- Study protocol
- Open Access
Study protocol: Transition from localized low back pain to chronic widespread pain in general practice: Identification of risk factors, preventive factors and key elements for treatment – A cohort study
BMC Musculoskeletal Disorders volume 13, Article number: 77 (2012)
Chronic localized pain syndromes, especially chronic low back pain (CLBP), are common reasons for consultation in general practice. In some cases chronic localized pain syndromes can appear in combination with chronic widespread pain (CWP). Numerous studies have shown a strong association between CWP and several physical and psychological factors. These studies are population-based cross-sectional and do not allow for assessing chronology. There are very few prospective studies that explore the predictors for the onset of CWP, where the main focus is identifying risk factors for the CWP incidence. Until now there have been no studies focusing on preventive factors keeping patients from developing CWP.
Our aim is to perform a cross sectional study on the epidemiology of CLBP and CWP in general practice and to look for distinctive features regarding resources like resilience, self-efficacy and coping strategies. A subsequent cohort study is designed to identify the risk and protective factors of pain generalization (development of CWP) in primary care for CLBP patients.
Fifty-nine general practitioners recruit consecutively, during a 5 month period, all patients who are consulting their family doctor because of chronic low back pain (where the pain is lasted for 3 months). Patients are asked to fill out a questionnaire on pain anamnesis, pain-perception, co-morbidities, therapy course, medication, socio demographic data and psychosomatic symptoms. We assess resilience, coping resources, stress management and self-efficacy as potential protective factors for pain generalization. Furthermore, we raise risk factors for pain generalization like anxiety, depression, trauma and critical life events. During a twelve months follow up period a cohort of CLBP patients without CWP will be screened on a regular basis (3 monthly) for pain generalization (outcome: incident CWP).
This cohort study will be the largest study which prospectively analyzes predictors for transition from CLBP to CWP in primary care setting. In contrast to the typically researched risk factors, which increase the probability of pain generalization, this study also focus intensively on protective factors, which decrease the probability of pain generalization.
German Clinical Trial Register DRKS00003123
Chronic localized pain syndromes, especially chronic low back pain (CLBP), are common reasons for consultation in general practice. CLBP is usually defined as pain, on most days of a three months period, in the back area from underneath the costal margin to the gluteal fold . In some cases chronic localized pain syndromes can appear in combination with chronic widespread pain (CWP). Wolfe et al. defined CWP as pain in the left and right side of the body as well as above and below the waist plus pain in the axial skeleton . A Swedish cross-sectional-study found a CWP prevalence of 28% out of all female CLBP patients in primary health care . It is still unclear whether CWP is a complication of chronic local pain or an independent pain syndrome .
The association of CWP and several physical and psychological factors are well-documented. Studies show high prevalence of comorbidities  (most common are anxiety and somatization disorders). CWP patients are more often of older age, female, less educated and have decreased health related quality of life . They show restricted functional ability  and frequently receive a disability pension . In addition, there is a high social and economic burden of chronic pain, especially CWP . These studies are population-based cross-sectional and cannot determine the temporal relationship between predictors and the development of CWP (generalization of pain). There are few prospective studies that explore predictors for the onset of CWP. Gupta and colleagues performed a population-based prospective study (EPIFUND-study) . They identified the following disorders to be associated with CWP: psychological distress (in this case anxiety, depression, somatization disorders) , health related quality of life , physical inactivity , and sleep disorders .
Previous research, including the study of Gupta et al., primarily focused on risk factors (i.e., negative aspects advancing the development of the disease and increasing the probability of illness ). Our aim, on the other hand, is to identify protective factors (predictors decreasing the probability of illness ). Our research approach has been derived from the salutogenetic concept of Aaron Antonovsky . His model of salutogenesis focuses on factors enhancing health and wellbeing, which protect (healthy) individuals from potentially damaging influences. Resources like resilience, self-efficacy and coping strategies are under consideration for being protective factors for incident chronic pain syndromes. Costa et al. found a strong relationship between pain self-efficacy, pain intensity and disability in patients with a recent onset of chronic low back pain . Another study by Ong et al. illustrated that psychologically resilient individuals rebound from daily pain catastrophizing through experiences of positive emotions . Finally, a study by Tan et al. studied the relationship between coping, beliefs and the adjustment to chronic pain .
General practitioners (GP) are often the main coordinators of CLBP and CWP patients’ management. They provide longitudinal continuity of care and play a major role with respect to appropriate care and health service utilisation . Therefore, epidemiological data and knowledge about distinctive features between CLBP patients and CWP patients is needed, especially for primary care setting. GPs need to have predictors to identify CLBP patients at risk of developing CWP. Knowledge about protective factors will help to support GPs in an individualized treatment approach.
Aim of the study
The aim of our study is to provide prevalence data on CLBP and CWP for the primary care setting. The differences between both pain localizations, with respect to pain characterisation and comorbidities, will be determined. In addition, we search for risk factors and protective factors of pain generalization in primary care CLBP patients.
A 12 month cohort study is performed with baseline data collection (T0) and four follow ups (after 3, 6, 9 and 12 months, T1-T4).
This project is part of the research Consortium LOGIN “Localized and Generalized Muskuloskeletal Pain: Psychobiological Mechanisms and Implications for Treatment“ funded by the German Federal Ministry of Education and Research.
For a multi centre data collection, general practitioners in the State of Hessen, Germany are approached. Due to logistical reasons, recruitment is conducted in four waves. Participating practices (doctors and assistant personnel) are asked to recruit all eligible patients who consult for CLBP during a 5 months period, including patients consulting in home visits and emergency calls. Detailed inclusion and exclusion criteria are shown in Table 1. Trained clinical monitors visit the practices to insure validity and consecutive recruitment, during two times (at beginning and at half time of recruitment period).
The number of patients, who deny participation is documented along with the reasons (in an anonymized way), and these patients are accounted for our prevalence analyzes.
A pen and paper questionnaire is used for data collection. After written consent is obtained, patients are asked to fill in the first questionnaire. In addition, general practitioners complete a case report form for every participant. CLBP patients, having no CWP at baseline, are included in the cohort study with a 12 months follow up. They receive mailed follow up questionnaires every three months (T1-T4), and if necessary, followed by two telephone reminders. In cases where participants are unreachable, we do ten calling attempts, during different day times before aborting the reminding process. Participants, who do not return questionnaire and do not explicitly refuse future participation, will be sent the next questionnaire as scheduled.
For investigating distinctive features (e.g. pain characteristics) between CLBP patients and CWP patients as well as potential risk and protective factors, the following physical and psychological parameters are collected at baseline (Table 2):
Description of sample characteristics - pain characteristics
For pain localisations and consequently for definition of CLBP and CWP we chose the body pain drawing model from Pfau et al. , where we modified the picture of the head and food. For definition of CWP, the ACR criteria from Wolfe et al. are used . To allow for a standardized, objective analysis and classification we developed an evaluation template according to Diesner et al.  and Harkness .
We used the “German Pain Questionnaire” to determine the characteristics and history of the pain . It is the official pain questionnaire from the German Association for the Study of Pain. The questions cover the following aspects: socio demographic data, subjective pain description and perception, factors of pain alleviation and exacerbation, disturbance as a result of pain, subjective pain model, screening for depression and anxiety disorders, health care utilization, as well as medical and psychological comorbidities. Nagel et al. tested the feasibility and content validity in a sample of 3000 patients . Comparison with external criteria (e.g. medical and psychiatric-psychological diagnoses, physician-determined chronicity of pain) showed good content validity and excellent reliability of patients statements . For this study we selected the following modules: pain duration, -characteristics and –course, socio demographic data, health care utilization and medication.
To assess the partner’s reaction in response to patient’s pain, we use the social support subscale (3 items) of the “West Haven-Yale Multidimensional Pain Inventory” [25, 26]. It is a 12 scales questionnaire measuring the impact of pain on a patient’s life, the responses of others to the patients’ communications of pain and the extent to which patients participate in common daily activities.
The reliability test of the German version (MPI-D) from Flor et al. showed moderate to high internal consistency of the different subscales (α = 0.63-0.90) . For validation, every subscale was correlated with an external instrument showing moderate to high validity .
To classify subjective severity of chronic pain we use the “Graded Chronic Pain” questionnaire (GCP) according to von Korff . The self-report measure uses ratings of pain intensity and pain related disability. The author suggests a hierarchical model of pain severity where medium pain intensity is represented in the lower range of pain severity, whereas measurements of intense pain together with pain related disability are higher on the scale . This is a 7 item questionnaire resulting in four hierarchical categories: Grade I, low disability - low pain intensity; Grade II, low disability - high pain intensity; Grade III, high disability - moderately limiting; Grade IV, high disability - severely limiting. Grade III and IV usually imply high pain intensity. According to Klasen et al. , the German version of the GCP, the factor 'Disability Score' showed a high internal consistency (α = 0.88), whereas the internal consistency of the factor 'Characteristic Pain Intensity' was moderate (α = 0.68) . There is a moderate to high correlation of the German GCP and its subscales to other instruments on the patient's disability (Funktionsfragebogen Hannover: Spearman’s Rho = −0.34; Pain Disability Index: Spearman’s Rho = 0.56) .
Description of sample characteristics - comorbidities
Comorbidities are assessed by the “Self Administered Comorbidity Questionnaire” (SACQ) [29, 30]. Participants are asked to comment on 12 frequent medical conditions (heart disease, high blood pressure, lung disease, diabetes, ulcer or stomach disease, kidney disease, liver disease, anemia or other blood disease, cancer, depression, arthritis, and back pain). For each medical condition patients are asked whether they suffer from this problem, if he/she receives treatment for it, and if the problem causes functional limitations. The test-retest reliability for the SCQ was 0.94 (95% confidence interval: 0.72 to 0.99) as calculated by the intra class correlation coefficient . Regarding validity, the Spearman correlation between the SACQ and the Charlson Index was 0.55 for the instrument .
Description of sample characteristics - psychosomatic symptoms
To identify psychosomatic symptoms, we use the somatization subscale of the “Symptom Check-List-90-R” (SCL-90-R) . It is a commonly used psychological status symptom inventory for mental illness. It is built up of nine dimensions: somatization, obsessive compulsive, interpersonal sensitivity, depression, anxiety, anger/hostility, phobic anxiety, paranoid ideation and psychoticism. The instrument supports the computation of three overall scales, comprising the number of symptoms in general and their mean impact. Items are rated on the 5-point Likert Scale of distress, ranging from “not at all” to “extremely”. Schmitz et al. described a high reliability (internal consistency of somatization subscale α = 0.81) and a moderate concurrent validity compared to the “General Health Questionnaire” (0.52) .
Risk factor - anxiety and depression
The “Hospital Anxiety and Depression Scale” (HADS) [33, 34] screens for anxiety disorders and depression. It consists of two 7-item subscales (anxiety and depression). Each item scores on a four-point Likert scale and assesses symptoms in the last week. Psychometric properties of the HADS were assessed in numerous studies. Herrmann et al. reported high reliability of the anxiety and depression subscales (internal consistency anxiety α = 0.80; depression α = 0.81) as well as high validity (correlated with external anxiety scales r = 0.65; depression scales r = 0.70) of the German version of HADS .
Protective factor - coping resources for back pain
We use the FBR-questionnaire “Fragebogen zu Bewältigungsressourcen bei Rückenschmerzen” from Tamcam et al. to assess coping resources for back pain . It was specially developed for identifying helpful coping resources of patients with back pain in primary care setting. While other scales rather ask for the knowledge of pain coping skills and resources, the 12-item-FBR explicitly asks for their perceived helpfulness . Items are rated on an eleven-point Likert scale ranging from “not helpful” to “very helpful”.
Protective factor - resilience
Resilience as a potential protective factor towards pain generalisation is estimated using the resilience scale RS-11, a shortened and validated German form of the Wagnild & Young questionnaire [36, 37]. It measures the capacity to withstand life stressors. We use the 11-item short version of the 25-item original scale. It consists of two subscales (Personal Competence and Acceptance of Self and Life). Reliability testing by Schumacher et al. proved high internal consistence (α = 0.91). In addition, validity of RS-11 was demonstrated by a high correlation with the construct of self-efficacy .
Supplementary baseline measurements for CWP patients
CLBP patients, having CWP at baseline, get supplementary concluding measurement instruments (SES, Brief COPE, GSE, PDS-d-1, critical life events, apart from therapy course, medication, MPI and body pain drawing model), like the cohort group gets during follow ups. Taking into account the length of the questionnaires they are assessed after 3 months. An extensive description of the measurement instruments and our motivation for using it is described in the next chapter.
Follow up measurements for CLBP patients (cohort group)
To identify incidental CWP (primary outcome), we collected data every three months to screen for pain generalization using the body pain drawing model (T0-T4).
In addition the following physical and psychological parameters are collected at follow up (Table 2):
Description of sample characteristics - pain perception
We assess pain perception with the “Schmerzempfindungsskala” (SES) during the first follow up . The questionnaire consists of 24 items with two global dimensions “affective aspects of pain perception” and “sensory aspects of pain perception”. The items ask for different pain perceptions (for example: “My pain feels hot.”) and patients have to judge their degree of agreement on a four-point Likert scale ranging from “not true” to “absolutely true”. Psychometric tests showed high reliability (internal consistency of the affective subscale/sensory subscale α = 0.92/α = 0.81) and good validity .
Description of sample characteristics - health care utilization and medication
Just like at baseline, health care utilization and medication during the preceding half year are assessed after the 6th and 12th month (T2 and T4).
During the 12 months follow up the following data will be collected:
Protective factor - coping
To assess stress management competence (coping), we use the Brief COPE from Carver et al. [39, 40]). It is a shorter version of the original COPE questionnaire and consists of 14 subscales, where each subscale is represented by two items. Participants are asked to think of their usual thoughts and actions while faced with a difficult situation and to indicate their answers on a four-point Likert-type scale, rating the resemblance of each item to coping efforts pursued. The response scale ranges from “not at all”, “a little bit”, “considerably” to “very much”. Cooper et al. tested reliability of Brief COPE to patients with Alzheimer’s disease. They assessed average internal consistencies for emotion-focused (α = 0.72), problem-focused (α = 0.84), and dysfunctional (α = 0.75) subscales . Regression analyses indicate convergent and concurrent validity .
Protective factor - self-efficacy
We use the “general self-efficacy-questionnaire” (GSE) to assess self-efficacy [42, 43]. It applies to a patient’s self-assessment of their ability to improve their daily troubles and how they cope with critical situations. The questionnaire consists of 10 items to be rated by four-point-Likert-scale ranging from “very uncertain”, “rather uncertain”, “rather certain” to “very certain”. Hintze et al. showed a high reliability (internal consistency α = 0.92) and good validity (correlation with the resilience scale r = 0.68) of the German version of GSE .
Risk factor – trauma
We use Part 1 of the “Posttraumatic Diagnostic Scale” (PTDS)  to assess whether patients suffer from traumatic life events. It is a self-report screening instrument based on the type, time duration, and circumstances of traumatic experiences . Griesel et al. reported high reliability (internal consistency of the total scale was α = 0.94) and high validity (correlation with the “Clinician Administered PTSD Scale” (CAPS) r = 0.76; p = 0.001) of the German PTDS .
Risk factor - critical life events
The critical life events questionnaire from the work of Leist et al. are used . Participants are asked to select if and when they experienced any possibly life changing events on a 22 items list.
Description of sample characteristics - pain characteristics
Finally, during the fourth follow up measurement point (T4) participants are asked to complete the “West Haven-Yale Multidimensional Pain Inventory” [25, 26]. This is done to investigate if our CLBP patients can be classified into the three clusters (dysfunctional, interpersonally distressed, adaptive copers) that have been widely shown to represent different subgroups of patients with fibromyalgia .
General practitioners case report
GPs are asked to comment on the individual presence of red flags with every patient included in the study. Red flags are frequently used risk factors for identifying serious disorders causing low back pain . In addition, we ask GPs for their personal opinion about whether the patient’s prognosis will be better, equal or worse in one year. GPs are asked to estimate each patient’s probability for pain generalization during the follow up.
Based on the results of the cohort study a qualitative sub-study will be performed, after completed follow up, regarding patients’ and physicians’ perspectives of a resource based treatment approach for prevention and therapy of CLBP and CWP.
Group comparisons of CWP and CLBP patients will be performed. For this we use measures of central tendency (mean and standard deviation, median, percentile, frequency and percentages) as well as chi-square tests for categorical data. The t-test is applied for comparing means. Effect sizes will be expressed in terms of odds ratios for categorical dependent variables and, for quantitative dependent variables, in terms of group differences or differences per unit change of a quantitative predictor variable.
For identification of predictors logistic regression analysis will be performed using incidental CWP as dependent variable. We use baseline risk and protective factors as independent variables or predictors. All analyses are supervised and advised by a senior statistician of the Institute of Genetic Epidemiology (IGE), University of Munich and Helmholtz Zentrum München.
Focus groups: The results of the focus groups are analyzed according to predefined main topics. Answers of patients and physicians are contrasted.
Based on results from previous studies we presumed a CWP prevalence of 10%  leading to 900 patients to be included in the cohort study (localized chronic pain only). Assuming a 10% rate of patients developing generalized pain (n = 90)  up to 9 independent variables may be included in the logistic regression analysis (corresponding to 10 events per independent variable [51, 52]).
Assumptions: Prevalence of generalized chronic back pain of 10%. A change of an independent variable by one standard deviation in the population implies an odds ratio of 1.65. Calculated power: 0.83 for alpha = 0.005, which means after adjustment of multiple testing of 9–10 variables an overall probability of the type one error of 0.05 will not be exceeded. The power has been calculated by performing simulations using the software R (R Development Core Team 2010).
The study was approved by the local ethics commission of Philipps-University Marburg (Ethik: 11.06.2010, AZ 88/10) and is in accordance with the Declaration of Helsinki.
This cohort study will be the largest study which prospectively analyzes predictors for transition from CLBP to CWP in primary care setting. In contrast to the typically researched risk factors, which increase the probability of pain generalization, this study also focus intensively on protective factors, which decrease the probability of pain generalization. The identified risk and protective factors might aloud GPs to identify patients at risk for development of CWP. Furthermore, the acquired knowledge about protective factors will help us to develop an individualized treatment approach for GPs.
Selection bias is often the major limitation of a cohort study. The amount of psychological constructs measured in this study can be rather demanding in terms of endurance and intellectual abilities compared to usual studies in primary care setting. For our primary care study population, which includes a high proportion of older people and persons with lower educational background, it may be a problem to deal with the questionnaires. These patients might be more likely to deny participation or abort follow up.
It might be possible, that GPs are more likely to remember study recruitment, in special cases (e.g. patients with higher disease severity or special characters) or during times with a lower workload. An incomplete recruitment brings forth the risk of selection bias and lowers external validity.
Results of the baseline analysis are expected in the course of this year (2012). Follow up data will be completed, next year (2013).
Chronic low back pain
Chronic widespread pain
West Haven-Yale Multidimensional Pain Inventory
German version of the West Haven-Yale Multidimensional Pain Inventory
Graded Chronic Pain
Self Administered Comorbidity Questionnaire
Hospital Anxiety and Depression Scale
Fragebogen zu Bewältigungsressourcen bei Rückenschmerzen (questionnaire for assessing coping resources for back pain)
Pain perception scale
Measurement instrument for coping
Posttraumatic Diagnostic Scale.
Airaksinen O, Brox JI, Cedraschi C, Hildebrandt J, Klaber-Moffett J, Kovacs F: Chapter 4. European guidelines for the management of chronic nonspecific low back pain. Eur Spine J. 2006, 15 (Suppl 2): S192-S300.
Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL: The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990, 33 (2): 160-172. 10.1002/art.1780330203.
Nordeman L, Gunnarsson R, Mannerkorpi K: Prevalence and characteristics of widespread pain in female primary health care patients with chronic low back pain. Clin J Pain. 2012, 28 (1): 65-72. 10.1097/AJP.0b013e318223622c.
Natvig B, Bruusgaard D, Eriksen W: Localized low back pain and low back pain as part of widespread musculoskeletal pain: two different disorders? A cross-sectional population study. J Rehabil Med. 2001, 33 (1): 21-25. 10.1080/165019701300006498.
Vandenkerkhof EG, Macdonald HM, Jones GT, Power C, Macfarlane GJ: Diet, lifestyle and chronic widespread pain: results from the 1958 British Birth Cohort Study. Pain Res Manag. 2011, 16 (2): 87-92.
Cho NH, Kim I, Lim SH, Kim HA: Prevalence of widespread pain and its influence on quality of life: population study in Korea. J Korean Med Sci. 2012, 27 (1): 16-21. 10.3346/jkms.2012.27.1.16.
Amris K, Waehrens EE, Jespersen A, Bliddal H, Danneskiold-Samsoe B: Observation-based assessment of functional ability in patients with chronic widespread pain: a cross-sectional study. Pain. 2011, 152 (11): 2470-2476. 10.1016/j.pain.2011.05.027.
Overland S, Harvey SB, Knudsen AK, Mykletun A, Hotopf M: Widespread pain and medically certified disability pension in the Hordaland Health Study. Eur J Pain. 2011, : -
Becker A, Held H, Redaelli M, Strauch K, Chenot JF, Leonhardt C: Low back pain in primary care: costs of care and prediction of future health care utilization. Spine (Phila Pa 1976). 2010, 35 (18): 1714-1720. 10.1097/BRS.0b013e3181cd656f.
Gupta A, Silman AJ, Ray D, Morriss R, Dickens C, MacFarlane GJ: The role of psychosocial factors in predicting the onset of chronic widespread pain: results from a prospective population-based study. Rheumatology (Oxford). 2007, 46 (4): 666-671.
Nicholl BI, Macfarlane GJ, Davies KA, Morriss R, Dickens C, McBeth J: Premorbid psychosocial factors are associated with poor health-related quality of life in subjects with new onset of chronic widespread pain - results from the EPIFUND study. Pain. 2009, 141 (1–2): 119-126.
McBeth J, Nicholl BI, Cordingley L, Davies KA, Macfarlane GJ: Chronic widespread pain predicts physical inactivity: results from the prospective EPIFUND study. Eur J Pain. 2010, 14 (9): 972-979. 10.1016/j.ejpain.2010.03.005.
Davies KA, Macfarlane GJ, Nicholl BI, Dickens C, Morriss R, Ray D: Restorative sleep predicts the resolution of chronic widespread pain: results from the EPIFUND study. Rheumatology (Oxford). 2008, 47 (12): 1809-1813. 10.1093/rheumatology/ken389.
Petermann D, Schmidt M: Ressourcen - ein Grundbegriff dr Entwicklungspsychologie und Entwicklungspsychopathologie?. Kindheit und Entwicklung. 2006, 15 (2): 118-127. 10.1026/0942-5403.15.2.118.
Health, stress and coping. Edited by: Antonovsky A. 1979, Jossey-Bass, San Francisco
Costa Lda C, Maher CG, McAuley JH, Hancock MJ, Smeets RJ: Self-efficacy is more important than fear of movement in mediating the relationship between pain and disability in chronic low back pain. Eur J Pain. 2011, 15 (2): 213-219. 10.1016/j.ejpain.2010.06.014.
Ong AD, Zautra AJ, Reid MC: Psychological resilience predicts decreases in pain catastrophizing through positive emotions. Psychol Aging. 2010, 25 (3): 516-523.
Tan G, Teo I, Anderson KO, Jensen MP: Adaptive versus maladaptive coping and beliefs and their relation to chronic pain adjustment. Clin J Pain. 2011, 27 (9): 769-774. 10.1097/AJP.0b013e31821d8f5a.
European Academy of Teachers in General Practice (Network within WONCA Europe): The european defintion of general practice/family practice. 2005
Pfau DB, Rolke R, Nickel R, Treede RD, Daublaender M: Somatosensory profiles in subgroups of patients with myogenic temporomandibular disorders and Fibromyalgia Syndrome. Pain. 2009, 147 (1–3): 72-83.
Diesner S: Drei Methoden zur Erfassung der Schmerzausbreitung bei chronischen Schmerzpatienten im Vergleich. 2007, , Heidelberg, -
Harkness EF, Macfarlane GJ, Silman AJ, McBeth J: Is musculoskeletal pain more common now than 40 years ago?: Two population-based cross-sectional studies. Rheumatology (Oxford). 2005, 44 (7): 890-895. 10.1093/rheumatology/keh599.
Deutscher Schmerzfragebogen. 1997, Deutsche Gesellschaft zum Studium des Schmerzes e.V. (DGSS), Köln
Nagel B, Gerbershagen HU, Lindena G, Pfingsten M: Development and evaluation of the multidimensional German pain questionnaire. Schmerz. 2002, 16 (4): 263-270. 10.1007/s00482-002-0162-1.
Kerns RD, Turk DC, Rudy TE: The West Haven-Yale Multidimensional Pain Inventory (WHYMPI). Pain. 1985, 23: 345-356. 10.1016/0304-3959(85)90004-1.
Flor H, Rudy TE, Birbaumer N, Streit B, Schugens MM: The applicability of the West Haven-Yale Multidimensional Pain Inventory in German-speaking countries: Data on the reliability and validity of the MPI-D. Der Schmerz. 1990, 4: 82-87. 10.1007/BF02527839.
Von Korff M, Dworkin SF, Resche LL: Graded chronic pain status: an epidemiologic evaluation. Pain. 1990, 40: 179-291.
Klasen BW, Hallner D, Schaub C, Willburger R, Hasenbring M: Validation and reliability of the German version of the Chronic Pain Grade questionnaire in primary care back pain patients. Psychosoc Med. 2004, 1: Doc07-
Sangha O, Stucki G, Liang MH, Fossel AH, Katz JN: The Self-Administered Comorbidity Questionnaire: a new method to assess comorbidity for clinical and health services research. Arthritis Rheum. 2003, 49 (2): 156-163. 10.1002/art.10993.
Hüppe A, Raspe H: Amplifizierte Rückenschmerzen und Komorbidität in der Bevölkerung. Der Schmerz. 2009, 23: 275-283.
Franke GH, Stäcker KH: Reliabilität und Validität der Symptom-Check-Liste (SCL-90-R; Derogatis 1986) bei Standardreihenfolge versus inhaltshomogener Itemblockbildung. Diagnostica. 1995, 41: 349-373.
Schmitz N, Hartkamp N, Kiuse J, Franke GH, Reister G, Tress W: The Symptom Check-List-90-R (SCL-90-R): a German validation study. Qual Life Res. 2000, 9 (2): 185-193. 10.1023/A:1008931926181.
Zigmont AS, Snaith RP: The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983, 67: 361-370. 10.1111/j.1600-0447.1983.tb09716.x.
Herrmann C: International experiences with the Hospital Anxiety and Depression Scale – A review of validation data and clinical results. J Psychosom Res. 1997, 42: 17-41. 10.1016/S0022-3999(96)00216-4.
Tamcan Ö, Bantli S, Abel T, Barth J: Coping resources for back pain: a new assessment tool for clinical practice. Z Med Psychol. 2010, 19: 21-29.
Wagnild GM, Young HM: Development and psychometric evaluation of the Resilience Scale. Winter. 1993, 1 (2): 165-178.
Schumacher J, Leppert K, Gunzelmann T, Strauß B, Brähler E: Die Resilienzskala – Ein Fragebogen zur Erfassung der psychischen Widerstandsfähigkeit als Personmerkmal. Z Klin Psychol Psychiatr Psychother. 2005, 53: 16-39.
Die Schmerzemfindungsskalan (SES). Edited by: Geissner E. 1996, Hogrefe, Göttingen
Carver CS: You want to measure coping but your protocol's too long: consider the brief COPE. Int J Behav Med. 1997, 4 (1): 92-100. 10.1207/s15327558ijbm0401_6.
Knoll N, Rieckmann N, Schwarzer R: Coping as a Mediator Between Personality and Stress Outcomes: A Longitudinal Study with Cataract Surgery Patients. Eur J Personal. 2005, 19: 229-247. 10.1002/per.546.
Cooper C, Katona C, Livingston G: Validity and Reliability of the Brief COPE in Carers of People with Dementia. The LASER-AD Study. J Nerv Ment Dis. 2008, 196 (11): 838-843. 10.1097/NMD.0b013e31818b504c.
Schwarzer R, Jerusalem M: Generalized Self-Efficacy scale. Measures in health psychology: A user’s portfolio Causal and control beliefs. Edited by: Weinman J, Wright S, Johnston M. 1995, NFER-Nelson, Windsor, UK, 35-37.
Hinz A, Schumacher J, Albani C, Schmid G, Brähler E: Bevölkerungsrepräsentative Normierung der Skala zur Allgemeinen Selbstwirksamkeitserwartung. Diagnostica. 2006, 52 (1): 26-32. 10.1026/0012-19188.8.131.52.
Posttraumatic Stress Diagnostic Scale: Manual. Edited by: Foa EB. 1995, National Computer Systems, Minneapolis
Griesel D, Wessa M, Flor H: Psychometric qualities of the German version of the Posttraumatic Diagnostic Scale (PTDS). Psychol Assess. 2006, 18 (3): 262-268.
Leist A: Autobiographisches Erinnern kritischer Lebensereignisse. Die Stiftung von Kohärenz im Lebensrückblick. 2008, Universität Trier
Thieme K, Spies C, Sinha P, Turk DC, Flor H: Predictors of pain behaviors in fibromyalgia syndrome. Arthritis Rheum. 2005, 53 (3): 343-350. 10.1002/art.21158.
van Tulder M, Becker A, Bekkering T, Breen A, del Real MT, Hutchinson A: Chapter 3. European guidelines for the management of acute nonspecific low back pain in primary care. Eur Spine J. 2006, 15 (Suppl 2): S169-S191.
Huppe A, Brockow T, Raspe H: Chronic widespread pain and tender points in low back pain: a population-based study. Z Rheumatol. 2004, 63 (1): 76-83. 10.1007/s00393-004-0531-5.
Macfarlane G: Fibromyalgia and chronic widespread pain. Epidemiology of pain. Edited by: Crombie I, Croft P, Linton S, LeResche L, Korff M. 1999, IASP Press, Seattle, 113-123.
Concato J, Peduzzi P, Holford TR, Feinstein AR: Importance of events per independent variable in proportional hazards analysis. I. Background, goals, and general strategy. J Clin Epidemiol. 1995, 48 (12): 1495-1501. 10.1016/0895-4356(95)00510-2.
Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR: A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol. 1996, 49 (12): 1373-1379. 10.1016/S0895-4356(96)00236-3.
The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2474/13/77/prepub
This work is funded by the German Federal Ministry of Education and Research.
We thank all participating doctors and patients.
Annika Viniol does not state any financial or non-financial conflicts of interest.
Nikita Jegan does not state any financial or non-financial conflicts of interest.
Konstantin Strauch does not state any financial or non-financial conflicts of interest.
Markus Brugger does not state any financial or non-financial conflicts of interest.
Jürgen Barth does not state any financial or non-financial conflicts of interest.
Erika Baum does not state any financial or non-financial conflicts of interest.
Corinna Leonhardt does not state any financial or non-financial conflicts of interest.
Annette Becker was a consultant for Grünenthal GmbH, from whom she has also received a speaker’s fee.
Annika Viniol collected and analyzed data and wrote the manuscript. Nikita Jegan collected and analyzed data. Konstantin Strauch and Markus Brugger gave statistical support and planned the study. Jürgen Barth and Erika Baum planned and revised study design. Corinna Leonhardt and Annette Becker planned the study, discussed the results and revised the manuscript critically. All authors edited the drafted version of the manuscript. All authors read and approved the final manuscript.
About this article
Cite this article
Viniol, A., Jegan, N., Leonhardt, C. et al. Study protocol: Transition from localized low back pain to chronic widespread pain in general practice: Identification of risk factors, preventive factors and key elements for treatment – A cohort study. BMC Musculoskelet Disord 13, 77 (2012) doi:10.1186/1471-2474-13-77
- Chronic pain
- Widespread pain
- Low back pain
- Primary care
- Self efficacy