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Multidisciplinary and multifaceted outpatient management of patients with osteoarthritis: protocol for a randomised, controlled trial
© Moe et al; licensee BioMed Central Ltd. 2010
Received: 26 September 2010
Accepted: 1 November 2010
Published: 1 November 2010
Osteoarthritis (OA) is a prevalent joint disorder with a need for efficient and evidence-based management strategies.
The primary purpose of this study is to compare the effects of a multidisciplinary outpatient clinic, including a brief group-based educational programme, with a traditional individual outpatient clinic for patients with hip, knee, hand or generalized OA. A secondary purpose is to investigate the effects of a telephone follow-up call.
This is a pragmatic randomised single-blind controlled study with a total of 400 patients with hip, knee, hand or generalized OA between 40 and 80 years referred to an outpatient rheumatology hospital clinic. The randomisation is stratified according to the diagnostic subgroups. The experimental group is exposed to a multidisciplinary and multifaceted intervention, including a 3.5 hour group-based patient education programme about OA in addition to individual consultations with members of a multidisciplinary team. The control intervention is based on regular care with an individual outpatient consultation with a rheumatologist (treatment as usual). Primary outcomes are patient satisfaction measured at 4 months and cost-effectiveness measured at 12 months. Secondary outcomes are pain and global disease activity measured on a numeric rating scales (NRS), generic and disease specific functioning and disability using Short Form-36 (SF-36) health survey, the Western Ontario and McMaster Universities Osteoarthritis Index 3 (WOMAC), the Australian/Canadian Osteoarthritis Hand Index (AUSCAN), and a patient-generated measure of disability (Patient-Specific Functional scale, PSFS). Global perceived effect of change in health status during the study period is also reported. At 4-month follow-up, patients in both groups will be randomly allocated to a 10-minute telephone call or no follow-up ("treatment as usual"). After additional 8 months (12-month follow-up) the four groups will be compared in a secondary analysis with regard to health outcomes and health care costs.
This trial will provide results on how multidisciplinary and multifaceted management of patients with OA affects health outcomes and health care costs.
Current Controlled Trials ISRCTN25778426
Osteoarthritis (OA) is the most prevalent joint disorder and is associated with pain, functional disability and impaired quality of life . The degenerative disease process of synovial joints leads to radiographic signs and the clinical symptoms like pain, stiffness and reduced joint motion. OA is strongly associated with aging, has most commonly an onset after the age of 50 years, and is ranked as the fourth most common condition in older women and the eight most common in older men [2–4].
OA poses significant burdens in terms of reduced general health , work disability , and large societal costs which may be comparable to rheumatoid arthritis and other inflammatory diseases [7–9]. With an increasing proportion of older people in the population, OA constitutes a growing public health problem. Effective and evidence-based preventive and treatment strategies for OA are important as they may reduce both the individual burden of OA, and the economic burden to the society.
Recommendations for management of OA focus on a combination of pharmacological and non-pharmacological treatments [3, 10, 11]. Most of the non-pharmacological treatments have been studied in patients with hip and knee OA with a special focus on exercise, physical activity, patient education and weight control . Reduced pain and improved function has been documented in patients with knee OA, and exercises and information are considered as important non-pharmacological interventions for this patient group.
Non-pharmacological management of hand OA and generalized OA has been investigated in only a few studies . One recent systematic review concerning treatment of hand OA included 31 studies, most of them on the effect of pharmacological treatment . Even though a few of the treatment strategies did show effect in terms of reduced pain and improved function, methodological weaknesses made direct recommendations on treatments for hand OA impossible. Various patient education programmes have been used for treating chronic health conditions, but no consensus has been reached on how patient education should be applied; either using a disease specific or generic approach, group-based or individual education, and either given by health professionals or lay tutors [13, 14].
Standard treatment for OA in specialist care is an individual consultation with a rheumatologist, sometimes followed by referral to one or several other health professionals. However, many patients with OA experience this provision of health services as fragmented. Due to an increasing demand for a more coordinated approach, a pilot multidisciplinary OA outpatient clinic was established at Diakonhjemmet Hospital, Oslo, Norway, in 2003. The multidisciplinary team included rheumatologists, nurses, health secretaries, occupational therapists, physical therapists, pharmacists, orthopaedic surgeons and a dietician. Over a two year period, approximately 300 patients with OA were referred to the OA clinic by their general practitioners or specialists. Of these 300, 73 patients were followed for 1 year . Most (78%) of these patients were women (mean age 61 years (range 24-92)). More than 60% reported to have pain in their knees and/or hands, while 40% had pain primarily localized to the hip. Approximately one fourth of the patients used NSAIDS and/or other types of analgesics. At the one year follow-up, 95% of the patients were very satisfied with the team care received, and pain and functioning was moderately improved . This first evaluation with an open longitudinal design without a control group warranted the need for a more systematically and thorough evaluation of the effect and cost-benefits of this multidisciplinary, coordinated outpatient OA clinic.
The number of referrals to the clinic increased in the pilot period. To meet patients' need for information, a brief group-based educational programme was developed. Thus, in the updated multidisciplinary OA clinic, starting from 2005, patients first receive a 3.5 hours group education. After a lunch brake, they have individual consultations with a rheumatologist and thereafter, dependent on identified needs, also have encounters with other health professionals.
Few other studies have evaluated the effect of group-based educational programmes for OA in combination with a pragmatic individual approach, especially in a setting of a randomised clinical trial (RCT) .
The purposes of this study are 1) to compare the effect of a multidisciplinary outpatient clinic, including a brief group-based educational programme, with a regular care individual outpatient clinic for patients with hip, knee, hand and/or generalized OA, and 2) to compare the effect of a telephone follow-up call with follow-up "as usual" for patients with hip, knee, hand and/or generalized OA.
1) Patients with hip, knee, hand and/or generalized OA who receive a multidisciplinary and multifaceted intervention will be more satisfied with the health service at 4-month follow up compared to patients who receive individual consultation(s) in a regular care individual outpatient clinic.
2) The multidisciplinary and multifaceted outpatient clinic will reduce the use of health services and thus, this intervention will be more cost-effective at 12-month follow up than the traditional individual outpatient clinic.
3) Patients who receive a telephone call after 4 months will at 12-month follow-up report more satisfaction with the health service than those within the same group allocation who do not receive any telephone follow-up.
4) At 4- and 12-month follow-up, changes in the secondary outcomes VAS pain, global disease activity, generic and disease specific functioning and disability (measured by SF-36, WOMAC and AUSCAN) will not be different between patients who are managed in a multidisciplinary outpatient clinic and patients who receive regular care in a traditional individual outpatient clinic.
Patients are randomised into the two interventions within three strata: patients with primary hand, hip or knee problems. A project coordinator includes patients and coordinates the patient-reported data collection with questionnaires. Health professionals who are taking part in the two interventions are not involved in the data collection. Blinding of providers and patients is not possible in this type of study, but the outcome assessors as well as those who perform the follow up telephone call are blinded. All patients involved in the project have signed an informed consent and have been informed according to the Helsinki declaration. The data inspectorate and the regional ethical committee (REK) reviewed and approved the project (REK ref 156-06073 1.2006.598); the ISRCTN trial number is 25778426.
Study sample and setting
A total of 400 participants referred to an outpatient hospital rheumatology clinic with a diagnosis of hip, knee, hand and/or generalized OA, will be recruited for the study.
Clinical diagnosis osteoarthritis
Referral from general practitioner or specialist
Inability to read and understand Norwegian
Recent trauma in the extremities, other known or relevant co-morbidities such as rheumatoid arthritis and cancer
The experimental intervention is a multidisciplinary and multifaceted intervention, in which the referred patients first receive a 3.5 hour group-based educational programme, and thereafter individual consultations with a rheumatologist and other members of the multidisciplinary team, dependent on identified needs. The multidisciplinary team consists of rheumatologists, an orthopaedic surgeon, nurses, health secretaries, physiotherapists, occupational therapists, a pharmacist and a dietician.
The group-based educational programme contains four main themes identified through qualitative interviews with patient advocates. The themes are: a) What is OA? b) Activity possibilities or limitations, what can we do ourselves? c) Treatment options and d) How to live with OA.
The control intervention is regular care in an individual outpatient clinic. The patients are referred to and examined by a rheumatologist. According to usual procedures they are referred to other specialists or health professionals such as orthopaedic surgeons, physiotherapists, occupational therapists etc. dependent on identified needs. The access to health care providers is in principle similar to the access in the experimental group, but encounters occur according to referral.
Patients in both the primary groups are randomised to either a short 'telephone call' or 'no telephone call' after they have completed the 4-month follow-up assessment. Patients who receive 'no telephone call' are treated as usual, which imply that they can contact the outpatient clinic if they have additional questions or comments. Patients who receive the 'telephone call' are asked the following three questions: "how are you doing?", "did you receive the help you needed for your OA when you were at the hospital?", and "do you want to add any further information concerning your health status and the treatment given"?
All referrals from general practitioners to the outpatient clinic with focus on OA are screened for eligibility according to the inclusion and exclusion criteria. A research coordinator contacts patients who are potentially eligible for the study by telephone, inform them about the study and ask whether they want to participate. In the same telephone contact, a screening tool for classification of OA is used in the cases in which an OA diagnosis was evident based on information in the referral letter . If the OA diagnosis cannot be clinically confirmed during the examination by the rheumatologist during the first appointment, the participant will be excluded. Written consent according to the declarations of Helsinki is obtained before enrolment to the study. In addition, they are sent the first questionnaire by mail to be filled in before the first appointment at the outpatient clinic.
All patients are randomly allocated to one of two groups, experimental or control group. This randomisation is performed after completion of the baseline questionnaires. To ensure equal-sized treatment groups, random permuted blocks of 4-8 participants are used . The stratified random allocation schedule is computer generated by a statistician who is not otherwise involved in recruitment, assessment or treatment of participants. The randomisation sequence is carried out in sequentially numbered, opaque, sealed envelopes.
The participants are at the 4-month follow-up asked to complete a mailed questionnaire, and return it by mail. After completion of the questionnaire, participants are randomly allocated to either a brief 'telephone call' of approximately 10 minutes or follow-up "as usual", which means that the patients may contact the clinic if they need to.
The final follow-up is a mailed questionnaire at 12 months, which is mailed back to the project group after completion. In addition to these two mailed follow-up questionnaires, the participants complete a monthly diary regarding use of health care.
Questionnaires and assessments in the study
Age, gender, height, weight, marital status
Work situation (profession, % of full time)
Earlier and current treatments
Pain and functioning
Pain during the last week (NRS 0-10)
Health related quality of life
Satisfaction with care
Satisfaction with care (numeric rating scale 0-10)
Various data at follow-up
Use of health care and services (diary)
Global question on change of health status
The primary outcome measure is patient satisfaction with the health service, which will be evaluated on a 11 point numeric rating scale (NRS) from 0 = not satisfied to 10 = very satisfied . The co-primary outcome is cost-effectiveness, which will be based on changes in utility-scores based on EQ-5D in the denominator  and direct and indirect costs related to OA in the numerator. The costs will be assessed by recording the use of health care by patient self-report. All patients will receive a diary and all consultations and costs related to OA care during the follow-up will be recorded in this diary. Indirect costs related to the disease, like sick leave, lost working days and the use of social security will also be included in this cost-effectiveness analysis.
Secondary outcomes are pain and global disease activity, generic and disease specific functioning and disability using the component summary scales in the SF-36 health survey, WOMAC, AUSCAN, a patient-generated measure of disability (PSFS), and global perceived effect of change in health status during the study period.
Pain is measured on a NRS (range 0-10) with the anchor words 'no pain at all' and 'unbearable pain'. Global disease activity is measured on a NRS (0-10) with the anchor words 'no symptoms' and 'extremely severe', answering the question: "All symptoms taken into account, what do you think about your condition the last week?"
Health related quality of life is measured by the generic questionnaire SF-36 . The SF-36 Health Survey is a widely used generic instrument that comprises eight health scales that contribute to two higher order health scales, the Physical Component Summary (PCS) and Mental Component Summary (MCS) summary scores which give a mean (SD) of 50 based on normative data from the general population (Ware, 1995). The SF-36 is often used to assess health related quality of life in the general population and in different diseases. The English version has been translated to and validated in Norwegian .
Disease specific functioning in daily life is assessed by the WOMAC  for patients with hip or knee OA. This instrument is responsive and valid for measuring pain (5 items), stiffness (2 items) and physical function (17 items). The Likert scale version of the scale is used with response options none, mild, moderate, severe, extreme.
For patients with hand OA disease specific health problems are self-reported by the AUSCAN, which comprises 15 items relating to hand stiffness (one item), pain (five items) and problems with performance of activities (nine items). This study used the five-point descriptive scale version of the AUSCAN with response options none, mild, moderate, severe, extreme .
Through the use of the PSFS, all patients will also be asked to describe the three most important activity limitations caused by their OA and score each of these on a 0-10 point scale according to the ability to perform these activities . Patients will be interviewed regarding their activity limitations during the telephone interview at baseline before randomisation.
The global perceived effect of change in health status during the study period will be assessed on a 5-point scale ranging from much better through unchanged to much worse.
Self-efficacy will be evaluated using the Arthritis Self Efficacy Scale (ASES) for pain and functioning .
All patients are asked to fill in a questionnaire at inclusion, containing information on socio-demographics (age, gender, height, weight, marital status, work situation, emotional distress and physical activity), earlier and current pharmacological and non-pharmacological treatment for their OA and co-morbidities. They are also asked to complete standardised instruments for measurement of pain; functioning and health related quality of life.
Additional therapies and co-interventions are also registered. Patients who withdraw from the study will be registered by a research secretary. Delivery of interventions in both groups will be registered by the health professionals responsible for the intervention. Registering co-interventions will be part of the diary.
As no satisfactory data on patient satisfaction and cost-effectiveness were available, power calculations were based on the secondary outcome pain with data from the pilot study and previous research on OA from our group [26–28]. In this RCT we compare two independent equally sized groups. We assume comparable variation in both groups, set alpha to 5%, beta to 80%, and assume a smallest clinical important difference between the groups of 0.20 based on an estimated difference for pain measured by WOMAC/AUSCAN. The standardized difference (0.20)/SD (0.70)) will be 0.25. According to the Altman nomogram, approximately 200 patients will be needed in each of the two treatment groups.
Primary data analysis will be performed in a blinded manner, by conducting the effect analyses without knowing which intervention each of the two groups received. The treatment groups will be examined for baseline comparability. Both parametric and nonparametric statistical analyses will be used, dependent on how the variance is distributed. Effect of the interventions will be analyzed according to intention-to treat principles. Further, exploratory analyses will be performed to study the treatment effect within the three subgroups hip, knee and hand OA.
To our knowledge, this will be one of the first RCT's that will examine how a multidisciplinary approach affects treatment outcomes for patients with OA. Primary outcome will be patient satisfaction with health service assessed at 4 months, while, cost-effectiveness will be the co-primary outcome assessed at 12 months, and various aspects of health status are the secondary outcomes at both time-points.
A rheumatologist and a project coordinator examine all referrals to the multidisciplinary OA clinic at Diakonhjemmet Hospital. Patients aged 18-80 years are recruited to the study by a screening-form for OA based on clinical criteria of OA in hand hip or knee. Patients who may be eligible for the study receive oral and written information about the methods and aims of the study and are informed that participation is voluntary and can be terminated at any time without stating a reason and without any impact on their care. Informed consent will be obtained from all patients. They receive questionnaires by mail before the clinical examinations and if they have problems answering questions, a project assistant at the first encounter provide assistance. A smaller self-reported questionnaire on function, pain and health status will be mailed to the patients for the 4- and 12-month assessments.
All health professionals in the multidisciplinary team are represented among the staff at the Department of Rheumatology and a research secretary will be responsible for performance of practical aspects and organisation.
Data collection is ongoing, and will be completed within 2011 which will be followed by a one-year period of data analyses and manuscript preparation.
The project will, by means of a randomised controlled trial, contribute to new knowledge on the effect of patient education for patients with OA. The project will also contribute with cost-effectiveness analyses comparing the two different methods of outpatient care.
The study was financed with aid from EXTRA funds from the Norwegian Foundation for Health and Rehabilitation, the University of Oslo, and Trygve Gythfeldt's legacy.
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