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  1. Activated platelets release serotonin that binds 5-HT2B receptor on fibroblasts leading to fibroblast activation. Clopidogrel, an inhibitor of ADP-dependent platelet activation prevents fibrosis in animal models ...

    Authors: Konstantinos Ntelis, Vasileios Gkizas, Alexandra Filippopoulou, Periclis Davlouros, Dimitrios Alexopoulos, Andrew P. Andonopoulos and Dimitrios Daoussis
    Citation: BMC Musculoskeletal Disorders 2016 17:213
    Content type: Research article Published on:

  2. This systematic review examines which patient related factors influence functional and clinical outcomes after total hip arthroplasty (THA) in patients with hip osteoarthritis (OA).

    Authors: Stefanie N. Hofstede, Maaike G. J. Gademan, Thea P. M. Vliet Vlieland, Rob G. H. H. Nelissen and Perla J. Marang-van de Mheen
    Citation: BMC Musculoskeletal Disorders 2016 17:212
    Content type: Research article Published on:

  3. Advanced osteoarthritis and total joint replacement (TJR) recovery are painful experiences and often prompt opioid use in developed countries. Physicians participating in the philanthropic medical mission Oper...

    Authors: Amy Yu, Christopher A. Devine, Rachel G. Kasdin, Mónica Orizondo, Wendy Perdomo, Aileen M. Davis, Laura M. Bogart and Jeffrey N. Katz
    Citation: BMC Musculoskeletal Disorders 2016 17:211
    Content type: Research article Published on:

  4. An anatomical reconstruction of the ankle congruity is the important prerequisite in the operative treatment of acute ankle fractures. Despite anatomic restoration patients regularly suffer from residual sympt...

    Authors: Mareen Braunstein, Sebastian F. Baumbach, Markus Regauer, Wolfgang Böcker and Hans Polzer
    Citation: BMC Musculoskeletal Disorders 2016 17:210
    Content type: Study protocol Published on:

  5. Duchenne muscular dystrophy (DMD) is an X-linked muscle disease that leads to fibre necrosis and progressive paralysis. At present, DMD remains a lethal disease without any effective treatment, requiring a bet...

    Authors: Florence Robriquet, Candice Babarit, Thibaut Larcher, Laurence Dubreil, Mireille Ledevin, Hélicia Goubin, Karl Rouger and Laëtitia Guével
    Citation: BMC Musculoskeletal Disorders 2016 17:209
    Content type: Research article Published on:

  6. Interleukin-17 plays important role in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to examine the associations between polymorphisms in the IL17A and IL17F genes and RA.

    Authors: Andrzej Pawlik, Daniel Kotrych, Damian Malinowski, Violetta Dziedziejko, Michal Czerewaty and Krzysztof Safranow
    Citation: BMC Musculoskeletal Disorders 2016 17:208
    Content type: Research article Published on:

  8. Farmers have an increased risk for musculoskeletal disorders (MSD) such as osteoarthritis of the hip, low back pain, and neck and upper limb complaints. The underlying mechanisms are not fully understood. Work...

    Authors: Bijar Ghafouri, Anders Carlsson, Sara Holmberg, Anders Thelin and Christer Tagesson
    Citation: BMC Musculoskeletal Disorders 2016 17:206
    Content type: Research article Published on:

  9. Peptidylarginine deiminase type 4 (PADI4) has been identified as a susceptibility gene for rheumatoid arthritis (RA) by genome-wide association studies. PADI4 is highly expressed in the bone marrow, macrophage...

    Authors: Akari Suzuki, Yuta Kochi, Hirofumi Shoda, Yu Seri, Keishi Fujio, Tetsuji Sawada, Ryo Yamada and Kazuhiko Yamamoto
    Citation: BMC Musculoskeletal Disorders 2016 17:205
    Content type: Research article Published on:

  10. Several posture evaluation devices have been used to detect deviations of the vertebral column. However it has been observed that the instruments present measurement errors related to the equipment, environmen...

    Authors: Debora Soccal Schwertner, Raul Oliveira, Giovana Zarpellon Mazo, Fabiane Rosa Gioda, Christian Roberto Kelber and Alessandra Swarowsky
    Citation: BMC Musculoskeletal Disorders 2016 17:204
    Content type: Research article Published on:

  11. Seligman’s theory of causal attribution predicts that patients with a pessimistic explanatory style will have less favorable health outcomes. We investigated this hypothesis using self-reported hip pain and hi...

    Authors: Jasvinder A. Singh, Robert C. Colligan, Megan M. O’Byrne and David G. Lewallen
    Citation: BMC Musculoskeletal Disorders 2016 17:203
    Content type: Research article Published on:

  12. Studies have shown a negative social gradient in the incidence of early retirement. To prevent undesired early retirement, there is a need for knowledge of specific predictors in addition to social factors wit...

    Authors: Lone Donbæk Jensen, Jens Peter Ellekilde Bonde, Michael Victor Christensen and Thomas Maribo
    Citation: BMC Musculoskeletal Disorders 2016 17:202
    Content type: Research article Published on:

  13. Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed for elderly patients, particularly after a hip fracture. However, we are not clear about the effect of NSAIDs on the risk of a second hi...

    Authors: Po-Yao Chuang, Shih-Hsun Shen, Tien-Yu Yang, Tsan-Wen Huang and Kuo-Chin Huang
    Citation: BMC Musculoskeletal Disorders 2016 17:201
    Content type: Research article Published on:

  14. Limb-girdle muscular dystrophies are characterized by predominant involvement of the shoulder and pelvic girdle and trunk muscle groups. Currently, there are 31 genes implicated in the different forms of limb-...

    Authors: Inna Inashkina, Eriks Jankevics, Janis Stavusis, Inta Vasiljeva, Kristine Viksne, Ieva Micule, Jurgis Strautmanis, Maruta S. Naudina, Loreta Cimbalistiene, Vaidutis Kucinskas, Astrida Krumina, Algirdas Utkus, Birute Burnyte, Ausra Matuleviciene and Baiba Lace
    Citation: BMC Musculoskeletal Disorders 2016 17:200
    Content type: Research article Published on:

  15. The neuropeptide calcitonin gene-related peptide (CGRP) has been described to have an inhibitory effect on endotoxin- and wear particle-induced inflammation in the early stages of periprosthetic osteolysis. In...

    Authors: Heidrun Jablonski, Heike Rekasi and Marcus Jäger
    Citation: BMC Musculoskeletal Disorders 2016 17:199
    Content type: Research article Published on:

  16. Total Hip Replacement (THR) is an effective treatment for end-stage hip osteoarthritis. Since the introduction of total joint replacement, the effect on the Sexual Quality of Life (SQoL) following THR has been...

    Authors: Rita Th. E. Harmsen, Tsjitske M. Haanstra, Inger N. Sierevelt, Elise P. Jansma, Peter A. Nolte, Melianthe P. J. Nicolai, Peter D. H. Wall and Barend J. Van Royen
    Citation: BMC Musculoskeletal Disorders 2016 17:198
    Content type: Research article Published on:

  17. Both musculoskeletal pain-intensity in relation to a specific location (e.g. lower back or shoulder) and pain in multiple body regions have been shown to be associated with impaired function and sickness absen...

    Authors: Søren Mose, David Høyrup Christiansen, Jens Christian Jensen and Johan Hviid Andersen
    Citation: BMC Musculoskeletal Disorders 2016 17:197
    Content type: Research article Published on:

  18. Lateral hip pain is common, particularly in females aged 40–60 years. The pain can affect sleep and daily activities, and is frequently recalcitrant. The condition is often diagnosed as trochanteric bursitis, ...

    Authors: Rebecca Mellor, Alison Grimaldi, Henry Wajswelner, Paul Hodges, J. Haxby Abbott, Kim Bennell and Bill Vicenzino
    Citation: BMC Musculoskeletal Disorders 2016 17:196
    Content type: Study protocol Published on:

  19. A substantial portion of women diagnosed with osteoporosis (OP) do not initiate pharmacotherapy to reduce fracture risk. In clinical practice, gastrointestinal (GI) events have been linked with OP therapy disc...

    Authors: Bernard Cortet, Ankita Modi, Jackson Tang, Chun-Po Steve Fan, Shiva Sajjan and Jessica Papadopoulos Weaver
    Citation: BMC Musculoskeletal Disorders 2016 17:195
    Content type: Research article Published on:

  20. Chronic multiple-site joint pain (MSJP) is common in older people and associated with poor outcomes, yet under-researched. Our aim was to detail the clinical characteristics of people with MSJP and their utili...

    Authors: Rafi Raja, Bright Dube, Elizabeth M. A. Hensor, Sarah F. Hogg, Philip G. Conaghan and Sarah R. Kingsbury
    Citation: BMC Musculoskeletal Disorders 2016 17:194
    Content type: Research article Published on:

  21. Recent studies clearly characterize the anatomical parameters of the knee anterolateral ligament (ALL). The potential clinical importance of this ligament is exemplified by some patients with possible combined...

    Authors: Camilo Partezani Helito, Marcelo Batista Bonadio, João Stefan Rozas, João Marcelo Pedroso Wey, Cesar Augusto Martins Pereira, Tulio Pereira Cardoso, José Ricardo Pécora, Gilberto Luis Camanho and Marco Kawamura Demange
    Citation: BMC Musculoskeletal Disorders 2016 17:193
    Content type: Research article Published on:

  22. We examined the effects of fat deposition on radiographic osteoarthritis (OA) to determine the role of obesity in the pathogenesis of radiographic OA.

    Authors: Lihui Wen, Ji-Hyoun Kang, Yi-Rang Yim, Ji-Eun Kim, Jeong-Won Lee, Kyung-Eun Lee, Dong-Jin Park, Tae-Jong Kim, Yong-Wook Park, Sun-Seog Kweon, Young-Hoon Lee, Yong-Woon Yun, Min-Ho Shin and Shin-Seok Lee
    Citation: BMC Musculoskeletal Disorders 2016 17:192
    Content type: Research article Published on:

  23. Herniated discs may exhibit calcification, and calcified discs may complicate surgical treatment. However, the osteogenic potential and expression of osteogenic markers in degenerative discs of different degen...

    Authors: Jia Shao, Miao Yu, Liang Jiang, Feng Wei, Fengliang Wu, Zhongjun Liu and Xiaoguang Liu
    Citation: BMC Musculoskeletal Disorders 2016 17:191
    Content type: Research article Published on:

  24. Carpal tunnel syndrome (CTS) causes a substantial burden of disease in society. While CTS can be resolved by surgical carpal tunnel release, it still remains unclear as to what degree outcomes depend on patien...

    Authors: Catharina Conzen, Michael Conzen, Nicole Rübsamen and Rafael Mikolajczyk
    Citation: BMC Musculoskeletal Disorders 2016 17:190
    Content type: Research article Published on:

  25. Though several studies have reported the incidence of intraspinal neural axis abnormalities in infantile and juvenile “presumed idiopathic” scoliosis, there has been a varying prevalence ranging from 11.1 to 2...

    Authors: Wen Zhang, Shifu Sha, Leilei Xu, Zhen Liu, Yong Qiu and Zezhang Zhu
    Citation: BMC Musculoskeletal Disorders 2016 17:189
    Content type: Research article Published on:

  26. Cross-linked hyaluronan—also called Hylan G-F 20—is a medical device developed to treat osteoarthritis of the knee. However, it is still controversial whether Hylan G-F 20 has a cartilage protective effect in ...

    Authors: Katsuaki Yanagisawa, Takeshi Muneta, Nobutake Ozeki, Yusuke Nakagawa, Mio Udo, Ryusuke Saito, Hideyuki Koga, Kunikazu Tsuji and Ichiro Sekiya
    Citation: BMC Musculoskeletal Disorders 2016 17:188
    Content type: Research article Published on:

  27. Adolescent idiopathic scoliosis (AIS) surgery usually require prolonged operative times with extensive soft tissue dissection and significant perioperative blood loss, and allogeneic blood products are frequen...

    Authors: Wen-yuan Sui, Fang Ye and Jun-lin Yang
    Citation: BMC Musculoskeletal Disorders 2016 17:187
    Content type: Research article Published on:

  28. Previous studies showed that among persons with radiographic knee OA, periarticular lesions were significantly more common among participants with knee pain than those without. However, data were derived mostl...

    Authors: In Je Kim, Dong Hyun Kim, Yeoung Wook Song, Ali Guermazi, Michel D. Crema, David J. Hunter, Young-Il Seo and Hyun Ah Kim
    Citation: BMC Musculoskeletal Disorders 2016 17:186
    Content type: Research article Published on:

  29. Arthroplasty is a proven treatment option for glenohumeral osteoarthritis. Common indications include primary or posttraumatic osteoarthritis, avascular necrosis of the humeral head, rotator cuff tear arthropa...

    Authors: Tobias Peter Merkle, Nicholas Beckmann, Tom Bruckner and Felix Zeifang
    Citation: BMC Musculoskeletal Disorders 2016 17:185
    Content type: Case report Published on:

  31. Closed drainage after primary total knee arthroplasty (TKA) has been used routinely for many decades, but controversies have arisen in recent years. The purposes of this study were to compare the clinical outc...

    Authors: Hai-bo Si, Ti-min Yang, Yi Zeng and Bin Shen
    Citation: BMC Musculoskeletal Disorders 2016 17:183
    Content type: Research article Published on:

  32. In spite of the increasing incidence of total knee arthroplasties (TKA), evidence is limited regarding risk factors for revision. The objective of this scoping review was to identify and assess demographic, su...

    Authors: L.L. Jasper, C. A. Jones, J. Mollins, S. L. Pohar and L. A. Beaupre
    Citation: BMC Musculoskeletal Disorders 2016 17:182
    Content type: Research article Published on:

  33. Very few studies have investigated differences in musculoskeletal health due to gender in a large rural population. The aim of this study is to investigate factors affecting musculoskeletal health in terms of ...

    Authors: J. M. Brismée, S. Yang, M. E. Lambert, M. C. Chyu, P. Tsai, Y. Zhang, J. Han, C. Hudson, Eunhee Chung and C. L. Shen
    Citation: BMC Musculoskeletal Disorders 2016 17:181
    Content type: Research article Published on:

  34. A tenosynovial giant cell tumor (T-GCT) is a benign synovial tumor arising from the synovium, bursae, or tendon sheath. It can be intra- or extra-articular and localized or diffuse. Diffuse T-GCT is considered...

    Authors: Akihiko Takeuchi, Norio Yamamoto, Katsuhiro Hayashi, Shinji Miwa, Masayuki Takahira, Kiyokazu Fukui, Taku Oikawa and Hiroyuki Tsuchiya
    Citation: BMC Musculoskeletal Disorders 2016 17:180
    Content type: Case report Published on:

  35. Cognitive behavioural therapy (CBT) has been shown to improve outcomes for patients with fibromyalgia, and its cardinal feature chronic widespread pain (CWP). Prediction models have now been developed which id...

    Authors: Gary J. Macfarlane, Marcus Beasley, Gordon Prescott, Paul McNamee, Philip Keeley, Majid Artus, John McBeth, Philip Hannaford, Gareth T. Jones, Neil Basu, John Norrie and Karina Lovell
    Citation: BMC Musculoskeletal Disorders 2016 17:179
    Content type: Study protocol Published on:

  36. A few studies have documented associations between socioeconomic position and gait speed, but the knowledge about factors from various domains (personal factors, lifestyle, occupation…) which contribute to the...

    Authors: S. Plouvier, M. Carton, D. Cyr, S. Sabia, A. Leclerc, M. Zins and A. Descatha
    Citation: BMC Musculoskeletal Disorders 2016 17:178
    Content type: Research article Published on:

  37. Injury incidence and prevalence in running populations have been investigated and documented in several studies. However, knowledge about injury etiology and prevention is needed. Training errors in running ar...

    Authors: Daniel Ramskov, Rasmus Oestergaard Nielsen, Henrik Sørensen, Erik Parner, Martin Lind and Sten Rasmussen
    Citation: BMC Musculoskeletal Disorders 2016 17:177
    Content type: Study protocol Published on:

  38. Manual therapy as spinal manipulation, spinal mobilization, stretching and massage are common treatment methods for neck and back pain. The objective was to compare the treatment effect on pain intensity, pain...

    Authors: Kari Paanalahti, Lena W. Holm, Margareta Nordin, Jonas Höijer, Jessica Lyander, Martin Asker and Eva Skillgate
    Citation: BMC Musculoskeletal Disorders 2016 17:176
    Content type: Research article Published on:

  39. There is limited evidence to guide treatment for pediatric cervical spinal tuberculosis with kyphosis (PCSTK). This study retrospectively evaluates the safety, feasibility and efficacy of 360-degree arthrodesi...

    Authors: Hao Zeng, Xiongjie Shen, Chengke Luo, Zhengquan Xu, Yupeng Zhang, Zheng Liu, Xiyang Wang and Yong Cao
    Citation: BMC Musculoskeletal Disorders 2016 17:175
    Content type: Research article Published on:

  40. Wear-induced osteolysis is the main factor in reducing the longevity of total hip arthroplasty (THA). The transmembrane Receptor Activator of Nuclear Factor κ B (RANK) and its corresponding ligand RANKL is an ...

    Authors: Olof Sköldenberg, Agata Rysinska, Thomas Eisler, Mats Salemyr, Henrik Bodén and Olle Muren
    Citation: BMC Musculoskeletal Disorders 2016 17:174
    Content type: Study protocol Published on:

  41. In-hospital progressive resistance training (PRT) has been shown to be an effective method of rehabilitation following hip surgery. The aim of this study was to assess whether a home-based PRT program would be...

    Authors: Tosan Okoro, Rhiannon Whitaker, Andrew Gardner, Peter Maddison, John G. Andrew and Andrew Lemmey
    Citation: BMC Musculoskeletal Disorders 2016 17:173
    Content type: Research article Published on:

  42. Rheumatoid arthritis (RA) is an autoimmune disease which causes significant pain, joint deformity, functional disability. The pathological hallmark of RA is inflammation of the synovium characterized by involv...

    Authors: Maria Filkova, Andrew Cope, Tim Mant and James Galloway
    Citation: BMC Musculoskeletal Disorders 2016 17:172
    Content type: Debate Published on:

  43. Work disability following motor vehicle related orthopaedic trauma is a significant contributor to the burden of injury and disease. Early identification of predictors for return to work (RTW) is essential for...

    Authors: Darnel F. Murgatroyd, Ian A. Harris, Yvonne Tran and Ian D. Cameron
    Citation: BMC Musculoskeletal Disorders 2016 17:171
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2016 17:229

  44. Incidental durotomy is a well-known complication during surgery for degenerative lumbar spinal stenosis (DLSS). In this prospective multicenter cohort study including eight medical centers our aim was to asses...

    Authors: Nils H. Ulrich, Jakob M. Burgstaller, Florian Brunner, François Porchet, Mazda Farshad, Giuseppe Pichierri, Johann Steurer and Ulrike Held
    Citation: BMC Musculoskeletal Disorders 2016 17:170
    Content type: Research article Published on:

  45. Gout is the most common type of inflammatory arthritis and is largely managed in primary care. It classically affects the first metatarsophalangeal joint and distal peripheral joints, whereas the axial joints ...

    Authors: Megan Bevis, Michelle Marshall, Trishna Rathod and Edward Roddy
    Citation: BMC Musculoskeletal Disorders 2016 17:169
    Content type: Research article Published on:

  47. Although self-assessment questionnaires for the wrist joint are numerous, most validation studies focus on a specific pathology and patient collectives. In addition the available questionnaires focus on subjec...

    Authors: Marc Beirer, Julian Serly, Helen Vester, Dominik Pförringer, Moritz Crönlein, Stephan Deiler, Peter Biberthaler and Chlodwig Kirchhoff
    Citation: BMC Musculoskeletal Disorders 2016 17:167
    Content type: Research article Published on:

  48. The Western Ontario Rotator Cuff Index (WORC) is a widely used instrument to measure quality of life in patients with subacromial pain or rotator cuff syndrome.

    Authors: Soheila Zhaeentan, Markus Legeby, Susanne Ahlström, André Stark and Björn Salomonsson
    Citation: BMC Musculoskeletal Disorders 2016 17:165
    Content type: Research article Published on:

  49. C1 posterior arch screw placement is one of the most effective treatments for atlantoaxial instability (AAI), which can be performed by either pedicle or lateral mass screw fixation. This study attempted to co...

    Authors: Liang Yan, Baorong He, Tuanjiang Liu, Lixue Yang and Dingjun Hao
    Citation: BMC Musculoskeletal Disorders 2016 17:164
    Content type: Research article Published on:

  50. Solitary bone cysts (SBC) are benign, tumor-like lesions, which most frequently occur in the proximal metaphyseal-diaphyseal region of the humerus and femur of children and adolescents. The lack of a clear pat...

    Authors: Frank Traub, Oliver Eberhardt, Fransico F. Fernandez and Thomas Wirth
    Citation: BMC Musculoskeletal Disorders 2016 17:162
    Content type: Research article Published on:
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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