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Comparison between two pedicle screw augmentation instrumentations in adult degenerative scoliosis with osteoporosis
- Yang Xie†1,
- Qiang Fu†1,
- Zi-qiang Chen†1,
- Zhi-cai Shi1,
- Xiao-dong Zhu1,
- Chuan-feng Wang1 and
- Ming Li1Email author
© Xie et al; licensee BioMed Central Ltd. 2011
Received: 26 June 2011
Accepted: 21 December 2011
Published: 21 December 2011
The operative treatment of adult degenerative scoliosis combined with osteoporosis increase following the epidemiological development. Studies have confirmed that screws in osteoporotic spines have significant lower-screw strength with more frequent screw movements within the vertebra than normal spines. Screws augmented with Polymethylmethacrylate (PMMA) or with autogenous bone can offer more powerful corrective force and significant advantages.
A retrospective analysis was conducted on 31 consecutive patients with degenerative lumbar scoliosis combined with osteoporosis who had surgery from December 2000. All had a minimum of 2-year follow-up. All patients had posterior approach surgery. 14 of them were fixed with pedicle screw by augmentation with Polymethylmethacrylate (PMMA) and the other 17 patients with autogenous bone. Age, sex and whether smoking were similar between the two groups. Surgical time, blood loss, blood transfusion, medical cost, post surgery ICU time, hospital day, length of oral pain medicines taken, Pre-and postoperative Oswestry disability index questionnaire and surgical revision were documented and compared. Preoperative, postoperative and final follow up Cobb angle, sagittal lumbar curve, correction rate, and Follow up Cobb loss were also compared.
No significant differences were found between the autogenous bone group and Polymethylmethacrylate group with regards to all the targets above except for length of oral pain medicines taken and surgery cost. 2 patients were seen leakage during operation, but there is neither damage of nerve nor symptom after operation. No revision was needed.
Both augmentation pedicle screw with Polymethylmethacrylate (PMMA) and autogenous bone treating degenerative lumbar scoliosis combined with osteoporosis can achieve a good surgical result. Less oral pain medicines taken are the potential benefits of Polymethylmethacrylate augmentation, but that is at the cost of more medical spending.
KeywordsDegenerative scoliosis Osteoporosis Pedicle screw instrumentation augmentation Polymethylmethacrylate Autogenous bone
Degenerative scoliosis(DS) is one of the most prevalent findings in the elderly population. DS is defined as curvature of the spine in the coronal plane of greater than 10°Cobb angulation, which develops after skeletal maturity with a predominant lumbar location. DS is believed to develop as the result of osteoporosis, degenerative disc disease, osteoarthritic changes of the facet joints, compression fractures, and lateral olisthesis [1–6]. The patient often complains of low back pain and neurogenic claudication [7–9]. Surgery is indicated for severe back and/or radicular symptoms refractory to conservative treatment [7, 10]. The operative treatment of DS is a formidable challenge to every spinal deformity surgeon. Narayan et al.  presented that in cases of posterolateral lumbar spinal fusion with pedicle screws, degenerative scoliosis has a lower (70%) fusion rate than degenerative disc disease alone (91%). In addition, senile osteoporosis makes pedicle screw instrumentation difficult to be anchored . Pedicle screws rely primarily on cancellous bone for purchase, with the pedicle providing approximately 60% of the pullout strength . Polymethylmethacrylate (PMMA) augmentation is regarded as an efficient way to enhance screw strength in osteoporotic bones [13, 14].
Pedicle screw instrumentation by augmentation with PMMA is thought to be more effective than with autogenous bone in degenerative lumbar scoliosis combined with osteoporosis. However, using PMMA leads to relative more complications, such as bone cement leakage. Also this method may cause longer operation-time, more blood loss and more payment, etc. To our best knowledge, there is no study that compares these two techniques. The purpose of our study is to compare the results of pedicle screw by augmentation with PMMA versus with autogenous bone in degenerative lumbar scoliosis combined with osteoporosis. This is a retrospective, cohort study comparing the clinical and radiographic outcomes using two methods.
Hospital records were reviewed for patients' medical comorbidities, smoking history, estimated intraoperative blood loss, operative time, and hospital stay. Hypertension, diabetes, heart disease, pulmonary disease, gastrointestinal disease, and kidney disease were considered to have medical comorbidities. The number of levels fused and the number of levels decompressed were measured. Complications were defined as any event for which the patient required specific treatment.
Anteroposterior and lateral radiographs were reviewed preoperatively, postoperatively and in final follow up periods. The Cobb angle and lumbar lordosis were assessed. Lumbar lordosis was measured from the upper endplate of L1 to the lower endplate of L5. Clinical outcomes were assessed with the Oswestry disability index. All patients were asked to fill Oswestry disability index scale perioperative and in the last follow-up.
The statistical analysis was performed using SPSS version 13.0. We used independent sample t-test. The significance was defined as P < 0.05.
Patients had undergone segmental pedicle screw instrumentation and autogenous iliac bone graft augmentation. 14 patients accepted the operation with PMMA augmentation.
For the autogenous bone graft augmentation group, using a burr, the pedicle entry point crossed by the longitudinal lateral edge of bony crest of superior articular process and the horizontal line that bisects the middle of the transverse process was prepared. A blunt tip 1.6 mm Kirschner-wire (K-wire) was gently tapped with mallet through the pedicle to the anterior cortex of vertebral body. The K-wire position was checked with fluoroscope image to make sure the K-wire was properly inside the pedicle and vertebral body, and then the K-wire was removed. A blunt tip 3-mm diameter K-wire was used to dilate the pedicle tract, and then it was removed.
The tract was palpated with a straight sensor probe to make sure the pedicle wall of the tract and the anterior cortex of the vertebral body were not violated. Then all the iliac bone graft were chipped to 2-3 mm and weighed by electronic balance. About 2 g graft was filled in to the pre-drilled pedicle screw tract for per screw. For the PMMA group, the preparation for the pedicel screw tract is the same. A 4 mm diameter bone biopsy needle (Allegiance, Healthcare Co.) was used for cement injection. About 2 ml PMMA was injected per screw with none requiring the use of autogenous iliac crest bone graft. Local bone graft (spinous processes) were used in all cases. Both of the two groups had decompression surgery at the level of spinal stenosis and had posterior or posterolateral fusion. All patients were braced with thoracolumbosacral orthosis for 3 months after surgery.
The autogenous bone group, the average number of levels fused was 6.0 ± 2.5 segments, ranging from 2 to 10 segments. The upper instrumented vertebra was T9 in 1 patient, T10 in 4 patients, T11 in 1 patients, L1 in 4 patients, L2 in 5 patients, and L3 in 2 patients,. The lower instrumented vertebra was L4 in 5 patient, L5 in 8 patients, and the sacrum in 4 patients.
The PMMA group, the average number of levels fused was 5.9 ± 1.9 segments, ranging from 3 to 9 segments. The upper instrumented vertebra was T9 in 1 patient, T10 in 2 patients, T11 in 1 patients, T12 in 1 patient, L1 in 5 patients, L2 in 3 patients, L3 in 1 patients. The lower instrumented vertebra was L4 in 3 patient, L5 in 8 patients, and the sacrum in 3 patients.
Demographics and baseline characteristics between Polymethylmethacrylate group and autogenous bone group
63.14 ± 8.98
58.96 ± 6.64
2.98 ± 0.36
3.08 ± 0.34
239 ± 45
246 ± 62
1828 ± 911
1758 ± 770
Blood transfusion (m1)
1421 ± 957
1188 ± 541
Post surgery ICU time(day)
1.0 ± 0.7
0.9 ± 0.5
Length for Hospital stay(day)
17.9 ± 10.2
19.6 ± 7.0
length of oral pain medicines taken(day)
5.5 ± 1.9
13.1 ± 8.0
Length of fusion(n)
5.9 ± 1.9
6.0 ± 2.5
157898.6 ± 46116.3
121721.9 ± 45589.8
Pre-operation Cobb angle(°)
23.8 ± 9.8
28.7 ± 10.6
Post-operation Cobb angle(°)
15.2 ± 6.2
17.9 ± 6.6
Cobb angle correction rate(%)
36.4 ± 13.5
35.7 ± 12.7
Follow up Cobb angle(°)
20.2 ± 7.2
17.0 ± 6.9
Follow up Cobb loss
1.8 ± 2.7
2.3 ± 2.7
Pre-operation sagittal lumbar curve(°)
34.4 ± 9.6
36.2 ± 12.5
Post -operation sagittal lumbar curve(°)
35.6 ± 3.9
34.6 ± 5.5
Follow up sagittal lumbar curve(°)
35.1 ± 5.2
37.6 ± 3.5
49.8 ± 11.5
46.5 ± 13.0
17.9 ± 6.2
18.7 ± 5.3
ODI change Rate(%)
62.7 ± 13.2
57.9 ± 12.6
The numbers of medical co-morbidities were similar in both groups. Medical co-morbidities included hypertension in 10 patients, heart disease in 5 patients, DM in 4 patients, arthritis deformans disease in 2 patients.
Urinary tract infection
Loosening of screws
Breakage of screws
Pain of iliac bone
Pedicle screws are the workhorse of spinal instrumentation for the adult spine. Not long ago, osteoporotic patients with progressive deformity or fracture, even with neurologic manifestations, were considered inoperable by many spine surgeons for the reason that fixation strength of the pedicle screws decreases in frail spines of elderly osteoporotic patients [15–17]. With advances in surgical and instrumentation techniques, various methods have been used to improve the fixation strength. Pedicle screws rely primarily on cancellous bone for purchase, with the pedicle providing approximately 60% of the pullout strength .
Fixation in marginal bone was more regularly successful through augmentation of screw fixation with autogenous bone or bone cement . The augmentation of pedicle screw fixation with various bone cements such as PMMA, calcium phosphate and calcium sulfate cement has been studied to address potential solutions to inadequate fixation [19–21]. Polymethylmethacrylate is the most commonly used bone cement in spinal procedures today [13, 14, 22]. Some studies demonstrated that PMMA has stronger augmentation power than calcium phosphate and calcium sulfate cement in primary screw augmentation [23, 24]. In most of the experimental studies, the amount of various cement injection was 1 to 3 ml, and the pull-out strength of pedicle screw can be significantly increased up to 147% to 300% [23–26]. Chang et al.  did a retrospective study to evaluate the clinical results of patients with osteoporosis and various spinal diseases treated surgically with PMMA augmented pedicle screw. In their study there was neither neurologic deterioration nor symptomatic cement leakage after surgery. Evans et al. conducted a study to investigate the effect of using either a low-viscosity bone cement(Palacos LV) or a bone augmentation material(Cortoss) on the pullout strength of pedicle screws. The pullout strength of the non-augmented screws was 1203 ± 260 N, while the pullout strength of the augmented screws was 1970 ± 220 N(Palacos LV) and 2021 ± 342 N(Cortoss). Both Palacos LV and Cortoss significantly increased the pullout strength. There was no significant difference between the Palacos LV and Cortoss groups. Pain was significantly released and kyphotic deformity was significantly corrected. The average loss of kyphosis correction was 3° at the final follow up. There was no significant screw migration when the screws distances just after operation and at the final follow-up were compared. So they considered the technique of PMMA for augmentation of pedicle screw is a safe, reliable, and practical technique for osteoporotic patients who also had various spinal diseases and need spinal instrumentation. Burval et al. take a research to compare the pullout strengths of pedicle screws fixed in osteoporotic vertebrae using polymethyl methacrylate delivered by 2 augmentation techniques, a standard transpedicular approach and kyphoplasty type approach. They found that pedicle screw augmentation with polymethyl methacrylate improves the initial fixation strength and fatigue strength of instrumentation in osteoporotic vertebrae. Pedicle screws augmented using the kyphoplasty technique had significantly greater pullout strength than those augmented with transpedicular augmentation technique and those placed in healthy control vertebrae with no augmentation . However, the use of bone cement is associated with difficulty in removing the screw and bone cement leakage into the spinal canal or neural foramina.
In our study, we compared these two techniques of autogenous bone or bone cement augmentation of screw fixation. Pedicle screw instrumentation by augmentation with PMMA didn't show more effective than with autogenous bone in degenerative lumbar scoliosis combined with osteoporosis as we ever thought. Both can achieve a similar curve corrective force. Also the operation result is similar according to ODI scores. However, using PMMA leads to relative more complications, such as cement leakage, but all of them were spotty or linear minor leakages without any sign of neurovascular injury. Although the direct injection method with cement amount of 2 to 3 ml for each pedicle is safe, fluoroscope monitoring during the cement injection is suggested to avoid major cement leakage.
The two methods had similar operation-time and blood loss. The reasons for this result may be that although the injection of cement may cause more time cost and blood loss but the procedure for taking iliac bone even prolong the operation time and cause more blood loss. The intraoperative blood loss was 1828 ± 911 in PMMA group and 1758 ± 770 in autogenous bone group. The reason for such large amount of blood loss may be as follows: a) All the patients received a long post-exposure and augmentation either with PMMA or autogenous bone. The augmentation was a little bit time consuming for us due to the learning curve for this technique. The surgical time is certainly longer than surgery without augmentation and may caused more blood loss. b) The process to get autogenous bone graft from supply area of iliac bone also increace blood loss. C)The fusion levels for some of the patients was as long as 10 segments suggested a really long fusion.
In this study, shorter time of oral pain medicines taken was seen in Polymethylmethacrylate augmentation group. The main pain caused by atuogenous bone group comes from the supply area of iliac bone, and this kind of pain caused as long as 3-4 weeks drug apply. Also, this difference could be attributed to the treatment of the pain caused by osteoporosis through the use of Polymethylemethacrylate. Although more analgetic is needed, the whole medical cost for autogenous bone augmentation is less than PMMA augmentation. The additional high price of PMMA may be the main reason.
a) In this group of patients with osteoporosis, we all use augmentation either with PMMA or autogenous bone and we didn't set a control group which didn't use any anugmentation. So it was not clear of the difference between patients with or without augmentation. b) BMD using DXA in the lumbar spine is a weak methodological point as the BMD measured in spine may be affected by the degenerative and sclerotic changes created by the deformity, vertebral rotation and compression of the vertebra. Biomechanical adaptation within the cancellous or cortical bone tissue in adult scoliosis patients may influence the value[29, 30]. c) Patients in the present research was heterogeneous such as short and long instrumentation were chosen individually.d) The present study may be limited by the small sample size and the strict criteria for patient selection.
Degenerative lumbar scoliosis combined with osteoporosis treated with pedicle screw by augmentation with Polymethylmethacrylate (PMMA) or autogenous bone both can achieve a good surgical result. Both of these two technique are safe, reliable, and practical. Less oral pain medicines taken are the potential benefits of Polymethylmethacrylate augmentation, but that is at the cost of more medical spending.
There is no acknowledgements and funding.
- Tribus CB: Degenerative lumbar scoliosis: evaluation and management. J Am Acad Orthop Surg. 2003, 11 (3): 174-183.View ArticlePubMedGoogle Scholar
- Birknes JK, White AP, Albert TJ, Shaffrey CI, Harrop JS: Adult degenerative scoliosis: a review. Neurosurgery. 2008, 63 (3 Suppl): 94-103.View ArticlePubMedGoogle Scholar
- Farfan HF, Huberdeau RM, Dubow HI: Lumbar intervertebral disc degeneration: the influence of geometrical features on the pattern of disc degeneration--a post mortem study. J Bone Joint Surg Am. 1972, 54 (3): 492-510.PubMedGoogle Scholar
- Grubb SA, Lipscomb HJ, Coonrad RW: Degenerative adult onset scoliosis. Spine (Phila Pa 1976). 1988, 13 (3): 241-245. 10.1097/00007632-198803000-00004.View ArticleGoogle Scholar
- Pritchett JW, Bortel DT: Degenerative symptomatic lumbar scoliosis. Spine (Phila Pa 1976). 1993, 18 (6): 700-703. 10.1097/00007632-199305000-00004.View ArticleGoogle Scholar
- Kirkaldy-Willis WH, Farfan HF: Instability of the lumbar spine. Clin Orthop Relat Res. 1982, 110-123. 165Google Scholar
- Daffner SD, Vaccaro AR: Adult degenerative lumbar scoliosis. Am J Orthop (Belle Mead NJ). 2003, 32 (2): 77-82. discussion 82Google Scholar
- Fraser JF, Huang RC, Girardi FP, Cammisa FP: Pathogenesis, presentation, and treatment of lumbar spinal stenosis associated with coronal or sagittal spinal deformities. Neurosurg Focus. 2003, 14 (1): e6-View ArticlePubMedGoogle Scholar
- Aebi M: The adult scoliosis. Eur Spine J. 2005, 14 (10): 925-948. 10.1007/s00586-005-1053-9.View ArticlePubMedGoogle Scholar
- Simmons ED: Surgical treatment of patients with lumbar spinal stenosis with associated scoliosis. Clin Orthop Relat Res. 2001, 45-53. 384Google Scholar
- Narayan P, Haid RW, Subach BR, Comey CH, Rodts GE: Effect of spinal disease on successful arthrodesis in lumbar pedicle screw fixation. J Neurosurg. 2002, 97 (3 Suppl): 277-280.PubMedGoogle Scholar
- Hirano T, Hasegawa K, Takahashi HE, Uchiyama S, Hara T, Washio T, Sugiura T, Yokaichiya M, Ikeda M: Structural characteristics of the pedicle and its role in screw stability. Spine (Phila Pa 1976). 1997, 22 (21): 2504-2509. 10.1097/00007632-199711010-00007. discussion 2510View ArticleGoogle Scholar
- Frankel BM, Jones T, Wang C: Segmental polymethylmethacrylate-augmented pedicle screw fixation in patients with bone softening caused by osteoporosis and metastatic tumor involvement: a clinical evaluation. Neurosurgery. 2007, 61 (3): 531-537. 10.1227/01.NEU.0000290899.15567.68. discussion 537-538View ArticlePubMedGoogle Scholar
- Lonstein JE, Denis F, Perra JH, Pinto MR, Smith MD, Winter RB: Complications associated with pedicle screws. J Bone Joint Surg Am. 1999, 81 (11): 1519-1528.PubMedGoogle Scholar
- Halvorson TL, Kelley LA, Thomas KA, Whitecloud TS, Cook SD: Effects of bone mineral density on pedicle screw fixation. Spine (Phila Pa 1976). 1994, 19 (21): 2415-2420. 10.1097/00007632-199411000-00008.View ArticleGoogle Scholar
- McLain RF, McKinley TO, Yerby SA, Smith TS, Sarigul-Klijn N: The effect of bone quality on pedicle screw loading in axial instability. A synthetic model. Spine (Phila Pa 1976). 1997, 22 (13): 1454-1460. 10.1097/00007632-199707010-00006.View ArticleGoogle Scholar
- Burval DJ, McLain RF, Milks R, Inceoglu S: Primary pedicle screw augmentation in osteoporotic lumbar vertebrae: biomechanical analysis of pedicle fixation strength. Spine (Phila Pa 1976). 2007, 32 (10): 1077-1083. 10.1097/01.brs.0000261566.38422.40.View ArticleGoogle Scholar
- Taniwaki Y, Takemasa R, Tani T, Mizobuchi H, Yamamoto H: Enhancement of pedicle screw stability using calcium phosphate cement in osteoporotic vertebrae: in vivo biomechanical study. J Orthop Sci. 2003, 8 (3): 408-414. 10.1007/s10776-003-0639-6.View ArticlePubMedGoogle Scholar
- Yerby SA, Toh E, McLain RF: Revision of failed pedicle screws using hydroxyapatite cement. A biomechanical analysis. Spine (Phila Pa 1976). 1998, 23 (15): 1657-1661. 10.1097/00007632-199808010-00008.View ArticleGoogle Scholar
- Abshire BB, McLain RF, Valdevit A, Kambic HE: Characteristics of pullout failure in conical and cylindrical pedicle screws after full insertion and back-out. Spine J. 2001, 1 (6): 408-414. 10.1016/S1529-9430(01)00119-X.View ArticlePubMedGoogle Scholar
- Renner SM, Lim TH, Kim WJ, Katolik L, An HS, Andersson GB: Augmentation of pedicle screw fixation strength using an injectable calcium phosphate cement as a function of injection timing and method. Spine (Phila Pa 1976). 2004, 29 (11): E212-216. 10.1097/00007632-200406010-00020.View ArticleGoogle Scholar
- Sarzier JS, Evans AJ, Cahill DW: Increased pedicle screw pullout strength with vertebroplasty augmentation in osteoporotic spines. J Neurosurg. 2002, 96 (3 Suppl): 309-312.PubMedGoogle Scholar
- Moore DC, Maitra RS, Farjo LA, Graziano GP, Goldstein SA: Restoration of pedicle screw fixation with an in situ setting calcium phosphate cement. Spine (Phila Pa 1976). 1997, 22 (15): 1696-1705. 10.1097/00007632-199708010-00003.View ArticleGoogle Scholar
- Yilmaz C, Atalay B, Caner H, Altinors N: Augmentation of a loosened sacral pedicle screw with percutaneous polymethylmethacrylate injection. J Spinal Disord Tech. 2006, 19 (5): 373-375. 10.1097/01.bsd.0000210115.94273.76.View ArticlePubMedGoogle Scholar
- Linhardt O, Luring C, Matussek J, Hamberger C, Plitz W, Grifka J: Stability of pedicle screws after kyphoplasty augmentation: an experimental study to compare transpedicular screw fixation in soft and cured kyphoplasty cement. J Spinal Disord Tech. 2006, 19 (2): 87-91. 10.1097/01.bsd.0000177212.52583.bd.View ArticlePubMedGoogle Scholar
- Lotz JC, Hu SS, Chiu DF, Yu M, Colliou O, Poser RD: Carbonated apatite cement augmentation of pedicle screw fixation in the lumbar spine. Spine (Phila Pa 1976). 1997, 22 (23): 2716-2723. 10.1097/00007632-199712010-00003.View ArticleGoogle Scholar
- Chang MC, Liu CL, Chen TH: Polymethylmethacrylate augmentation of pedicle screw for osteoporotic spinal surgery: a novel technique. Spine (Phila Pa 1976). 2008, 33 (10): E317-324. 10.1097/BRS.0b013e31816f6c73.View ArticleGoogle Scholar
- Evans SL, Hunt CM, Ahuja S: Bone cement or bone substitute augmentation of pedicle screws improves pullout strength in posterior spinal fixation. J Mater Sci Mater Med. 2002, 13 (12): 1143-1145. 10.1023/A:1021133819646.View ArticlePubMedGoogle Scholar
- Yagi M, King AB, Boachie-Adjei O: Characterization of osteopenia/osteoporosisin adult scoliosis: does bone density affect surgical outcome?. Spine. 2011, 36 (20): 1652-1657. 10.1097/BRS.0b013e31820110b4.View ArticlePubMedGoogle Scholar
- Pappou IP, Girardi FP, Sandhu HS, Parvataneni HK, Cammisa FP, Schneider R, Frelinghuysen P, Lane JM: Discordantly high spinal bone mineral density values in patients with adult lumbar scoliosis. Spine. 2006, 31 (14): 1614-1620. 10.1097/01.brs.0000222030.32171.5f.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2474/12/286/prepub
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