Skip to main content

Use of Teriparatide in preventing delayed bone healing and nonunion: a multicentric study on a series of 20 patients



Delayed bone healing and nonunions represent a great challenge for the orthopedic surgeon. In addition to traditional surgical approaches, increasing attention is being given to the use of systemic anabolic therapy with Teriparatide, whose efficacy in preventing osteoporotic fractures is widely validated and whose application as a promoter of bone healing has been described but it is still debated. The aim of the study was to evaluate bone healing in a series of patients with delayed unions or nonunions treated with Teriparatide in conjunction with eventual appropriate surgical procedure.


Twenty patients with an unconsolidated fracture that were treated at our Institutions from 2011 to 2020 with Teriparatide were retrospectively included into the study. The pharmacological anabolic support was used off-label with a planned duration of 6 months; radiographic healing was evaluated at 1-, 3- and 6-months follow-up outpatient visits over plain radiographs. Also, eventual side-effects were registered.


Radiographic signs indicative of favorable evolution of the bone callus were observed as early as at 1 month of therapy in 15% of cases; at 3 months, healing progression was appreciated in 80% of cases and complete healing in 10%; at 6 months, 85% of delayed and nonunions had healed. In all patients, the anabolic therapy was well tolerated.


In accordance to Literature, this study suggests that Teriparatide plays a potentially important role in the treatment of some forms of delayed unions or nou-nions, even in the presence of failure of hardware. The results suggest a greater effect of the drug when associated with a condition in which the bone is in an active phase of callogenesis, or with a “revitalizing” treatment which represents a local (mechanical and/or biological) stimulus to the healing process. Despite the small sample size and the variety of cases, the efficacy of Teriparatide in treating delayed unions or nonunions emerged, highlighting how this anabolic therapy can represent a useful pharmacological support in the treatment of such a pathology. Although the results obtained are encouraging, further studies, particularly prospective and randomized, are needed to confirm the efficacy of the drug, and define a specific treatment algorithm.

Peer Review reports


Delayed bone healing and nonunion represent today some of the greatest challenges for orthopedic surgeons [1, 2]. Nonunion of bone is the body's inability to heal a fracture. The most agreed-upon standard definition of nonunion made by the Food and Drug Administration (FDA) is a fracture that persists for a minimum of nine months without signs of healing for three months [3, 4]. In addressing these issues, in addition to traditional surgical approaches, increasing attention is being paid to the possibility of using systemic anabolic therapy with Teriparatide. Teriparatide is the synthetic recombinant 1–34 N-terminal peptide of human parathyroid hormone, approved by the FDA for its effect in the treatment of osteoporosis as in increasing the bone mass and in preventing osteoporotic bone fractures [5,6,7]. While the use and the efficacy of Teriparatide in this field is widely validated, its use as a promoter of fracture healing and in the prevention of complications has been proposed and it is still debated [1, 8,9,10].

Numerous studies conducted both in vitro and in vivo in animal models have shown a positive effect of this drug with improvement in both the volume and mineralization of bone callus, as well as an increase in the mechanical strength of the bone [11,12,13,14]. Despite the lack of randomized controlled trials in humans, there is a growing presence in the Literature of case reports and case series that highlight a potentially important role in the treatment of some forms of delayed union and nonunions, also in the presence of failed hardware, as well as complex fractures [15, 16] particularly where bone metabolism is compromised [17,18,19,20].

The aim of this paper is to present the results of a series of patients with delayed unions and nonunions treated with Teriparatide associated with eventual appropriate surgical procedure in two Hospitals. At both our Institutions, no Institutional Review Board nor Ethical Committee Approval is necessary for retrospective studies. Patients gave their consent to data collection and anonymous use of them for scientific and teaching purposes.

Materials and methods

In 2011 at the University Hospital of Pisa, the administration of Teriparatide to patients with a variety of pathologies (difficult-to-treat fractures, fractures in patients with suspected or diagnosed impaired bone biology, aseptic or sterilized delayed bone healing or nonunions) different from registered indications for the drug was started [11, 14]. Same approach was introduced at the University Hospital of Siena in 2016 [15, 16, 21]. No Ethical Committee approval is necessary for such a sporadic off-label use of already registered drugs at both Institutions. Such a prescription is made under direct medical responsibility previous patient’s information and consent. From the combined and shared database of patients undergoing off-label administration of Teriparatide, a retrospective extrapolation of patients treated between 2011 and December 2020 for unconsolidated fractures with delayed unions or nonunions was conducted. Inclusion criteria for the present study were diagnosis of delayed unions or nonunions after surgical treatment for fractures of long bones done at our Institutions, patients adult of age and sound of mind, and completion of a 6-months follow-up period. Exclusion criteria were delayed unions or nonunions of short bones, infection as a cause (or a contributing cause) of the pathology, patients with history of active or previous oncologic disease, primary hyperparathyroidism, and other contraindications as on the drug data sheet.

Patients’ past and present medical history was assessed, with particular attention to the presence of osteoporosis, diabetes and history of previous fracture(s), which all represent important risk factors for fractures and nonunions [22,23,24]. Smoking and alcohol abuse, as well as current medical therapies, were also assessed. In particular, drugs with potential action on bone metabolism such as bisphosphonates (BPs) and glucocorticoids (GCs) were considered in order to evaluate any risk factors for delays in bone healing [25,26,27].

All patients were subjected to a full panel of blood tests and were studied for phosphocalcic metabolism (Table 1). Also, mineralometric evaluation was conducted in all patients. Before starting treatment, written informed consent was acquired from all patients, specifically with regards to the off-label use of the drug, and data were prospectively collected in a database. Teriparatide dosing schedule consisted in 20 μg/day subcutaneously [28], until bone healing would have occurred, and for a maximum of 24 months [29, 30] In addition, all patients received supplementary vitamin D with variable dosage with respect to blood levels. Calcium supplement was prescribed when dietary introduction was considered insufficient (less than 1.000 mg per day).

Table 1 Suggested “short” phosphocalcic metabolic panel, including only blood testing without any precise preparation nor a 24-h urine collection

All patients were assessed at 1, 3, and 6 months after the start of the therapy with Teriparatide. Plain radiographs in the antero-posterior and lateral views were obtained at each outpatient visit and were independently evaluated in each center. New bone appearance at cortical site were considered, and fracture healing was defined in accordance with the modified radiographic union scale in tibial fractures (mRUST) score [31,32,33].

Statistical analysis was performed with the Mann–Whitney U test and the Kruskal–Wallis ANOVA, used for continuous parameters, and the Fisher’s exact test with the Freeman-Halton extension, used for categorical parameters. The significance level was set at p < 0.05; p was reported as not significant (n.s.) in text and with exact values in tables. All data were elaborated with XlsStat 2020 software (Addinsoft, New York City, NY) for MS Excel (Microsoft, Seattle, WA, USA).


Twenty patients met the inclusion criteria: there were 12 males (60%) and 8 females (40%) with a mean age ± standard deviation at intervention of 55.3 ± 20.9 years (range 18–82 years). Pathology was localized to the lower limb in 16 cases (80%) including 13 to the femur, and 3 to the tibia, and to the upper limb in 4 cases (20%) including 1 to the humerus and 3 to the forearm. Patients demographics and clinical data are shown in Table 2. Differences were identified among subgroups, with regards to demographics and comorbidities. There was a statistically significant difference between the mean ages of males (46.8 ± 19.3 years) and females (68.0 ± 17.0 years) (p = 0.025), and in the prevalence of osteoporosis between genders with a higher frequency in females (p = 0.0007). When comparing the mean ages of patients with and without comorbidities (smoke, alcohol abuse, diabetes, previous fractures, osteoporosis), the difference became statistically significant only when considering osteoporosis (73.5 ± 11.1 vs 47.4 ± 19.2, p = 0.0065) (Table 3). Delayed union was present in 95% of cases (19 out of 20 patients), while in one case a nonunion of an atypical femoral fracture was present. The average time interval between index fracture and the start of treatment with Teriparatide was 8.9 (range 2 – 27) months. When considering the time elapsed between the last procedure received, also intended as hardware breakage or failure as from a biomechanical point of view could be considered equivalent to an “auto-dynamization” of the fracture, and the start of therapy, a minimum time of 7 days and a maximum of 7 months was observed.

Table 2 Patients’ demographic and clinical details, treatment modalities and outcomes
Table 3 Differences between subgroups showing statistical differences in mean age of patients regarding to gender (male younger than females) and to osteoporosis (patients affected by osteoporosis older than non-affected ones)

At the time of the index fracture, 4 patients had already been treated with BPs which were discontinued before starting the treatment with Teriparatide. Hypovitaminosis D (25-hydroxyvitamin D less than 20 ng/mL) was found in 6 out of 20 patients (30%) before the start of therapy with Teriparatide. All patients were corrected by calcifediol or cholecalciferol oral supplementation [34,35,36]. Serum calcium and phosphorus levels did not change significantly, nor did blood creatinine levels during the entire treatment period. Mineralometric evaluation showed values ​​compatible with osteoporosis in 6 patients (30%) and with osteopenia in one patient (5%), and normal values in 13 patients (65%). The duration of therapy with Teriparatide ranged from 3 to 24 months, with a mean period of 6.6 ± 5.3 months. The median time to healing was 5.2 ± 1.1 months when considering patients healed within 6 months of starting therapy, and 6.3 ± 4.4 when considering all the patients recovered. Taking into consideration the patients’ gender, a non-statistically difference in the median time to healing was highlighted: 5.0 ± 1.2 months for men and 8.0 ± 6.5 months for women.

After 1 month of therapy, radiographic signs of favorable evolution were observed in 3 cases (15%), while no cases showed complete bone healing. At 3 months of therapy, complete fracture healing was observed in 2 patients (10%), partial improvement in 16 patients (80%), and no or poor improvement in 2 patients (10%). At 6 months, plain radiographs showed partial improvement in 3 patients (15%) and complete healing in 17 patients (85%) (p < 0.0001). Differences in bone healing were found with regard to gender of patients, although not statistically significant: 7 out of 8 females (87.5%) showed an improvement in the healing process but no case of complete healing at 3 months of therapy, while among males 2 out of 12 (16.7%) radiologically healed after 3 months of therapy (p = n.s.). At 6 months of therapy, 11 males (91.7%) completely healed while only 6 females (75%) did (p = n.s.). Also, some differences in the healing process were observed when considering comorbidities, but they were not statistically significant. Between osteoporotic patients (all females), none underwent complete recovery in the first three months of therapy but 5 out of 6 (83.3%) had a partial improvement (p = n.s.), while at 6 months 5 patients (83.3%) fully healed (p = n.s.). Out of the 10 patients with a history of previous fracture(s), 8 (80%) experienced a partial improvement and one (10%) achieved radiographic healing after 3 months of therapy (p = n.s.). At 6 months, 8 patients (80%) had healed (p = n.s.). All the smokers (7 patients) showed a partial improvement in the first 3 months of therapy (one of them was deemed radiographically healed) (p = n.s.), while at 6 months only one smoker (14.3%) had not yet completely healed (p = n.s.). Only one out of the 2 (50%) patients with a history of alcohol abuse showed an improvement in the pathological condition after the first 3 months of therapy (p = n.s.), but both healed completely after 6 months of therapy (p = n.s.).

Lastly, with regards to patients’ age, the mean age of the subjects who showed partial improvement in the first 3 months of therapy was 54.1 ± 21.8 years, while in the subjects who did not improve the mean age was 74.5 ± 4.9 years, and in those who were deemed radiographically healed the mean age was 45.5 ± 12.0 years (p = n.s.). At 6 months, patients who recovered had an average age of 52.0 ± 20.9 years, while those who did not undergo radiographic recovery had an average age of 73.7 ± 4.7 years (p = n.s.). In all patients, therapy was well tolerated, and no treatment interruptions were necessary due to the occurrence of side effects. Results are recapped in Tables 3, and 4 cases are shown in Figs. 1, 2 and  3.

Table 4 Radiographic results of the healing process at 1, 3 and 6 months after the start of therapy with Teriparatidea in the study group
Fig. 1
figure 1

A case of a 45 years-old female who suffered from proximal femur fracture in a polytrauma scenario treated with urgent damage control (A) and subsequent cephalomedullary nailing (B), who experienced hardware breakage (C) at 4 months from surgery.  Teriparatide was administered and bone healing was evident at 6 months (D)

Fig. 2
figure 2

A case of a 50 years-old male who suffered from an open fracture of the right leg (A), treated with external fixation (B). Dynamization of the external fixator at 2 months from surgery and start of Teriparatide (C). Radiographic assessment after 3 months of therapy showed complete healing (D)

Fig. 3
figure 3

A case of a 51 years-old female who suffered from a peri-implant fracture of the left femur (A), who underwent revision surgery (B). Delayed union at 3 months from surgery (C) and start of Teriparatide. Complete healing at 3 months therapy (D)

Of the 3 patients who did not completely heal at 6 months, one patient with an oligosymptomatic nonunion of the tibia over an intramedullary nail was lost to follow-up at 1-year, a patient with an oligosymptomatic nonunion of the humerus prosecuted therapy for 24 months, with follow-up visits at 6-months interval, and eventually the fracture radiographically healed at last radiographical control. The last patient required re-intervention for a symptomatic nonunion of the distal femur with malalignment.


In general, about 5–10% of all fractures fail to heal, developing a nonunion whose symptomatology depends on various aspects, including patient’s level of activity and deambulatory status, other than the specific pattern of nonunion. A larger number of cases present delayed consolidation [34]. Both complications are the macroscopic expression of a lack of biological efficiency in bone healing process, the presence of a mechanical impairment, or both. They represent a major challenge for the orthopedic surgeon, also demonstrating a negative impact on health economics [37, 38]. The bone healing mechanism is triggered by a cascade of multiple factors that interact with each other [39]. Some of these are patient-dependent, such as age, osteoporosis, menopause, smoking, alcohol abuse and the use of drug such as BPs or GCs, but others depend on the trauma in its complexity and on the stability of fixation obtained [33].

Over time, many osteoporotic medications have been studied in bone healing, in delayed unions and nonunions [40]. Nowadays is largely validated, both in animal studies and in vitro, the use of Teriparatide as an anabolic drug effective in improving bone performance and preventing fractures in the osteoporotic patient. In accordance with recent Literature, it can also provide an extra weapon to the orthopedic surgeon who deals with fractures at risk of non-consolidation or nonunions, for the above-mentioned reasons [41,42,43].

The present study confirms the positive effect of Teriparatide in improving bone healing. In our previous experience [11, 15, 37], Teriparatide showed its maximum efficacy if associated with a stimulus that induces the revitalization of the healing process, such as re-intervention to refresh the nonunion site, dynamization in elastic construct (intramedullary nailing or external fixator), or even the failure with rupture of internal hardware that biomechanically represents a “self-dynamization” of the fracture [44]. Also, the use of pulse electromagnetic fields had shown a positive effect in improving bone healing in deleyed unions and nonunions [45]. However, Teriparatide seemed to be effective even in cases in which bone did not received any local mechanical or biological stimulus, if it is started early after surgery. In all cases in which we had early recovery at 3 months, Teriparatide had in practice been started immediately 7 days after the stimulus.

Current Literature suggests that there is no reason to believe that Teriparatide could only be effective in specific bones. However, in accordance with Literature where most case-reports concern the use of Teriparatide in long bones, we also used the drug in these types of fractures. This probably reflects the fact that delayed and nonunion is more common in long bones [46].

Compared with the use of Teriparatide in osteoporosis, where it is administered for a maximum duration of 2 years to maximize the anabolic effect of the drug, the use in bone healing after a fracture has been suggested for shorter periods. At 3 months of therapy, 80% of our patients showed a radiographic improvement, while 85% of patients had radiographically healed at 6 months. There was no need to prosecute the therapy in healed patients, except than in those with concomitant osteoporosis. In Literature, although the ideal duration of treatment depends on individual patients’ factors and the personality of the fracture, the duration of therapy is typically described to last between 2 and 9 months on average [17]. Regarding the maximum duration of treatment, however, since the use of Teriparatide for osteoporosis is only approved for a total duration of 24 months, it seems reasonable to apply this limit even in the off-label uses of this drug.

Several metabolic abnormalities have been associated with impaired fracture healing; most of them directly affect bone metabolism during the healing process and may have a prevalence of up to 50% in certain populations [47]. For this reason, a study of the phosphocalcic metabolism prior to the prescription of Teriparatide is mandatory, to identify and correct any eventually present abnormality such as hypovitaminosis D, other than to exclude potential contraindications to its administration. All contraindications reported in the drug data sheet were observed. Moreover, because of the proposed use was an off-label indication, we broadened exclusion criteria (infections and previous oncologic diseases not affecting bone) for higher safety.

As for the union rate, in the present study bone healing occurred in 85% at 6 months and in 95% at 24 months, comparing to existing literature that suggest union rate as high as 95% [36]. Also, in the present study it appears that bone healing was achieved in shorter time in male patients; however, it must be taken into consideration that mean age among females was higher that among males. Moreover, among elderly abnormal bone metabolism and compromised bone healing are often present and can be considered predisposing factors of delayed healing [48, 49]. Despite the small sample size, no significant difference between patients affected or not by prior fractures was observed; no difference emerged between smokers and nonsmokers either, nor in relation to alcohol abuse. Lastly, no adverse events were reported, in accordance with the review of Canintika who concluded that Teriparatide application in nonunions and delayed unions is safe [38].

Limitations are present in the current study. It is a retrospective study with a limited number of patients with miscellaneous district of nonunions and non-homogeneous characteristic. It may be difficult to correctly generalize the data obtained because of the small sample size. Moreover, the low patients’ number limits the power of the statistical analysis performed, and as a result, differences that could otherwise be identified in a larger sample have not necessarily been detected.


When a fracture shows signs of difficulty in healing in time (delayed union) or in cases of overt nonunion, all available surgical and non-surgical treatment strategies need to be employed. Among the latter, systemic anabolic support with Teriparatide has already proved its effectiveness, and the present study confirms the positivity of this trend in the Literature. From our experience, a greater effect of the drug emerges when associated with a condition in which the bone is in an “active” phase of callogenesis, linked to a revitalizing treatment such as a re-intervention or dynamization, which represents a local mechanical and biological stimulus to the healing process.

Despite the low number of patients involved, this study showed a significant improvement in the pathological condition of subjects suffering from nonunion during the months of treatment with Teriparatide, highlighting how this therapy can play a leading role in the treatment of this pathology. Although the results obtained are encouraging, further studies, particularly prospective and randomized, are necessary to confirm the efficacy of the drug and define a specific treatment algorithm.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.


  1. Tzioupis C, Giannoudis PV. Prevalence of long-bone non-unions. Injury. 2007;38(Suppl 2):S3–9.

    Article  PubMed  Google Scholar 

  2. Hak DJ, Fitzpatrick D, Bishop JA, et al. Delayed union and nonunions: epidemiology, clinical issues, and financial aspects. Injury. 2014;45 Suppl 2(SUPPL. 2).

  3. Cunningham BP, Brazina S, Morshed S, Miclau T. Fracture healing: A review of clinical, imaging and laboratory diagnostic options. Injury. 2017;48:S69–75.

    Article  PubMed  Google Scholar 

  4. Perisano C, Cianni L, Polichetti C, et al. Plate Augmentation in Aseptic Femoral Shaft Nonunion after Intramedullary Nailing: A Literature Review. Bioengineering (Basel, Switzerland). 2022;9(10). doi:

  5. Kocijan R, Klaushofer K, Misof BM. Osteoporosis Therapeutics 2020. Handb Exp Pharmacol. 2020;262:397–422.

    Article  CAS  PubMed  Google Scholar 

  6. Campbell EJ, Campbell GM, Hanley DA. The effect of parathyroid hormone and teriparatide on fracture healing. Expert Opin Biol Ther. 2015;15(1):119–29.

    Article  CAS  PubMed  Google Scholar 

  7. Caffarelli C, Mondanelli N, Crainz E, Giannotti S, Frediani B, Gonnelli S. The Phenotype of Bone Turnover in Patients with Fragility Hip Fracture: Experience in a Fracture Liaison Service Population. Int J Environ Res Public Health. 2022;19(12). doi:

  8. Lee YK, Ha YC, Koo KH. Teriparatide, a nonsurgical solution for femoral nonunion? A report of three cases. Osteoporos Int. 2012;23(12):2897–900.

    Article  PubMed  Google Scholar 

  9. Babu S, Sandiford NA, Vrahas M. Use of Teriparatide to improve fracture healing: What is the evidence? World J Orthop. 2015;6(6):457–61.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Ciurlia E, Tranquilli Leali P, Doria C. Use of teriparatide off-label: our experience and review of literature. Clin Cases Miner Bone Metab. 2017;14(1):28–34.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Giannotti S, Bottai V, Dell’Osso G, De Paola G, Pini E, Guido G. Atrophic femoral nonunion successfully treated with teriparatide. Eur J Orthop Surg Traumatol. 2013;23(Suppl 2):S291–4.

    Article  PubMed  Google Scholar 

  12. Collinge C, Favela J. Use of teriparatide in osteoporotic fracture patients. Injury. 2016;47(Suppl 1):S36–8.

    Article  PubMed  Google Scholar 

  13. Yoon BH, Kim KC. Does Teriparatide Improve Fracture Union?: A Systematic Review. J Bone Metab. 2020;27(3):167–74.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Giannotti S, Bottai V, Pini E, Dell’osso G, De Paola G, Guido G. Clinical and surgical approach of severe bone fragility fracture: clinical case of 4 fragility fracture in patient with heavy osteoporosis. Clin Cases Miner Bone Metab. 2013;10(1):52–5.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Cesari M, Mondanelli N, Gonnelli S, Caffarelli C, Bottai V, Giannotti S. Atypical femoral fracture on a deformed bone, treated with a multimodal approach. A case report. Clin Cases Miner Bone Metab. 2019;16(1):62–5.

    Google Scholar 

  16. Mondanelli N, Troiano E, Facchini A, et al. Combined Surgical and Medical Treatment for Vancouver B1 and C Periprosthetic Femoral Fractures: A Proposal of a Therapeutic Algorithm While Retaining the Original Stable Stem. Geriatr Orthop Surg Rehabil. 2021;12:1–15.

    Article  Google Scholar 

  17. Ismailidis P, Suhm N, Clauss M, Mündermann A, Cadosch D. Scope and Limits of Teriparatide Use in Delayed and Nonunions: A Case Series. Clin Pract. 2021;11(1):47–57.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Aslan D, Andersen MD, Gede LB, et al. Mechanisms for the bone anabolic effect of parathyroid hormone treatment in humans. Scand J Clin Lab Invest. 2012;72(1):14–22.

    Article  CAS  PubMed  Google Scholar 

  19. Kastirr I, Reichardt M, Andresen R, et al. Therapy of aseptic nonunions with parathyroid hormone. Eur J Orthop Surg Traumatol. 2019;29(1):169–73.

    Article  CAS  PubMed  Google Scholar 

  20. Bottai V, Gariffo G, Ipponi E, et al. Use of teriparatide in preventing delayed bone healing in complex biosseous leg fracture : a case report. Int J Bone Frag. 2021;1(1):14–6.

    Article  Google Scholar 

  21. Mondanelli N, Troiano E, Facchini A, Cesari M, Colasanti GB, Bottai V, Muratori F, Caffarelli C, Gonnelli S, Giannotti S. Combined Surgical and Medical Treatment for Vancouver B1 and C Periprosthetic Femoral Fractures: A Proposal of a Therapeutic Algorithm While Retaining the Original Stable Stem. Geriatr Orthop Surg Rehabil. 2021;12:21514593211067072.

  22. Giannoudis PV, Gudipati S, Harwood P, Kanakaris NK. Long bone non-unions treated with the diamond concept: a case series of 64 patients. Injury. 2015;46(Suppl 8):S48–54.

    Article  PubMed  Google Scholar 

  23. Marongiu G, Dolci A, Verona M, Capone A. The biology and treatment of acute long-bones diaphyseal fractures: Overview of the current options for bone healing enhancement. Bone Reports. 2020;12:100249

  24. Richards CJ, Graf KW, Mashru RP. The Effect of Opioids, Alcohol, and Nonsteroidal Anti-inflammatory Drugs on Fracture Union. Orthop Clin North Am. 2017;48(4):433–43.

    Article  PubMed  Google Scholar 

  25. Moroni A, Faldini C, Hoang-Kim A, Pegreffi F, Giannini S. Alendronate improves screw fixation in osteoporotic bone. J Bone Joint Surg Am. 2007;89(1):96–101.

    Article  PubMed  Google Scholar 

  26. Truntzer J, Vopat B, Feldstein M, Matityahu A. Smoking cessation and bone healing: optimal cessation timing. Eur J Orthop Surg Traumatol. 2015;25(2):211–5.

    Article  PubMed  Google Scholar 

  27. Pearson RG, Clement RGE, Edwards KL, Scammell BE. Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis? A systematic review with meta-analysis. BMJ open. 2016;6(11). doi:

  28. Tachiiri H, Okuda Y, Yamasaki T, Kusakabe T. Weekly teriparatide administration for the treatment of delayed union: a report of two cases. Arch Osteoporos. 2014;9:179.

    Article  PubMed  Google Scholar 

  29. Coppola C, Del Buono A, Maffulli N. Teriparatide in Fracture Non-Unions. Transl Med UniSa. 2014;12:4.

    Google Scholar 

  30. Matsumoto T, Ando M, Sasaki S. Effective treatment of delayed union of a lumbar vertebral fracture with daily administration of teriparatide in a patient with diffuse idiopathic skeletal hyperostosis. Eur Spine J. 2015;24(Suppl 4):573–6.

    Article  Google Scholar 

  31. Corrales LA, Morshed S, Bhandari M, Miclau T. Variability in the assessment of fracture-healing in orthopaedic trauma studies. J Bone Joint Surg Am. 2008;90(9):1862–8.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Whelan DB, Bhandari M, Stephen D, et al. Development of the radiographic union score for tibial fractures for the assessment of tibial fracture healing after intramedullary fixation. J Trauma. 2010;68(3):629–32.

    Article  PubMed  Google Scholar 

  33. Schmal H, Brix M, Bue M, et al. Nonunion - consensus from the 4th annual meeting of the Danish Orthopaedic Trauma Society. EFORT Open Rev. 2020;5(1):46–57.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30.

    Article  CAS  PubMed  Google Scholar 

  35. Tarantino U, Iolascon G, Cianferotti L, et al. Clinical guidelines for the prevention and treatment of osteoporosis: summary statements and recommendations from the Italian Society for Orthopaedics and Traumatology. J Orthop Traumatol. 2017;18(Suppl 1):3–36.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Haines N, Kempton LB, Seymour RB, et al. The effect of a single early high-dose vitamin D supplement on fracture union in patients with hypovitaminosis D: a prospective randomised trial. Bone Joint J. 2017;99-B(11):1520–5.

    Article  CAS  PubMed  Google Scholar 

  37. Giannotti S, Bottai V, Dell’osso G, et al. Current medical treatment strategies concerning fracture healing. Clin Cases Miner Bone Metab. 2013;10(2):116–20.

    PubMed  PubMed Central  Google Scholar 

  38. Canintika AF, Dilogo IH. Teriparatide for treating delayed union and nonunion: A systematic review. J Clin Orthop Trauma. 2020;11(Suppl 1):S107–12.

    Article  PubMed  Google Scholar 

  39. Ghiasi MS, Chen J, Vaziri A, Rodriguez EK, Nazarian A. Bone fracture healing in mechanobiological modeling: A review of principles and methods. Bone reports. 2017;6:87–100.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Maccagnano G, Pesce V, Vicenti G, et al. The effect of combined drug therapy in lateral fragility fractures of the femur: a prospective observational study. Eur Rev Med Pharmacol Sci. 2022;26(1 Suppl):43–52.

    Article  CAS  PubMed  Google Scholar 

  41. Cheung WH, Miclau T, Chow SKH, Yang FF, Alt V. Fracture healing in osteoporotic bone. Injury. 2016;47(Suppl 2):S21–6.

    Article  PubMed  Google Scholar 

  42. Giannotti S, Bottai V, Dell’Osso G, De Paola G, Ghilardi M, Guido G. Pseudoarthrosis in atypical femoral fracture: case report. Osteoporos Int. 2013;24(11):2893–5.

    Article  CAS  PubMed  Google Scholar 

  43. Tsuchie H, Miyakoshi N, Iba K, et al. The effects of teriparatide on acceleration of bone healing following atypical femoral fracture: comparison between daily and weekly administration. Osteoporos Int. 2018;29(12):2659–65.

    Article  CAS  PubMed  Google Scholar 

  44. Litrenta J, Tornetta P, Vallier H, et al. Dynamizations and Exchanges: Success Rates and Indications. J Orthop Trauma. 2015;29(12):569–73.

    Article  PubMed  Google Scholar 

  45. Vicenti G, Bizzoca D, Solarino G, Moretti F, Ottaviani G, Simone F, Zavattini G, Maccagnano G, Noia G, Moretti B. The role of biophysical stimulation with pemfs in fracture healing: from bench to bedside. J Biol Regul Homeost Agents. 2020;34(5 Suppl. 1):131–35. IORS Special Issue on Orthopedics.

  46. Nicholson JA, Makaram N, Simpson AHRW, Keating JF. Fracture nonunion in long bones: A literature review of risk factors and surgical management. Injury. 2021;52(Suppl 2):S3–11.

    Article  PubMed  Google Scholar 

  47. Huang TW, Chuang PY, Lin SJ, et al. Teriparatide Improves Fracture Healing and Early Functional Recovery in Treatment of Osteoporotic Intertrochanteric Fractures. Medicine. 2016;95(19).

  48. Nauth A, Lee M, Gardner MJ, et al. Principles of Nonunion Management: State of the Art. J Orthop Trauma. 2018;32(Suppl 1):S52–7.

    Article  PubMed  Google Scholar 

  49. Chen X, Hu Y, Geng Z, Su J. The “Three in One” Bone Repair Strategy for Osteoporotic Fractures. Frontiers in endocrinology. 2022;13.

Download references


Not applicable.


None reported.

Author information

Authors and Affiliations



FDS, RC and GG cured data acquisition collection and analysis, and interpreted the data; FF and ET drafted the paper and prepared figures and tables; VB, NM, RC and SG conceptualized the study, wrote the paper and cured editing. All Authors reviewed the manuscript, approved the submitted version and agreed to be accountable for all aspects of the work.

Corresponding author

Correspondence to Nicola Mondanelli.

Ethics declarations

Ethics approval and consent to participate

At both Institutions, no Institutional Review Board nor Ethical Committee approval is necessary for retrospective studies nor for a sporadic off-label use of already registered drugs; a preventive waive for all retrospective study has been stated by both the Comitato Etico Azienda Ospedaliero Universitaria Pisana and the Comitato Etico Azienda Ospedaliero Universitaria Senese). All methods were carried out in accordance with relevant guidelines and regulations, and all subjects and/or their legal guardians gave their informed consent to the proposed therapy. All subjects and/or their legal guardians gave their informed consent to data collection and their anonymous use for scientific and teaching purposes.

Consent for publication

Not applicable.

Competing interests

The Authors declare they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gariffo, G., Bottai, V., Falcinelli, F. et al. Use of Teriparatide in preventing delayed bone healing and nonunion: a multicentric study on a series of 20 patients. BMC Musculoskelet Disord 24, 184 (2023).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: