Table 1 Cartilage and bone parameters of the tibial epiphysis. Data are displayed as mean percentage difference (δ) or absolute difference (for Mankin grade and SMI) of the experimental OA joint relative to the contralateral control joint, for the groove model and ACLT model, at 3, 10, and 20 weeks post-surgery.
| Â | Cartilage | Epiphyseal trabecular bone | Metaphysis | Subchondral plate | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | GAG | Mankin | BV/TV | TbTh | SMI | CD | BV | PlTh | PlPor | |||||||||
|  | δ(%) | p | δ(-) | p | δ(%) | p | δ(%) | p | δ(-) | p | δ(%) | p | δ(%) | p | δ(%) | p | δ(%) | p |
Groove | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
3w | -4.5 | 0.137 | +0.17 | 0.055 | +3.9 | 0.465 | 0.0 | 1.000 | -0.05 | 0.465 | +3.8 | 0.068 | -0.9 | 0.715 | -40.7 | 0.068 | +84.8 | 0.068 |
10w | -11.1 | 0.233 | +2.15 | 0.034 | +6.0 | 0.068 | +4.2 | 0.144 | -0.30 | 0.068 | +0.3 | 1.00 | -3.1 | 0.068 | -28.6 | 0.068 | +47.7 | 0.068 |
20w | -20.9 | 0.034 | +1.56 | 0.034 | -3.5 | 0.144 | -4.2 | 0.144 | +0.28 | 0.068 | +15.3 | 0.068 | -12.5 | 0.144 | -35.7 | 0.068 | +72.2 | 0.068 |
ACLT | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
10w | -22.3 | 0.022 | +1.95 | 0.021 | -16.6 | 0.043 | -12.2 | 0.043 | +0.67 | 0.043 | +20.9 | 0.225 | -28.1 | 0.042 | -28.7 | 0.043 | +37.5 | 0.043 |
20w | -16.5 | 0.022 | +1.45 | 0.021 | -17.2 | 0.043 | -13.6 | 0.043 | +0.77 | 0.043 | +19.5 | 0.043 | -16.0 | 0.043 | -30.9 | 0.043 | +26.2 | 0.043 |