- Research article
- Open Access
The global burden of pressure ulcers among patients with spinal cord injury: a systematic review and meta-analysis
BMC Musculoskeletal Disorders volume 21, Article number: 334 (2020)
Pressure ulcers (PU), one of the common challenging public health problems affecting patient with spinal cord injury. PUs occurs over bony areas of the body where pressure and tissue distortion is greatest. It has a significant impact to the patient and health care system. Moreover, it has psychological, physical, social burden and decrease the quality of life (QoL) of patients. Despite its serious complications, limited evidence is available on the global magnitude of pressure ulcers among patient with spinal cord injury. Hence, this review and meta-analysis aimed to estimate the global magnitude of pressure ulcers among patient with spinal cord injury.
PubMed, Scopus, Google Scholar, African Journals Online, PsycINFO, and Web of Science were systematically searched to retrieve related articles. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guideline was followed. DerSimonian and Laird random-effects model was applied to obtain the pooled effect size. To investigate heterogeneity across the included studies, I2 test was employed. Publication bias was examined using funnel plot and Egger’s regression test statistic. Sensitivity analysis was deployed to see the effect of a single study on the overall estimation. Analysis was done using STATA™ Version 14 software.
A total of 24 studies which comprises of 600,078 participants were included in this study. The global pooled magnitude of pressure ulcers among patients with spinal cord injury was 32.36% (95% CI (28.21, 36.51%)). Based on the subgroup analysis, the highest magnitude of pressure ulcer was observed in Africa 41.19% (95% CI: 31.70, 52.18).
This systematic review and meta-analysis revealed that about one in three patients with spinal cord injury had pressure ulcers. This implies that the overall global magnitude of pressure ulcer is relatively high. Therefore, policy maker and other concerned body should be design country context- specific preventive strategies to reduce the burden of pressure ulcers in patients with spinal cord injury.
Spinal cord injury (SCI) is a life-threatening and debilitating injury with tremendous immediate and long-term extensive impact on the medical, social, psychological and economic aspects of clients, their caregivers and the society [1,2,3]. The annual incidence rate of SCI is 44 cases per 1, 000, 000 people in Tehran , and 5.5 to 195.4 cases per million in European countries . Spinal cord injured patients have a high risk of developing pressure ulcers due to motor and sensory impairments, immobility, changes in skin composition, and prolonged hospital stays [6, 7]. PUs are a serious, costly, and life-long complication of SCI. Around, 30–40% of clients with spinal cord injuries develop pressure ulcers during the acute and rehabilitation phases .
Pressure ulcer and its treatment is one of the most challenging clinical problems in hospitals specially among patients with spinal cord injury . Even though several pressure ulcer classification systems are available, National Pressure Ulcer Advisory Panel (NPUAP) is the commonest method. According to the NPUAP consensus development conference, pressure ulcers are classified based on severity from suspected deep tissue injury through unstageable, with suspected deep tissue injury representing the earliest stage of pressure ulcer formation, and unstageable is defined as “full thickness tissue loss in which the base of the ulcer is covered by slough (yellow, tan, gray, green, or brown) and/or eschar (tan, brown, or black) in the wound bed” .
Though PU is largely preventable patient safety problems, they have major impacts to the affected individual and on the health care system. It highly affects the psychological, physical, social well-being and the quality of life of the affected individuals [11,12,13]. Likewise, it leads to recurrent hospitalizations, multiple surgeries, potentially devastating complications, increased costs for patient care, morbidity and early mortality [9, 14, 15]. PU carry a significant economic burden, with treatment costs of a PU far exceeding preventive costs. For example, a study done in Canada, revealed that the total monthly cost for treatment of PU among SCI was 18,758 USD . Pressure ulcer may account for 25% of the overall cost of treating paraplegic and tetraplegic persons . Moreover, a study done in Canada showed average monthly cost for treatment of PU in patients with SCI was $4745 .
Large differences have been reported on the magnitude of PUs patients with SCI in different studies. For instance, it varying from 11 to 50% in the current publications [6, 18]. Similarly, a study done in Switzerland reported that the incidence of PU was 2.31 per patient-year . Poor pressure relief practices lead to PU development in persons with SCI . Management and care of PU has become a serious public health challenge, with longer hospital stays than for other causes. Preventive measures to decrease the development of PUs consisted of basic skin care, pressure dispersion using fenestrated foams and alternating weight-bearing sites by regular frequent positioning . In addition, the key targets for interventions has been advocated to reduce the burden of pressure ulcers in patient with SCI. These interventions includes identification of risk factors, patient education, acute intensive care, and support body surfaces .
The etiology of PUs is complex and rooted in multiple risk factors. Studies suggest that risk factors for PU in patient with SCI include duration after SCI (> 1 year) , age (older age), sex (being male) [20, 21], poor nutritional status , quadriplegia [23,24,25], smoking [6, 26], comorbidity [23, 27], severe Braden scores , weight (being underweight) , lower level of education [20, 21], and lack of an intimate partner  were some of the risk factors associated with PU. Similarly, it has been reported that patients with higher-level spinal cord injuries are more susceptible than those with lower-level lesions . Hence, identification of risk factors used as benchmarks to design appropriate prevention measure, to improve client safety and efficient utilization of resources.
PUs among SCI clients remains unrelenting problem and a major issue in nursing care across the globe. Prevention of PU is a key role of nurses, and is considered a quality indicator of nursing care . Thought most previous studies have been conducted, to assess the magnitude of PU in acute care setting, intensive care unit, and on public hospitals; however the global magnitude of PU among patient with SCI remains unknown. Hence, this study aimed to estimate the global burden of PU among spinal cord injured patients. Findings from the current study could be serve as benchmark for institutional health care policy-makers to implement appropriate preventive measures to reduce and prevent PU. In addition, it will assist clinicians in estimating burden of PU as part of an overall quality indicator for facilities and an assessment of the effectiveness prevention strategies.
Search strategy and database
A two-step search strategy was used to identify all relevant literature. First, six electronic databases such as PubMed, Google Scholar, Africa Journals Online, Scopus, Web of Science, and PsycINFO were systematically searched. Second, a manual search of grey literatures was performed to identify additional relevant research to augment our meta-analysis. All electronic sources of information were searched for the period of January 1, 2000 to July 2, 2019. The search was conducted using the following terms and phrases: “pressure ulcer”, “pressure injury”, “decubitus ulcer”, “spinal cord injury”, and “prevalence”. Boolean operators like “AND” and “OR” were used to combine search terms.
Studies were included if they fulfilled the following criteria: (1) All observational studies which report the prevalence PU among SCI; (2) articles published in peer reviewed journals and grey literature:(3) published in the English language between 2000 to 2019; (4) we imposed no restriction on the area where it is conducted; and (5) the group of patients admitted without PUs. Studies were excluded on any one of the following conditions: (1) Patients admitted with PU; (2) they have poor quality score as per the stated criteria; and (3) articles in which fail to estimate the outcome (PU).
Selection and quality assessment
Data were extracted by three authors using a pre-piloted and standardized data extraction format prepared in a Microsoft excel. For each included study, the following data were extracted: the name(s) of the author (‘s), year of publication, study area, study design, sample size, prevalence, data collection year, and data collection methods. The quality of each included study was assessed using the Newcastle-Ottawa scale (NOS). Articles were included in the analysis if they scored ≥7 out of 10 points in three domains of the equally weighted modified NOS components for a cohort studies , (Additional file 1). In addition, for cross-sectional studies quality assessment tool, score of ≥5 out of 10 considered as high quality score , (Additional file 2). On the other hand, to assess the risk of bias within studies tools developed for observational studies by Hoy and colleagues was used . The tool has ten items to assess the risk of bias (i.e. external validity has four items and internal validity has six items). Based on these items the overall risk of study bias could be summary as low risk of bias, moderate risk of bias, and high risk of bias. The quality score of each study were extracted from each incorporated article by three independent authors. Any disagreements during data extraction were resolved by discussion and consensus.
To obtain the meta-weighted burden of pressure ulcer among SCI, a meta-analysis using random-effects model DerSimonian and Laird method was employed. Cochran’s Q chi-square statistics and I2 statistical test was conducted to assess the random variations between primary studies . In case of high heterogeneity, subgroup analysis to reduce heterogeneity, and meta regression analysis to explore sources of heterogeneity were utilized. Publication bias was assessed by visual inspection of a funnel plot and objectively using the Egger bias test [34, 35]. Sensitivity analysis was performed to investigate whether the pooled effect size was influenced by individual studies. The data were analysed using STATA™ Version 14 statistical software .
Data synthesis and reporting
The results of this review were reported based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed . Moreover, results were presented using forest plots and summary tables.
We found a total of 1053 articles. Of these, 1027 studies were found from PubMed (611), Scopus (171), PsycINFO (10), Google Scholar (76), Web of Science (92), and Africa Journals Online (67). In addition, the remaining 26 were retrieved through manual search. Of these, 529 articles were excluded due to duplication. Following the removal of duplicate studies, the titles and abstracts were evaluated, and 407 studies were excluded after reading of titles and abstracts base on the pre-specified inclusion criteria. Then, a total 117 full text articles were assessed for their eligibility based on the pre-set inclusion criteria. After reviewing the full text, based on the pre-defined criteria and quality assessment, 24 articles were included for the final analysis (Fig. 1).
Baseline characteristic of the included studies
A total of 24 studies with 600,078 study participants were included to estimate the pooled prevalence of PU among SCI patients. In this meta-analysis, various countries were represented across a globe: 8 of studies were from America [6, 38,39,40,41,42,43], 7 from Europe [18, 23, 44,45,46,47,48], 5 from Asia [20, 28, 49,50,51], and 4 from Africa [7, 22, 24, 52]. The highest prevalence of PU (56%) was reported from Europe , whereas the lowest prevalence (11%) was reported in a study conducted in America . With respect to sample size, the number of study participants varied from 38 to 7489. The quality score of each primary study, based on the Newcastle- Ottawa quality score assessment, was moderate to high for all 24 articles assessed (Table 1).
Global burden of pressure ulcer among patients with spinal cord injury
The finding of current meta-analysis using a random effects model indicated that the global pooled magnitude of PU in patients with SCI was found to be 32.36% (95% CI: 28.21–36.51), (Fig. 2) with a substantial level of heterogeneity (I2 = 97.1%; P < 0.001).
The presence of significant heterogeneity among the primary studies requires the need to conduct subgroup analysis. As a result, the finding of subgroup analysis using study design showed that the highest magnitude of pressure ulcer was observed among study done using cohort design which was 34.85% (95% CI: 28.50, 41.19), I2 = 88.4%) (Fig. 3). Concerning with study continent, high magnitude of pressure ulcers was observed among study done in Africa which was 41.94%(95% CI: 31.70, 52.18), I2 = 72.7%) of our included primary studies, (Fig. 4).
Meta- regression analysis
In the present review, we conducted meta-regression analysis by considering year of publication, and sample size as covariates of interest to identify the possible sources of random variations across primary studies. But, the result of the meta-regression analysis showed that both covariates were not statistically significant source of heterogeneity (Table 2).
To identify the presence of publication bias funnel plot, and Egger’s regression test were performed. Therefore, we obtained that there was no publication bias among the included studies, as illustrated by the symmetrical distribution of a funnel plot (Fig. 5). Likewise, Egger’s regression test results, showed that there was no statistically significant publication bias across the included studies as evidenced by (P = 0.74).
The finding of sensitivity analysis using random effects model revealed that no single study affected the overall magnitude of pressure ulcer among SCI (Fig. 6).
The current meta-analysis provided up-to-date knowledge on the magnitude of PU among spinal cord injured patients. The present findings revealed that the global pooled prevalence of PU in patients with SCI was 32.36% (95% CI: 28.21, 36.51%). This finding is much higher than a meta-analysis study done on global prevalence of PU in public hospitals at14.8% . This indicated that PU is highly prevalent among patients with spinal cord injury, and reflect an inadequately prevention and management of PU risk factors.
The result of the subgroup analysis based on study design (cross-sectional vs cohort) showed that the highest pooled prevalence of PU was observed from those studies with cohort design 34.85% (95%CI: 28.50, 41.19). This variation might be in case of cohort design the outcome variable was obtained through observation, skin assessment, physical examination, and with certain follow up time, whereas in cross-sectional studies data were collected with document review and self-report. Therefore, these situations may contribute for variation across study designs. Similarly, the result of subgroup analysis based on continent revealed that the highest magnitude of PU was reported in Africa 41.94%, followed by Europe 37.47%. The possible explanations for this variation might be due methodological differences, variation in quality of care, differences in health seeking behavior between the populations, policy and strategy difference [9, 55].
This study has clinical implications in that the increase burden of PU in SCI patients should alarm policy makers and clinician to enhance patient awareness on the impact of PU, to adhere preventive measures, to improve patient safety, to minimize treatment cost, and to design treatment strategies for PU among patients with SCI. In addition, the finding serves as a bench mark to health care professional to provide a attention on the application of standardized care, and represents a marker of quality of care.
The current review and meta-analysis has some limitations: First, inclusion of English only articles, when this was international based review; Second, this study do not identify the predictors of pressure ulcers among patients with spinal cord injury; Third, it may not be representative of the entire content, as no data were found form all of the globe; and fourth, all included studies were reported hospital-based data.
This systematic review and meta-analysis revealed that about one in three patients with spinal cord injury had pressure ulcers. This implies that the overall global magnitude of pressure ulcer is relatively high. Therefore, policy makers and other concerned body should be design country context specific effective preventive strategies to decrease the burden of PU among patients with SCI, and to improve the overall quality of healthcare service at large. Furthermore, further research is needed to identify associated factors for the development of PU among patient with SCI.
Availability of data and materials
The data analyzed during the current meta-analysis is available from the corresponding author on reasonable request.
National Pressure Ulcer Advisory Panel
Preferred Reporting Items for Systematic Reviews and Meta-Analyses
Spinal Cord Injury
Jang Y, Wang Y-H, Wang J-D. Return to work after spinal cord injury in Taiwan: the contribution of functional independence. Arch Phys Med Rehabil. 2005;86(4):681–6.
Dumont RJ, Okonkwo DO, Verma S, Hurlbert RJ, Boulos PT, Ellegala DB, Dumont AS. Acute spinal cord injury, part I: pathophysiologic mechanisms. Clin Neuropharmacol. 2001;24(5):254–64.
White BA, Dea N, Street JT, Cheng CL, Rivers CS, Attabib N, Kwon BK, Fisher CG, Dvorak MF. The economic burden of urinary tract infection and pressure ulceration in acute traumatic spinal cord injury admissions: evidence for comparative economics and decision analytics from a matched case-control study. J Neurotrauma. 2017;34(20):2892–900.
Rahimi-Movaghar V, Moradi-Lakeh M, Rasouli MR, Vaccaro AR. Burden of spinal cord injury in Tehran, Iran. Spinal Cord. 2010;48(6):492.
Jazayeri SB, Beygi S, Shokraneh F, Hagen EM, Rahimi-Movaghar V. Incidence of traumatic spinal cord injury worldwide: a systematic review. Eur Spine J. 2015;24(5):905–18.
Li C, DiPiro N, Cao Y, Szlachcic Y, Krause J. The association between metabolic syndrome and pressure ulcers among individuals living with spinal cord injury. Spinal Cord. 2016;54(11):967.
Iyun AO, Malomo AO, Oluwatosin OM, Ademola SA, Shokunbi MT. Pattern of presentation of pressure ulcers in traumatic spinal cord injured patients in university college hospital, Ibadan. Int Wound J. 2012;9(2):206–13.
Mathew A, Samuelkamaleshkumar S, Radhika S, Elango A. Engagement in occupational activities and pressure ulcer development in rehabilitated south Indian persons with spinal cord injury. Spinal Cord. 2013;51(2):150.
Kruger EA, Pires M, Ngann Y, Sterling M, Rubayi S. Comprehensive management of pressure ulcers in spinal cord injury: current concepts and future trends. J Spinal Cord Med. 2013;36(6):572–85.
Black J, Baharestani MM, Cuddigan J, Dorner B, Edsberg L, Langemo D, Posthauer ME, Ratliff C, Taler G. National Pressure Ulcer Advisory Panel's updated pressure ulcer staging system. Adv Skin Wound Care. 2007;20(5):269–74.
Ghaisas S, Pyatak EA, Blanche E, Blanchard J, Clark F. Lifestyle changes and pressure ulcer prevention in adults with spinal cord injury in the pressure ulcer prevention study lifestyle intervention. Am J Occup Ther. 2015;69(1):6901290020p6901290021–10.
Gorecki C, Brown JM, Nelson EA, Briggs M, Schoonhoven L, Dealey C, Defloor T, Nixon J, group EQoLPUP. Impact of pressure ulcers on quality of life in older patients: a systematic review. J Am Geriatr Soc. 2009;57(7):1175–83.
Lala D, Dumont FS, Leblond J, Houghton PE, Noreau L. Impact of pressure ulcers on individuals living with a spinal cord injury. Arch Phys Med Rehabil. 2014;95(12):2312–9.
Krause JS, Saunders LL. Health, secondary conditions, and life expectancy after spinal cord injury. Arch Phys Med Rehabil. 2011;92(11):1770–5.
Krause JS, Zhai Y, Saunders LL, Carter RE. Risk of mortality after spinal cord injury: an 8-year prospective study. Arch Phys Med Rehabil. 2009;90(10):1708–15.
Le Fort M, Espagnacq M, Albert T, Lefèvre C, Perrouin-Verbe B, Ravaud J-F. Risk of pressure ulcers in tetraplegic people: a French survey crossing regional experience with a long-term follow-up. Eur J Pub Health. 2018;28(6):993–9.
Chan BC, Nanwa N, Mittmann N, Bryant D, Coyte PC, Houghton PE. The average cost of pressure ulcer management in a community dwelling spinal cord injury population. Int Wound J. 2013;10(4):431–40.
Van der Wielen H, Post M, Lay V, Gläsche K, Scheel-Sailer A. Hospital-acquired pressure ulcers in spinal cord injured patients: time to occur, time until closure and risk factors. Spinal Cord. 2016;54(9):726.
Zakrasek E, Creasey G, Crew J. Pressure ulcers in people with spinal cord injury in developing nations. Spinal Cord. 2015;53(1):7.
Eslami V, Saadat S, Arejan RH, Vaccaro A, Ghodsi S, Rahimi-Movaghar V. Factors associated with the development of pressure ulcers after spinal cord injury. Spinal Cord. 2012;50(12):899.
Chen Y, DeVivo MJ, Jackson AB. Pressure ulcer prevalence in people with spinal cord injury: age-period-duration effects. Arch Phys Med Rehabil. 2005;86(6):1208–13.
Idowu O, Yinusa W, Gbadegesin S, Adebule G. Risk factors for pressure ulceration in a resource constrained spinal injury service. Spinal Cord. 2011;49(5):643.
Verschueren J, Post M, De Groot S, Van der Woude L, Van Asbeck F, Rol M. Occurrence and predictors of pressure ulcers during primary in-patient spinal cord injury rehabilitation. Spinal Cord. 2011;49(1):106.
Joseph C, Wikmar LN. Prevalence of secondary medical complications and risk factors for pressure ulcers after traumatic spinal cord injury during acute care in South Africa. Spinal Cord. 2016;54(7):535.
Correa G, Fuentes M, Gonzalez X, Cumsille F, Pineros J, Finkelstein J. Predictive factors for pressure ulcers in the ambulatory stage of spinal cord injury patients. Spinal Cord. 2006;44(12):734.
Krause JS, Vines CL, Farley TL, Sniezek J, Coker J. An exploratory study of pressure ulcers after spinal cord injury: relationship to protective behaviors and risk factors. Arch Phys Med Rehabil. 2001;82(1):107–13.
Gould LJ, Olney CM, Nichols JS, Block AR, Simon RM, Guihan M. Spinal cord injury survey to determine pressure ulcer vulnerability in the outpatient population. Med Hypotheses. 2014;83(5):552–8.
Fazel FS, Derakhshanrad N, Yekaninejad MS, Vosoughi F, Derakhshanrad A, Saberi H. Predictive value of Braden risk factors in pressure ulcers of outpatients with spinal cord injury. Acta Medica Iranica. 2018;56:56–61.
Pancorbo-Hidalgo PL, et al. Risk assessment scales for pressure ulcer prevention: a systematic review. J Adv Nurs. 2006;54(1):94–110.
McPheeters ML, Kripalani S, Peterson NB, Idowu RT, Jerome RN, Potter SA, Andrews JC. Quality improvement interventions to address health disparities: closing the quality gap-revisiting the state of the science. In: Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews. UK: Centre for Reviews and Dissemination; 2012.
Modesti PA, Reboldi G, Cappuccio FP, Agyemang C, Remuzzi G, Rapi S, Perruolo E, Parati G, Settings EWGoCRiLR. Panethnic differences in blood pressure in Europe: a systematic review and meta-analysis. PLoS One. 2016;11(1):e0147601.
Hoy D, Brooks P, Woolf A, Blyth F, March L, Bain C, Baker P, Smith E, Buchbinder R. Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. J Clin Epidemiol. 2012;65(9):934–9.
Borenstein M, Hedges L, Higgins J, Rothstein H. Introduction to meta-analysis. Chichester: Wiley; 2009.
Egger M, Davey-Smith G, Altman D. Systematic reviews in health care: meta-analysis in context: Wiley; 2008.
Rücker G, Schwarzer G, Carpenter J. Arcsine test for publication bias in meta-analyses with binary outcomes. Stat Med. 2008;27(5):746–63.
StataCorp L. Stata statistical software (version release 14). College Station: Author; 2015.
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;6(7):e1000100.
Brienza D, Krishnan S, Karg P, Sowa G, Allegretti A. Predictors of pressure ulcer incidence following traumatic spinal cord injury: a secondary analysis of a prospective longitudinal study. Spinal Cord. 2018;56(1):28.
DeJong G, Hsieh C-HJ, Brown P, Smout RJ, Horn SD, Ballard P, Bouchard T. Factors associated with pressure ulcer risk in spinal cord injury rehabilitation. Am J Phys Med Rehabil. 2014;93(11):971–86.
Garber SL, Rintala DH, Hart KA, Fuhrer MJ. Pressure ulcer risk in spinal cord injury: predictors of ulcer status over 3 years. Arch Phys Med Rehabil. 2000;81(4):465–71.
Krishnan S, Karg PE, Boninger ML, Brienza DM. Association between presence of pneumonia and pressure ulcer formation following traumatic spinal cord injury. J Spinal Cord Med. 2017;40(4):415–22.
Richard-Denis A, Thompson C, Bourassa-Moreau É, Parent S, Mac-Thiong J-M. Does the acute care spinal cord injury setting predict the occurrence of pressure ulcers at arrival to intensive rehabilitation centers? Am J Phys Med Rehabil. 2016;95(4):300–8.
Saunders LL, Krause JS, Acuna J. Association of race, socioeconomic status, and health care access with pressure ulcers after spinal cord injury. Arch Phys Med Rehabil. 2012;93(6):972–7.
Ash D. An exploration of the occurrence of pressure ulcers in a British spinal injuries unit. J Clin Nurs. 2002;11(4):470–8.
Haisma JA, Van Der Woude LH, Stam HJ, Bergen MP, Sluis TA, Post MW, Bussmann JB. Complications following spinal cord injury: occurrence and risk factors in a longitudinal study during and after inpatient rehabilitation. J Rehabil Med. 2007;39(5):393–8.
Raghavan P, Raza W, Ahmed Y, Chamberlain M. Prevalence of pressure sores in a community sample of spinal injury patients. Clin Rehabil. 2003;17(8):879–84.
Scheel-Sailer A, Wyss A, Boldt C, Post M, Lay V. Prevalence, location, grade of pressure ulcers and association with specific patient characteristics in adult spinal cord injury patients during the hospital stay: a prospective cohort study. Spinal Cord. 2013;51(11):828.
Sheerin F, Gillick A, Doyle B. Pressure ulcers and spinal-cord injury: incidence among admissions to the Irish national specialist unit. J Wound Care. 2005;14(3):112–5.
Kovindha A, Kammuang-Lue P, Prakongsai P, Wongphan T. Prevalence of pressure ulcers in Thai wheelchair users with chronic spinal cord injuries. Spinal Cord. 2015;53(10):767.
Tchvaloon E, Front L, Gelernter I, Ronen J, Bluvshtein V, Catz A. Survival, neurological recovery and morbidity after spinal cord injuries following road accidents in Israel. Spinal Cord. 2008;46(2):145.
Taghipoor KD, Arejan RH, Rasouli MR, Saadat S, Moghadam M, Vaccaro AR, Rahimi-Movaghar V. Factors associated with pressure ulcers in patients with complete or sensory-only preserved spinal cord injury: is there any difference between traumatic and nontraumatic causes? J Neurosurg Spine. 2009;11(4):438–44.
Löfvenmark I, Wikmar LN, Hasselberg M, Norrbrink C, Hultling C. Outcomes 2 years after traumatic spinal cord injury in Botswana: a follow-up study. Spinal Cord. 2017;55(3):285.
Chopra T, Marchaim D, Awali RA, Levine M, SM S, Chalana IK, Ahmed F. Risk factors and acute in-hospital costs for infected pressure ulcers among gunshot-spinal cord injury victims in southea stern Michigan. Am J Infect Control. 2016;44(3):315–9.
Al Mutairi KB, Hendrie D. Global incidence and prevalence of pressure injuries in public hospitals: a systematic review. Wound Med. 2018;22:23–31.
Xakellis GC Jr, Frantz RA, Lewis A, Harvey P. Translating pressure ulcer guidelines into practice: it's harder than it sounds. Adv Skin Wound Care. 2001;14(5):249–58.
Ethics approval and consent to participate
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Shiferaw, W.S., Akalu, T.Y., Mulugeta, H. et al. The global burden of pressure ulcers among patients with spinal cord injury: a systematic review and meta-analysis. BMC Musculoskelet Disord 21, 334 (2020). https://doi.org/10.1186/s12891-020-03369-0
- Pressure ulcers
- Spinal cord injury
- Systematic review