Jeffcoate WJ, Harding KG. Diabetic foot ulcers. Lancet. 2003;361(9368):1545–51.
International Diabetes Federation. IDF Diabetes Atlas. 9th ed. Brussels, Belgium; 2019. https://www.diabetesatlas.org
Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y. Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. Ann Med. 2017;49(2):106–16.
Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376(24):2367–75.
Lazzarini PA, Crews RT, van Netten JJ, Bus SA, Fernando ME, Chadwick PJ, et al. Measuring plantar tissue stress in people with diabetic peripheral neuropathy: a critical concept in diabetic foot management. J Diabetes Sci Technol. 2019;13(5):869–80.
Bandyk DF. The diabetic foot: pathophysiology, evaluation, and treatment. Semin Vasc Surg. 2018;31(2–4):43–8.
Mak A , Ming Z , Tam E . Biomechanics of pressure ulcer in body tissues interacting with external forces during locomotion[J]. Annual Review of Biomedical Engineering. 2010;12(1):29–53.
Prompers L, Huijberts M, Apelqvist J, Jude E, Piaggesi A, Bakker K, et al. High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Baseline results from the Eurodiale study. Diabetologia. 2007;50(1):18–25.
Yazdanpanah L, Nasiri M, Adarvishi S. Literature review on the management of diabetic foot ulcer. World J Diabetes. 2015;6(1):37–53.
Madsen SM, Thorup AC, Overgaard K, Bjerre M, Jeppesen PB. Functional and structural vascular adaptations following 8 weeks of low volume high intensity interval training in lower leg of type 2 diabetes patients and individuals at high risk of metabolic syndrome. Arch Physiol Biochem. 2015;121(5):178–86.
Suntraluck S, Tanaka H, Suksom D. The relative efficacy of land-based and water-based exercise training on macro- and microvascular functions in older patients with type 2 diabetes. J Aging Phys Act. 2017;25(3):446–52.
Liao FY, An RP, Pu F, Burns S, Shen S, Jan YK. Effect of exercise on risk factors of diabetic foot ulcers a systematic review and meta-analysis. Am J Phys Med Rehabil. 2019;98(2):103–16.
Wu F-L, Wang WT-J, Liao F, Elliott J, Jain S, Jan Y-K. Effects of walking speeds and durations on plantar skin blood flow responses. Microvasc Res. 2020;128:103936.
Burnfield JM, Few CD, Mohamed FS, Perry J. The influence of walking speed and footwear on plantar pressures in older adults. Clin Biomech. 2004;19(1):78–84.
Bus SA, Lavery LA, Monteiro-Soares M, Rasmussen A, Raspovic A, Sacco ICN, et al. Guidelines on the prevention of foot ulcers in persons with diabetes (IWGDF 2019 update). Diabetes Metab Res Rev. 2020;36:e3269.
Maluf KS, Mueller MJ. Comparison of physical activity and cumulative plantar tissue stress among subjects with and without diabetes mellitus and a history of recurrent plantar ulcers. Clin Biomech. 2003;18(7):567–75.
Shah KM, Mueller MJ. Effect of selected exercises on in-shoe plantar pressures in people with diabetes and peripheral neuropathy. Foot (Edinburgh, Scotland). 2012;22(3):130–4.
Pu F, Ren W, Fu H, Zheng X, Yang M, Jan Y-K, et al. Plantar blood flow response to accumulated pressure stimulus in diabetic people with different peak plantar pressure: a non-randomized clinical trial. Med Biol Eng Comput. 2018;56(7):1127–34.
Chatwin KE, Abbott CA, Boulton AJM, Bowling FL, Reeves ND. The role of foot pressure measurement in the prediction and prevention of diabetic foot ulceration-A comprehensive review. Diabetes-Metab Res Rev. 2020;36(4):e3258.
Waaijman R, de Haart M, Arts MLJ, Wever D, Verlouw AJWE, Nollet F, et al. Risk factors for plantar foot ulcer recurrence in neuropathic diabetic patients. Diabetes Care. 2014;37(6):1697–705.
Zhu X, Wu F-L, Zhu T, Liao F, Ren Y, Jan Y-K. Effects of preconditioning local vibrations on subsequent plantar skin blood flow response to walking. Int J Lower Extrem Wounds. 2020;20:143–9.
Jan Y-K, Shen S, Foreman RD, Ennis WJ. Skin blood flow response to locally applied mechanical and thermal stresses in the diabetic foot. Microvasc Res. 2013;89:40–6.
Petrofsky JS, Bains GS, Prowse M, Lellan KM, Ethiraju G, Lee S, et al. The influence of age and diabetes on the skin blood flow response to local pressure. Med Sci Monit. 2009;15(7):CR325–31.
Hsi WL, Chai HM, Lai JS. Comparison of pressure and time parameters in evaluating diabetic footwear. Am J Phys Med Rehabil. 2002;81(11):822–9.
Dipnarine K, Barak S, Martinez CA, Carmeli E, Stopka CB. Pain-free treadmill exercise for patients with intermittent claudication: are there gender differences? Vascular. 2016;24(3):304–14.
Martinez CA, Carmeli E, Barak S, Stopka CB. Changes in pain-free walking based on time in accommodating pain-free exercise therapy for peripheral arterial disease. J Vasc Nurs. 2009;27(1):2–7.
Chao CYL, Zheng Y-P, Cheing GLY. Epidermal thickness and biomechanical properties of plantar tissues in diabetic foot. Ultrasound Med Biol. 2011;37(7):1029–38.
Jan Y-K, Lung C-W, Cuaderes E, Rong D, Boyce K. Effect of viscoelastic properties of plantar soft tissues on plantar pressures at the first metatarsal head in diabetics with peripheral neuropathy. Physiol Meas. 2013;34(1):53–66.
Periyasamy R, Anand S, Ammini AC. Investigation of shore meter in assessing foot sole hardness in patients with diabetes mellitus - a pilot study. Int J Diab Dev Count. 2012;32(3):169–75.
Schaper NC, van Netten JJ, Apelqvist J, Bus SA, Hinchliffe RJ, Lipsky BA, et al. Practical guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update). Diabetes Metab Res Rev. 2020;36:e3266.
Lalli P, Chan A, Garven A, Midha N, Chan C, Brady S, et al. Increased gait variability in diabetes mellitus patients with neuropathic pain. J Diabetes Complicat. 2013;27(3):248–54.
Sartor CD, Hasue RH, Cacciari LP, Butugan MK, Watari R, Passaro AC, et al. Effects of strengthening, stretching and functional training on foot function in patients with diabetic neuropathy: results of a randomized controlled trial. BMC Musculoskelet Disord. 2014;15:137.
Wen CP, Wai JPM, Tsai MK, Yang YC, Cheng TYD, Lee M-C, et al. Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet. 2011;378(9798):1244–53.
Caselli A, Pham H, Giurini JM, Armstrong DG, Veves A. The forefoot-to-rearfoot plantar pressure ratio is increased in severe diabetic neuropathy and can predict foot ulceration. Diabetes Care. 2002;25(6):1066–71.
Leenders N, Nelson TE, Sherman WM. Ability of different physical activity monitors to detect movement during treadmill walking. Int J Sports Med. 2003;24(1):43–50.
Cefalu WT, Berg EG, Saraco M, Petersen MP, Uelmen S, Robinson S, et al. Lifestyle management: standards of medical care in diabetes-2019. Diabetes Care. 2019;42:S46–60.
Crews RT, Schneider KL, Yalla SV, Reeves ND, Vileikyte L. Physiological and psychological challenges of increasing physical activity and exercise in patients at risk of diabetic foot ulcers: a critical review. Diabetes Metab Res Rev. 2016;32(8):791–804.
Jakicic JM, Kraus WE, Powell KE, Campbell WW, Janz KF, Troiano RP, et al. Association between bout duration of physical activity and health: systematic review. Med Sci Sports Exerc. 2019;51(6):1213–9.
Khalafi M, Symonds ME. The impact of high-intensity interval training on inflammatory markers in metabolic disorders: a meta-analysis. Scand J Med Sci Sports. 2020;30(11):2020–36.
Boule NG, Haddad E, Kenny GP, Wells GA, Sigal RJ. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus - a meta-analysis of controlled clinical trials. JAMA. 2001;286(10):1218–27.
MacAnaney O, Reilly H, O'Shea D, Egana M, Green S. Effect of type 2 diabetes on the dynamic response characteristics of leg vascular conductance during exercise. Diab Vasc Dis Res. 2011;8(1):12–21.
Bagher P, Segal SS. Regulation of blood flow in the microcirculation: role of conducted vasodilation. Acta Physiol. 2011;202(3):271–84.
Segal SS. Regulation of blood flow in the microcirculation. Microcirculation. 2005;12(1):33–45.
Kellogg DL Jr, Zhao JL, Wu Y. Endothelial nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo. Am J Phys Heart Circ Phys. 2008;295(1):H123–9.
Wong VK, Stotts NA. Physiology and prevention of heel ulcers: the state of science. J Wound Ostomy Continence Nurs. 2003;30(4):191–8.
Chao CYL, Cheing GLY. Microvascular dysfunction in diabetic foot disease and ulceration. Diabetes Metab Res Rev. 2009;25(7):604–14.
Fromy B, Abraham P, Bouvet C, Bouhanick B, Fressinaud P, Saumet JL. Early decrease of skin blood flow in response to locally applied pressure in diabetic subjects. Diabetes. 2002;51(4):1214–7.
Cracowski J-L, Minson CT, Salvat-Melis M, Halliwill JR. Methodological issues in the assessment of skin microvascular endothelial function in humans. Trends Pharmacol Sci. 2006;27(9):503–8.
Gefen A, Megido-Ravid M, Azariah M, Itzchak Y, Arcan M. Integration of plantar soft tissue stiffness measurements in routine MRI of the diabetic foot. Clin Biomech. 2001;16(10):921–5.
Cheung JTM, Zhang M, Leung AKL, Fan YB. Three-dimensional finite element analysis of the foot during standing - a material sensitivity study. J Biomech. 2005;38(5):1045–54.
Piaggesi A, Romanelli M, Schipani E, Campi F, Magliaro A, Baccetti F, et al. Hardness of plantar skin in diabetic neuropathic feet. J Diabetes Complicat. 1999;13(3):129–34.
Fouchard M, Misery L, Le Garrec R, Sigaudo-Roussel D, Fromy B. Alteration of pressure-induced vasodilation in aging and diabetes, a neuro-vascular damage. Front Physiol. 2019;10:862.
Nass N, Bartling B, Santos AN, Scheubel RJ, Boergermann J, Silber RE, et al. Advanced glycation end products, diabetes and ageing. Zeitschrift Fur Gerontologie Und Geriatrie. 2007;40(5):349–56.
Rhee SY, Kim YS. The role of advanced glycation end products in diabetic vascular complications. Diab Metab J. 2018;42(3):188–95.
Held M, Bender D, Krauss S, Wenger A, Daigeler A, Rothenberger J. Quantitative analysis of heel skin microcirculation using laser Doppler Flowmetry and tissue spectrophotometry. Adv Skin Wound Care. 2019;32(2):88–92.