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Patient gender and rotator cuff surgery: are there differences in outcome?

Abstract

Background

Although rotator cuff syndrome is common and extensively studied from the perspective of producing healed tendons, influence of gender on patient-reported outcomes is less well examined. As activity and role demands may vary widely between men and women, clarity on whether gender is an important factor in outcome would enhance patient education and expectation management. Our purpose was to determine if differences exist in patient-reported outcomes between men and women undergoing rotator cuff surgery.

Methods

One hundred forty-eight participants (76 W:72 M) aged 35–75 undergoing surgery for unilateral symptomatic rotator cuff syndrome were followed for 12 months after surgery. Demographics, surgical data, and the Western Ontario Rotator Cuff (WORC) scores were collected. Surgery was performed by two fellowship-trained shoulder surgeons at a single site.

Results

There were no gender-based differences in overall WORC score or subcategory scores by 12 months post-op. Pain scores were similar at all time points in men and women. Women were more likely to have dominant-arm surgery and had smaller rotator cuff tears than men. Complication rates were low, and satisfaction was high in both groups.

Conclusion

Patient gender doesn’t appear to exert an important effect on patient-reported rotator cuff outcomes in this prospective cohort. Further work examining other covariates as well as the qualitative experience of going through rotator cuff repair should provide greater insight into factors that influence patient-reported outcomes.

Peer Review reports

Introduction

Approximately 180,000Footnote 1 Canadian adults will develop symptomatic rotator cuff syndrome (a symptomatic rotator cuff tear, with or without accompanying long biceps tendon or acromioclavicular pathology) each year, experiencing the pain and disability that results [1]. Sufferers classically experience pain and weakness with reaching activities and fragmented sleep due to night pain [2]. The negative impact of rotator cuff syndrome on daily life varies, but some are unable to work, some are unable to be care-givers, and many experience loss of recreational activities important to their physical and emotional health.

The patient population facing symptomatic rotator cuff repairs is diverse: from roughly 30–80 years old, men and women, office workers and labourers, physically active and sedentary [3]. Much effort has focused on biological and technical factors to improve the rates of “successful” surgery. It is becoming increasingly clear, however, that addressing structural elements alone does not always produce the expected treatment outcomes from a patient perspective [4]. In addition to biological factors identified as important to structural outcomes such as increasing age, current smoking, and diabetes [5], patient-specific factors such as gender and psychosocial diversity may also have a role to play in patient-reported outcomes of rotator cuff surgery.

Despite gender being one of the most foundational demographic traits, it has rarely been explicitly researched as a primary factor in rotator cuff outcomes. It is important to appreciate that there is a distinction between a person’s gender and that person’s sex. The World Health Organization differentiates them as follows: “Gender refers to the characteristics of women, men, girls and boys that are socially constructed. This includes norms, behaviours and roles associated with being a woman, man, girl or boy, as well as relationships with each other.” Sex, then “refers to the different biological and physiological characteristics of females, males and intersex persons, such as chromosomes, hormones and reproductive organs.” [6].

Investigating potential influences of gender on rotator cuff outcomes is important because functioning of the upper extremities may impact gender-specific behaviors and activities of daily living differently for men and women. While more attention is being paid to this, the picture is incomplete. Previous studies on rotator cuff outcomes have not made a distinction between gender and sex, and some have not even provided any data regarding either factor. Others have conducted secondary analyses with patient “gender” examined for its role in outcomes [7,8,9,10,11,12,13,14,15] with little commentary on the significance of any related findings. This may be understandable because gender was not the primary focus of any of the foregoing studies. On the other hand, this does limit the ability to discuss the impact of patient gender in patient-reported outcomes of rotator cuff surgery.

However, a few studies have provided insight into gender and outcomes. Razmjou et al. [16] and Gibson et al. [17] both found gender-based differences in lifestyle scores on the Western Ontario Rotator Cuff Index in pre-operative rotator cuff patients. A prospective cohort from Daniels et al. [18] showed females had greater early VAS pain scores and poorer ASES scores until around 3 months post-operatively, and by 1 year post-op, outcomes in males and females were similar. Recent work by Pauly et al. [19] examined the relationship between patient sex, age, and rate of collagen-1 deposition, MRI healing at 1 year, and clinical scores at 1 year (ASES, WORC) and found no sex-based differences at 1 year. Continuing to flesh out the implications of gender-based differences in patient-reported outcomes may help construct future outcome studies and aid in more effective expectation management for patients.

Although the focus of this work will be on gender-based factors, physical factors such as patient height (which is typically different between males and females) could also influence the outcomes of a condition that affects overhead reaching activities.

The purpose of this study is to use a prospective cohort to explicitly examine the role of patient gender in patient-reported outcomes of rotator cuff surgery. We hypothesized that gender would not be a major influence on patient-reported outcomes. Potential confounding influence of height on outcomes was also examined.

Methods

Participants

Eligible participants were aged 35–75 years undergoing elective surgery for unilateral partial and/or full-thickness rotator cuff tendon tears confirmed by ultrasound or MRI and were recruited by one of two fellowship-trained shoulder surgeons at a single-center between February 2016 and June 2017. Exclusion criteria were bilateral symptomatic rotator cuff disease, previous surgery on the operative shoulder, rotator cuff arthropathy, significant alternate sources of pain such as cervical spine disease or a chronic pain disorder (such as fibromyalgia or complex regional pain syndrome), and inability to complete questionnaires in English. Participants with known psychiatric diagnoses such as anxiety, depression, or related conditions were not excluded, nor were patients with potential gain issues, such as Workers’ Compensation board claims, litigation, or those injured in motor vehicle collisions. Transgendered participants were placed in the gender category that best matched their self-identified gender (affected 1 participant). No participants were excluded for being unable to identify with either of the two gender groups, although no openly non-binary or gender-fluid patients were screened during this time. Informed consent was obtained from all participants prior to enrollment. Figure 1 traces the path of the cohort from time of screening until final follow-up, accounting for where losses occurred. The project was reviewed and approved by the local Research Ethics Board (REB 15–1229) and was conducted according to the principles of the Declaration of Helsinki.

Fig. 1
figure1

Flow diagram of patient recruitment and loss to follow-up

Variables and outcome measures

Demographic data collected included gender, hand dominance, medical comorbidities, current medications, and smoking history. The disease-specific patient-reported outcome measure used was the Western Ontario Rotator Cuff score (WORC). The WORC score is a validated, self-reported measure of rotator cuff disease severity [20]. It consists of 21 questions in 5 domains, each with a 100 mm visual analogue scale (VAS). Higher total scores on the WORC indicate increased pain and functional disability. For the 2-week and 6-week visit, pain levels were determined by two 100 mm VAS scales drawn from the WORC-Pain domain to reduce patient questionnaire burden and to allow direct tracking of the evolution of pain over time. Post-operatively, VAS pain scores were collected at 2 and 6 weeks, while WORC scores were collected at 12 and 24 weeks, and 1 year post-operatively.

Rotator cuff tear characteristics were grouped based on intra-operative findings as follows: (1) any single partial-thickness tear in a single tendon, (2) partial-thickness tears in two or more tendons, (3) any full-thickness tear in a single tendon, (4) any full-thickness tear in a single tendon and any partial-thickness tear in a second tendon, and (5) full-thickness tears in two or more tendons.

Post-operative complications such as infection, nerve injury, excessive pain, excessive stiffness, failure of repair, and re-operation were also monitored for the duration of the study.

Surgical intervention and post-operative care

Two fellowship-trained shoulder surgeons performed all surgical procedures. All patients presented for rotator cuff repair, with additional procedures relating to the long biceps tendon or acromioclavicular joint at the discretion of the surgeon based on clinical presentation.

All patients received pre-operative antibiotics and were treated most commonly with combined general and regional anesthesia, with a minority receiving either regional only or general anesthesia only. All procedures were conducted arthroscopically. Biceps tenodeses were conducted through arthroscopic or mini-open approaches depending on surgeon preference and clinical situation.

All patients received a diagnostic arthroscopy, a subacromial bursectomy and rotator cuff assessment. Two patients out of the cohort were found to have partial thickness tears smaller than anticipated based on pre-operative imaging and therefore received only an arthroscopic bursectomy.

Choice of anchors and type of repair were at the surgeon’s discretion and influenced by tear size, morphology, and mobility. Augmentation was used in 1 patient. Partial repairs were undertaken in situations where a full repair was not possible. Partial tears that were high grade were typically completed and repaired.

Post-operative care consisted of wearing a sling for 6 weeks, with active-assisted range of motion commenced at 2 weeks post-op. Two protocols were employed based on small-medium tears and large-massive tears. The progressions were similar, but the large-massive protocol progressed slightly more slowly than the small-medium program. These protocols are summarized in Additional file 1. Each patient selected a physiotherapist to guide rehab according to the protocol provided by the surgeon. Adjustments to progression through the protocol were also made at surgeon’s discretion based on patient progress and specific rehabilitation deficits. The large geographic area served by this center precluded having all patients see the same team of therapists.

Post-operative imaging of the operative shoulder was at the surgeon’s discretion based on clinical indication and was not conducted routinely as that does not reflect real-world clinical practice in the environment in which this study was conducted.

Sample size and data analysis

Our primary endpoint was chosen to be the difference in WORC score at 12-month follow-up. Using the MCID and available psychometric data on the WORC, it was determined that we required 35 men and 35 women to complete 12-month follow-up to have 80% power to detect a difference of 11.5% (the MCID). Since additional subgroup analysis was desired, this sample was increased to allow detection of medium effect sizes in such analyses. For example, n = 134 would allow for 80% power to detect an f2 = 0.1 for a multiple linear regression analysis with 5 variables, while n = 138 would allow a 2-group 4-timepoint repeated measures ANOVA analysis to detect an effect size of 0.1 at 80% power. A practice audit revealed that a loss to follow-up of up to 30% would need to be planned for. With the aid of a dedicated research assistant, it was felt this could be reduced to about 25%. Thus, we aimed to recruit 92 men and 92 women for the cohort.

Descriptive statistical analysis was conducted with t-tests (for example, age, height, BMI) and chi-square tests (for example, occupation, comorbidities, tear pattern or size) as appropriate. Analysis of the patients not completing the study was performed with one-way ANOVA (age), Kruskal-Wallis H-test (WORC score), Fischer Exact tests (remainder of characteristics). Pearson product-moment correlation between height and WORC score was also performed. Repeated-measures ANOVA testing was used with gender and time as inputs. Several patients (20 of 148) had missing data points between time 0 and 12 months and so were excluded from repeated-measures analyses. Normality of the data distribution for the repeated measures ANOVA was confirmed through a histogram of the residuals demonstrating a normal distribution. Graph Pad (San Diego, CA) and R (version 3.6.3, 2020/02/29, R Foundation for Statistical Computing, Vienna, Austria) was used for the analyses. Statistical advice was sought from affiliated biostatisticians prior to the commencement of the study for sample size determination (including the decisions about scaling the sample size as described)Footnote 2 and for the higher-level analyses at the conclusion of the study (including the repeated measures ANOVA and discussion of the normality of the residuals).Footnote 3

Results

Demographics and characteristics of the women and men

A total of 148 patients completed 12 months of follow-up (Fig. 1). Table 1 shows the relevant demographics of this cohort. Of note, the women were more likely to carry a past diagnosis of a mood disorder. Women were much more likely to be presenting for surgery on their dominant arm compared to men. There were similar types of occupation in both groups, and similar rates of smoking and diabetes. No differences between those withdrawing or being lost to follow-up and those completing the study were noted. The cohort represented a mixture of acute, acute-on-chronic, and chronic tears. For those with a clear onset of symptoms or injury (102 participants), the median time from symptoms to surgery was 15.5 months (range 1–112 months). There were no differences between those who did not complete the 12 months of follow-up and those who did with respect to age (p = 0.57), baseline WORC score (p = 0.72), secondary gain concerns (p = 0.65), tear size (p = 0.35), tear pattern (p = 0.48), smoking status (p = 0.22), gender (p = 0.46), dominant arm operated (p = 1.0), diabetes mellitus (p = 0.32), presence of a mood disorder (p = 0.66), or occupation type (p = 0.78).

Table 1 Demographic information for women and men completing 1 year follow-up

Table 2 shows the intra-operative findings. All tear patterns were represented, with superior and anterosuperior being the most commonly found. Women tended to have smaller tears than men in this cohort. “Complete in 1 of Multiple” refers to a situation in which a large to massive posterosuperior tear only allowed for a portion of infraspinatus to be repaired rather than, for example, all of infraspinatus but none of supraspinatus. A higher rate of partial repair in men was observed.

Table 2 Operative findings and interventions

Patient-reported rotator cuff outcomes

Fig. 2 shows the comparison of WORC score at baseline and at 12 months for men and women. Both groups improved substantially, but there were no differences between men and women at either time 0 or at 12 months follow-up. Figure 3 shows the progression of pain scores over time for both genders. This VAS was a summed total of reported sharp pain and dull pain taken from the WORC pain section. Again, both genders showed a substantial improvement in pain over the course of the post-operative year with no difference between groups at any time points.

Fig. 2
figure2

Western Ontario Rotator Cuff (WORC) Score before and after surgery in women and men. No differences were noted between genders at either time point. All values are shown mean ± standard deviation

Fig. 3
figure3

Pain scores in men and women over time after surgery. There were no differences between men and women at any time point as determined with a two-ways repeated measures ANOVA (p = 0.29, n = 126)

The WORC score is divided into 5 domains that are assessed. No differences between men and women were noted for the Physical (p = 0.83, CI -7.29-5.83), Sports (p = 0.19, CI -2.90-14.21), Work (p = 0.7, CI -6.48-9.61), Lifestyle (p = 0.18, CI -2.17-11.37), or Emotions (p = 0.98, CI -7.42-7.18).

Relationship between WORC score and tear pattern and size

The influence of intra-operative tear size on WORC score was also examined. Tear shape (anterior, anterosuperior, superior, posterosuperior, and massive) was not associated with significant differences in WORC score at baseline (p = 0.84) or at 12 months post-operative (p = 0.48). Tear size was similarly not associated with significant differences at baseline (p = 0.98) or 12 months post-operatively (p = 0.82).

Relationship between patient height and WORC score

An examination of the relationship between height and WORC score revealed that although women were significantly shorter than men in this cohort (Table 1), patient height did not prove to have an important influence on WORC score (R = 0.035).

Gender, satisfaction, and patient feedback

At the 12-month follow-up, patients were asked three yes/no questions about their experience. First, whether they were satisfied with the results of their rotator cuff surgery (W:93% yes, M:91% yes). Second, if they knew at time of electing for surgery what they know now, would they have the surgery again(W:92% yes, M:98% yes)? Third, if a friend or family member had a similar shoulder problem, would they recommend surgery to them (W:97% yes, M:100% yes)? No significant differences were noted between men and women for each of the three questions, although there was a trend towards women being less likely to want to go through surgery again (p = 0.07).

Complications

Complication rate was low for the cohort. There were no deep infections. Two patients experienced neurological symptoms in the lower arm, one of which had partially improved at 1 year. One underwent revision surgery for a failed biceps tenodesis. Two underwent reoperation with a non-study surgeon to receive a Superior Capsular Reconstruction. In addition, a further 5 patients had a documented repair failure, most of whom underwent revision surgery. One retear had a documented fall before 12 weeks post-op. Three patients received corticosteroid injection therapy during the year after surgery.

Discussion

This study has demonstrated no significant difference in patient-reported outcome of rotator cuff surgery between men and women 1 year after surgery. It has also demonstrated no significant relationship between tear pattern or tear size and patient-reported outcome at 1 year following surgery. Women were more likely to be undergoing surgery on their dominant arm, more likely to have a smaller tear size, and more likely to have had a full rotator cuff repair than men. There were more women with litigation related to their shoulder problem than men. Both women and men experienced statistically and clinically significant improvement in WORC score from pre-op to final follow-up.

Patient height and WORC score

Because people of a wide range of height have to negotiate standardized environments at home and in the workplace, we did examine the relationship between patient height and WORC score. Height is not evenly distributed across genders. Our hypothesis was that since persons of smaller stature likely spend more of their activity with their arms at/above shoulder height, their reported outcomes may reflect greater individual activity limitations related to rotator cuff disease even after surgery. This did not prove to be the case here.

Gender and outcome

Existing literature examining the relationship between gender and outcome has mainly dealt with gender as a subanalysis, with mixed findings. Table 3 provides a summary of the relevant literature commenting on the outcome of rotator cuff surgery in female patients derived from secondary analyses. Despite the liberal use of the term “gender” in these studies, the author intent was more consistent with “sex” in all but the Ramzjou study [16]. Comparison between studies is challenging because of the diversity of outcome measures used, but the trend was towards poorer outcomes in female patients.

Table 3 Summary of Outcomes of Rotator Cuff Surgery

One closely relevant work on gender and rotator cuff disease to this current study is from Ramzjou et al. in 2006 [16]. They assessed 279 patients (108 women) undergoing rotator cuff surgery. They noted differences in prevalence of emotional disturbance in women (using the WORC-Emotions scale), and the structural pathology was distributed differently between younger men and women. This difference faded with age. They also noted a trend towards differences in the WORC-Lifestyle scale by gender. This difference was also noted by Gibson et al. in a more recent investigation [17]. The Ramzjou paper proposed that there may be gender-based role activities that account for this difference (such as different grooming and dressing practices) [16].

In a subsequent report from Ramzjou et al., women were found to have poorer pre and post-op WORC scores than the men in the cohort [21]. One difference between the cohorts was that patients undergoing decompression-only as the intended procedure were included (whereas our cohort was intended to include a rotator cuff repair from enrollment). This may be important as decompression surgery is not clinically significantly better than non-operative treatment [22], thereby potentially performing differently from a rotator cuff repair. More women in the 170-patient cohort had decompression-only. Their cohort had similar tear sizes between genders, where women in this cohort tended to have tears confined to the supraspinatus. Their post-operative outcomes were collected at 6 months after surgery, whereas this cohort was followed for 1 year. In contrast to the Ramzjou cohort, this cohort did not note gender-based differences in the WORC total score or subscores at the 1-year follow-up. It is not possible to directly compare gender-based satisfaction from this cohort to the Razmjou cohort [21] as they approached this question differently. Further work will delve into potential explanations for why this potential difference might be so.

A second prospective cohort followed by Daniels et al. [18] included 283 patients (130F:153M) for 1 year using the ASES score as their primary disease-specific outcome measure. They found differences at baseline and for the first 3 months after rotator cuff repair between males and females, which disappeared by 1 year. Our cohort affirms their findings of similar 1-year results in both genders. It is possible that their larger sample size allowed for a smaller effect size to be statistically significant. In our cohort, small differences in VAS pain scores could be seen, but these were neither statistically nor clinically significant. Literature on patient sex and sensitivity to various clinical and experimental pain modalities show mixed results, but tend to favor females being more sensitive to painful stimuli, making this variation plausible [23].

In view of this, some questions arise. Do women have more symptoms for a given tear size than men, or could it be that tear size isn’t well correlated to patient-reported symptoms? We looked at tear size by number of tendons involved, and by tear pattern, and there were no differences in WORC score in either analysis. This is consistent with the work by Wylie et al. which suggested that tear size and symptoms may not cohere well [24]. Interestingly, although their work did show relation between tear size and VAS function scales, this current study did not relate tendon involvement to WORC score. Differing techniques of measurement and different instruments limit direct comparisons in this domain. This follow-up question is well-suited to a case-control design rather than a cohort design.

We also noted a striking difference between dominant operative arms between the men and women. Women were much more likely to be undergoing surgery on their dominant arm (86% vs 58%). Ramzjou et al. [21] didn’t explicitly state the percentage of dominant arms operated by gender, but more women were right-handed and underwent right-sided surgery. Again, direct comparison is challenging due to different ways of presenting the data. This again may gesture towards gender-based differences in activity demands.

Although Gibson et al. noted a small but significant difference in WORC-Lifestyle scores by gender in the pre-operative analysis of this cohort [17], this difference is no longer statistically or clinically significant at 1 year follow-up. It would be interesting to determine whether this represents a consistent return of function to baseline or pre-morbid activity, or whether this represents a long-term acceptance and adaptation of lifestyle activities as part of a holistic post-operative recovery.

Whether meaningful differences in outcomes of rotator cuff surgery depends on patient gender is likely subject to one of two realities. First, as this current study and others have shown, no significant differences at minimum 1-year follow-up exists and this is a true finding. Alternatively, our clinical tools are not well configured to detect gender-based differences in patient-reported outcomes. Furtado et al. reflect on the short-WORC and the variably applicability of items such as dressing/undressing and hair styling across genders [25]. Whether enough gender difference exists to merit rethinking our patient-reported outcomes is beyond the scope of this study, and assuming no important differences exist may be premature.

Sex, gender, and the future of outcomes research

As our understanding of sex and gender becomes more developed and substantially more complex, it is worth considering how outcomes research should approach this important issue. The Canadian Institutes for Health Research [26] actively encourages consideration of sex and gender in research design. Outcome measures to assess gender now exist.

The intent of this current work was explicitly to approach outcomes based on gender, not sex. An argument can be made to approach patient-reported outcomes on a gender basis given that they quantify lived experience moreso than a physiologic or structural outcome. However, this is a blunt distinction that doesn’t provide much guidance on how to clearly and consistently decide between gender and sex, nor does it help with adequate inclusion of patients and participants who do not identify as man or woman. It is hoped that with time, some clarity may be added to this complex discussion. In the meantime, a step forward is to be conscious that sex and gender are not interchangeable terms and this should be deliberately addressed in study design.

Limitations

This study was appropriately powered for its primary endpoint, but may be underpowered for the subanalyses. There are several limitations. A pragmatic approach was taken to have this study reflect clinical practice as much as possible. It is not feasible or practical to continue follow-up for patients past 1 year. There is emerging evidence to suggest that longer follow-up may not be fruitful15. Longer follow-up might reveal improved WORC scores beyond those reported, but whether those differences are clinically meaningful to offset the potential exposure of more repair failures or retears is unclear.

Second, it is not feasible to obtain timely pre-operative MRI scans on all patients prior to rotator cuff surgery in the setting of this study. It is also not feasible to re-image all post-operative patients with MRI. While post-operative imaging was at surgeon discretion based on clinical indications, the final status of the repairs at 12 months has not been confirmed across all participants. Repair status was not a primary outcome of this study, but it does limit ability to comment on asymptomatic or mildly symptomatic retears.

Third, we elected to use categories rather than measurements of tear size. Because of the mixed imaging modalities pre-operatively, tendon involvement was obtained from the operative record. While this reduces measurement errors between assessors and avoids classification errors based on highly variable patient and tendon footprint size, it does complicate ability to compare directly with studies where tear length/area is reported in detail. Amongst existing classifications of rotator cuff tear size, some focus more on number/location of involved tendons more than absolute linear size. For example, Wylie et al.24 did use both quantitative and qualitative data for tear size.

Fourth, this was a single-center study. While this increases the consistency of surgical interventions, it could limit generalizability.

Fifth, there was the potential for heterogeneity in post-operative rehabilitation amongst the cohort. Despite all patients being provided with the same protocols, we were not able to monitor all the physiotherapists that could have had contact during the time of the study. It is possible that this introduces a factor not quantified by the study.

Finally, this cohort contains a high proportion of sedentary workers which may limit the generalizability of these results to heavy laborers or athletes of either gender.

Conclusions

In this prospective cohort of 148 patients, we have shown that patient gender does not have an important effect on WORC scores 1 year after arthroscopic rotator cuff repair. In comparing the men and women in this study, we do note that women were more likely to be having surgery on a dominant arm and tended to have smaller structural pathology than the participating men. Further work examining other covariates as well as the qualitative experience of going through rotator cuff repair should provide greater insight into factors that influence patient-reported outcomes.

Availability of data and materials

All data generated and analysed for this report are available as deidentified data upon reasonable request from the corresponding author.

Notes

  1. 1.

    Calculated from 2016 Stats Can Data http://www.statcan.gc.ca/tables-tableaux/sum-som/l01/cst01/demo10a-eng.htm

  2. 2.

    The team would like to thank Dr. E Oddonne-Paolucci for her advice on sample size determination.

  3. 3.

    The team would like to thank Dr. K Rondeau for her assistance with final analysis.

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Acknowledgements

We would like to thank Ms. Sarah Reitzel, Mr. Eric Gibson, Ms. Tina Samuel, Ms. Martina Vergouwen, Ms. Penny Claeys, Ms. Fiona Wycliffe-Jones, Ms. Susie Torrance, Mr. John Warner, Mr. Jordan Perchard, and Ms. Allison Visser for their assistance in data collection during the course of this work. We would like to acknowledge the contributions of Drs E Oddone-Paolucci, K Rondeau, and G Elmi Assadzadeh to the planning and statistical analysis of this work, and also Dr. M Clark for her pre-submission review.

Funding

This project has been funded by the following groups:

1. Canadian Orthopaedic Foundation

2. Surgery Strategic Clinical Network, Alberta, Canada

3. Section of Orthopaedic Surgery, University of Calgary

None of these funding bodies had a role in the study design, data collection/analysis, or manuscript preparation.

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Authors

Contributions

MTS: Primary investigator, study design, patient recruitment, surgeon, data collection, data analysis, manuscript preparation. JL: patient recruitment, data collection, surgeon, manuscript review. KH: study design, manuscript review. The author(s) read and approved the final manuscript.

Corresponding author

Correspondence to Marlis T. Sabo.

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Ethics approval and consent to participate

This study was reviewed and approved by the University of Calgary CHREB (Conjoint Health Research Ethics Board) under review number 15–1229. The study was conducted in accordance with Declaration of Helsinki guidelines. All patients provided written consent to participate in the study.

Consent for publication

All participants provided written informed consent at the time of enrollment including for data collection and use of de-identified data for analysis and publication.

Competing interests

None.

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Sabo, M.T., LeBlanc, J. & Hildebrand, K.A. Patient gender and rotator cuff surgery: are there differences in outcome?. BMC Musculoskelet Disord 22, 838 (2021). https://doi.org/10.1186/s12891-021-04701-y

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