Patients waiting or recovering from total joint arthroplasty (TJA) are at risk for falls which can lead to restriction of activity and negatively impact recovery. The objective of this scoping review is to critically appraise and synthesize the evidence in the reported number of falls, fear of falling, and risk factors associated with falls in older patients waiting for or recovering from TJA.
Seven electronic databases were searched with no date limits and using language restriction (English). The inclusion criteria were 1) cohorts that included older adults 60+ years of age, 2) reported prevalence of falls, fear of falling, and/or risk factors for falls in patients who were waiting or recovering from TJA and 3) cross-sectional studies, cohort studies, and case control study designs. The quality assessment of selected articles was assessed using the SIGN Guidelines Checklist.
Of the 866 citations identified, 12 studies met the inclusion criteria and were reviewed. Prevalence of falls in pre-operative TJA patients and post-operative TJA patients ranged from 23 to 63%, and 13 to 42%, respectively. Of those five studies that examined fear of falling, pre-operative TJA patients reported greater fear of falling than post-operative patients. Modifiable risk factors for falls included fear of falling, joint range of motion, and depression.
An increased risk of falls in patients with TJA was reported both for patients waiting for and recovering from surgery. A number of modifiable risk factors were identified including fear of falling that could be targeted in fall prevention programs for TJA.
Falls in older adults is a major public health problem given that it is the leading cause of injury in community dwelling older adults . Osteoarthritis (OA) which is a prevalent disabling condition in older adults, is associated with increased fall risk (OR: 2.4; 95% CI: 1.6, 5.4) . While total joint arthroplasty (TJA) is an effective surgical option for advanced OA of the hip and knee , little evidence has examined falls in patients with TJA. The few reviews examining falls with TJA have reported a higher rate of falls with TKA and identified intrinsic risk factors such as balance and postural control [4, 5].
Causes of falls are typically multifaceted and can be attributed to intrinsic or extrinsic risk factors [6, 7]. Intrinsic risk factors for falls commonly seen in OA, include muscle weakness , balance deficits , pain , and fear of falling . Others, however, have reported that balance deficits may not have a direct effect on falls in older adults with hip OA , yet balance deficits, knee muscle weakness, and increasing number of symptomatic joints were regarded as risk factors for falls with knee OA . Pain is associated with muscle weakness, impaired balance and mobility limitations which may, in turn, be related to falls . Evidence from a large longitudinal study reported that the risk of falls was greater for older women with lower extremity musculoskeletal pain; however, the risk was lowered with the use of analgesic medication . Others have not found the use of analgesics for OA was associated with falls [9, 11].
Fear of falling is a modifiable risk factor for falls which limits mobility for older adults [14, 15]. Specifically, fear of falling is a constant concern about falling that can lead to self-imposed limitation of daily activities . Fear of falling is a prevalent risk factor in older adults regardless of whether they have a history of falls. Anywhere up to 65% of older adults who have not fallen and 92% of those who have fallen have a fear of falling . A high level of fear of falling after surgery can also reduce self-efficacy, or one’s perception of their ability. Although few studies have examined fear of falling in this patient population [4, 5], fear of falling is reported to be higher in patients with TJA as compared to community controls .
Because few systematic reviews have specifically defined or examined falls in TJA [4, 5, 19], the purpose of this scoping review is to critically appraise and synthesize the evidence for falls in patients with TJA and to map current evidence of falls, fear of falling and risk factors associated with falls in TJA patients during the perioperative period. The specific objective is to identify existing evidence on the reported number of falls, fear of falling, and known risk factors for falls in older adults who are waiting for or recovering from TJA.
We conducted a scoping review using the method outlined by Arksey and O’Malley . Inclusion criteria were 1) cohorts of older adults; 60+ years of age, 2) reported prevalence of falls, fear of falling, and/or risk factors for falls in patients who were waiting or recovering from TJA, and 3) cross-sectional studies, cohort studies, and case control study designs. Excluded studies consisted of articles that used indirect balance measures to predict falls such as Timed Up and Go, Dynamic Gait Index, and the Berg Balance Test.
Data sources and search strategies
The search strategies were developed and implemented by a health sciences librarian for 7 electronic databases (Pubmed, Medline, CENTRAL, Embase, CINAHL Plus with Full Text, Web of Science, and SCOPUS) and was completed on April 6, 2017. The search strategy included the following keyword terms and concepts: 1) arthroplasty 2) knee joint or hip joint 3) replacement 4) osteoarthritis 5) accidental falls (Additional file 1: Appendix A). Research in-progress was searched via abstracts from Pubmed’s epub. Non-English studies with English abstracts were included in the literature search then excluded at the time of abstract review to provide an overview of possible publications in non-English journals. The decision to restrict to English articles was based on findings from systematic research evidence that reported no empirical evidence of bias was seen if papers written in languages other than English were excluded .
Screening and data extraction
Citations were exported to Refworks and exact duplicates were electronically removed. The remaining citations were imported into COVIDENCE, a screening and data extraction tool, for abstract screening, full text review and data extraction . Titles were reviewed for eligibility criteria by one reviewer (SC). Two reviewers (SC, DP) independently screened the remaining abstracts based on the inclusion criteria using a standard study selection form. Articles were then reviewed by two reviewers with “moderate” inter-rater reliability agreement (Kappa =0.69) . Disagreement of article inclusion was resolved through consensus between reviewers or, if the reviewers did not arrive upon consensus, a third party adjudication (CAJ) was consulted for the final decision. One reviewer (SC) assessed the full-text articles. Data extraction was done by one reviewer (SC) and checked by a second reviewer (DP).
The SIGN Guidelines Checklist 3: Cohort Studies  was used to assess individual study quality through completion of a cohort or cross-sectional checklist. The checklist included 14 questions that addressed four areas: (1) selection of subjects (2) assessment of outcome, (3) confounding, and (4) statistical analysis. Studies were given either a “high”, “acceptable”, or “low” rating. Because of the methodological and clinical heterogeneity of the included studies, meta-analyses could not be conducted.
A total of 866 citations were retrieved: 293 in EMBASE with an additional 240 in SCOPUS, 174 in MEDLINE, 82 in Web of Science, 45 in CINAHL, 25 in CENTRAL, five in PubMed (of pub ahead of print only), two in Cochrane Central Register of Controlled Trials. All articles were imported into Covidence where 335 duplicates were removed. We assessed 47 full articles, of which 12 studies were included in this review [18, 25,26,27,28,29,30,31,32,33,34,35] regardless of methodological quality. The summary of study selection and reasons for exclusion is presented within the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) diagram (Fig. 1). Two studies used the same cohort; however, had different primary objectives [30, 32]. Six studies were cross-sectional studies [25,26,27,28,29,30] of which one was an abstract , four were prospective cohort studies [18, 31,32,33], and two were retrospective cohort studies [34, 35] (Additional file 2: Table S1). Eight studies [25,26,27,28,29, 32, 33, 35] had a comparison group, comparing self-reported “fallers” to “non-fallers”.
The definition of falls varied among the studies. Six studies used a traditionally accepted definition of falls [25, 26, 30,31,32,33], which was “an unexpected event in which the participant comes to rest on the ground, floor, or lower level, not as a result of a major intrinsic event such as a faint or stroke, seizure, or an overwhelming external hazard”. The remaining studies did not explicitly define what constituted a fall in their study population [18, 27,28,29, 34, 35]. Sample sizes ranged from 31 to 413 participants. Data from the Osteoarthritis Initiative database were used for 2 studies with 413  and 269  participants. Three studies were conducted in the UK [28, 33, 34], two in Japan [25, 31], two in Australia [18, 29], two in USA [27, 35], two in Greece [30, 32] and one in Thailand .
Based on SIGN guidelines, four studies were poor quality [25,26,27,28] six were acceptable quality [18, 29, 30, 32, 34, 35] and two were high quality [31, 33]. Assignment of poor quality was due to several factors including missing confidence interval estimates (n = 1) and failure to discuss presence of potential bias (n = 2).
The mean ages of participants reported ranged from 63.9 ± 6.8  to 75.0 ± 6.0  years with cohorts comprised of 41%  to 100%  females. Seven studies examined total knee arthroplasties (TKA) [18, 26, 30,31,32,33, 35]; one pre-operative  and two post-operative [26, 31] and four both pre-operative and post-operative [18, 32, 33, 35]. Two articles examined total hip arthroplasties (THA) [25, 27], one preoperative  and the other post-operative . Three studies examined TJA combining findings from both THA and TKA [28, 29, 34].
The number of falls in three prospective cohort studies [18, 32, 33] reported a higher proportion of falls in pre-operative patients than during the post-operative recovery (Fig. 2). Of the 8 studies that examined pre-operative falls, the recall period ranged from one month to one year (Table 1). The number of reported falls ranged from 23%  to 63% . Post-operative falls were reported in 7 articles and the number of falls ranged from 13%  to 42% . Patients who were in the recovery phase were typically asked to recall falls over a one year period; however, post-operative recruitment ranged from 6 months to 6 years. One post-operative TKA study had a recall period that extended into the pre-operative phase and reported the greatest number of reported falls (42%) with a 6 year post-operative follow-up period .
Fear of falling
Fear of falling was reported in five studies [18, 29,30,31,32] and used several different instruments including Activities-Specific Balance scale , Falls Efficacy Scale International (FES-I)  and the Modified Falls Efficacy Scale . Fall status did not significantly affect fear of falling scores. Three of the five studies reported that fear of falling did not differ between fallers and non-fallers regardless of TJA pre- post-operative status [29, 31, 33]. One study reported that pre-operative patients were more fearful than those recovering from TJA surgery regardless of fall status (p < 0.001)  (Table 2). When compared to community dwelling older adults, patients with TKA had higher FES-I scores which was indicative of greater fear of falling (p < 0.01) .
Risk factors for falls
Type of total joint arthroplasty (TKA/THA)
In one study that examined risk factors for falls in both THA and TKA patients, patients with TKA had a greater number of factors associated with falls than patients with THA . Fear of falling was a risk factor in both joint groups, while pain, function and mental health were other risk factors reported in two TKA cohorts [29, 34].
Joint specific pain, stiffness and function
Of the twelve reviewed articles, seven articles measured joint pain, function and stiffness using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores [18, 26, 28,29,30, 32, 33]. Most studies did not find significant WOMAC differences between fallers and non-fallers after TJA. Two of the three studies that reported significant differences in WOMAC subscales: pain, stiffness, and function between faller and non-fallers were rated “poor” quality which may be indicative of confounding effects such as age [26, 28]. One cross-sectional study reported that 40% (n = 282) of pre-operative patients indicated that their fall was related to the painful joint .
Joint range of motion
Two studies which examined joint range of motion (ROM) and the risk of falls, reported significant joint range differences between fallers and non-fallers [27, 31]. Patients with TKA who had a 10-degree increase in knee flexion reduced the odds of falling by 72.3% (OR: 0.28; 95% CI: 0.09, 0.87) at 1-year after surgery; whereas, a 5-degree increase in ankle plantar flexion reduced the odds of falling by 40% . In a cross-sectional study of 31 THA patients, total hip ROM and knee extension were significantly more restricted in fallers than non-fallers .
Number of comorbid conditions
The association between the number of comorbid conditions and falls is not clearly delineated in the TJA literature. Three of five studies that specifically examined comorbid conditions and falls, reported no differences in number of self-reported co-morbid conditions between fallers and non-fallers before [30, 33] and after TKA .
Of the five cross-sectional studies that examined falls and depression, three [28, 29, 35] reported a significant association between depression and a greater number of falls.
One cross-sectional study of 199 TJA patients reported a higher proportion of those with history of falls (13/75; 17%) took antidepressants as compared to those who had not fallen (8/119; 7%) (p = 0.02) . No statistical adjustments for other factors were done. In contrast, a high quality longitudinal study concluded that use of antidepressants did not increase the risk of falls after adjusting for age, gender, number of comorbid conditions and pre-operative WOMAC scores (OR: 1.18, 95% CI: 0.16, 0.88) . The use of other medications that may impact falls risk were not evaluated in any of the other studies.
Twelve articles were included in this scoping review that specifically examined falls in patients with TJA. Falls occurring during the peri-operative period of TJA is an emerging area of interest, with 10 of the 12 studies published after 2010. A preponderance of articles, however, were small, single-center studies with the majority examining TKA. Although 3 studies examined TJA as a single cohort, the type of joint may impact the risk of falls. The few studies that followed patients before and after surgery, reported a higher proportion of falls before surgery than afterwards. Risk factors, such as environmental hazards and use of walking assistive devices are known extrinsic risk factors for community-dwelling older adults  and have direct applicability for TJA, yet this type of risk factor was reported in few studies.
The pattern of falls during the perioperative period is an understudied area which has clinical implications. Within this review, two studies reported the number of falls increased dramatically as the number of risk factors increase [39, 40]. Patients waiting for TJAs may be at a high risk for falling due to increased pain and disability, while patients are also at a high risk of falling immediately after surgery due to limited mobility . Up to 17% of patients admitted for short-term hospitalization reported a fall while in the hospital , reporting a higher incidence of in-hospital falls with TKA than THA .
Pain is a risk factor for falls in older adults with knee and back pain [43, 44]. It is possible that high levels of pain before surgery may, in part, account for the high number of falls with TJA. Presence of knee and hip pain may potentially explain the increased risk of falls in pre-operative patients compared to post-operative patients. Surprisingly, joint-specific pain as measured by the WOMAC was not identified as a risk factor for falls.
Restricted knee and ankle ROM was associated with falls with TKA, in particular, knee extension and ankle plantar flexion were associated with falls, while total hip ROM and knee extension were associated with falls with THA. These findings support the current evidence in the literature, that significant restricted hip ROM (extension, internal rotation), and ankle dorsiflexion were seen in fallers as compared to non-fallers . Given the association with falls, increasing or maintaining ROM may be one modifiable factor in preventing falls.
Fear of falling is a well known risk factor for falls in OA patients . Although TJA provides significant pain relief and large improvements with function , fear of falling may be problematic for this patient population, particularly when encouraging physical activity during recovery. Fear of falling is one of the few modifiable risk factors for falls, therefore adding cognitive behavioural interventions aimed at reducing fear of falling may be beneficial to improve long term functional outcomes in TJA patients post surgery . Significant improvements have been reported with fear of falling in older adults with a combined program of exercise and education [47, 48].
The primary aim of this review was to determine the scope of the literature that assessed falls, fear of falling, and risk factors for falls in older adults during the perioperative TJA period. Of the 12 articles identified, the majority of studies were of low or moderate quality. More than half of the studies included in this review had small sample sizes (n < 74), which may not be reflective of the fall rate in this patient population. Methodological considerations of falls centred on defining what constituted a fall and the recall period. All studies used retrospective self-report of falls, which could lead to under-reporting, especially if the recall time is longer than 12 months . Monthly falls diaries have been cited as a validated method of collecting falls data ; however, only two studies used this method. With advancements of personal activity monitors, electronic monitoring of falls may limit the bias associated with recalling and recording falls.
A consideration with any scoping review is the inclusion of all studies regardless of methodological quality. In this case, we examined methods used for ascertaining falls and fear of falling both before and after surgery. This approach allowed us to look at the evidence over the peri-operative period to identify possible gaps in the literature. While others have done systematic reviews on falls only with TKA [4, 5] or during the post-operative phase , we performed a scoping review which took a broader view looking at both THA and TKA, as well as falls during the peri-operative period. Because the literature was sparse, a scoping review provided a scan of the literature on this clinically relevant topic.
In light of the high prevalence rate of falls in this patient population, the clinical implications indicate that falls prevention should be addressed both before and after surgery. Quality indicators for rehabilitation of TJA recommend balance and fall risk assessments before surgery with balance retraining during the recovery phase for both THA and TKA . Relative to fall prevention programs in older adults in the community, few falls prevention programs specific to TJA exist. The majority of these TJA-specific programs have dealt with in-hospital falls and centred on the educational component [52,53,54]. Joint range, fear of falling and depression are modifiable risk factors for falls that could be specifically targeted. Although the etiology of falling is typically multifactorial, effective fall prevention interventions can reduce the number of falls by almost a third  and improve balance confidence in older adults . However, the most effective time to deliver fall prevention programs during pre- and post-operative periods need to be identified.
Substantial evidence for fall prevention exists for older adults; however, relatively few studies have reported prevalence of falls and risk factors in patients with TJA. The findings from this scoping review suggest there are a number of intrinsic risk factors for falling in patients with TJA, both pre- and post-operative, yet further investigation needs to examine extrinsic risk factors. A number of modifiable intrinsic risk factors were identified including fear of falling which should be targeted in fall prevention programs for TJA. The findings not only advocate for high quality large scale investigations examining the burden of falls, but also warrant research of interventions to prevent falls in this patient population.
Availability of data and materials
The datasets used during the current review are available from the corresponding author on reasonable request.
Falls Efficacy Scale International
Range of motion
Total hip arthroplasty
Total joint arthroplasty
Total knee arthroplasty
Western Ontario and McMaster Universities Osteoarthritis Index
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SC, CAJ, and DV made substantial contributions to the conception and design of the study. SC and DP completed the acquisition of data. SC, CAJ, DP, DV contributed to the data analysis and interpretation. SC has full access to the data and takes responsibility for the content and guarantees the integrity and accuracy of the work undertaken. All authors have read, provided critical feedback on intellectual content, and approved the final manuscript.
Table S1_SUBMITTED.pdf. Table S1. Characteristics of included studies. Extracted data from included studies.
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Chen, S.K., Voaklander, D., Perry, D. et al. Falls and fear of falling in older adults with total joint arthroplasty: a scoping review.
BMC Musculoskelet Disord20, 599 (2019). https://doi.org/10.1186/s12891-019-2954-9