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Table 3 Expired gas analysis data

From: Topical cutaneous application of carbon dioxide via a hydrogel for improved fracture repair: results of phase I clinical safety trial

 

Unit

Before CO2 therapy

During CO2 therapy

Difference between the means

95%CI for the difference

ETCO2

%

4.78 (4.16–5.59)

4.76 (4.28–5.51)

−0.02 (− 0.34 to 0.35)

[−0.13 to 0.09]

ETO2

%

16.05 (4.57–17.43)

16.08 (14.08–17.09)

0.03 (−0.96 to 0.95)

[−0.21 to 0.28]

R

N/A

0.98 (0.83–1.25)

1.00 (0.79–1.23)

0.02 (−0.06 to 0.21)

[−0.02 to 0.06]

VCO2

mL/min

279.58 (136.36–570.26)

280.05 (54.75–575.90)

0.47 (− 116.0 to 93.08)

[−22.66 to 23.61]

VE

L/min

9.48 (5.99–15.30)

9.47 (2.20–15.20)

−0.01 (−4.54 to 3.30)

[− 0.85 to 0.82]

VE/VCO2

N/A

38.74 (20.54–59.23)

39.71 (23.26–61.19)

0.97 (−7.48 to 12.58)

[−1.38 to 3.32]

VE/VO2

N/A

36.82 (20.39–49.54)

38.20 (26.04–49.56)

1.39 (−8.02 to 12.88)

[−1.51 to 4.29]

VO2

mL/min

274.04 (63.67–499.26)

272.64 (53.00–518.14)

−1.40 (− 105.4 to 144.33)

[−32.32 to 29.52]

  1. Values are expressed as mean (range). n = 19
  2. ETCO2 end tidal carbon dioxide, ETO2 end tidal oxygen, R respiratory exchange ratio (VCO2/VO2), VCO2 carbon dioxide output volume, VE expiratory minute ventilation, VO2 oxygen uptake volume, 95%CI 95% confidence interval, N/A not applicable