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  1. Anterior cervical discectomy with interbody fusion cages is considered the standard surgical procedure in patients with cervical disc herniation. However, PEEK or metal cages have some undesirable imaging char...

    Authors: Mark P Arts, Jasper FC Wolfs and Terry P Corbin
    Citation: BMC Musculoskeletal Disorders 2013 14:244
  2. In the field of rehabilitation, patients are supposed to be experts on their own lives, but the patient’s own desires in this respect are often not reported. Our objectives were to describe the patients’ desir...

    Authors: Kristi Elisabeth Heiberg, Arne Ekeland and Anne Marit Mengshoel
    Citation: BMC Musculoskeletal Disorders 2013 14:243
  3. To inform the clinical management of patients with suspected carpal tunnel syndrome (CTS) and case definition for CTS in epidemiological research, we explored the relation of symptoms and signs to sensory nerv...

    Authors: Georgia Ntani, Keith T Palmer, Cathy Linaker, E Clare Harris, Richard Van der Star, Cyrus Cooper and David Coggon
    Citation: BMC Musculoskeletal Disorders 2013 14:242
  4. We have previously proposed that sensory nerve conduction (SNC) in the median nerve should be classed as abnormal when the difference between conduction velocities in the little and index fingers is > 8 m/s. I...

    Authors: David Coggon, Georgia Ntani, E Clare Harris, Cathy Linaker, Richard Van der Star, Cyrus Cooper and Keith T Palmer
    Citation: BMC Musculoskeletal Disorders 2013 14:241
  5. To explore whether risk factors for neurophysiologically confirmed carpal tunnel syndrome (CTS) differ from those for sensory symptoms with normal median nerve conduction, and to test the validity and practica...

    Authors: David Coggon, Georgia Ntani, E Clare Harris, Cathy Linaker, Richard Van der Star, Cyrus Cooper and Keith T Palmer
    Citation: BMC Musculoskeletal Disorders 2013 14:240
  6. A health promotion intervention was developed for inflammatory arthritis patients, based on goal management. Elevated levels of depression and anxiety symptoms, which indicate maladjustment, are found in such ...

    Authors: Roos Y Arends, Christina Bode, Erik Taal and Mart AFJ Van de Laar
    Citation: BMC Musculoskeletal Disorders 2013 14:239
  7. The primary aim of this study was to investigate the association between BMI and musculoskeletal symptoms in interaction with physical workload. In addition, it was aimed to obtain insight into whether overwei...

    Authors: Laura Viester, Evert ALM Verhagen, Karen M Oude Hengel, Lando LJ Koppes, Allard J van der Beek and Paulien M Bongers
    Citation: BMC Musculoskeletal Disorders 2013 14:238
  8. Cardiac conduction disturbances are common in spondyloarthropathies such as ankylosing spondylitis (AS). Whether their occurrence can be linked to signs and symptoms of rheumatic disease activity is an unsettl...

    Authors: Helena Forsblad-d’Elia, Hanna Wallberg, Eva Klingberg, Hans Carlsten and Lennart Bergfeldt
    Citation: BMC Musculoskeletal Disorders 2013 14:237
  9. Mitochondrion has an important role in the osteoarthritis (OA) pathology. We have previously demonstrated that the alteration of the mitochondrial respiratory chain (MRC) contributes to the inflammatory respon...

    Authors: Berta Cillero-Pastor, Ignacio Rego-Pérez, Natividad Oreiro, Carlos Fernandez-Lopez and Francisco J Blanco
    Citation: BMC Musculoskeletal Disorders 2013 14:235
  10. Previous studies in patients with hip and knee osteoarthritis (OA) have advocated the relevance of assessing the number of painful joint sites, other than the primary affected joint, in both research and clini...

    Authors: Liseth Siemons, Peter M ten Klooster, Mart A F J van de Laar, Cornelia H M van den Ende and Thomas J Hoogeboom
    Citation: BMC Musculoskeletal Disorders 2013 14:234
  11. Up to one third of BKP treated cases shows no appreciable height restoration due to loss of both restored height and kyphotic realignment after balloon deflation. This shortcoming has called for an improved me...

    Authors: Peter Diel, Christoph Röder, Gosia Perler, Thomas Vordemvenne, Matti Scholz, Frank Kandziora, Sebastian Fürderer, Soren Eiskjaer, Gianluca Maestretti, Robert Rotter, Lorin Michael Benneker and Paul Friedhelm Heini
    Citation: BMC Musculoskeletal Disorders 2013 14:233
  12. The benefits of exercise in mild and moderate knee or hip osteoarthritis (OA) are apparent, but the evidence in severe OA is less clear. We recently reported that neuromuscular training was well tolerated and ...

    Authors: Eva Ageberg, Anna Nilsdotter, Eva Kosek and Ewa M Roos
    Citation: BMC Musculoskeletal Disorders 2013 14:232
  13. There is a growing tendency for complex proximal humerus fractures (PHF) in osteoporotic patients to be treated with reverse shoulder arthroplasty (RSA). It has been proposed that RSA has more benefits than ot...

    Authors: Georg Mattiassich, Lucian Lior Marcovici, Rolf Michael Krifter, Reinhold Ortmaier, Peter Wegerer and Albert Kroepfl
    Citation: BMC Musculoskeletal Disorders 2013 14:231
  14. Blood loss in hip and knee arthroplasties may necessitate allogeneic blood transfusions. Different blood-saving measures (BSMs) were introduced to reduce these transfusions. Purpose of the present study was to...

    Authors: Veronique MA Voorn, Perla J Marang-van de Mheen, Manon M Wentink, Cynthia So-Osman, Thea PM Vliet Vlieland, Ankie WMM Koopman-van Gemert, Rob GHH Nelissen and Leti Van Bodegom-Vos
    Citation: BMC Musculoskeletal Disorders 2013 14:230
  15. Currently available biomarkers for the early tissue process leading to joint damage in rheumatoid arthritis are insufficient and lack prognostic accuracy, possibly a result of variable activity of the disease ...

    Authors: Maria L E Andersson, Björn Svensson, Ingemar F Petersson, Ingiäld Hafström, Kristina Albertsson, Kristina Forslind, Dick Heinegård and Tore Saxne
    Citation: BMC Musculoskeletal Disorders 2013 14:229
  16. Osteoarthritis is the most widespread joint-affecting disease. Patients with osteoarthritis experience pain and impaired mobility resulting in marked reduction of quality of life. A progressive cartilage loss ...

    Authors: Lorenzo Di Cesare Mannelli, Laura Micheli, Matteo Zanardelli and Carla Ghelardini
    Citation: BMC Musculoskeletal Disorders 2013 14:228
  17. Computer users often report musculoskeletal complaints and pain in the upper extremities and the neck-shoulder region. However, recent epidemiological studies do not report a relationship between the extent of...

    Authors: Pascal Madeleine, Steffen Vangsgaard, Johan Hviid Andersen, Hong-You Ge and Lars Arendt-Nielsen
    Citation: BMC Musculoskeletal Disorders 2013 14:226
  18. Knee pain is common during adolescence. Adolescents and their parents may think that knee pain is benign and self-limiting and therefore avoid seeking medical care. However, long-term prognosis of knee pain is...

    Authors: Michael S Rathleff, Sune K Skuldbøl, Mads N B Rasch, Ewa M Roos, Sten Rasmussen and Jens L Olesen
    Citation: BMC Musculoskeletal Disorders 2013 14:225
  19. Low bone mass and high bone turnover have been reported in HIV-infected individuals, both as a consequence of HIV infection itself, as well as from treatment with highly active antiretroviral therapy (HAART). ...

    Authors: Lixia Zhang, Yuanbo Su, Evelyn Hsieh, Weibo Xia, Jing Xie, Yang Han, Ying Cao, Yanling Li, Xiaojing Song, Ting Zhu, Taisheng Li and Wei Yu
    Citation: BMC Musculoskeletal Disorders 2013 14:224
  20. Bone marrow-derived mesenchymal stromal cells (BM-MSCs) play an important role in modern tissue engineering, while distinct variations of culture media compositions and supplements have been reported. Because ...

    Authors: Sebastien Hagmann, Babak Moradi, Sebastian Frank, Thomas Dreher, Peer Wolfgang Kämmerer, Wiltrud Richter and Tobias Gotterbarm
    Citation: BMC Musculoskeletal Disorders 2013 14:223
  21. Periprosthetic infection about the knee is a devastating complication that may affect between 1% and 5% of knee replacement. With over 79 000 knee replacements being implanted each year in the UK, periprosthet...

    Authors: James PM Masters, Nicholas A Smith, Pedro Foguet, Mike Reed, Helen Parsons and Andrew P Sprowson
    Citation: BMC Musculoskeletal Disorders 2013 14:222
  22. The biological mechanisms involved in non-contact musculoskeletal soft tissue injuries (NCMSTI) are poorly understood. Genetic risk factors may be associated with susceptibility to injuries, and may exert mark...

    Authors: Ricard Pruna, Rosa Artells, Jordi Ribas, Bruno Montoro, Francesc Cos, Carme Muñoz, Gil Rodas and Nicola Maffulli
    Citation: BMC Musculoskeletal Disorders 2013 14:221
  23. Anterior lumbar interbody fusion (ALIF) followed by pedicle screw fixation (PSF) is used to restore the height of the intervertebral disc and provide stability. Recently, stand-alone interbody cage with anteri...

    Authors: Kyung-Chul Choi, Kyeong-Sik Ryu, Sang-Ho Lee, Yeong Hyeon Kim, Sung Jae Lee and Chun-Kun Park
    Citation: BMC Musculoskeletal Disorders 2013 14:220
  24. Knee osteoarthritis (kOA) risk is increased by obesity and physical activities (PA) which mechanically stress the joint. We examined the associations of midlife kOA with body mass index (BMI) and activity expo...

    Authors: Kathryn R Martin, Diana Kuh, Tamara B Harris, Jack M Guralnik, David Coggon and Andrew K Wills
    Citation: BMC Musculoskeletal Disorders 2013 14:219
  25. Earlier studies have found a positive effect of alcohol consumption, with a reduced disease activity in rheumatoid arthritis (RA). The aim of this study was to assess alcohol consumption and its association wi...

    Authors: Stefan Bergman, Sofia Symeonidou, Maria L Andersson and Maria K Söderlin
    Citation: BMC Musculoskeletal Disorders 2013 14:218
  26. Although percutaneous posterior-ring tension-band metallic plate and percutaneous iliosacral screws are used to fix unstable posterior pelvic ring fractures, the biomechanical stability and compatibility of bo...

    Authors: Hongwei Chen, Lijun Wu, Rongmei Zheng, Yan Liu, Yang Li and Zihai Ding
    Citation: BMC Musculoskeletal Disorders 2013 14:217
  27. Interleukin-1β (IL-1β) is a major mediator of local inflammation present in injured joints. In this study, we aimed at comparing the effect of IL-1β on engineered tissues from MCs, BMSCs and co-cultured MCs an...

    Authors: Anika Chowdhury, Louis W Bezuidenhout, Aillette Mulet-Sierra, Nadr M Jomha and Adetola B Adesida
    Citation: BMC Musculoskeletal Disorders 2013 14:216
  28. Muscle morphology, age and gender may be determinants of muscle strength in older adults. However, very few research studies have directly examined such correlation in the ageing spine. The aim of the study wa...

    Authors: Devinder Kaur Ajit Singh, Martin Bailey and Raymond Lee
    Citation: BMC Musculoskeletal Disorders 2013 14:215
  29. The progressive nature of knee osteoarthritis (OA) leads to not only to physical but also to psychosocial decline; this aspect can influence knee pain experience, manifestations and inevitably diagnostic accur...

    Authors: Duarte Pereira, Milton Severo, Henrique Barros, Jaime Branco, Rui A Santos and Elisabete Ramos
    Citation: BMC Musculoskeletal Disorders 2013 14:214
  30. Among blue-collar workers, high physical work demands are generally considered to be the main cause of musculoskeletal pain and work disability. However, current available research on this topic has been criti...

    Authors: Marie Birk Jørgensen, Mette Korshøj, Julie Lagersted-Olsen, Morten Villumsen, Ole Steen Mortensen, Jørgen Skotte, Karen Søgaard, Pascal Madeleine, Birthe Lykke Thomsen and Andreas Holtermann
    Citation: BMC Musculoskeletal Disorders 2013 14:213
  31. Symptomatic external snapping hip is a painful condition, where pain in the trochantor region and limitations of daily activity dominate clinical findings. The aetiology of symptomatic external snapping hip is...

    Authors: Julie S Jacobsen, Uwe G Kersting, Michael S Rathleff, Ole Simonsen, Kjeld Søballe and Michael Ulrich
    Citation: BMC Musculoskeletal Disorders 2013 14:212
  32. The aim of the present study was to compare one-year-follow-up data on disability and health-related quality of life (HRQoL) between spinal fusion patients and age- and sex-matched general population.

    Authors: Liisa Pekkanen, Marko H Neva, Hannu Kautiainen, Joost Dekker, Kirsi Piitulainen, Marko Wahlman and Arja Häkkinen
    Citation: BMC Musculoskeletal Disorders 2013 14:211
  33. Little is known about the impact of the reason for revision total hip arthroplasty (THA) on the outcomes following revision THA. In this study, our objective was to assess the association of operative diagnosi...

    Authors: Jasvinder A Singh and David G Lewallen
    Citation: BMC Musculoskeletal Disorders 2013 14:210
  34. The purpose of the study was to understand the function and expression of ATF2 by JNK and p38 signal pathways in the chondrocytes apoptosis of articular cartilage of the Kashin-Beck disease (KBD).

    Authors: Jing Han, Xiong Guo, Wuhong Tan, Feng Zhang, Jiangtao Liu, Weizhuo Wang, Peng Xu and Mikko J Lammi
    Citation: BMC Musculoskeletal Disorders 2013 14:209
  35. Muscle loss and fat gain contribute to the disability, pain, and morbidity associated with knee osteoarthritis (OA), and thigh muscle weakness is an independent and modifiable risk factor for it. However, whil...

    Authors: Stephen P Messier, Shannon L Mihalko, Daniel P Beavers, Barbara J Nicklas, Paul DeVita, J Jeffery Carr, David J Hunter, Jeff D Williamson, Kim L Bennell, Ali Guermazi, Mary Lyles and Richard F Loeser
    Citation: BMC Musculoskeletal Disorders 2013 14:208
  36. Osteoporotic hip fractures with a significant morbidity and excess mortality among the elderly have imposed huge health and economic burdens on societies worldwide. In this age- and sex-matched case control st...

    Authors: Wo-Jan Tseng, Li-Wei Hung, Jiann-Shing Shieh, Maysam F Abbod and Jinn Lin
    Citation: BMC Musculoskeletal Disorders 2013 14:207
  37. Clinical examination of patients with chronic lumbar radiculopathy aims to clarify whether there is nerve root impingement. The aims of this study were to investigate the association between findings at clinic...

    Authors: Trond Iversen, Tore K Solberg, Bertil Romner, Tom Wilsgaard, Øystein Nygaard, Knut Waterloo, Jens Ivar Brox and Tor Ingebrigtsen
    Citation: BMC Musculoskeletal Disorders 2013 14:206
  38. Not only joint destruction but also muscle wasting due to rheumatoid cachexia has been problem in terms of quality of life of patients with rheumatoid arthritis (RA). In the present study, we performed histopa...

    Authors: Naoto Horai, Takaharu Nagaoka, Itsuro Higuchi, Hayato Kasai, Takako Yoshioka, Yoshihisa Umekita, Koichiro Fukuzaki, Ryoichi Nagata, Atsuro Miyata and Kazuhiro Abeyama
    Citation: BMC Musculoskeletal Disorders 2013 14:205
  39. Back extension exercises are often used in the rehabilitation of low back pain. However, at present it is not clear how the posterior muscles are recruited during different types of extension exercises. Theref...

    Authors: Eline MD De Ridder, Jessica O Van Oosterwijck, Andry Vleeming, Guy G Vanderstraeten and Lieven A Danneels
    Citation: BMC Musculoskeletal Disorders 2013 14:204
  40. People suffering from musculoskeletal shoulder pain are frequently referred to physiotherapy. Physiotherapy generally involves a multimodal approach to management that may include; exercise, manual therapy and...

    Authors: Rachel Chester, Lee Shepstone, Helena Daniell, David Sweeting, Jeremy Lewis and Christina Jerosch-Herold
    Citation: BMC Musculoskeletal Disorders 2013 14:203
  41. The use of Computer Assisted Surgery (CAS) for knee replacements is intended to improve the alignment of knee prostheses in order to reduce the number of revision operations. Is the cost effectiveness of compu...

    Authors: Øystein Gøthesen, James Slover, Leif Havelin, Jan Erik Askildsen, Henrik Malchau and Ove Furnes
    Citation: BMC Musculoskeletal Disorders 2013 14:202
  42. Knowledge about the prevalence and consequences of osteoarthritis (OA) in the Norwegian population is limited. This study has been designed to gain a greater understanding of musculoskeletal pain in the genera...

    Authors: Nina ØsterÃ¥s, May Arna Risberg, Tore K Kvien, Lars Engebretsen, Lars Nordsletten, Dag Bruusgaard, Unni-Berit Schjervheim, Ida K Haugen, Hilde Berner Hammer, Sella Provan, Britt Elin Øiestad, Anne Grete Semb, Silvia Rollefstad, KÃ¥re Birger Hagen, Till Uhlig, Barbara Slatkowsky-Christensen…
    Citation: BMC Musculoskeletal Disorders 2013 14:201
  43. Reproducible and suitable animal models are required for in vivo experiments to investigate new biodegradable and osteoinductive biomaterials for augmentation of bones at risk for osteoporotic fractures. Sheep ha...

    Authors: Karina Klein, Enrico Zamparo, Peter W Kronen, Katharina Kämpf, Mariano Makara, Thomas Steffen and Brigitte von Rechenberg
    Citation: BMC Musculoskeletal Disorders 2013 14:200
  44. The Forkhead/Fox transcription factor Foxc2 is a critical regulator of osteogenesis and angiogenesis of cells. Bone marrow mesenchymal stem cells (BMSCs) have the capacity to differentiate into osteoblasts, ch...

    Authors: Wulin You, Hongwei Gao, Lihong Fan, Dapeng Duan, Chunsheng Wang and Kunzheng Wang
    Citation: BMC Musculoskeletal Disorders 2013 14:199
  45. Magnetic Resonance Imaging (MRI) is the gold standard for detailed visualisation of spinal pathological and degenerative processes, but the prevailing view is that such imaging findings have little or no clini...

    Authors: Rikke K Jensen, Tue S Jensen, Per Kjaer and Peter Kent
    Citation: BMC Musculoskeletal Disorders 2013 14:198
  46. Osteoporosis is a skeletal disease leading to an increased risk of bone fracture. Using a mouse osteoporosis model induced by administration of a receptor activator of nuclear factor kappa-B ligand (RANKL), sa...

    Authors: Hiroki Yokota, Kazunori Hamamura, Andy Chen, Todd R Dodge, Nancy Tanjung, Aysan Abedinpoor and Ping Zhang
    Citation: BMC Musculoskeletal Disorders 2013 14:197
  47. Although insomnia is common in patients with low back pain (LBP), it is unknown whether commonly used self-report sleep measures are sufficiently accurate to screen for insomnia in the LBP population. This stu...

    Authors: Saad M Alsaadi, James H McAuley, Julia M Hush, Delwyn J Bartlett, Nicholas Henschke, Ronald R Grunstein and Chris G Maher
    Citation: BMC Musculoskeletal Disorders 2013 14:196
  48. Low back pain is an important public health problem that is associated with poor quality of life and disability. Among the electrophysical treatments, interferential current (IFC) has not been studied in patie...

    Authors: Juliana Barbosa Corrêa, Leonardo Oliveira Pena Costa, Naiane Teixeira Bastos de Oliveira, Kathleen A Sluka and Richard Eloin Liebano
    Citation: BMC Musculoskeletal Disorders 2013 14:195

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