglio score was evaluated in one study  and frequency of initial severity was reported with the Harrold-Walker classification in two studies [26, 27]. Other definitions of primary outcome included: the number of days in casts , number of patients treated without extensive surgery , a plantigrade foot [24, 28, 29], no residual deformity , deformity status compared to previous visits  and parent reported outcomes on impact of treatment . Limited definition terms included “complete correction”  and “satisfactory outcome” . The approach to reporting severity scores varied (Table 3).
There was wide variation in the measurement of process outcomes. The point in treatment when the number of casts was calculated was either before or after the final post tenotomy cast and was inconsistently described. Studies either reported frequency of tenotomy per child or per foot. Definition of relapse or recurrence of deformity differed in the included studies and technical details were only described in five studies (23%).
One study assessed parent reported outcomes. The study aimed to determine the impact of the casting and bracing phases of the Ponseti method on the family. Each caregiver completed three questionnaires  in order to examine the level of impact that Ponseti treatment had on lives of caregivers and the coping strategies employed.
Reported process outcomes are presented in Table 4.
According to the quality assessment (Additional file 2 outlines the individual study results using the Downs and Black (1998) criteria), the mean quality score of the included studies was 14.8 (5–21).
Reporting was the highest scoring category of the quality assessment. All studies included a clear study hypothesis and aim and the majority (17/22) clearly described the characteristics of the patients and the intervention. However, while some distributions of principle confounders were partially described, few studies accounted for confounding in the study design or analysis. Loss to follow up was only reported in half of the studies. Few studies demonstrated a comprehensive attempt to measure adverse effects.
Many children were recruited from University and tertiary hospitals or national centres and therefore external validity was limited as the interventions undertaken in a specialist centre are likely unrepresentative of the hospitals most of the source population would attend.
Internal validity – Bias and confounding
Randomisation is not possible in cohort studies and in the studies where randomisation was used, it was not possible to determine if the intervention assignment was concealed from both parents and staff until recruitment was complete and irrevocable. Characteristics of losses of patient follow up were inconsistently taken into account and reported in seven (32%) studies. Statistical tests used to assess the main outcomes and why they were chosen were inconsistently described; for example, median, mean and maximum of the number of casts used to achieve correction are reported in different papers. Power calculations were only outlined in three studies.
This literature review comprises results from case series, prospective trials and cross-sectional surveys in sub-Saharan Africa. There were few comparative studies concerning the Ponseti method in the region and there were no agreed protocols for reporting the results and outcome of treatment. Due to ethical considerations, most trials investigating treatment of clubfoot are not randomised controlled trials (RCTs) but comparisons of treatments or a review of cohort outcomes. Potential sources of bias in observational studies are well documented  and whilst systematic reviews of health care interventions most often focus on RCTs, the inclusion of cohort studies in this review highlights the need for quality design and reporting of studies to increase the strength of evidence.
Principal findings and considerations
A definition of a primary outcome (success) was described in 14 of the 22 studies. Successful outcome ranged from 68% to 98% of cases using different definitions in the 14 studies. There was no consensus on how to define a successful outcome of treatment. There was selective reporting of positive results with little detail given to treatment failure . A range of process measures was included in the studies. The mean number of casts required ranged from 4.6 to 8.7 and is likely affected by the point at which the last cast was measured (pre- or post-tenotomy) and the unlimited age range of the review criteria. The studies used different criteria for relapse recognition and management. Two studies reported patient attrition over 30% [28, 36] however the length of follow-up in the majority of studies was short and few data were available on characteristics of children lost to follow up.
Acknowledging the limitations of the available reported papers, this review suggests that the Ponseti method appears to give successful correction of clubfoot during the correction phase when measured by the Pirani score, Dimeglio classification or simple clinical assessment. However, the lack of a consistent measure of success and insufficient follow up of cases restricts the conclusions that can be made about what happens during the bracing phase, be it success, recurrence or loss to follow-up.
Main findings as related to other publications
The included studies report success in 68% to 98% of cases after the correction (casting) phase. In contrast, global success rates after the correction phase are cited as approximately 90% [18, 37]. Comprehensive tools to assess function (e.g. as described by Laaveg and Ponseti (12), the Roye tool , the Bangla tool  or the Clubfoot Assessment Protocol (CAP) ) are not reported in the studies from sub-Saharan Africa.
Implications of findings
We found that the differences between study populations, methodology and the way that outcomes are described contribute to the variation in results reported for the Ponseti method in sub-Saharan Africa. Currently, different scores are used for the assessment of clubfoot severity. Standardisation is required to define successful outcome of clubfoot management so that risk factors for good and poor outcome can be determined and services can be monitored and evaluated.
The Pirani score was the most frequent clinical assessment used. It has been validated in younger children and demonstrates acceptable interrater reliability . A short assessment time is required and it is easy to use, however to ensure consistency more guidance would be helpful on how to measure the individual components, as similarly provided by the diagrams and video produced to aid assessment with the Dimeglio score. The Pirani scoring system is the only assessment that has evidence for use by paramedics, and is in our opinion the easiest severity measure to use in young children before walking age.
To our knowledge, this is the first systematic review of outcomes to measure success of the Ponseti method in sub-Saharan Africa. The observation of explicit methodology and lack of language restriction are strengths of this study. The literature available to assess success of clubfoot treatment is characterised by a lack of standardisation of outcomes. Studies routinely use the term “success rates” but do not define a successful outcome. Given that Ponseti management involves both correction and maintenance, the definition of success should always reflect both of these important endpoints and we encourage researchers to measure and report both. Bias in internal validity arose from studies where differences in follow up were regularly ignored, however compliance with the corrective phase of the intervention was generally reported as being good. Studies must include follow-up or acknowledge the limitations of selecting one part of the treatment process.
The potential for confounding in the reviewed studies to obscure true effects is significant as the majority are observational. Randomisation may be considered unethical in certain circumstances and well designed controlled trials may provide more opportunities to analyse different outcomes. Studies intended to address comparative effectiveness of management for clubfoot should use a careful control for covariates such as unilateral or bilateral clubfoot as disproportionate weighting is given to bilateral cases .
Although a number of studies are available on initial treatment (correction phase) outcomes, very few studies are available on long term outcomes and follow up in the bracing phase, which are essential for measuring success of the entire Ponseti method.
No study compared different scoring systems. A study comparing multiple assessments in the same patient before and after treatment would be of value in assessing the equivalence or superiority of measurement techniques.
Studies need to control for the side of clubfoot and previous treatment, account for loss to follow up and adjust for confounding in methods or analysis in order to avoid the shortfalls of the current observational literature.
Consensus is needed to standardise the reporting of outcomes and how success after Ponseti management is defined. For sub-Saharan Africa the definition needs to be appropriate for use by trained therapists who are managing children with clubfoot. This systematic review contributes to the knowledge about the importance of providing evidence to improve clubfoot services.
The lack of good quality studies, variation in definition of success and limited follow-up of patients means the success rate of clubfoot treatment using the Ponseti method in sub-Saharan Africa is uncertain. There is need for an agreed definition of good outcome following both the correction and the bracing phase to monitor and evaluate service delivery and identify reasons for poor outcome. It is very important that children who complete the correction phase are followed through the bracing phase and results on success, recurrence and loss to follow up are reported. Studies are also required to document the correlation between clinical outcome, functional outcome and patient/family reported satisfaction.
Congenital Talipes Equinovarus
Foot Abduction Brace
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Professor Daniel Chandramohan for early concept considerations.
The Beit Trust and CBM are gratefully acknowledged for funding provided to TS.
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Data sharing not applicable to this article as no datasets were generated or analysed during the current study. Two web appendices are attached: detailed search terms and quality assessment scores.
TS conceived the study. TS AF and CL designed the study protocol. TS and DM searched the literature and extracted data for analysis. TS analysed and interpreted the extracted information. AF CL HK and DM critically revised the manuscript for intellectual content. All authors read and approved the final manuscript.
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Smythe, T., Mudariki, D., Kuper, H. et al. Assessment of success of the Ponseti method of clubfoot management in sub-Saharan Africa: a systematic review. BMC Musculoskelet Disord 18, 453 (2017). https://doi.org/10.1186/s12891-017-1814-8
- Congenital talipes equinovarus