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Table 1 in vitro and in vivo studies of the LIPUS effect on stem cells

From: Human adipose-derived Mesenchymal stem cells, low-intensity pulsed ultrasound, or their combination for the treatment of knee osteoarthritis: study protocol for a first-in-man randomized controlled trial

First author /Year

Model

Conclusions

Ref.

Ikeda /2006

In Vitro

LIPUS stimulation converts the differentiation pathway of C2C12 cells into the osteoblast and/or chondroblast lineage.

24

Schumann/2006

In vitro

LIPUS could improve in vitro preparation of optimized tissue engineering implants for cartilage repair.

25

Cook /2008

canine

LIPUS improved interface cartilage repair of autologous osteochondral plugs.

26

S.R.Angle /2011

Rat

Ultrasound have a positive effect on osteogenic differentiation of rat bone marrow stromal cells.

27

Ji Hao Cui/2007

Mouse

Ultrasound could be an effective cue to upregulate chondrogenic differentiation of MSCs .

28

Jiang, T /2012

In vitro

LIPUS may induce the osteogenic differentiation of ADSCs in vitro.

29

Jang /2014

In vitro

LIPUS might be used to promote cartilage healing by inducing the migration of CPCs to injured sites.

30

Yamaguchi

/2016

Rat

MSC injection with LIPUS is more effective than either treatment in promoting concurrent cartilage repair .

32

  1. MSC Mesenchymal stem cells, ADSC Adipose stem cells, CPC Chondrogenic progenitor cell