Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO, Weisman MH, Jackson CG: Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006, 354 (8): 795-808. 10.1056/NEJMoa052771.
Article
CAS
PubMed
Google Scholar
Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE, Gossett C: Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001, 357 (9252): 251-256. 10.1016/S0140-6736(00)03610-2.
Article
CAS
PubMed
Google Scholar
Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC: Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med. 2002, 162 (18): 2113-2123. 10.1001/archinte.162.18.2113.
Article
CAS
PubMed
Google Scholar
Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G: Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev. 2006, CD005321-2
Uitterlinden EJ, Jahr H, Koevoet JL, Jenniskens YM, Bierma-Zeinstra SM, Degroot J, Verhaar JA, Weinans H, van Osch GJ: Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants. Osteoarthritis Cartilage. 2006, 14 (3): 250-257. 10.1016/j.joca.2005.10.001.
Article
CAS
PubMed
Google Scholar
Mandl EW, Jahr H, Koevoet JL, van Leeuwen JP, Weinans H, Verhaar JA, van Osch GJ: Fibroblast growth factor-2 in serum-free medium is a potent mitogen and reduces dedifferentiation of human ear chondrocytes in monolayer culture. Matrix Biol. 2004, 23 (4): 231-241. 10.1016/j.matbio.2004.06.004.
Article
CAS
PubMed
Google Scholar
Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001, 25 (4): 402-408. 10.1006/meth.2001.1262.
Article
CAS
PubMed
Google Scholar
Orth MW, Peters TL, Hawkins JN: Inhibition of articular cartilage degradation by glucosamine-HCl and chondroitin sulphate. Equine Vet J Suppl. 2002, 224-229. 34
Dodge GR, Jimenez SA: Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes. Osteoarthritis Cartilage. 2003, 11 (6): 424-432. 10.1016/S1063-4584(03)00052-9.
Article
CAS
PubMed
Google Scholar
Gouze JN, Bordji K, Gulberti S, Terlain B, Netter P, Magdalou J, Fournel-Gigleux S, Ouzzine M: Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes. Arthritis Rheum. 2001, 44 (2): 351-360. 10.1002/1529-0131(200102)44:2<351::AID-ANR53>3.0.CO;2-M.
Article
CAS
PubMed
Google Scholar
Sandy JD, Gamett D, Thompson V, Verscharen C: Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine. Biochem J. 1998, 335 (Pt 1): 59-66.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fenton JI, Chlebek-Brown KA, Caron JP, Orth MW: Effect of glucosamine on interleukin-1-conditioned articular cartilage. Equine Vet J Suppl. 2002, 219-223. 34
Byron CR, Orth MW, Venta PJ, Lloyd JW, Caron JP: Influence of glucosamine on matrix metalloproteinase expression and activity in lipopolysaccharide-stimulated equine chondrocytes. Am J Vet Res. 2003, 64 (6): 666-671. 10.2460/ajvr.2003.64.666.
Article
CAS
PubMed
Google Scholar
Bassleer C, Rovati L, Franchimont P: Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro. Osteoarthritis Cartilage. 1998, 6 (6): 427-434. 10.1053/joca.1998.0146.
Article
CAS
PubMed
Google Scholar
Bassleer C, Henrotin Y, Franchimont P: In-vitro evaluation of drugs proposed as chondroprotective agents. Int J Tissue React. 1992, 14 (5): 231-241.
CAS
PubMed
Google Scholar
Lippiello L: Glucosamine and chondroitin sulfate: biological response modifiers of chondrocytes under simulated conditions of joint stress. Osteoarthritis Cartilage. 2003, 11 (5): 335-342. 10.1016/S1063-4584(03)00026-8.
Article
CAS
PubMed
Google Scholar
Vidal y Plana RR, Bizzarri D, Rovati AL: Articular cartilage pharmacology: I. In vitro studies on glucosamine and non steroidal antiinflammatory drugs. Pharmacol Res Commun. 1978, 10 (6): 557-569. 10.1016/S0031-6989(78)80054-X.
Article
CAS
PubMed
Google Scholar
McCarty MF: Enhanced synovial production of hyaluronic acid may explain rapid clinical response to high-dose glucosamine in osteoarthritis. Med Hypotheses. 1998, 50 (6): 507-510. 10.1016/S0306-9877(98)90272-9.
Article
CAS
PubMed
Google Scholar
McCarty MF, Russell AL, Seed MP: Sulfated glycosaminoglycans and glucosamine may synergize in promoting synovial hyaluronic acid synthesis. Med Hypotheses. 2000, 54 (5): 798-802. 10.1054/mehy.1999.0954.
Article
CAS
PubMed
Google Scholar
Uitterlinden EJ, Jahr H, Koevoet JL, Bierma-Zeinstra SM, Verhaar JA, Weinans H, van Osch GJ: Glucosamine reduces anabolic as well as catabolic processes in bovine chondrocytes cultured in alginate. Osteoarthritis Cartilage. 2007, 15 (11): 1267-1274. 10.1016/j.joca.2007.04.004.
Article
CAS
PubMed
Google Scholar
Laurent TC, Fraser JR: Hyaluronan. Faseb J. 1992, 6 (7): 2397-2404.
CAS
PubMed
Google Scholar
Laurent TC, Laurent UB, Fraser JR: The structure and function of hyaluronan: An overview. Immunol Cell Biol. 1996, 74 (2): A1-7. 10.1038/icb.1996.32.
Article
CAS
PubMed
Google Scholar
Dahl LB, Dahl IM, Engstrom-Laurent A, Granath K: Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies. Ann Rheum Dis. 1985, 44 (12): 817-822. 10.1136/ard.44.12.817.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fam H, Bryant JT, Kontopoulou M: Rheological properties of synovial fluids. Biorheology. 2007, 44 (2): 59-74.
CAS
PubMed
Google Scholar
Jiang D, Liang J, Noble PW: Hyaluronan in Tissue Injury and Repair. Annu Rev Cell Dev Biol . 2007, 23: 435-61. 10.1146/annurev.cellbio.23.090506.123337.
Article
CAS
PubMed
Google Scholar
Wang CT, Lin YT, Chiang BL, Lin YH, Hou SM: High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. Osteoarthritis Cartilage. 2006, 14 (12): 1237-1247. 10.1016/j.joca.2006.05.009.
Article
PubMed
Google Scholar
Prehm P: Hyaluronate is synthesized at plasma membranes. Biochem J. 1984, 220 (2): 597-600.
Article
CAS
PubMed
PubMed Central
Google Scholar
Recklies AD, White C, Melching L, Roughley PJ: Differential regulation and expression of hyaluronan synthases in human articular chondrocytes, synovial cells and osteosarcoma cells. Biochem J. 2001, 354 (Pt 1): 17-24. 10.1042/0264-6021:3540017.
Article
CAS
PubMed
PubMed Central
Google Scholar
Persiani S, Rotini R, Trisolino G, Rovati LC, Locatelli M, Paganini D, Antonioli D, Roda A: Synovial and plasma glucosamine concentrations in osteoarthritic patients following oral crystalline glucosamine sulphate at therapeutic dose. Osteoarthritis Cartilage. 2007, 15 (7): 764-772. 10.1016/j.joca.2007.01.019.
Article
CAS
PubMed
Google Scholar
Fenton JI, Chlebek-Brown KA, Peters TL, Caron JP, Orth MW: The effects of glucosamine derivatives on equine articular cartilage degradation in explant culture. Osteoarthritis Cartilage. 2000, 8 (6): 444-451. 10.1053/joca.1999.0320.
Article
CAS
PubMed
Google Scholar
de Mattei M, Pellati A, Pasello M, de Terlizzi F, Massari L, Gemmati D, Caruso A: High doses of glucosamine-HCl have detrimental effects on bovine articular cartilage explants cultured in vitro. Osteoarthritis Cartilage. 2002, 10 (10): 816-825. 10.1053/joca.2002.0834.
Article
CAS
PubMed
Google Scholar
Fenton JI, Chlebek-Brown KA, Peters TL, Caron JP, Orth MW: Glucosamine HCl reduces equine articular cartilage degradation in explant culture. Osteoarthritis Cartilage. 2000, 8 (4): 258-265. 10.1053/joca.1999.0299.
Article
CAS
PubMed
Google Scholar
Gouze JN, Bianchi A, Becuwe P, Dauca M, Netter P, Magdalou J, Terlain B, Bordji K: Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathway. FEBS Lett. 2002, 510 (3): 166-170. 10.1016/S0014-5793(01)03255-0.
Article
CAS
PubMed
Google Scholar
Mello DM, Nielsen BD, Peters TL, Caron JP, Orth MW: Comparison of inhibitory effects of glucosamine and mannosamine on bovine articular cartilage degradation in vitro. Am J Vet Res. 2004, 65 (10): 1440-1445. 10.2460/ajvr.2004.65.1440.
Article
CAS
PubMed
Google Scholar
Mroz PJ, Silbert JE: Effects of [3H]glucosamine concentration on [3H]chondroitin sulphate formation by cultured chondrocytes. Biochem J. 2003, 376 (Pt 2): 511-515. 10.1042/BJ20030982.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mroz PJ, Silbert JE: Use of (3)H-glucosamine and (35)S-sulfate with cultured human chondrocytes to determine the effect of glucosamine concentration on formation of chondroitin sulfate. Arthritis Rheum. 2004, 50 (11): 3574-3579. 10.1002/art.20609.
Article
CAS
PubMed
Google Scholar
Laverty S, Sandy JD, Celeste C, Vachon P, Marier JF, Plaas AH: Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses. Arthritis Rheum. 2005, 52 (1): 181-191. 10.1002/art.20762.
Article
CAS
PubMed
Google Scholar