Radin EL, Rose RM: Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop. 1986, 34-40.
Google Scholar
Burr DB: The importance of subchondral bone in osteoarthrosis. Curr Opin Rheumatol. 1998, 10: 256-262. 10.1097/00002281-199805000-00017.
Article
CAS
PubMed
Google Scholar
Grynpas MD, Alpert B, Katz I, Lieberman I, Pritzker KP: Subchondral bone in osteoarthritis. Calcif Tissue Int. 1991, 49: 20-26. 10.1007/BF02555898.
Article
CAS
PubMed
Google Scholar
Bobinac D, Spanjol J, Zoricic S, Maric I: Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans. Bone. 2003, 32: 284-290. 10.1016/S8756-3282(02)00982-1.
Article
PubMed
Google Scholar
Patel V, Issever AS, Burghardt A, Laib A, Ries M, Majumdar S: MicroCT evaluation of normal and osteoarthritic bone structure in human knee specimens. J Orthop Res. 2003, 21: 6-13. 10.1016/S0736-0266(02)00093-1.
Article
PubMed
Google Scholar
Messent EA, Ward RJ, Tonkin CJ, Buckland-Wright C: Osteophytes, juxta-articular radiolucencies and cancellous bone changes in the proximal tibia of patients with knee osteoarthritis. Osteoarthritis Cartilage. 2007, 15: 179-186. 10.1016/j.joca.2006.06.020.
Article
CAS
PubMed
Google Scholar
Li B, Aspden RM: Mechanical and material properties of the subchondral bone plate from the femoral head of patients with osteoarthritis or osteoporosis. Ann Rheum Dis. 1997, 56: 247-254.
Article
CAS
PubMed
PubMed Central
Google Scholar
Day JS, Ding M, van der Linden JC, Hvid I, Sumner DR, Weinans H: A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage. J Orthop Res. 2001, 19: 914-918. 10.1016/S0736-0266(01)00012-2.
Article
CAS
PubMed
Google Scholar
Chappard C, Peyrin F, Bonnassie A, Lemineur G, Brunet-Imbault B, Lespessailles E, Benhamou CL: Subchondral bone micro-architectural alterations in osteoarthritis: a synchrotron micro-computed tomography study. Osteoarthritis Cartilage. 2006, 14: 215-223. 10.1016/j.joca.2005.09.008.
Article
CAS
PubMed
Google Scholar
Pelletier JP, Boileau C, Brunet J, Boily M, Lajeunesse D, Reboul P, Laufer S, Martel-Pelletier J: The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K. Bone. 2004, 34: 527-538. 10.1016/j.bone.2003.11.021.
Article
CAS
PubMed
Google Scholar
Dedrick DK, Goldstein SA, Brandt KD, O'Connor BL, Goulet RW, Albrecht M: A longitudinal study of subchondral plate and trabecular bone in cruciate-deficient dogs with osteoarthritis followed up for 54 months. Arthritis Rheum. 1993, 36: 1460-1467. 10.1002/art.1780361019.
Article
CAS
PubMed
Google Scholar
Boyd SK, Muller R, Leonard T, Herzog W: Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis. Osteoarthritis Cartilage. 2005, 13: 235-242. 10.1016/j.joca.2004.11.004.
Article
CAS
PubMed
Google Scholar
Boyd SK, Muller R, Matyas JR, Wohl GR, Zernicke RF: Early morphometric and anisotropic change in periarticular cancellous bone in a model of experimental knee osteoarthritis quantified using microcomputed tomography. Clin Biomech (Bristol, Avon). 2000, 15: 624-631. 10.1016/S0268-0033(00)00023-1.
Article
CAS
Google Scholar
Layton MW, Goldstein SA, Goulet RW, Feldkamp LA, Kubinski DJ, Bole GG: Examination of subchondral bone architecture in experimental osteoarthritis by microscopic computed axial tomography. Arthritis Rheum. 1988, 31: 1400-1405. 10.1002/art.1780311109.
Article
CAS
PubMed
Google Scholar
Ding M, Danielsen CC, Hvid I: Age-related three-dimensional microarchitectural adaptations of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int. 2006, 78: 113-122. 10.1007/s00223-005-0028-5.
Article
CAS
PubMed
Google Scholar
Batiste DL, Kirkley A, Laverty S, Thain LM, Spouge AR, Holdsworth DW: Ex vivo characterization of articular cartilage and bone lesions in a rabbit ACL transection model of osteoarthritis using MRI and micro-CT. Osteoarthritis Cartilage. 2004, 12: 986-996. 10.1016/j.joca.2004.08.010.
Article
PubMed
Google Scholar
Brandt KD, Myers SL, Burr D, Albrecht M: Osteoarthritic changes in canine articular cartilage, subchondral bone, and synovium fifty-four months after transection of the anterior cruciate ligament. Arthritis Rheum. 1991, 34: 1560-1570.
Article
CAS
PubMed
Google Scholar
Caron JP, Fernandes JC, Martel-Pelletier J, Tardif G, Mineau F, Geng C, Pelletier JP: Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression. Arthritis Rheum. 1996, 39: 1535-1544. 10.1002/art.1780390914.
Article
CAS
PubMed
Google Scholar
Manicourt DH, Altman RD, Williams JM, Devogelaer JP, Druetz-Van Egeren A, Lenz ME, Pietryla D, Thonar EJ: Treatment with calcitonin suppresses the responses of bone, cartilage, and synovium in the early stages of canine experimental osteoarthritis and significantly reduces the severity of the cartilage lesions. Arthritis Rheum. 1999, 42: 1159-1167. 10.1002/1529-0131(199906)42:6<1159::AID-ANR12>3.0.CO;2-Q.
Article
CAS
PubMed
Google Scholar
Pelletier JP, Lascau-Coman V, Jovanovic D, Fernandes JC, Manning P, Connor JR, Currie MG, Martel-Pelletier J: Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors. J Rheumatol. 1999, 26: 2002-2014.
CAS
PubMed
Google Scholar
Yu LP, Smith GN, Brandt KD, Myers SL, O'Connor BL, Brandt DA: Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline. Arthritis Rheum. 1992, 35: 1150-1159. 10.1002/art.1780351007.
Article
PubMed
Google Scholar
Marijnissen AC, van Roermund PM, TeKoppele JM, Bijlsma JW, Lafeber FP: The canine 'groove' model, compared with the ACLT model of osteoarthritis. Osteoarthritis Cartilage. 2002, 10: 145-155. 10.1053/joca.2001.0491.
Article
CAS
PubMed
Google Scholar
Marijnissen AC, van Roermund PM, Verzijl N, Tekoppele JM, Bijlsma JW, Lafeber FP: Steady progression of osteoarthritic features in the canine groove model. Osteoarthritis Cartilage. 2002, 10: 282-289. 10.1053/joca.2001.0507.
Article
CAS
PubMed
Google Scholar
Mastbergen SC, Marijnissen AC, Vianen ME, van Roermund PM, Bijlsma JW, Lafeber FP: The canine 'groove' model of osteoarthritis is more than simply the expression of surgically applied damage. Osteoarthritis Cartilage. 2006, 14: 39-46. 10.1016/j.joca.2004.07.009.
Article
PubMed
Google Scholar
van Valburg AA, van Roermund PM, Marijnissen AC, Wenting MJ, Verbout AJ, Lafeber FP, Bijlsma JW: Joint distraction in treatment of osteoarthritis (II): effects on cartilage in a canine model. Osteoarthritis Cartilage. 2000, 8: 1-8. 10.1053/joca.1999.0263.
Article
CAS
PubMed
Google Scholar
Lafeber FP, Vander Kraan PM, Huber-Bruning O, Vanden Berg WB, Bijlsma JW: Osteoarthritic human cartilage is more sensitive to transforming growth factor beta than is normal cartilage. Br J Rheumatol. 1993, 32: 281-286. 10.1093/rheumatology/32.4.281.
Article
CAS
PubMed
Google Scholar
Mankin HJ, Dorfman H, Lippiello L, Zarins A: Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am. 1971, 53: 523-537.
CAS
PubMed
Google Scholar
Lafeber FP, Vander Kraan PM, Van Roy JL, Huber-Bruning O, Bijlsma JW: Articular cartilage explant culture; an appropriate in vitro system to compare osteoarthritic and normal human cartilage. Connect Tissue Res. 1993, 29: 287-299. 10.3109/03008209309016834.
Article
CAS
PubMed
Google Scholar
Waarsing JH, Day JS, Weinans H: An improved segmentation method for in-vivo micro-CT imaging. J Bone Miner Res. 2004, 19: 1640-1650. 10.1359/JBMR.040705.
Article
PubMed
Google Scholar
Hildebrand T, Ruegsegger P: A new method for the model-independent assessment of thickness in three-dimensional images. J Micros. 1997, 185: 67-75. 10.1046/j.1365-2818.1997.1340694.x.
Article
Google Scholar
Hildebrand T, Ruegsegger P: Quantification of Bone Microarchitecture with the Structure Model Index. Comput Methods Biomech Biomed Engin. 1997, 1: 15-23. 10.1080/01495739708936692.
Article
PubMed
Google Scholar
Odgaard A, Gundersen HJ: Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions. Bone. 1993, 14: 173-182. 10.1016/8756-3282(93)90245-6.
Article
CAS
PubMed
Google Scholar
Dayal N, Chang A, Dunlop D, Hayes K, Chang R, Cahue S, Song J, Torres L, Sharma L: The natural history of anteroposterior laxity and its role in knee osteoarthritis progression. Arthritis Rheum. 2005, 52: 2343-2349. 10.1002/art.21277.
Article
PubMed
Google Scholar
Fahlgren A, Andersson B, Messner K: TGF-beta1 as a prognostic factor in the process of early osteoarthrosis in the rabbit knee. Osteoarthritis Cartilage. 2001, 9: 195-202. 10.1053/joca.2000.0376.
Article
CAS
PubMed
Google Scholar
Hayami T, Pickarski M, Wesolowski GA, McLane J, Bone A, Destefano J, Rodan GA, Duong le T: The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum. 2004, 50: 1193-1206. 10.1002/art.20124.
Article
CAS
PubMed
Google Scholar
van Beuningen HM, van der Kraan PM, Arntz OJ, van den Berg WB: Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint. Lab Invest. 1994, 71: 279-290.
CAS
PubMed
Google Scholar
Blom AB, van Lent PL, Holthuysen AE, van der Kraan PM, Roth J, van Rooijen N, van den Berg WB: Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. Osteoarthritis Cartilage. 2004, 12: 627-635. 10.1016/j.joca.2004.03.003.
Article
PubMed
Google Scholar
Hayami T, Pickarski M, Zhuo Y, Wesolowski GA, Rodan GA, Duong LT: Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone. 2006, 38: 234-243. 10.1016/j.bone.2005.08.007.
Article
PubMed
Google Scholar
Botter SM, van Osch GJVM, Waarsing JH, Day JS, Verhaar JAN, Pols HAP, van leeuwen JPTM, Weinans H: Quantification of subchondral bone changes in a murine osteoarthritis model using micro-CT. Biorheology. 2006, 43: 379-388.
CAS
PubMed
Google Scholar
Buckwalter JA, Mankin HJ: Articular cartilage: degeneration and osteoarthrosis, repair, regeneration, and transplantation. J Bone Joint Surg Am. 1997, 79: 612-362.
Google Scholar
Lafeber FP, van Roy H, Wilbrink B, Huber-Bruning O, Bijlsma JW: Human osteoarthritic cartilage is synthetically more active but in culture less vital than normal cartilage. J Rheumatol. 1992, 19: 123-129.
CAS
PubMed
Google Scholar
Westacott CI, Webb GR, Warnock MG, Sims JV, Elson CJ: Alteration of cartilage metabolism by cells from osteoarthritic bone. Arthritis Rheum. 1997, 40: 1282-1291.
Article
CAS
PubMed
Google Scholar