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  1. Osteoarthritis (OA) is a prevalent chronic disease and a leading cause of disability in adults. For people with knee and hip OA, symptoms (e.g., pain and fatigue) can interfere with mobility and physical activ...

    Authors: Susan L Murphy, Angela K Lyden, Maria Clary, Michael E Geisser, Raymond L Yung, Daniel J Clauw and David A Williams
    Citation: BMC Musculoskeletal Disorders 2011 12:177
    Content type: Study protocol Published on:

  2. Neck pain is related to impaired postural balance among patients and is highly prevalent among workers with high postural demands, for example, cleaners. We therefore hypothesised, that cleaners with neck pain...

    Authors: Marie B Jørgensen, Jørgen H Skotte, Andreas Holtermann, Gisela Sjøgaard, Nicolas C Petersen and Karen Søgaard
    Citation: BMC Musculoskeletal Disorders 2011 12:176
    Content type: Research article Published on:

  3. Beside symptoms and clinical signs radiological findings are crucial in the diagnosis of lumbar spinal stenosis (LSS). We investigate which quantitative radiological signs are described in the literature and w...

    Authors: Johann Steurer, Simon Roner, Ralph Gnannt and Juerg Hodler
    Citation: BMC Musculoskeletal Disorders 2011 12:175
    Content type: Research article Published on:

  4. Hypersensitivity of the central nervous system is widely present in pain patients and recognized as one of the determinants of chronic pain and disability. Electronic pressure algometry is often used to explor...

    Authors: Niklaus Egloff, Nicole Klingler, Roland von Känel, Rafael JA Cámara, Michele Curatolo, Barbara Wegmann, Elizabeth Marti and Marie-Louise Gander Ferrari
    Citation: BMC Musculoskeletal Disorders 2011 12:174
    Content type: Research article Published on:

  5. In the light of both the importance and large numbers of case series and cohort studies (observational studies) in orthopaedic literature, it is remarkable that there is currently no validated measurement tool...

    Authors: Bart G Pijls, Olaf M Dekkers, Saskia Middeldorp, Edward R Valstar, Huub JL van der Heide, Henrica MJ Van der Linden-Van der Zwaag and Rob GHH Nelissen
    Citation: BMC Musculoskeletal Disorders 2011 12:173
    Content type: Research article Published on:

  6. The expectations of patients for managing pain induced by exercise and mobilization (PIEM) have seldom been investigated. We identified the views of patients and care providers regarding pain management induce...

    Authors: Sophie Alami, Dominique Desjeux, Marie Martine Lefèvre-Colau, Anne Sophie Boisgard, Eric Boccard, François Rannou and Serge Poiraudeau
    Citation: BMC Musculoskeletal Disorders 2011 12:172
    Content type: Research article Published on:

  7. There is a need for outcome measurement instruments for evaluation of disability after trauma. The Patient-Rated Wrist Evaluation (PRWE) is a self-administered region-specific outcome measuring instrument deve...

    Authors: Cecilia Mellstrand Navarro, Sari Ponzer, Hans Törnkvist, Leif Ahrengart and Gunnar Bergström
    Citation: BMC Musculoskeletal Disorders 2011 12:171
    Content type: Research article Published on:

  8. While there is growing evidence for the efficacy of SM to treat LBP, little is known on the mechanisms and physiologic effects of these treatments. Accordingly, the purpose of this study was to determine wheth...

    Authors: Brian C Clark, David A Goss Jr, Stevan Walkowski, Richard L Hoffman, Andrew Ross and James S Thomas
    Citation: BMC Musculoskeletal Disorders 2011 12:170
    Content type: Research article Published on:

  9. Many adults experience bothersome neck/shoulder pain. While research and treatment strategies often focus on the upper trapezius, other neck/shoulder muscles may be affected as well. The aim of the present stu...

    Authors: Lars L Andersen, Klaus Hansen, Ole S Mortensen and Mette K Zebis
    Citation: BMC Musculoskeletal Disorders 2011 12:169
    Content type: Research article Published on:

  10. Assessment of shoulder mobility is essential for clinical follow-up of shoulder treatment. Only a few high sophisticated instruments for objective measurements of shoulder mobility are available. The interobse...

    Authors: Bilal Farouk El-Zayat, Turgay Efe, Annett Heidrich, Udo Wolf, Nina Timmesfeld, Thomas J Heyse, Stefan Lakemeier, Susanne Fuchs-Winkelmann and Markus D Schofer
    Citation: BMC Musculoskeletal Disorders 2011 12:168
    Content type: Research article Published on:

  11. Monitoring osteoporosis therapy by measurement of bone turnover markers (BTMs) might detect non-compliance in an earlier stage of anti-osteoporosis treatment and improve persistence.

    Authors: Danielle A Eekman, Irene EM Bultink, Annemieke C Heijboer, Ben AC Dijkmans and Willem F Lems
    Citation: BMC Musculoskeletal Disorders 2011 12:167
    Content type: Research article Published on:

  12. To determine safe surgical margins for soft tissue sarcoma, it is essential to perform a general evaluation of the extent of tumor, responses to auxiliary therapy, and other factors preoperatively using multip...

    Authors: Masahiro Yokouchi, Mikio Terahara, Satoshi Nagano, Yoshiya Arishima, Michihisa Zemmyo, Takako Yoshioka, Akihide Tanimoto and Setsuro Komiya
    Citation: BMC Musculoskeletal Disorders 2011 12:166
    Content type: Research article Published on:

  13. Clinical analgesic trials typically report response as group mean results. However, research has shown that few patients are average and most have responses at the extremes. Moreover, group mean results do not...

    Authors: Paul M Peloso, Arnold Gammaitoni, Steven S Smugar, Hongwei Wang and Andrew R Moore
    Citation: BMC Musculoskeletal Disorders 2011 12:165
    Content type: Research article Published on:

  14. Tenascin-C (TN-C) is an extracellular matrix glycoprotein that is involved in tissue injury and repair processes. We analyzed TN-C expression in normal and osteoarthritic (OA) human cartilage, and evaluated it...

    Authors: Lisha Patel, Weiyong Sun, Sonya S Glasson, Elisabeth A Morris, Carl R Flannery and Priya S Chockalingam
    Citation: BMC Musculoskeletal Disorders 2011 12:164
    Content type: Research article Published on:

  15. BMP-2 is known to accelerate fracture healing and might also enhance osseointegration and implant fixation. Application of recombinant BMP-2 has a time-limited effect. Therefore, a gene transfer approach with ...

    Authors: Benjamin Faensen, Britt Wildemann, Christian Hain, Julius Höhne, Yvonne Funke, Christan Plank, Axel Stemberger and Gerhard Schmidmaier
    Citation: BMC Musculoskeletal Disorders 2011 12:163
    Content type: Research article Published on:

  16. Increased center of pressure excursions are well documented in patients suffering from non-specific low back pain, whereby the altered postural sway includes both higher mean sway velocities and larger sway ar...

    Authors: Alexander Ruhe, René Fejer and Bruce Walker
    Citation: BMC Musculoskeletal Disorders 2011 12:162
    Content type: Research article Published on:

  17. Despite the large volume of research dedicated to understanding chronic low back pain (CLBP), patient outcomes remain modest while healthcare costs continue to rise, creating a major public health burden. Heal...

    Authors: Andrew M Briggs, Joanne E Jordan, Peter B O'Sullivan, Rachelle Buchbinder, Angus F Burnett, Richard H Osborne and Leon M Straker
    Citation: BMC Musculoskeletal Disorders 2011 12:161
    Content type: Research article Published on:

  18. The pathogenesis of osteonecrosis of the femoral head (ONFH) has been implicated in hypofibrinolysis and blood supply interruption. Previous studies have demonstrated that decreased fibrinolytic activity due t...

    Authors: Hye- Ok Kim, Chang- Hoon Cho, Yoon- Je Cho, Seong- Ho Cho, Kyung- Sik Yoon and Kang- Il Kim
    Citation: BMC Musculoskeletal Disorders 2011 12:160
    Content type: Research article Published on:

  19. Authors: Wayne Hoskins, Henry Pollard, Chris Daff, Andrew Odell, Peter Garbutt, Andrew McHardy, Kate Hardy and George Dragasevic
    Citation: BMC Musculoskeletal Disorders 2011 12:159
    Content type: Retraction Note Published on:

    The original article was published in BMC Musculoskeletal Disorders 2010 11:241

  20. Authors: Wayne Hoskins, Henry Pollard, Chris Daff, Andrew Odell, Peter Garbutt, Andrew McHardy, Kate Hardy and George Dragasevic
    Citation: BMC Musculoskeletal Disorders 2011 12:158
    Content type: Retraction Note Published on:

    The original article was published in BMC Musculoskeletal Disorders 2009 10:38

  21. Musculoskeletal diseases are becoming increasingly important due to population aging. However, studies on the economic burden of musculoskeletal disease in Korea are scarce. Therefore, we conducted a populatio...

    Authors: In-Hwan Oh, Seok-Jun Yoon, Hye-Young Seo, Eun-Jung Kim and Young Ae Kim
    Citation: BMC Musculoskeletal Disorders 2011 12:157
    Content type: Research article Published on:

  22. There is limited evidence for the clinical and cost effectiveness of occupational therapy (OT) approaches in the management of hand osteoarthritis (OA). Joint protection and hand exercises have been proposed b...

    Authors: Krysia S Dziedzic, Susan Hill, Elaine Nicholls, Alison Hammond, Helen Myers, Tracy Whitehurst, Jo Bailey, Charlotte Clements, David GT Whitehurst, Sue Jowett, June Handy, Rhian W Hughes, Elaine Thomas and Elaine M Hay
    Citation: BMC Musculoskeletal Disorders 2011 12:156
    Content type: Study protocol Published on:

  23. Even though technological progress has provided us with more and more sophisticated equipment for making goniometric measurements, the most commonly used clinical tools are still the universal goniometer and, ...

    Authors: Pablo Herrero, Patricia Carrera, Elena García, Eva M Gómez-Trullén and Bárbara Oliván-Blázquez
    Citation: BMC Musculoskeletal Disorders 2011 12:155
    Content type: Research article Published on:

  24. Subacromial disorders are considered to be one of the most common pathologies affecting the shoulder. Optimal therapy for shoulder pain (SP) in primary care is yet unknown, since clinical history and physical ...

    Authors: Ramon PG Ottenheijm, Manuela A Joore, Geert HIM Walenkamp, René E Weijers, Bjorn Winkens, Jochen WL Cals, Rob A de Bie and Geert-Jan Dinant
    Citation: BMC Musculoskeletal Disorders 2011 12:154
    Content type: Study protocol Published on:

  25. Canakinumab is a fully human anti-interleukin IL-1beta monoclonal antibody, being investigated for the treatment of rheumatoid arthritis (RA). This multicenter, phase II, randomized, double-blind, placebo-cont...

    Authors: Rieke Alten, Juan Gomez-Reino, Patrick Durez, Andre Beaulieu, Anthony Sebba, Gerhard Krammer, Ralph Preiss, Udayasankar Arulmani, Albert Widmer, Xavier Gitton and Herbert Kellner
    Citation: BMC Musculoskeletal Disorders 2011 12:153
    Content type: Research article Published on:

  26. Brief intervention programs are clinically beneficial, and cost efficient treatments for low back pain, when offered at 8-12 weeks, compared with treatment as usual. However, about 30% of the patients do not r...

    Authors: Silje E Reme, Torill H Tveito, Trudie Chalder, Tormod Bjørkkjær, Aage Indahl, Jens I Brox, Egil Fors, Eli M Hagen and Hege R Eriksen
    Citation: BMC Musculoskeletal Disorders 2011 12:152
    Content type: Study protocol Published on:

  27. Posttraumatic osteoarthritis can develop after an intra-articular extremity fracture, leading to pain and loss of function. According to international guidelines, anatomical reduction and fixation are the basi...

    Authors: M Suzan H Beerekamp, Dirk Th Ubbink, Mario Maas, Jan SK Luitse, Peter Kloen, Taco JM Blokhuis, Michiel JM Segers, Meir Marmor, Niels WL Schep, Marcel GW Dijkgraaf and J Carel Goslings
    Citation: BMC Musculoskeletal Disorders 2011 12:151
    Content type: Study protocol Published on:

  28. Regulation of cell death and cell division are key processes during chondrogenesis and in cartilage homeostasis and pathology. The oncogene survivin is considered to be critical for the coordination of mitosis...

    Authors: Philipp Lechler, Sanjeevi Balakrishnan, Jens Schaumburger, Susanne Grässel, Clemens Baier, Joachim Grifka, Rainer H Straub and Tobias Renkawitz
    Citation: BMC Musculoskeletal Disorders 2011 12:150
    Content type: Research article Published on:

  29. A high quality decision requires that patients who meet clinical criteria for surgery are informed about the options (including non-surgical alternatives) and receive treatments that match their goals. The aim...

    Authors: Karen R Sepucha, Dawn Stacey, Catharine F Clay, Yuchiao Chang, Carol Cosenza, Geoffrey Dervin, Janet Dorrwachter, Sandra Feibelmann, Jeffrey N Katz, Stephen A Kearing, Henrik Malchau, Monica Taljaard, Ivan Tomek, Peter Tugwell and Carrie A Levin
    Citation: BMC Musculoskeletal Disorders 2011 12:149
    Content type: Research article Published on:

  30. Ankle fractures are common. Management of ankle fractures generally involves a period of immobilisation followed by rehabilitation to reduce pain, stiffness, weakness and swelling. The effects of a rehabilitat...

    Authors: Paula R Beckenkamp, C Christine Lin, Robert D Herbert, Marion Haas, Kriti Khera and Anne M Moseley
    Citation: BMC Musculoskeletal Disorders 2011 12:148
    Content type: Study protocol Published on:

  31. The present study was conducted to address whether the intervertebral disc of rabbit could be considered (i) as a valuable model to provide new insights into the tissue and cellular changes of Nucleus pulposus...

    Authors: Johann Clouet, Marianne Pot-Vaucel, Gaël Grimandi, Martial Masson, Julie Lesoeur, Borhane H Fellah, Olivier Gauthier, Marion Fusellier, Yan Cherel, Yves Maugars, Jérôme Guicheux and Claire Vinatier
    Citation: BMC Musculoskeletal Disorders 2011 12:147
    Content type: Research article Published on:

  33. Patients with non-specific back pain are not a homogeneous group but heterogeneous with regard to their bio-psycho-social impairments. This study examined a sample of 173 highly disabled patients with chronic ...

    Authors: Martin L Verra, Felix Angst, J Bart Staal, Roberto Brioschi, Susanne Lehmann, André Aeschlimann and Rob A de Bie
    Citation: BMC Musculoskeletal Disorders 2011 12:145
    Content type: Research article Published on:

  34. One of the sources of knee pain in osteoarthritis (OA) is believed to be related to local chronic inflammation of the knee joints, which involves the production of inflammatory cytokines such as tumor necrosis...

    Authors: Sumihisa Orita, Takana Koshi, Takeshi Mitsuka, Masayuki Miyagi, Gen Inoue, Gen Arai, Tetsuhiro Ishikawa, Eiji Hanaoka, Keishi Yamashita, Masaomi Yamashita, Yawara Eguchi, Tomoaki Toyone, Kazuhisa Takahashi and Seiji Ohtori
    Citation: BMC Musculoskeletal Disorders 2011 12:144
    Content type: Research article Published on:

  35. Previous research has found that acceptance of pain is more successful than cognitive coping variables for predicting adjustment to pain. This research has a limitation because measures of cognitive coping rel...

    Authors: Baltasar Rodero, Benigno Casanueva, Juan V Luciano, Margalida Gili, Antoni Serrano-Blanco and Javier García-Campayo
    Citation: BMC Musculoskeletal Disorders 2011 12:143
    Content type: Research article Published on:

  36. Low-contact-stress (LCS) mobile-bearing total knee arthroplasty (TKA) (Johnson & Johnson, New Brunswick, NJ; previously: DePuy, Warsawa, USA) provides excellent functional results and wear rates in long-term f...

    Authors: Patrick Sadoghi, Andreas Leithner, Patrick Weber, Jörg Friesenbichler, Gerald Gruber, Norbert Kastner, Katrin Pohlmann, Volkmar Jansson and Bernd Wegener
    Citation: BMC Musculoskeletal Disorders 2011 12:142
    Content type: Research article Published on:

  37. Patients with osteoarthritis of the knee may change their gait in an attempt to reduce loading of the affected knee, thereby reducing pain. Especially changes in lateral trunk motion may be potentially effecti...

    Authors: Martin van der Esch, Martijn PM Steultjens, Jaap Harlaar, Josien C van den Noort, Dirk L Knol and Joost Dekker
    Citation: BMC Musculoskeletal Disorders 2011 12:141
    Content type: Research article Published on:

  38. Polymethylmethacrylate (PMMA) assisted ventral discectomy has been criticized for high rates of graft migration and pseudarthrosis when compared with various other fusion procedures for the treatment of cervic...

    Authors: Mario Cabraja, Daniel Koeppen, Wolfgang R Lanksch, Klaus Maier-Hauff and Stefan Kroppenstedt
    Citation: BMC Musculoskeletal Disorders 2011 12:140
    Content type: Research article Published on:

  39. Shoulder pain is reported to be highly prevalent and tends to be recurrent or persistent despite medical treatment. The pathophysiological mechanisms of shoulder pain are poorly understood. Furthermore, there ...

    Authors: Carel Bron, Jan Dommerholt, Boudewijn Stegenga, Michel Wensing and Rob AB Oostendorp
    Citation: BMC Musculoskeletal Disorders 2011 12:139
    Content type: Research article Published on:

  40. Although no prospective studies have compared functional results of trochanteric osteotomy and a non-trochanteric approach, most surgeons feel that trochanteric osteotomy is outdated in simple hip arthroplasty...

    Authors: Margot van der Grinten, Max Reijman, Frans C van Biezen and Jan AN Verhaar
    Citation: BMC Musculoskeletal Disorders 2011 12:138
    Content type: Research article Published on:

  41. Corticosteroid injections can be performed blind (landmark-guided) or with image guidance, and this may account for variable clinical outcomes. The objective of this study was to assess the effectiveness and s...

    Authors: Edmund Soh, Wenyun Li, Keh Oon Ong, Wen Chen and Dianne Bautista
    Citation: BMC Musculoskeletal Disorders 2011 12:137
    Content type: Research article Published on:

  42. Dupuytren's disease is a progressive fibroproliferative disorder which can result in fixed flexion contractures of digits and impaired hand function. Standard treatment involves surgical release or excision fo...

    Authors: Christina Jerosch-Herold, Lee Shepstone, Adrian J Chojnowski, Debbie Larson, Elisabeth Barrett and Susan P Vaughan
    Citation: BMC Musculoskeletal Disorders 2011 12:136
    Content type: Research article Published on:

  43. There remains uncertainty regarding the appropriate therapeutic management of hip fracture patients. The primary aim of our study was to examine whether large loading doses in addition to daily vitamin D offer...

    Authors: Alexandra Papaioannou, Courtney C Kennedy, Lora Giangregorio, George Ioannidis, Janet Pritchard, David A Hanley, Leonardo Farrauto, Justin DeBeer and Jonathan D Adachi
    Citation: BMC Musculoskeletal Disorders 2011 12:135
    Content type: Research article Published on:

  44. The exact mechanism of knee osteoarthritis (OA)-associated pain is unclear, whereas mixed evidence of inflammatory pain and neuropathic pain has been noted. We aimed to investigate pain-related sensory innerva...

    Authors: Sumihisa Orita, Tetsuhiro Ishikawa, Masayuki Miyagi, Nobuyasu Ochiai, Gen Inoue, Yawara Eguchi, Hiroto Kamoda, Gen Arai, Tomoaki Toyone, Yasuchika Aoki, Takekazu Kubo, Kazuhisa Takahashi and Seiji Ohtori
    Citation: BMC Musculoskeletal Disorders 2011 12:134
    Content type: Research article Published on:

  45. Recent systematic reviews on psychological therapies of fibromyalgia syndrome (FMS) did not consider hypnosis/guided imagery (H/GI). Therefore we performed a systematic review with meta-analysis of the efficac...

    Authors: Kathrin Bernardy, Nicole Füber, Petra Klose and Winfried Häuser
    Citation: BMC Musculoskeletal Disorders 2011 12:133
    Content type: Research article Published on:

  46. Achieving adequate follow-up in clinical trials is essential to establish the validity of the findings. Achieving adequate response rates reduces bias and increases probability that the findings can be general...

    Authors: John D Childs, Deydre S Teyhen, Joshua J Van Wyngaarden, Brett F Dougherty, Bryan J Ladislas, Gary L Helton, Michael E Robinson, Samuel S Wu and Steven Z George
    Citation: BMC Musculoskeletal Disorders 2011 12:132
    Content type: Research article Published on:

  47. Many studies have identified smoking as a risk factor for osteoporosis, but it is unclear whether passive smoking has an effect on bone mineral density and bone turnover and if such an effect could cause osteo...

    Authors: Shu-guang Gao, Kang-hua Li, Mai Xu, Wei Jiang, Hong Shen, Wei Luo, Wen-shuo Xu, Jian Tian and Guang-hua Lei
    Citation: BMC Musculoskeletal Disorders 2011 12:131
    Content type: Research article Published on:

  48. Elbow dislocations can be classified as simple or complex. Simple dislocations are characterized by the absence of fractures, while complex dislocations are associated with fractures of the radial head, olecra...

    Authors: Niels WL Schep, Jeroen De Haan, Gijs IT Iordens, Wim E Tuinebreijer, Maarten WGA Bronkhorst, Mark R De Vries, J Carel Goslings, S John Ham, Steven Rhemrev, Gert R Roukema, Inger B Schipper, Jan Bernard Sintenie, Hub GWM Van der Meulen, Tom PH Van Thiel, Arie B Van Vugt, Egbert JMM Verleisdonk…
    Citation: BMC Musculoskeletal Disorders 2011 12:130
    Content type: Study protocol Published on:

  49. To evaluate the life-time prevalence of self reported whiplash injury and the relationship to chronic musculoskeletal complaints (MSCs) and headache in a large unselected adult population.

    Authors: Rigmor Myran, Knut Hagen, Sven Svebak, Oystein Nygaard and John-Anker Zwart
    Citation: BMC Musculoskeletal Disorders 2011 12:129
    Content type: Research article Published on:

  50. Bone stress injuries are common in athletes and military recruits. Only a minority of bone stress changes are available on plain radiographs. Acute bone stress is often visible on MRI as bone marrow edema, whi...

    Authors: Markus J Sormaala, Juha-Petri Ruohola, Ville M Mattila, Seppo K Koskinen and Harri K Pihlajamäki
    Citation: BMC Musculoskeletal Disorders 2011 12:128
    Content type: Research article Published on:
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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