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Table 2 Differences in baseline characteristics of patients included in the study regarding syndesmophyte status

From: Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis

Variable

Syndesmophytes

No syndesmophytes

p Value

Sex, n ♂ / n ♀

38 / 2

22 / 22

 < 0.001

Age in years, mean (± SD)

62 (± 12)

56.2 (± 13.6)

0.004

Body mass index in kg/m2, mean (± SD)

30.7 (± 4.5)

27.3 (± 4.4)

0.001

Treatment with NSAIDs / biologics, n (%;95% CI)

22 (55; 39.5, 69.8) / 18 (45; 30.2, 60.5)

21 (47.7; 33.3, 62.4) / 23 (52.3; 37.6, 66.6)

0.505

Disease duration in range of years, n (%;95% CI)

     > 10 years

     5–10 years

      < 5 years

27 (67.5; 51.9, 80.6)

9 (22.5; 11.6; 37.3)

4 ( 10; 3.26, 22.4)

28 (63.6; 48.7, 76.8)

8 (18.2; 8.8, 31.6)

8 (18.2; 8.8, 31.6)

0.543

    BASDAI, mean (± SD) (n = 22/30)

3.8 (± 2.3)

3.6 (± 2.2)

0.651

    BASFI, mean (± SD) (n = 23/29)

4.7(± 2)

3.9 (± 2.6)

0.225

    ASDAS, mean (± SD) (n = 18/20)

2.7 (± 0.9)

2.7 (± 0.8)

0.842

    CRP mg/L, median (IQR)

5 (48)

5 (53)

0.731

    ESR mm/h, median (IQR)

10 (57)

8 (50)

0.435

    25-OH-D ng/dL, median (IQR) (n = 38/40)

23 (66)

24.5 (55)

0.339

    Blood calcium mg/dL, mean (± SD) (n = 38/38)

9.37 (± 0.3)

9.33 (± 0.39)

0.669

    24-h urinary calcium, median (IQR) (n = 18/15)

125 (317)

145 (381)

0.448

    PTH pg/mL, median (IQR) (n = 23/17)

47 (107)

49 (65)

0.891

    ALP UI/L, median (IQR) (n = 31/39)

73 (180)

71 (77)

0.242

    β-CTX pg/mL, median (IQR) (n = 23/22)

352 (901)

396.5 (522)

0.394

    TBS values median (IQR) (n = 39/42)

1.31 (0.58)

1.33 (0.8)

0.187

    Lumbar spine BMD values mean (± SD)

1.37 (± 0.26)

1.14 (± 0.22)

 < 0.001

    Total hip BMD values mean (± SD) (n = 38/43)

0.99 (± 0.17)

0.96 (± 0.16)

0.463

    Femoral neck BMD values mean (± SD) (n = 38/43)

0.88 (± 0.14)

0.87 (± 0.14)

0.820

  1. n number of patients, SD standard deviation, IQR interquartile range, NSAIDs nonsteroidal anti-inflammatory drugs, CI confidence interval, BASDAI Bath Ankylosing Spondylitis Disease Activity Index, BASFI Bath Ankylosing Spondylitis Disease Functional Index, ASDAS Ankylosing Spondylitis Disease Activity Score, CRP C-reactive protein, ESR erythrocyte sedimentation rate, 25-OH-D 25-hydroxy vitamin D, PTH parathyroid hormone, ALP alkaline phosphatase, β-CTX β-CrossLaps (β-CTX), TBS trabecular bone score, BMD bone mineral density. Mean and standard deviation have been described for variables showing normal distribution and median and interquartile range for variables showing not normal distribution