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  1. Limb girdle muscular dystrophy (LGMD) type 2A is caused by mutations in the CAPN3 gene and complete lack of functional calpain 3 leads to the most severe muscle wasting. Calpain 3 is suggested to be involved i...

    Authors: Simon Hauerslev, Marie-Louise Sveen, Morten Duno, Corrado Angelini, John Vissing and Thomas O Krag
    Citation: BMC Musculoskeletal Disorders 2012 13:43
  2. An implant coating with poly(D, L-lactide) (PDLLA) releasing incorporated Zoledronic acid (ZOL) has already proven to positively effect osteoblasts, to inhibit osteoclasts and to accelerate fracture healing. Aim ...

    Authors: David A Back, Stephan Pauly, Lisa Rommel, Norbert P Haas, Gerhard Schmidmaier, Britt Wildemann and Stefan H Greiner
    Citation: BMC Musculoskeletal Disorders 2012 13:42
  3. Musculoskeletal symptoms among adolescents are related to the time spent using a computer, but little is known about the seriousness of the symptoms or how much they affect everyday life. The purpose of the pr...

    Authors: Paula T Hakala, Lea A Saarni, Raija-Leena Punamäki, Marjut A Wallenius, Clas-Håkan Nygård and Arja H Rimpelä
    Citation: BMC Musculoskeletal Disorders 2012 13:41
  4. The Bath Ankylosing Spondylitis Functional Index (BASFI) has been commonly used in rheumatology to quantify functional disability in patients with Ankylosing Spondylitis (AS). Our aim was to evaluate the discr...

    Authors: Ghizlane Wariaghli, Fadoua Allali, Kenza Berrada, Zineb Idrissi, Ihsane Hmamouchi, Redouane Abouqal and Najia Hajjaj-Hassouni
    Citation: BMC Musculoskeletal Disorders 2012 13:40
  5. Increased postural sway is well documented in patients suffering from non-specific low back pain, whereby a linear relationship between higher pain intensities and increasing postural sway has been described. ...

    Authors: Alexander Ruhe, René Fejer and Bruce Walker
    Citation: BMC Musculoskeletal Disorders 2012 13:39
  6. The aim of this study was to investigate whether perceived exertion, perceived comfort and working technique is associated with the incidence of neck and upper extremity symptoms among professional computer us...

    Authors: Agneta Lindegård, Jens Wahlström, Mats Hagberg, Rebecka Vilhelmsson, Allan Toomingas and Ewa Wigaeus Tornqvist
    Citation: BMC Musculoskeletal Disorders 2012 13:38
  7. To analyze changes in incidence and outcomes of patients undergoing revision total hip arthroplasty (RTHA) over an 8-year study period in Spain.

    Authors: Manuel Villanueva-Martınez, Valentın Hernandez-Barrera, Francisco Chana-Rodríguez, José Rojo-Manaute, Antonio Rıos-Luna, Jesus San Roman Montero, Angel Gil-de-Miguel and Rodrigo Jimenez-Garcıa
    Citation: BMC Musculoskeletal Disorders 2012 13:37
  8. Polyneuropathy is a complication of diabetes mellitus that has been very challenging for clinicians. It results in high public health costs and has a huge impact on patients' quality of life. Preventive interv...

    Authors: Cristina Dallemole Sartor, Ricky Watari, Anice Campos Pássaro, Andreja Paley Picon, Renata Haydée Hasue and Isabel CN Sacco
    Citation: BMC Musculoskeletal Disorders 2012 13:36
  9. Quality improvement is important to facilitate valid patient outcomes. Standardized examination procedures may improve the validity of US.

    Authors: Karen Ellegaard, Søren Torp-Pedersen, Robin Christensen, Michael Stoltenberg, Annette Hansen, Tove Lorenzen, Dorthe V Jensen, Hanne Lindegaard, Lars Juul, Henrik Røgind, Per Bülow, Stavros Chrysidis, Marcin Kowalski, Bente Danneskiold-Samsoe and Henning Bliddal
    Citation: BMC Musculoskeletal Disorders 2012 13:35
  10. Early diagnosis of Osteoarthritis (OA) is essential for preventing further cartilage destruction and decreasing severe complications. The aims of this study are to explore the relationship between OA pathologi...

    Authors: Hai-jun Niu, Qing Wang, Yue-xiang Wang, De-yu Li, Yu-bo Fan and Wu-fan Chen
    Citation: BMC Musculoskeletal Disorders 2012 13:34
  11. Fracture-healing depends on interfragmentary motion. For improved osteosynthesis and fracture-healing, the micromotion between fracture fragments is undergoing intensive research. The detection of 3D micromoti...

    Authors: Stefan Doebele, Sebastian Siebenlist, Helen Vester, Petra Wolf, Ulrich Hagn, Ulrich Schreiber, Ulrich Stöckle and Martin Lucke
    Citation: BMC Musculoskeletal Disorders 2012 13:33
  12. In the present study, 4 different metallic implant materials, either partly coated or polished, were tested for their osseointegration and biocompatibility in a pelvic implantation model in sheep.

    Authors: Michael Plecko, Christine Sievert, Daniel Andermatt, Robert Frigg, Peter Kronen, Karina Klein, Stefan Stübinger, Katja Nuss, Alexander Bürki, Stephen Ferguson, Ulrich Stoeckle and Brigitte von Rechenberg
    Citation: BMC Musculoskeletal Disorders 2012 13:32
  13. A high percentage of young children present with flatfeet. Although the percentage of those with flatfeet declines with age, about 15% of the population maintains a flat arch. A reduction in longitudinal arch ...

    Authors: Yi-Fen Shih, Chao-Yin Chen, Wen-Yin Chen and Hsiu-Chen Lin
    Citation: BMC Musculoskeletal Disorders 2012 13:31
  14. Lumbar spinal stenosis (LSS) is prevalent in those over the age of 65 years and the leading cause of spinal surgery in this population. Recent systematic reviews have examined the effectiveness of conservative...

    Authors: Mark S Jarrett, Joseph F Orlando and Karen Grimmer-Somers
    Citation: BMC Musculoskeletal Disorders 2012 13:30
  15. Musculoskeletal pain is detrimental to quality of life (QOL) and disruptive to activities of daily living. It also places a major economic burden on healthcare systems and wider society. In 2006, the Welsh Ass...

    Authors: Ceri J Phillips, Rhiannon Phillips (nee Buck), Chris J Main, Paul J Watson, Shân Davies, Angela Farr, Christie Harper, Gareth Noble, Mansel Aylward, Julie Packman, Matt Downton and Janine Hale
    Citation: BMC Musculoskeletal Disorders 2012 13:29
  16. Low back pain (LBP) and leisure time physical activity (LTPA) are considered to be closely related, and clinical guidelines for the treatment of acute LBP recommend patients stay physically active. However, th...

    Authors: Tobias Jespersen, Marie B Jørgensen, Jørgen V Hansen, Andreas Holtermann and Karen Søgaard
    Citation: BMC Musculoskeletal Disorders 2012 13:28
  17. Around one third to one half of patients with hip fractures require red-cell pack transfusion. The increasing incidence of hip fracture has also raised the need for this scarce resource. Additionally, red-cell...

    Authors: Máximo Bernabeu-Wittel, Reyes Aparicio, Manuel Romero, José Murcia-Zaragoza, Rafael Monte-Secades, Clara Rosso, Abelardo Montero, Alberto Ruiz-Cantero and María Melero-Bascones
    Citation: BMC Musculoskeletal Disorders 2012 13:27
  18. Physical activity (PA) is beneficial in reducing pain and improving function in lower limb osteoarthritis (OA), and is recommended as a first line treatment. Self-administered questionnaires are used to assess...

    Authors: Ida Svege, Elin Kolle and May Arna Risberg
    Citation: BMC Musculoskeletal Disorders 2012 13:26
  19. Several classification schemes, each with its own philosophy and categorizing method, subgroup low back pain (LBP) patients with the intent to guide treatment. Physiotherapy derived schemes usually have a move...

    Authors: Nicholas V Karayannis, Gwendolen A Jull and Paul W Hodges
    Citation: BMC Musculoskeletal Disorders 2012 13:24
  20. A consistent line of investigation suggests that autonomic nervous system dysfunction may explain the multi-system features of fibromyalgia (FM); and that FM is a sympathetically maintained neuropathic pain sy...

    Authors: Gilberto Vargas-Alarcon, Edith Alvarez-Leon, Jose-Manuel Fragoso, Angelica Vargas, Aline Martinez, Maite Vallejo and Manuel Martinez-Lavin
    Citation: BMC Musculoskeletal Disorders 2012 13:23
  21. Patients with fibromyalgia (FM) report widespread pain, fatigue, and other functional limitations. This study aimed to provide an assessment of the burden of illness associated with FM in France and its associ...

    Authors: Serge Perrot, Caroline Schaefer, Tyler Knight, Meghan Hufstader, Arthi B Chandran and Gergana Zlateva
    Citation: BMC Musculoskeletal Disorders 2012 13:22
  22. Acute lateral ankle ligament injuries are very common problems in present health care. Still there is no hard evidence about which treatment strategy is superior. Current evidence supports the view that a func...

    Authors: Suzanne Witjes, Femke Gresnigt, Michel PJ van den Bekerom, Jan G Olsman and Niek C van Dijk
    Citation: BMC Musculoskeletal Disorders 2012 13:21
  23. The objective of the study was to standardize a method using digital photographs to diagnose and grade hand osteoarthritis (HOA), to compare it with radiographs and clinical examination with regard to prevalen...

    Authors: Helgi Jonsson, Gudrun P Helgadottir, Thor Aspelund, Johanna E Sverrisdottir, Gudny Eiriksdottir, Sigurdur Sigurdsson, Gudmundur J Eliasson, Asbjorn Jonsson, Thorvaldur Ingvarsson, Tamara B Harris, Lenore Launer and Vilmundur Gudnason
    Citation: BMC Musculoskeletal Disorders 2012 13:20
  24. It has been suggested that knee height is a determinant of knee joint load. Nonetheless, no study has directly examined the relationship between anthropometric measures of height and knee joint structures, suc...

    Authors: Andrew J Teichtahl, Anita E Wluka, Boyd J Strauss, Yuanyuan Wang, Patricia Berry, Miranda Davies-Tuck and Flavia M Cicuttini
    Citation: BMC Musculoskeletal Disorders 2012 13:19
  25. The al-Andalus physical activity intervention study is a randomised control trial to investigate the effectiveness of a land- and water-based exercise intervention for reducing the overall impact of fibromyalgia ...

    Authors: Ana Carbonell-Baeza, Jonatan R Ruiz, Virginia A Aparicio, Francisco B Ortega, Diego Munguía-Izquierdo, Inmaculada C Álvarez-Gallardo, Víctor Segura-Jiménez, Daniel Camiletti-Moirón, Alejandro Romero, Fernando Estévez-López, Blanca Samos, Antonio J Casimiro, Ángela Sierra, Pedro A Latorre, Manuel Pulido-Martos, Pedro Femia…
    Citation: BMC Musculoskeletal Disorders 2012 13:18
  26. Painful shoulders pose a substantial socioeconomic burden. A prospective cost-of-illness study was performed to assess the costs associated with healthcare use and loss of productivity in patients with shoulde...

    Authors: Lena Virta, Pål Joranger, Jens Ivar Brox and Rikard Eriksson
    Citation: BMC Musculoskeletal Disorders 2012 13:17
  27. The optimal surgical management of dislocated three- and four-part fractures of the proximal humerus in elderly patients remains unclear. Most used techniques are hemiarthroplasty and angle-stable locking comp...

    Authors: Paul A Verbeek, Inge van den Akker-Scheek, Klaus W Wendt and Ron L Diercks
    Citation: BMC Musculoskeletal Disorders 2012 13:16
  28. African Americans are twice as likely as Caucasians to develop gout, but they are less likely to be treated with urate-lowering therapy (ULT). Furthermore, African Americans typically present with more comorbi...

    Authors: Alvin F Wells, Patricia A MacDonald, Solomon Chefo and Robert L Jackson
    Citation: BMC Musculoskeletal Disorders 2012 13:15
  29. It is often suggested that sagittal instability at the first tarso-metatarsal joint level is a primary factor for hallux valgus and that sagittal instability increases with the progression of the deformity. Th...

    Authors: Heiner Martin, Ulf Bahlke, Albrecht Dietze, Volker Zschorlich, Klaus-Peter Schmitz and Thomas Mittlmeier
    Citation: BMC Musculoskeletal Disorders 2012 13:14
  30. It is still unclear when latent myofascial trigger points (MTrPs) develop during early life. This study is designed to investigate the mechanical pain sensitivity of deep tissues in children in order to see th...

    Authors: Ting-I Han, Chang-Zern Hong, Fang-Chuan Kuo, Yueh-Ling Hsieh, Li-Wei Chou and Mu-Jung Kao
    Citation: BMC Musculoskeletal Disorders 2012 13:13
  31. Table tennis involves adoption of the semi-flexed knee and asymmetrical torsional trunk movements creating rotational torques on the knee joint which may predispose players to osteoarthritis (OA) of the knee. ...

    Authors: Reza Rajabi, Gillian M Johnson, Mohammad H Alizadeh and Nazanin Meghdadi
    Citation: BMC Musculoskeletal Disorders 2012 13:12
  32. Foot problems associated with Systemic Sclerosis (SSc)/Scleroderma have been reported to be both common and disabling. There are only limited data describing specifically, the mechanical changes occurring in t...

    Authors: Begonya Alcacer-Pitarch, Maya H Buch, Janine Gray, Christopher P Denton, Ariane Herrick, Nuria Navarro-Coy, Howard Collier, Lorraine Loughrey, Sue Pavitt, Heidi J Siddle, Jonathan Wright, Philip S Helliwell, Paul Emery and Anthony C Redmond
    Citation: BMC Musculoskeletal Disorders 2012 13:11
  33. Cervical radiculopathy is a common form of neck pain and has been shown to lead to severe disability. Clinical rehabilitation approaches for cervical radiculopathies commonly include exercise and manual therap...

    Authors: Pierre Langevin, Jean-Sébastien Roy and François Desmeules
    Citation: BMC Musculoskeletal Disorders 2012 13:10
  34. Self-reported knee pain is highly prevalent among adolescents. As much as 50% of the non-specific knee pain may be attributed to Patellofemoral Pain Syndrome (PFPS). In the short term, exercise therapy appears...

    Authors: Michael S Rathleff, Ewa M Roos, Jens L Olesen and Sten Rasmussen
    Citation: BMC Musculoskeletal Disorders 2012 13:9
  35. The common practice for insertion of distal locking screws of intramedullary nails is a freehand technique under fluoroscopic control. The process is technically demanding, time-consuming and afflicted to cons...

    Authors: Markus Windolf, Josh Schroeder, Ladina Fliri, Benno Dicht, Meir Liebergall and R Geoff Richards
    Citation: BMC Musculoskeletal Disorders 2012 13:8
  36. Most research on risk factors for low back pain has focused on long term exposures rather than factors immediately preceding the onset of low back pain. The aim of this study is to quantify the transient incre...

    Authors: Daniel Steffens, Manuela L Ferreira, Christopher G Maher, Jane Latimer, Bart W Koes, Fiona M Blyth and Paulo H Ferreira
    Citation: BMC Musculoskeletal Disorders 2012 13:7
  37. Low back pain (LBP) is one of the major concerns in health care. In Switzerland, musculoskeletal problems represent the third largest illness group with 9.4 million consultations per year. The return to work r...

    Authors: Mandy Scheermesser, Stefan Bachmann, Astrid Schämann, Peter Oesch and Jan Kool
    Citation: BMC Musculoskeletal Disorders 2012 13:5
  38. Low-back related leg pain with or without nerve root involvement is associated with a poor prognosis compared to low back pain (LBP) alone. Compared to the literature investigating prognostic indicators of out...

    Authors: Kika Konstantinou, Ruth Beardmore, Kate M Dunn, Martyn Lewis, Samantha L Hider, Tom Sanders, Sue Jowett, Simon Somerville, Siobhan Stynes, Danielle AWM van der Windt, Steven Vogel and Elaine M Hay
    Citation: BMC Musculoskeletal Disorders 2012 13:4
  39. Osteoporotic vertebral fractures are, as the hip fractures, associated with increased morbidity and mortality. Norway has one of the highest reported incidences of hip fractures in the world. Because of method...

    Authors: Svanhild Waterloo, Luai A Ahmed, Jacqueline R Center, John A Eisman, Bente Morseth, Nguyen D Nguyen, Tuan Nguyen, Anne J Sogaard and Nina Emaus
    Citation: BMC Musculoskeletal Disorders 2012 13:3
  40. Low bone mineral density (BMD) and falls are common problems encountered in the postmenopausal women. The purpose was to evaluate the association between postural balance and BMD in postmenopausal women and it...

    Authors: Luciana Mendes Cangussu, Jorge Nahas-Neto, Eliana Aguiar Petri Nahas, Ana Beatriz Cesar Rodrigues Barral, Davi de Araujo Buttros and Gilberto Uemura
    Citation: BMC Musculoskeletal Disorders 2012 13:2
  41. In workplace health promotion, all potential resources needs to be taken into consideration, not only factors relating to the absence of injury and the physical health of the workers, but also psychological as...

    Authors: Agneta Larsson, Lena Karlqvist, Mats Westerberg and Gunvor Gard
    Citation: BMC Musculoskeletal Disorders 2012 13:1
  42. Inflammation is the main cause of disease-associated muscle wasting. In a previous single blind study we have demonstrated improved recovery of muscle endurance following celecoxib treatment in hospitalized ge...

    Authors: Ingo Beyer, Ivan Bautmans, Rose Njemini, Christian Demanet, Pierre Bergmann and Tony Mets
    Citation: BMC Musculoskeletal Disorders 2011 12:292
  43. Knee rotation plays an important part in knee kinematics during weight-bearing activities. An external device for measuring knee rotation (the Rottometer) has previously been evaluated for validity by simultan...

    Authors: Per O Almquist, Charlotte Ekdahl, Per-Erik Isberg and Thomas Fridén
    Citation: BMC Musculoskeletal Disorders 2011 12:291
  44. Electrical stimulation of central nervous system areas with surgically implanted stimulators has been shown to result in pain relief. To avoid the risks and side effects of surgery, transcranial direct current...

    Authors: Kerstin Luedtke, Alison Rushton, Christine Wright, Tim P Juergens, Gerd Mueller and Arne May
    Citation: BMC Musculoskeletal Disorders 2011 12:290
  45. The optimal treatment of displaced femoral neck fractures in patients over 60 years is controversial. While much research has focused on the impact of total hip arthroplasty (THA) and hemiarthroplasty (HA) on ...

    Authors: Noor Alolabi, Bashar Alolabi, Raman Mundi, Paul J Karanicolas, Jonathan D Adachi and Mohit Bhandari
    Citation: BMC Musculoskeletal Disorders 2011 12:289
  46. Bone repair is dependent on the presence of osteocompetent progenitors that are able to differentiate and generate new bone. Muscle is found in close association with orthopaedic injury, however its capacity t...

    Authors: Renjing Liu, Oliver Birke, Alyson Morse, Lauren Peacock, Kathy Mikulec, David G Little and Aaron Schindeler
    Citation: BMC Musculoskeletal Disorders 2011 12:288
  47. Back, neck and shoulder pain are the most common causes of occupational disability. They reduce health-related quality of life and have a significant economic impact. Many different forms of physical treatment...

    Authors: Pedro Serrano-Aguilar, Francisco M Kovacs, Jose M Cabrera-Hernández, Juan M Ramos-Goñi and Lidia García-Pérez
    Citation: BMC Musculoskeletal Disorders 2011 12:287
  48. The operative treatment of adult degenerative scoliosis combined with osteoporosis increase following the epidemiological development. Studies have confirmed that screws in osteoporotic spines have significant...

    Authors: Yang Xie, Qiang Fu, Zi-qiang Chen, Zhi-cai Shi, Xiao-dong Zhu, Chuan-feng Wang and Ming Li
    Citation: BMC Musculoskeletal Disorders 2011 12:286

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