Pigmented villous nodular synovitis mimicking metastases on ¹⁸F-FDG PET/CT in a patient with rectal mucosal melanoma: a case report

Abstract

Background

Mucosal melanomas are rare and have a high potential for metastasizing. Surgical resection is the treatment of choice for single distant metastases. Malignant melanoma usually shows the highest uptake of fluorine-18 fluorodeoxyglucose (¹⁸F-FDG). ¹⁸F- FDG positron emission tomography /computed tomography (PET/CT) is usually used for melanoma staging. An extensive literature review revealed only 4 published case reports and an original paper involving 8 cases (12 cases in total) of patients with skin melanomas in whom pigmented villous nodular synovitis (PVNS) mimicked metastatic melanoma, however, none of the melanomas reported were of rectal mucosal origin.

Case presentation

A 60-year-old woman presented with recent diagnosis of rectal mucosal melanoma, two additional ¹⁸F-FDG-avid lesions in the left ankle and left foot were detected on ¹⁸F-FDG PET/CT. Metastases were initially suspected; however, the final diagnosis was PVNS.

Conclusions

This is the first report of PVNS mimicking metastases on ¹⁸F-FDG PET/CT in a patient with rectal mucosal melanoma. Although high ¹⁸F-FDG-avid lesions in patients with rectal mucosal melanoma are highly suspected to be metastasis and warrant an meticulous examination, the present case is a reminder that in such patients, not all lesions with high ¹⁸F-FDG uptake, especially those near a joint, are metastases and that more extensive resection is unnecessary.

Background

Only 1% of all melanomas arise from mucosa; most melanomas arise from skin [1]. Mucosal melanomas arise primarily in the head and neck, anorectal, and vulvovaginal regions. Of all colorectal malignancies, anorectal mucosal melanomas are rare (0.05%) [2], and they have a high potential for metastasis [1, 3, 4]. Surgical resection of the primary tumor, performed by wide local excision, is the mainstay of treatment.

Of all cancers, malignant melanoma usually shows the highest uptake of fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) [5]. Positron emission tomography/computed tomography (PET/CT) with ¹⁸F-FDG is a highly effective way to screen for metastases of malignant melanoma throughout the body [6,7,8]. ¹⁸F-FDG PET/CT can reveal unexpected metastases, often outside the field of view of the other imaging modalities; such findings necessitate a change in patient management [9]. Surgical excision of metastases is recommended if only one or a few sites of disease are apparent [10].

However, not all highly ¹⁸F-FDG-avid lesions are malignant. Benign conditions and lesions can have high ¹⁸F-FDG uptake, including hyperplasia, benign tumors, and any inflammation or infection [11, 12]. Therefore, lesions should be histologically confirmed, particularly when PET/CT findings might prompt a change of treatment.

Pigmented villous nodular synovitis (PVNS) represents an uncommon benign proliferative process characterized by focal or diffuse hyperplasia of synovial villi that affects the synovial joints, tendon sheaths, and bursa membranes. In asymptomatic cases, no additional treatment is required [13,14,15,16]. The knee, followed by the hip, is the most common location of PVNS. Other large joints affected include the ankle, the shoulder, and the elbow, in decreasing order of frequency. PVNS lesions have high ¹⁸F-FDG uptake and are known to have a false-positive appearance on ¹⁸F-FDG PET/CT [17, 18].

We describe the case of a patient with rectal mucosal melanoma and two additional ¹⁸F-FDG-avid lesions, one in the left ankle and one in the left foot. These lesions were detected on ¹⁸F-FDG PET/CT and initially suspected to be metastases, but the final diagnosis was PVNS. To our knowledge, this is the first report of PVNS that mimics metastases on ¹⁸F-FDG PET/CT in a patient with rectal mucosal melanoma.

Case presentation

A 60-year-old woman presented to her primary care physician with bloody stool for 2 months. Laboratory examination revealed Hb and Hct levels were 11.8 g/dL and 34.2%, (reference range: 11.6–14.8 g/dL and 34–44%), respectively. Stool occult blood was < 7 ng/mL (reference range: < 12 ng/mL). Physiological examination did not reveal any other skin lesion that could be suspected for melanoma. Colonoscopy and biopsy performed at another hospital revealed a malignant melanoma at the anorectal site; thereafter, the patient was transferred to our hospital only with pathology report for further management. Routine ¹⁸F-FDG PET/CT examination performed after the biopsy for melanoma staging revealed a highly ¹⁸F-FDG-avid lesion in the rectum (Fig. 1). The maximum standardized uptake value (SUV_max) was 15.3. Two additional high ¹⁸F-FDG-avid lesions were found in her left ankle and left foot (SUV_max, 8.9; Fig. 2).

Fig. 1

Anterior (left) and left lateral (right) whole-body Fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) maximum-intensity projections in a patient with rectal melanoma. An intensely ¹⁸F-FDG-avid lesion was present in the rectum (arrow) and two additional intensely ¹⁸F-FDG-avid lesions were present in the left ankle and in the left foot (arrowheads)

Fig. 2

Sagittal positron emission tomography (PET; a), computed tomography (CT; b), and fused Fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) PET/CT (c) of the patient’s left ankle and left foot. Two ¹⁸F-FDG-avid lesions were present in these locations beside the flexor hallucis longus muscle and tendon (arrows)

The lesion with the highest ¹⁸F-FDG avidity noted was diagnosed as rectal melanoma; moreover, the lesions in the left ankle and the left foot showed high ¹⁸F-FDG avidity. For these reasons, and because melanoma has a high metastatic potential, these lesions were first thought to be distant metastases.

The patient was referred to a surgical oncologist to undergo additional workup. Magnetic resonance images (MRI), sagittal T1-weighted turbo spin echo (TSE) image (Figs. 3 and 4a), sagittal T1-weighted TSE fat-suppressed with Ga-DTPA contrast -enhanced image with Ga-DTPA fat suppression (Figs. 3 and 4b), coronal proton density (PD)-weighted TSE fat -suppressed image (Figs. 3 and 4c), and transverse T1-weighted TSE fat-suppressed with contrast-enhanced image with Ga-DTPA fat suppression (Figs. 3 and 4d) of the left foot, obtained to further characterize the lesions, revealed the two masses beside the flexor hallucis longus muscle and tendon, which were locations suggestive of metastases from melanoma; however, the differential diagnosis included PVNS. Out of concern that they represented metastatic melanoma, she was taken to the operating room. Surgery on the left ankle revealed firm, yellowish subcutaneous tumors beneath the deep fascia and the Achilles tendon. Intraoperative pathological study revealed that the lesion in the left foot was benign; therefore, only the mass in the left ankle was resected (Fig. 5), and special pathological staining revealed that the correct diagnosis was PVNS (Fig. 6). Thus, this patient underwent abdominoperineal resection. However, a follow-up abdominal CT conducted 3 months later revealed new multiple liver metastases, and chemotherapy treatment was initiated. Fortunately, a follow-up abdominal CT conducted 2 years later revealed that the liver lesions were nearly in complete regression. The patient is alive, and after another 2 years after complete regression, the patient is stable at present.

Fig. 3

Magnetic resonance images of the patient’s left ankle. a Sagittal T1-weighted turbo spin echo (TSE) image. b Sagittal T1-weighted TSE contrast-enhanced image with Ga-DTPA fat -suppressed. c Coronal proton density (PD)-weighted TSE fat-suppressed image. d Transverse T1-weighted TSE contrast-enhanced image with Ga-DTPA fat-suppressed. A well-enhanced mass was identified beside the flexor hallucis longus muscle at the level of the ankle joint (arrows). Considering that the patient was diagnosed with melanoma, these appearances were in favor of metastases from melanoma according to a radiologist. However, the differential diagnosis was pigmented villous nodular synovitis

Fig. 4

Magnetic resonance images of the patient’s left foot. a Sagittal T1-weighted turbo spin echo (TSE) image. b Sagittal T1-weighted TSE contrast-enhanced image with Ga-DTPA fat -suppressed. c Coronal proton density (PD)-weighted TSE fat-suppressed image. d Transverse T1-weighted TSE contrast-enhanced image with Ga-DTPA fat-suppression. Another well-enhanced mass was identified beside the flexor hallucis longus tendon at the level of the talonavicular joint (arrows). Considering that the patient was diagnosed with melanoma, these appearances were in favor of metastases from melanoma according to a radiologist. However, the differential diagnosis was pigmented villous nodular synovitis

Fig. 5

Excision of the tumor in the left ankle. a The location was marked (arrow) before surgery. b The mass (arrow) was removed

Fig. 6

Pathological appearances of the mass from the left ankle. a Low-power view of the hypocellular, ovoid shaped tumor. b Focal areas had increased cellular infiltrates consisting of lymphocytes, macrophages, and multinucleated giant cells, surrounded by highly collagenized stroma. Special staining with Melan-A (c) and HMB45 (d), both of which are markers of melanoma, yielded negative results. The pathologically proved diagnosis was pigmented villous nodular synovitis (PVNS)

Discussion and conclusion

Because anorectal melanomas have a high metastatic potential and high ¹⁸F-FDG uptake, any distant lesion that is highly ¹⁸F-FDG-avid is suspected as being a possible metastasis, and for any resectable ¹⁸F-FDG-avid lesions that are identified, aggressive surgical management is presumably necessary. However, in the present case, intraoperative pathological tests revealed benign tumor. Therefore, only lesion excision was performed.

An extensive literature review revealed only four published case reports and an original paper about 8 cases (12 cases in total) of patients with skin melanomas in whom PVNS mimicked metastatic melanoma, but none of the melanomas were mucosal [18,19,20,21,22]. To our knowledge, our case is the first report of PVNS mimicking metastases on ¹⁸F-FDG PET/CT in a patient with rectal mucosal melanoma.

In retrospect, there can be two indications suggesting that these lesions are not metastases from melanoma. First, we noted that although the lesions in the left ankle and left foot showed high ¹⁸F-FDG uptake (SUV_max, 8.9), the uptake was moderately lower than that of the rectal melanoma (SUV_max, 15.3). This suggests that these lesions were not the highest ¹⁸F-FDG-avid lesions. Second, the lesions was located on the ankle and foot, which are sites preceded by the knee and hip as the most common sites; therefore, the locations of the lesions were not at the most common sites of PVNS.

Because the treatment of PVNS differs significantly from that of metastatic melanoma, PVNS should be included in the differential diagnosis of melanoma, especially in cases when ¹⁸F-FDG PET/CT identifies possible metastatic spread near the joints, as in this case (in the left ankle and the left foot).

Although any highly ¹⁸F-FDG-avid lesion in patients with rectal mucosal melanoma is high suspect for being a metastasis and warrants an aggressive workup, some benign conditions and lesions can have high ¹⁸F-FDG uptake. This case is a reminder that not all lesions with high ¹⁸F-FDG uptake, especially not extremely high ¹⁸F-FDG uptake and near the joint, are metastases and that more extensive resection may not be necessary.