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  1. In the absence of head-to-head trials, indirect comparisons of randomized placebo-controlled trials may provide a viable option to assess relative efficacy. The purpose was to estimate the relative efficacy of...

    Authors: Robert B Hopkins, Ron Goeree, Eleanor Pullenayegum, Jonathan D Adachi, Alexandra Papaioannou, Feng Xie and Lehana Thabane
    Citation: BMC Musculoskeletal Disorders 2011 12:209
  2. Non-specific low back pain (NSLBP) in subacute and chronic stages can be treated effectively with exercise therapy. Research guidelines recommend evaluating different treatments in defined subgroups of patient...

    Authors: Jeannette Saner, Jan Kool, Rob A de Bie, Judith M Sieben and Hannu Luomajoki
    Citation: BMC Musculoskeletal Disorders 2011 12:207
  3. Minimally invasive vertebral augmentation procedures are widely used to treat vertebral compression fractures although procedural polymethylmethacrylate cement leakage remains common. We report herein our init...

    Authors: Panagiotis Korovessis, Thomas Repantis, Larry E Miller and Jon E Block
    Citation: BMC Musculoskeletal Disorders 2011 12:206
  4. Although leisure-time physical activity is important for health, adherence to regular exercise is challenging for many adults. The workplace may provide an optimal setting to reach a large proportion of the ad...

    Authors: Mette K Zebis, Lars L Andersen, Mogens T Pedersen, Peter Mortensen, Christoffer H Andersen, Mette M Pedersen, Marianne Boysen, Kirsten K Roessler, Harald Hannerz, Ole S Mortensen and Gisela Sjøgaard
    Citation: BMC Musculoskeletal Disorders 2011 12:205
  5. The role played by the thoracolumbar fascia in chronic low back pain (LBP) is poorly understood. The thoracolumbar fascia is composed of dense connective tissue layers separated by layers of loose connective t...

    Authors: Helene M Langevin, James R Fox, Cathryn Koptiuch, Gary J Badger, Ann C Greenan- Naumann, Nicole A Bouffard, Elisa E Konofagou, Wei-Ning Lee, John J Triano and Sharon M Henry
    Citation: BMC Musculoskeletal Disorders 2011 12:203
  6. Prior studies that have concluded that disk degeneration uniformly precedes facet degeneration have been based on convenience samples of individuals with low back pain. We conducted a study to examine whether ...

    Authors: Pradeep Suri, Asako Miyakoshi, David J Hunter, Jeffrey G Jarvik, James Rainville, Ali Guermazi, Ling Li and Jeffrey N Katz
    Citation: BMC Musculoskeletal Disorders 2011 12:202
  7. Fractures of the distal radius are extremely common injuries in adults. However, the optimal management remains controversial. In general, fractures of the distal radius are treated non-operatively if the bone...

    Authors: Matthew L Costa, Juul Achten, Nick R Parsons, Amar Rangan, Richard P Edlin, Jaclyn Brown and Sarah E Lamb
    Citation: BMC Musculoskeletal Disorders 2011 12:201
  8. Maximal isometric quadriceps strength deficits have been widely reported in studies of knee osteoarthritis (OA), however little is known about the effect of osteoarthritis knee pain on submaximal quadriceps ne...

    Authors: Michael J Berger, David G Chess and Timothy J Doherty
    Citation: BMC Musculoskeletal Disorders 2011 12:199
  9. Choice of appropriate MR pulse sequence is important for any research studies using imaging-derived data. The aim of this study was to compare semiquantitative assessment of subchondral bone marrow edema-like ...

    Authors: Daichi Hayashi, Ali Guermazi, C Kent Kwoh, Michael J Hannon, Carolyn Moore, John M Jakicic, Stephanie M Green and Frank W Roemer
    Citation: BMC Musculoskeletal Disorders 2011 12:198
  10. The traditional view that the vast majority of midshaft clavicular fractures heal with good functional outcomes following non-operative treatment may be no longer valid for all midshaft clavicular fractures. R...

    Authors: Sylvia A Stegeman, Mireille de Jong, Cornelis FM Sier, Pieta Krijnen, Jan W Duijff, Tom PH van Thiel, Piet AR de Rijcke, Nicolaj MR Soesman, Tjebbe Hagenaars, Freek D Boekhoudt, Mark R de Vries, Gert R Roukema, Andras FK Tanka, Jephta van den Bremer, Hub GWM van der Meulen, Maarten WGA Bronkhorst…
    Citation: BMC Musculoskeletal Disorders 2011 12:196
  11. Although viscosupplementation is an effective symptomatic treatment for knee osteoarthritis (OA), the effect of longer term administration on articular cartilage has not been fully explored. We examined the ef...

    Authors: Yuanyuan Wang, Stephen Hall, Fahad Hanna, Anita E Wluka, Gail Grant, Paul Marks, Marie Feletar and Flavia M Cicuttini
    Citation: BMC Musculoskeletal Disorders 2011 12:195
  12. Low back pain (LBP), with high incidence and prevalence rate, is one of the most common reasons to consult the health system and is responsible for a significant amount of sick leave, leading to high health an...

    Authors: Anna Berenguera, Enriqueta Pujol-Ribera, Teresa Rodriguez-Blanco, Concepció Violan, Marc Casajuana, Nelleke de Kort and Marta Trapero-Bertran
    Citation: BMC Musculoskeletal Disorders 2011 12:194
  13. Although back complaints are common among older people, limited information is available in the literature about the clinical course of back pain in older people and the identification of older persons at risk...

    Authors: Jantine Scheele, Pim AJ Luijsterburg, Manuela L Ferreira, Chris G Maher, Leani Pereira, Wilco C Peul, Maurits W van Tulder, Arthur M Bohnen, Marjolein Y Berger, Sita MA Bierma-Zeinstra and Bart W Koes
    Citation: BMC Musculoskeletal Disorders 2011 12:193
  14. Impingement can be a serious complication after total hip arthroplasty (THA), and is one of the major causes of postoperative pain, dislocation, aseptic loosening, and implant breakage. Minimally invasive THA ...

    Authors: Tobias Renkawitz, Martin Haimerl, Lars Dohmen, Sabine Gneiting, Melanie Wegner, Nicole Ehret, Claudia Buchele, Mario Schubert, Philipp Lechler, Michael Woerner, Ernst Sendtner, Tibor Schuster, Kurt Ulm, Robert Springorum and Joachim Grifka
    Citation: BMC Musculoskeletal Disorders 2011 12:192
  15. Objectively assessed physical performance is a strong predictor for morbidity and premature death and there is an increasing interest in the role of sarcopenia in many chronic diseases. There is a need for rob...

    Authors: Lillemor A Nyberg, Mai-Lis Hellénius, Jan Kowalski, Per Wändell, Peter Andersson and Carl Johan Sundberg
    Citation: BMC Musculoskeletal Disorders 2011 12:191
  16. To compare data based on touch screen to data based on traditional paper versions of questionnaires frequently used to examine patient reported outcomes in knee osteoarthritis patients and to examine the impac...

    Authors: Henrik Gudbergsen, Else M Bartels, Peter Krusager, Eva E Wæhrens, Robin Christensen, Bente Danneskiold-Samsøe and Henning Bliddal
    Citation: BMC Musculoskeletal Disorders 2011 12:190
  17. Data on the clinical outcome after spinal fusion in the elderly patient are rare. To our knowledge there has been no clinical outcome assessment for instrumented spinal fusion in elderly patients comparing pos...

    Authors: Stefan Endres, Rene Aigner and Axel Wilke
    Citation: BMC Musculoskeletal Disorders 2011 12:189
  18. Shoulder problems are a common complaint of the musculoskeletal system. Physical therapists treat these patients with different modalities such as exercise, massage, and shoulder taping. Although different tec...

    Authors: Joeri Kalter, Adri T Apeldoorn, Raymond W Ostelo, Nicholas Henschke, Dirk L Knol and Maurits W van Tulder
    Citation: BMC Musculoskeletal Disorders 2011 12:188
  19. Osteoporosis is a major health problem worldwide, and is included in the WHO list of the top 10 major diseases. However, it is often undiagnosed until the first fracture occurs, due to inadequate patient educa...

    Authors: Leila Kolios, Caner Takur, Arash Moghaddam, Mirjam Hitzler, Heinrich Schmidt-Gayk, Arnold J Suda, Bernd Höner, Paul A Grützner and Christoph Wölfl
    Citation: BMC Musculoskeletal Disorders 2011 12:187
  20. Periprosthetic osteolysis is a major cause of aseptic loosening in joint arthroplasty. This study investigates the impact of CT (calcitonin) deficiency and CT substitution under in-vivo circumstances on partic...

    Authors: Max D Kauther, Hagen S Bachmann, Laura Neuerburg, Martina Broecker-Preuss, Gero Hilken, Florian Grabellus, Gabriele Koehler, Marius von Knoch and Christian Wedemeyer
    Citation: BMC Musculoskeletal Disorders 2011 12:186
  21. Skeletal muscle atrophy is a serious concern for the rehabilitation of patients afflicted by prolonged limb restriction. This debilitating condition is associated with a marked activation of NFκB activity. The...

    Authors: Annabelle Z Caron, Sonia Haroun, Élisabeth Leblanc, Frédéric Trensz, Chantal Guindi, Aziz Amrani and Guillaume Grenier
    Citation: BMC Musculoskeletal Disorders 2011 12:185
  22. Stiffness with decreased range of motion (ROM) has been described as a frustrating complication after TKA. If all methods of physiotherapeutic treatment have been exhausted trying to develop ROM, manipulation ...

    Authors: Ingmar Ipach, Falk Mittag, Julia Lahrmann, Beate Kunze and Torsten Kluba
    Citation: BMC Musculoskeletal Disorders 2011 12:184
  23. Modic changes (MCs) have been identified as a diagnostic subgroup associated with low back pain (LBP). The aetiology of MCs is still unknown and there is no effective treatment available. If MCs constitute a s...

    Authors: Rikke K Jensen and Charlotte Leboeuf-Yde
    Citation: BMC Musculoskeletal Disorders 2011 12:183
  24. The trapezius muscle is a neck muscle that is susceptible to chronic pain conditions associated with repetitive tasks, commonly referred to as chronic work-related myalgia, hence making the trapezius a muscle ...

    Authors: Jenny Hadrévi, Fredrik Hellström, Thomas Kieselbach, Christer Malm and Fatima Pedrosa-Domellöf
    Citation: BMC Musculoskeletal Disorders 2011 12:181
  25. The established treatment for bacterial arthritis of the knee joint is arthroscopic surgery with irrigation and debridement. The aim of this article is to summarize the relevant data in treating bacterial arth...

    Authors: Atesch Ateschrang, Dirk Albrecht, Steffen Schröter, Bernhard Hirt, Kuno Weise and Jürgen H Dolderer
    Citation: BMC Musculoskeletal Disorders 2011 12:180
  26. Chronic low back pain is a highly prevalent condition, which is associated with high direct and indirect costs to the society. Although this condition is highly prevalent, it is still extremely difficult to tr...

    Authors: Alessandra N Garcia, Francine LB Gondo, Renata A Costa, Fábio N Cyrillo, Tatiane M Silva, Luciola CM Costa and Leonardo OP Costa
    Citation: BMC Musculoskeletal Disorders 2011 12:179
  27. A study to evaluate the adherence to and appropriateness of anti-osteoporotic treatments in a cohort of men and women aged 50 and over participating in the ESOSVAL-R study.

    Authors: Gabriel Sanfélix-Gimeno, José Sanfélix-Genovés, Salvador Peiró, Isabel Hurtado, José Luis Trillo, Ruth Usó, Vicente Giner Ruiz, Manuel Pascual de la Torre and Inmaculada Ferreros
    Citation: BMC Musculoskeletal Disorders 2011 12:178
  28. Osteoarthritis (OA) is a prevalent chronic disease and a leading cause of disability in adults. For people with knee and hip OA, symptoms (e.g., pain and fatigue) can interfere with mobility and physical activ...

    Authors: Susan L Murphy, Angela K Lyden, Maria Clary, Michael E Geisser, Raymond L Yung, Daniel J Clauw and David A Williams
    Citation: BMC Musculoskeletal Disorders 2011 12:177
  29. Neck pain is related to impaired postural balance among patients and is highly prevalent among workers with high postural demands, for example, cleaners. We therefore hypothesised, that cleaners with neck pain...

    Authors: Marie B Jørgensen, Jørgen H Skotte, Andreas Holtermann, Gisela Sjøgaard, Nicolas C Petersen and Karen Søgaard
    Citation: BMC Musculoskeletal Disorders 2011 12:176
  30. Beside symptoms and clinical signs radiological findings are crucial in the diagnosis of lumbar spinal stenosis (LSS). We investigate which quantitative radiological signs are described in the literature and w...

    Authors: Johann Steurer, Simon Roner, Ralph Gnannt and Juerg Hodler
    Citation: BMC Musculoskeletal Disorders 2011 12:175
  31. Hypersensitivity of the central nervous system is widely present in pain patients and recognized as one of the determinants of chronic pain and disability. Electronic pressure algometry is often used to explor...

    Authors: Niklaus Egloff, Nicole Klingler, Roland von Känel, Rafael JA Cámara, Michele Curatolo, Barbara Wegmann, Elizabeth Marti and Marie-Louise Gander Ferrari
    Citation: BMC Musculoskeletal Disorders 2011 12:174
  32. In the light of both the importance and large numbers of case series and cohort studies (observational studies) in orthopaedic literature, it is remarkable that there is currently no validated measurement tool...

    Authors: Bart G Pijls, Olaf M Dekkers, Saskia Middeldorp, Edward R Valstar, Huub JL van der Heide, Henrica MJ Van der Linden-Van der Zwaag and Rob GHH Nelissen
    Citation: BMC Musculoskeletal Disorders 2011 12:173
  33. The expectations of patients for managing pain induced by exercise and mobilization (PIEM) have seldom been investigated. We identified the views of patients and care providers regarding pain management induce...

    Authors: Sophie Alami, Dominique Desjeux, Marie Martine Lefèvre-Colau, Anne Sophie Boisgard, Eric Boccard, François Rannou and Serge Poiraudeau
    Citation: BMC Musculoskeletal Disorders 2011 12:172
  34. There is a need for outcome measurement instruments for evaluation of disability after trauma. The Patient-Rated Wrist Evaluation (PRWE) is a self-administered region-specific outcome measuring instrument deve...

    Authors: Cecilia Mellstrand Navarro, Sari Ponzer, Hans Törnkvist, Leif Ahrengart and Gunnar Bergström
    Citation: BMC Musculoskeletal Disorders 2011 12:171
  35. While there is growing evidence for the efficacy of SM to treat LBP, little is known on the mechanisms and physiologic effects of these treatments. Accordingly, the purpose of this study was to determine wheth...

    Authors: Brian C Clark, David A Goss Jr, Stevan Walkowski, Richard L Hoffman, Andrew Ross and James S Thomas
    Citation: BMC Musculoskeletal Disorders 2011 12:170
  36. Many adults experience bothersome neck/shoulder pain. While research and treatment strategies often focus on the upper trapezius, other neck/shoulder muscles may be affected as well. The aim of the present stu...

    Authors: Lars L Andersen, Klaus Hansen, Ole S Mortensen and Mette K Zebis
    Citation: BMC Musculoskeletal Disorders 2011 12:169
  37. Assessment of shoulder mobility is essential for clinical follow-up of shoulder treatment. Only a few high sophisticated instruments for objective measurements of shoulder mobility are available. The interobse...

    Authors: Bilal Farouk El-Zayat, Turgay Efe, Annett Heidrich, Udo Wolf, Nina Timmesfeld, Thomas J Heyse, Stefan Lakemeier, Susanne Fuchs-Winkelmann and Markus D Schofer
    Citation: BMC Musculoskeletal Disorders 2011 12:168
  38. Monitoring osteoporosis therapy by measurement of bone turnover markers (BTMs) might detect non-compliance in an earlier stage of anti-osteoporosis treatment and improve persistence.

    Authors: Danielle A Eekman, Irene EM Bultink, Annemieke C Heijboer, Ben AC Dijkmans and Willem F Lems
    Citation: BMC Musculoskeletal Disorders 2011 12:167
  39. To determine safe surgical margins for soft tissue sarcoma, it is essential to perform a general evaluation of the extent of tumor, responses to auxiliary therapy, and other factors preoperatively using multip...

    Authors: Masahiro Yokouchi, Mikio Terahara, Satoshi Nagano, Yoshiya Arishima, Michihisa Zemmyo, Takako Yoshioka, Akihide Tanimoto and Setsuro Komiya
    Citation: BMC Musculoskeletal Disorders 2011 12:166
  40. Clinical analgesic trials typically report response as group mean results. However, research has shown that few patients are average and most have responses at the extremes. Moreover, group mean results do not...

    Authors: Paul M Peloso, Arnold Gammaitoni, Steven S Smugar, Hongwei Wang and Andrew R Moore
    Citation: BMC Musculoskeletal Disorders 2011 12:165
  41. Tenascin-C (TN-C) is an extracellular matrix glycoprotein that is involved in tissue injury and repair processes. We analyzed TN-C expression in normal and osteoarthritic (OA) human cartilage, and evaluated it...

    Authors: Lisha Patel, Weiyong Sun, Sonya S Glasson, Elisabeth A Morris, Carl R Flannery and Priya S Chockalingam
    Citation: BMC Musculoskeletal Disorders 2011 12:164
  42. BMP-2 is known to accelerate fracture healing and might also enhance osseointegration and implant fixation. Application of recombinant BMP-2 has a time-limited effect. Therefore, a gene transfer approach with ...

    Authors: Benjamin Faensen, Britt Wildemann, Christian Hain, Julius Höhne, Yvonne Funke, Christan Plank, Axel Stemberger and Gerhard Schmidmaier
    Citation: BMC Musculoskeletal Disorders 2011 12:163
  43. Increased center of pressure excursions are well documented in patients suffering from non-specific low back pain, whereby the altered postural sway includes both higher mean sway velocities and larger sway ar...

    Authors: Alexander Ruhe, René Fejer and Bruce Walker
    Citation: BMC Musculoskeletal Disorders 2011 12:162
  44. Despite the large volume of research dedicated to understanding chronic low back pain (CLBP), patient outcomes remain modest while healthcare costs continue to rise, creating a major public health burden. Heal...

    Authors: Andrew M Briggs, Joanne E Jordan, Peter B O'Sullivan, Rachelle Buchbinder, Angus F Burnett, Richard H Osborne and Leon M Straker
    Citation: BMC Musculoskeletal Disorders 2011 12:161
  45. The pathogenesis of osteonecrosis of the femoral head (ONFH) has been implicated in hypofibrinolysis and blood supply interruption. Previous studies have demonstrated that decreased fibrinolytic activity due t...

    Authors: Hye- Ok Kim, Chang- Hoon Cho, Yoon- Je Cho, Seong- Ho Cho, Kyung- Sik Yoon and Kang- Il Kim
    Citation: BMC Musculoskeletal Disorders 2011 12:160

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