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Quality of recovery after total hip and knee arthroplasty in South Africa: a national prospective observational cohort study

Abstract

Background

Encouraged by the widespread adoption of enhanced recovery protocols (ERPs) for elective total hip and knee arthroplasty (THA/TKA) in high-income countries, our nationwide multidisciplinary research group first performed a Delphi study to establish the framework for a unified ERP for THA/TKA in South Africa. The objectives of this second phase of changing practice were to document quality of patient recovery, record patient characteristics and audit standard perioperative practice.

Methods

From May to December 2018, nine South African public hospitals conducted a 10-week prospective observational study of patients undergoing THA/TKA. The primary outcome was ‘days alive and at home up to 30 days after surgery’ (DAH30) as a patient-centred measure of quality of recovery incorporating early death, hospital length of stay (LOS), discharge destination and readmission during the first 30 days after surgery. Preoperative patient characteristics and perioperative care were documented to audit practice.

Results

Twenty-one (10.1%) out of 207 enrolled patients had their surgery cancelled or postponed resulting in 186 study patients. No fatalities were recorded, median LOS was 4 (inter-quartile-range (IQR), 3–5) days and 30-day readmission rate was 3.8%, leading to a median DAH30 of 26 (25–27) days. Forty patients (21.5%) had pre-existing anaemia and 24 (12.9%) were morbidly obese. In the preoperative period, standard care involved assessment in an optimisation clinic, multidisciplinary education and full-body antiseptic wash for 67 (36.2%), 74 (40.0%) and 55 (30.1%) patients, respectively. On the first postoperative day, out-of-bed mobilisation was achieved by 69 (38.1%) patients while multimodal analgesic regimens (paracetamol and Non-Steroid-Anti-Inflammatory-Drugs) were administered to 29 patients (16.0%).

Conclusion

Quality of recovery measured by a median DAH30 of 26 days justifies performance of THA/TKA in South African public hospitals. That said, perioperative practice, including optimisation of modifiable risk factors, lacked standardisation suggesting that quality of patient care and postoperative recovery may improve with implementation of ERP principles. Notwithstanding the limited resources available, we anticipate that a change of practice for THA/TKA is feasible if ‘buy-in’ from the involved multidisciplinary units is obtained in the next phase of our nationwide ERP initiative.

Trial registration

The study was registered with ClinicalTrials.gov (NCT03540667).

Peer Review reports

Background

This article reports on work from an initiative to create a unified enhanced recovery protocol (ERP) for patients undergoing elective total hip and knee arthroplasty (THA and TKA, respectively) in South Africa. The work presented follows the consensus achieved for implementation of important perioperative care principles by our nationwide multidisciplinary research group in a previously conducted Delphi study [1].

ERPs and benchmark driven registries have been introduced to most surgical specialities in high-income countries (HICs) since Professor Henrik Kehlet’s seminal work on postoperative pathophysiology and rehabilitation more than two decades ago [2]. Improved patient outcomes and better utilisation of hospital resources have resulted in care pathways for THA and TKA adopting ERPs as standard care [3,4,5]. However, reports on the feasibility of implementation and influence on patient outcomes in low-and middle-income countries (LMICs) are limited [6].

Firstly, initiation of benchmark-driven audits of perioperative practice and surgical outcomes for elective procedures are challenged by the ever-present burden of urgent and emergency surgeries in LMICs [7]. Secondly, constrained financial resources result in a scarcity of health professionals working in non-digitalised inefficient health care infrastructures which impedes rethinking clinical practice. South African government hospitals only have 1.1 (inter-quartal-range (IQR) 0.7–2.1) specialists per 100.000 population (unpublished data from the African Surgical Outcome Study) [8], compared with WHO’s recommendations of 20–40 specialists per 100.000 [9]. As a result, knowledge regarding quality of surgical care in LMICs, which is a prerequisite to follow in the footsteps of HICs in the implementation of ERPs, is scarce [10].

That said, we believe that it is possible to institute practice change in a LMIC despite limited resources and that perioperative care for THA and TKA patients in South Africa can improve with implementation of ERP principles. The primary objective of this second phase of changing practice was to document quality of postoperative recovery for THA and TKA patients in the South African public healthcare sector. The secondary objectives were to record patient characteristics and audit standard perioperative practice.

Methods

The STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) statement has been followed for reporting [11].

From May 8 to December 4, 2018, nine South African public hospitals conducted a 10-week prospective observational study of patients scheduled for THA or TKA. Four hospitals (150–350 beds) were District and Regional Hospitals (DRHs) while 5 were Tertiary and Central Hospitals (TCHs), characterised as highly specialised referral centres (500–850 beds). Eight of the nine hospitals participated in our previous study [1].

To reduce selection bias, all patients who were planned to have their THA or TKA during the specified study period at each site were assessed for eligibility to participate in the study. Patients who were older than 18 years and able to understand study questions in either English, Afrikaans, Sesotho, isiZulu or isiXhosa (as preferred) were consecutively enrolled (Fig. 1). Ability to contact the patients telephonically after hospital discharge was a prerequisite. Data were captured by staff involved in the daily care of arthroplasty patients from departments of physiotherapy, anaesthesia and orthopaedic surgery using Research Electronic Data Capture (REDCap) [12]. Thirty days after index surgery, patients were contacted telephonically to ascertain days spent in a discharge destination other than home/with family and occurrence of postoperative complications leading to hospital readmission. Local site investigators confirmed day(s) spent in hospital during readmission and assisted in retrieving missing perioperative data by manual inspection of hospital folders (definitions of postoperative complications in Supplementary data, Table S1).

Fig. 1
figure1

Flowchart of perioperative data capture. * TUG test was performed on day two for patients discharged before day three. If day three after surgery was on a weekend and the physiotherapist was not available to perform the test, patients would have their TUG tests on the first coming weekday i.e. day four or five after surgery

Outcome measures

In line with the objectives, the primary outcome was ‘days alive and at home up to 30 days after surgery’ (DAH30) [13]. DAH30 is a patient-centred composite endpoint incorporating early death, hospital length of stay (LOS), discharge destination and readmission during the first 30 days after surgery. As such, a lower numerical value of DAH30 reports fewer days spent at home/with family during the first 30 postoperative days thus quantitatively documenting impaired quality of recovery (Supplementary data, Appendix 1).

The secondary outcomes were the ability to complete and time taken to perform the ‘timed up and go’ (TUG) test on day three after surgery as measures of early functional recovery [14] (Supplementary data, Appendix 2).

Patient profile and standard perioperative practice were recorded according to the prioritised items for optimising perioperative care for THA and TKA in South Africa [1] (Supplementary data, Tables S2-S5).

As the preoperative morbidity burden and in-hospital resources vary between general and specialist hospitals, a post-hoc decision was made to examine the outcomes of the primary and secondary objectives for patients managed in DRHs compared with TCHs.

Statistical analysis

Statistical analyses were conducted using IBM SPSS version 25 (SPSS Inc., Chicago, IL, USA).

Continuous data were presented as median (IQR), since testing for distribution of data using visual inspection of histograms, skewness, kurtosis and the Shapiro-Wilk test showed that the majority of data were not normally distributed. Comparisons were made using the Mann-Whitney U-test for non-parametric unrelated samples, and p-values < 0.05 were considered significant. Categorical data were expressed as frequencies and percentages, and groups were compared using Pearson’s chi-squared test or Fisher’s exact test as appropriate.

A formal sample size calculation was not performed for this descriptive hypothesis-generating study since the literature on patient characteristics, perioperative interventions and postoperative recovery after THA and TKA in South Africa and LMICs is scarce. The 10-week study period was chosen with the intention of providing a minimum of 20 patients per site, since some DRHs performed two THAs and TKAs per week at the time of protocol development.

Results

Twenty-one (10.1%) out of 207 enrolled patients had their scheduled surgery cancelled or postponed resulting in 186 study patients (Fig. 2). Patient characteristics are presented in Table 1.

Fig. 2
figure2

Flow diagram of the study cohort. n = patients

Table 1 Baseline characteristics of total hip and knee arthroplasty patients in nine hospitals

DAH30. Data capture was complete for all components of DAH30. Median (IQR) LOS in hospital was 4 (3–5) days with significantly shorter stay in DRHs [3 (3, 4) vs 4 (3–5) days, p <  0.001]. One hundred and seventy-one patients (98.8%) mobilised independently with assistive devices on day of discharge and only six patients (3.2%) were transferred to frail care or rehabilitation. No fatalities were encountered but one patient remained hospitalised during the 30-day study period after falling and requiring joint revision of her newly operated hip. Twelve patients (6.5%) developed postoperative complications [1 (1.8%) in DRHs vs 11 (8.5%) in TCHs, p = 0.1], (Table 2), and seven patients (3.8%) were readmitted to hospital [none from DRHs vs 7 (5.4%) from TCHs, p = 0.1]. The distribution of DAH30 was left-skewed, with a median of 26 (25–27) days (Fig. 3.c). Patients receiving surgery in DRHs had a median DAH30 of 27 (26, 27) days compared with 26 (24–27) days in TCHs, p <  0.001 (Fig. 3.a and 3.b, respectively).

Table 2 Thirty-day complication rate after total hip and knee arthroplasty in nine hospitals
Fig. 3
figure3

Distribution of DAH30. a DAH30 for District and Regional Hospitals (n = 57). b DAH30 for Tertiary and Central Hospitals (n = 129). c DAH30 for the full patient cohort (n = 186). Y-axis = Number of patients, X-axis = Days alive and at home up to 30 days after surgery (DAH30). The smoothing line represents normal distribution

Functional recovery

Data were missing for eight patients (4.3%). All 22 patients (12.4%) who were discharged before day three completed their TUG test, whereas 17/118 patients (14.4%) and 1/38 patients (2.6%) were unable to perform the test on day three and day four/five, respectively. The time taken to perform the test on day three was significantly shorter in DRHs (p = 0.02), (Supplementary data, Table S6).

Perioperative practice

Perioperative observations are shown in Table 3 and Supplementary data, Table S7.

Table 3 Perioperative practice for total hip and knee arthroplasty patients in nine hospitals

The preoperative period was characterised by limited implementation of measures to prepare patients for surgery. Sixty-seven patients (36.2%) were assessed in an optimisation clinic (p = 0.01 in favour of TCHs), multidisciplinary education was offered to 74 patients (40.0%) while full body anti-septic wash and optimised fasting regimens were implemented for less than a third of all patients.

Recordings of median operative times were 90 (75–106) minutes for THAs and 105 (85–125) minutes for TKAs with no significant difference between DRHs and TCHs for either procedure. Three intraoperative care principles were implemented for > 95% of the study population; antimicrobial prophylaxis (100%), prevention of perioperative blood loss with anti-fibrinolytics (96.2%) and maintaining normothermia (97.3%). Conversely a peripheral nerve block and/or local infiltration analgesia (PNB/LIA) were performed for 30 THA patients (36.1%) and 62 TKA patients (66.7%). Intergroup analysis showed significantly more TKA patients in DRHs received PNB and/or LIA (26, 92.9%; p < 0.001).

On the first postoperative day, out-of-bed mobilisation was achieved by 69 patients (38.1%) while multimodal opioid-sparing analgesic regimens with paracetamol and Non-Steroid-Anti-Inflammatory-Drugs (NSAIDs) were implemented for 29 patients (16.0%) (both significantly more frequent in DRHs). Although pain management teams assessed 103 patients (57.5%) on the first postoperative day, only 11 patients (7.0%) continued treatment with paracetamol and NSAIDs till the third postoperative day. Postoperative thromboprophylaxis was implemented for 80–85% of all patients on the first 3 days after surgery.

Documentation of missing data in Supplementary data, Table S8.

Discussion

This observational multicentre study has informed us that 30-day quality of recovery measured by DAH30 of 26 days justifies performance of THA and TKA in the South African public healthcare sector. However, the cancellation/postponement rate was high, postoperative functional recovery was delayed and perioperative practice including optimisation of modifiable risk factors lacked standardisation. The findings from this second study towards changing practice for THA and TKA patients in South Africa suggest that a nationwide initiative to implement ERP principles may improve quality of patient care and postoperative recovery.

The quality of postoperative recovery for THA and TKA patients

Both in-hospital and post-discharge qualitative and quantitative measures should ideally be reported to describe a patient’s recovery trajectory fully following surgery [15]. Our primary outcome, DAH30, provided such information for the first 30 days after surgery by merging patient-centred quality of recovery with objectively recorded quantitative outcomes [13].

DAH30 from our study of 26 days was similar to ‘days alive and out of hospital at 30 days after surgery’ in a Canadian study with > 280.000 THA and TKA patients [16] but inferior to a Danish study with > 16.000 patients operated within a fast-track protocol [17]. Although ‘days out of hospital’ does not account for time spent in a postoperative frail care or rehabilitation facility, neither of the two settings routinely use step down facilities [17, 18] which is why their results can be compared with our DAH30. The observation that a higher DAH30 was accomplished in fast-track settings is supported by results from a population-based study including > 1.5 million THA and TKA patients [19], where a greater utilisation of enhanced recovery components was associated with fewer complications and shorter LOS in hospital. When comparing results according to hospital level, a higher burden of comorbidities [16, 17, 20] and delayed mobilisation [19, 21] may have contributed to the significantly lower DAH30 observed for patients operated in TCHs.

Hospital readmissions (3.8%) and 30-day postoperative complications (6.5%) reflects quality of early recovery and result in fewer days spent at home/with family. Both variables are contained in DAH30 and both were similar to international data [18, 22,23,24]. However, our joint revisions accounted for 2.7% of the complications (three joint dislocations following THA (3.4%) and two periprosthetic infections following TKA (2.1%)) which is greater than 30-day THA and TKA data from HICs [17, 22].

Achieving early mobilisation after THA and TKA reflects functional recovery and return of homeostasis. Early ambulation is thus associated with reduced LOS [21] and is, as part of an ERP, believed to reduce postoperative complications by hindering the adverse physiological effects of bed rest [2, 19, 25]. Contrary to ERP goals of same day (as operation) mobilisation [26], only 38.1% of our study cohort mobilised out of bed on the first postoperative day while 14.4% of patients were unable to complete the TUG test on the third postoperative day. Inability to perform timely joint replacement is associated with musculoskeletal decompensation and delayed rehabilitation in LMICs [27]. Lack of standardised postoperative multimodal pain management, as was the case in our study, possibly further contributed to delayed mobilisation [26]. It was however noteworthy that patients operated in DRHs who were more likely to mobilise out of bed on the first postoperative day (p < 0.001), performed the TUG test faster on the third postoperative day (p = 0.02) making a case for enhanced mobilisation programmes in a setting like ours.

The patient characteristics and standard perioperative practice

ERPs were originally introduced as procedure specific evidence-based recommendations aiming to reduce the surgical stress response and enhance postoperative recovery [2]. However, in today’s arthroplasty practice, ERP components have been adopted from other surgical specialities (i.e. not procedure specific recommendations) and discrimination between standard care for modern surgical practice and ERP principles is less pronounced [28]. It follows, that the enhanced care programme developed by our multidisciplinary group which determined the design of this study also contained components considered standard practice in HICs [1].

Only three intraoperative care principles identified as being important for improving postoperative outcomes in our previous study were consistently implemented for more than 95% of patients; i. antimicrobial prophylaxis, ii. tranexamic acid to reduce perioperative blood loss and iii. Measures to maintain normothermia. Postoperative thromboprophylaxis treatment was instituted for 80–85% of our study population the first 3 days after surgery while all other components pertaining to patients’ perioperative journey were delivered with great variation.

However, informed of this inconsistency in patient care, we are now equipped to change practice and facilitate implementation of preoperative multidisciplinary involvement with the aim to ensure patients are physiologically and mentally fit for surgery (i.e. utilise the preoperative period as a ‘window of opportunity’) [29]. Such improvements should enhance patient safety (21.5% of our patients were anaemic [30] and 12.9% were morbidly obese with Body Mass Index (BMI) ≥ 40) [31]) and resource utilisation (10.1% of patients were cancelled/postponed prior to surgery). Further, in our setting with low literacy and limited ability to seek information, we are hopeful that a pragmatic approach to patient education would improve patient empowerment and participation in postoperative rehabilitation, as is standard practice in HICs [28]. Such measures along with implementation of anti-septic body wash and optimised fasting regimens would likely prepare patients better for their scheduled arthroplasty.

We now also have a strong case to educate patients, nurses and doctors in the importance of perioperative multimodal opioid-sparing analgesic regimens to facilitate early postoperative mobilisation. Both are considered core elements in ERPs for joint replacements [32] but with the exception of PNB/LIA for TKA in DRHs, neither were consistently implemented in our practice.

Finally, length of surgery is associated with postoperative complications and is as such a measure of quality of surgery [33, 34]. In support of the quality of surgery provided in our public hospitals, median operative times of 90 and 105 min for THA and TKA, respectively, were similar to results from US and Canadian databases [33, 34]. Although wide IQRs informed of great variation in the performance of joint replacements in both DRHs and TCHs, we believe that such variation in operative times was likely to be associated with the degree of pathology encountered, which in our setting with year-long waiting lists, is often severe. Consequently, we are confident that the quality of surgery was comparable to that of HICs.

Our study had many strengths. Firstly, eight out of nine involved sites had participated in our previous study which possibly heightened accountability for quality of data capture and limited missing data. We thus succeeded in creating a strong tracking system, with 100% data capture for our primary outcome. Secondly, we documented patients’ ability to mobilise independently before discharge. This allowed us to ensure that patients were not inappropriately discharged before adequate functional recovery which would have falsely improved the DAH30. We are therefore confident in the primary outcome reported. Thirdly, in support of the documented observations, 12 out of 16 strong recommendations for implementation from Enhanced Recovery After Surgery (ERAS) Society’s newly published consensus statement for THAs and TKAs were investigated [35]. Use of patient-centred outcome measures like DAH30 are furthermore recommended [36]. Finally, presenting the data according to hospital level has given us an appreciation of resources and challenges pertaining to hospital category. This will assist in facilitating change across different hospital levels.

Our study also had limitations. An observational study inherently carries a risk of selection bias, however, all patients scheduled for THA and TKA during the dedicated study period were invited to participate and with minimal exclusion criteria, we believe selection bias was low. Cognisant of the risk of ‘investigator fatigue’ in a non-funded study like ours, we designed a 10-week study to enrol a minimum of 20 patients per site. However, affected by the high cancellation/postponement rate and unexpected reduction in performance of elective joint replacements at certain sites (as a result of burden of non-elective surgery and/or shortage of personnel), only three hospitals (one DRH and two TCHs) succeeded in operating the minimum of 20 patients. While this observation illustrates ‘real-time’ challenges of providing timely joint arthroplasties in our setting, limited patient numbers can compromise external validity of the study results. However, by involving different level hospitals from four South African provinces, we believe our audit of perioperative practice and postoperative quality of recovery is representative for patients undergoing THA or TKA in the South African public healthcare sector.

Conclusion

Quality of recovery measured by a median DAH30 of 26 days justifies performance of THA and TKA in the South African public healthcare sector. That said, functional recovery was delayed and perioperative practice including optimisation of pre-existing modifiable risk factors lacked standardisation. These findings suggest that quality of patient care and postoperative recovery may improve with implementation of ERP principles. Notwithstanding the limited resources available in a LMIC like South Africa, we anticipate that a change of practice for THA and TKA is feasible if ‘buy-in’ from the involved multidisciplinary units is obtained in the next phase of our nationwide ERP initiative.

Availability of data and materials

The datasets used and analysed during the current study are available from the corresponding author on reasonable request.

Abbreviations

ERP:

Enhanced recovery protocols

HICs:

High-income countries

THA:

Total hip arthroplasty

TKA:

Total knee arthroplasty

LMICs:

Low-and middle-income countries

STROBE:

The STrengthening the Reporting of OBservational studies in Epidemiology

DRHs:

District and regional hospitals

TCHs:

Tertiary and central hospitals

REDCap:

Research Electronic Data Capture

DAH30 :

Days alive and at home up to 30 days after surgery

LOS:

Length of stay

TUG:

Timed up and go

PNB:

Peripheral nerve block

LIA:

Local infiltration analgesia

NSAID:

Non-Steroid-Anti-Inflammatory-Drugs

BMI:

Body Mass Index

ERAS:

Enhanced Recovery After Surgery.

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Acknowledgements

The authors would like to thank Dawid van Straaten for his technical support with the REDCap database and Lizel Loo for being instrumental in assisting setting up and running the study at the involved sites.

A special thanks to the following collaborators from departments of orthopaedic surgery, anaesthesia and physiotherapy, for their dedicated data capture: Aqeelah Amien, Pierre Claudius Arendse, Selma Armas, Delroy Arnolds, Anand Balasubramanian, Mehreen Ismail Bhorat, Benjamine Blankson, Brad Bonner, Bryan Botha, Anjane Brink, Elrika Calitz, Chian-Jia Eden Chiu, Franse Coetzer, Thaakirah Dawood, Waafiq Dawood, Christiaan de Villiers, Karen Dummer, Kathryn Fidler, Kevin Grunewald, Hammaad Gamieldien, Johann Groenewald, Simphiwe Gumede, Yusuf Hassan, Sureta Heyns, Jillian Isaacs, Liesl James, Lynn Karelse, Mishka Karsan, Allison Kouvarellis, Cherese Lapere, Kim Laubscher, Amanda Lebenya, Hettie le Roux, Mariam Maged, Rieneth Magwete, Sekoare Malatji, Sithombo Maqungo, Sayed Mia, Sisalindele Mkhize, Jabo Mofokeng, Zaheer Moonda, Sandile Mwelase, Abbas Omar, Mushaiedah Osborne, Clarie Louise Pfister, Tania Pretorius, Jessica Purcell-Jones, Pireshin Ramdharee, Mario Rankin, Ronald Sauls, Clive Schmuck, Delia Schuster, Myriches Thulile Sibusiswe Biyase, Jade Stellenboom, Andries Swart, Jan Van Dyk, Mary Anne Van Niekerk, Anjani Walford, Stefan Wever & Margaret Williamson.

Funding

This study did not receive any funding.

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Authors

Contributions

UP, RP, GLD, LG, RI, AM, DMN, MN, PR, WVS, HS, RES, RWS, SS, AT, JFvdM, NvdW and BB were responsible for overall conception and design of the study. SD, GLD, ZF, LG, PG, RI, NK, FML, AM, DMN, MN, GMN, NP, CR, JR, PR, WVS, HS, RES, RWS, SS, AT, JFvdM and NvdW made substantial contributions to acquisition of data and UP, RP and BB analysed and interpreted data and drafted the article. All authors critically revised the article, approved of the submitted version and agreed to be accountable for all aspects, accuracy and integrity of the work.

Corresponding author

Correspondence to Ulla Plenge.

Ethics declarations

Ethics approval and consent to participate

This study was approved by the relevant regional human research ethics committees of KwaZulu Natal, Gauteng, Free State and Western Cape, South Africa (KZN; BE305/18, GP; 138/2018, FS; 2018/0124 and WP; 817/2017) and registered with ClinicalTrials.gov (NCT03540667). Written consent to participate in the study was obtained minimum 1 day before surgery.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Plenge, U., Parker, R., Davids, S. et al. Quality of recovery after total hip and knee arthroplasty in South Africa: a national prospective observational cohort study. BMC Musculoskelet Disord 21, 721 (2020). https://doi.org/10.1186/s12891-020-03752-x

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Keywords

  • Total hip arthroplasty
  • Total knee arthroplasty
  • Quality of recovery
  • DAH30
  • Perioperative arthroplasty practice
  • Enhanced recovery protocols
  • Low-and middle-income countries
  • South Africa
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