Skip to main content
  • Research article
  • Open access
  • Published:

The relationship of the shear wave elastography findings of patients with unilateral lumbar disc herniation and clinical characteristics



The aim of this study was to find out whether the shear wave elastography (SWE) findings of patients with unilateral lumbar disc herniation (LDH) were related to clinical characteristics.


For this purpose, the study group included patients (N = 20; 13 male, 7 female) with complaints of unilateral sciatica, with foraminal stenosis caused by one level of LDH (L4-L5 or L5-S1). An gender-and age-matched control group (N = 27; 16 male, 11 female) was included. All the patients were examined on both the axial and longitudinal planes bilaterally at the same level using a convex array probe (1- 6 MHz, Supersonic Imagine, Aix en Provence, France).


The sciatic nerve stiffness measured on longitudinal planes of the affected side was significantly higher than unaffected side (p < 0.001) and the control group (P < 0.05). Furthermore, the symptom duration of unilateral LDH is positively correlated with the stiffness the sciatic nerve (r = 0.52, p = 0.019).


According to these findings, ultrasound imaging can be considered as a useful tool to detect changes in the sciatic nerve due to disc herniation. This technique will have a promising prospect for many patients with unilateral LDH in monitoring stiffness during rehabilitation and before or after surgery.

Peer Review reports


Many studies have shown that about 80% of the population suffers from low back pain (LBP) [1]. There are a variety of reasons for LBP, the most common reason is degenerative disc disease and LDH due to intervertebral degeneration [2]. Compression of the lumbosacral nerve roots by a herniated disc contribute to LBP. Nearly 40% of these patients sustain radicular pain along the sciatic nerve distribution [3]. These spine-related expenditure have steeped increased recently in the USA [4]. Because its prevalence and significant impact on personal life and social life, early diagnosis of LDH and assessment of sciatic nerve compression are of substantial significance.

Ultrasound is the most widely used imaging technique for clinical work due to its convenience, high repeatability and lack of ionizing radiation. Recently, sonoelastography, a noninvasive method for quantification of the stiffness of tissue, has also been reported as a promising technique for the detection of changes in the peripheral neuropathy. There are two primary techniques:strain elastography (SE) and SWE [5]. SE visualizes tissue deformation with compression applied by the examiner, and in SWE, shear waves are produced by the transducer [6]. SWE which calculates Young’s elastic modulus may give accurate values of stiffness in selected areas inside the box of the measurement, giving us the result in kilopascal (kPa) [7, 8]. Due to its particular mechanical relationship with lumbar disc, it was thought that as the history of LDH increases, the stiffness of the sciatic nerve will change. Therefore, the aim of this study was to examine the elastographic findings of the sciatic nerve in patients with unilateral LDH.


The study group included twenty patients with complaints of unilateral sciatica, with foraminal stenosis caused by one level of LDH (L4-L5 or L5-S1). A gender-and age-matched control group (N = 27; 16 male, 11 female) was formed healthy participants. Healthy participants did not have any indication of the sciatic nerve involvement. Participants who met any of the following criteria were excluded:diabetes mellitus, any type of polyneuropathy, trauma, previous history of back surgery, or piriformis syndrome. Participants with conditions that reduce image quality on US imaging (thick gluteal subcutaneous fat tissue, hip joint prosthesis and/or degeneration) or professional athletes were also excluded. Every subject were selected from those with MRI results in the department of spine surgery. All the patients underwent physical examination (manual muscle testing, sensory testing, and spine SLR test), a visual analog scale (VAS). Each subject was informed of the methods and procedures of this study. Every patient signed a consent form. The study protocol was approved by the local ethics committee.

Patients demographic data (gender、age、BMI、symptom duration) were recorded. MRI results including level of herniation、herniation type、classification of foraminal stenosis and nerve-root pressure (Fig. 1).

Fig. 1
figure 1

A 25-year-old male patient with complaints of sciatica for 10 months (a: T2WI sagittal, b: T2WI axial view), MRI illustrates L5/S1 disc herniation and right nerve root compression (white arrow)

All the patients were evaluated by an experienced sonographer, with more than one thousand patients of experience. The elastographic examination was performed with a Supersonic Aixplorer Ultrasound system (Supersonic Imagine, Aix en Provence, France) equipped with elastographic software and a 1-6 MHz convex array transducer. Coupling gel was used between the transducer and the skin to obtain images. Every subject was examined on both the axial and longitudinal planes bilaterally from subgluteal region to popliteal fossa in prone position during plantar flexion for the knee 180° condition. The sciatic nerve was identified on the axial plane of the subgluteal region and the sciatic nerve diameters (thickness and width) was measured. Then, the transducer was rotated 90° to obtain a longitudinal imaging plane at the same level (Fig. 2). Once the sciatic nerve was visualized on the longitudinal plane of the subgluteal region, the shear wave elastography examination was performed at the same level without compression. The operator kept the transducer stationary during SWE imaging acquisitions. The B-mode and elastographic images were shown simultaneously side by side on a split-screen monitor. The quantitative analysis of sciatic nerve stiffness with SWE used kilopascal measurement with a color scale of 0 to 70 kPa and a circular region of interest at an interval of 4 mm. The shear wave elastic modulus for each sciatic nerve was obtained in at least 3 measurements, and the average values were used for the statistical analysis. The images of each subjects were examined by the same experienced sonographer, the images were analyzed by another sonographer, and the two sonographers were not aware of the clinical case data of the subjects.

Fig. 2
figure 2

Subgluteal approach sonographic appearance in axial plane (a) and subgluteal approach sonographic appearance in longitudinal plane (b). (GT: Great trochanter, IT: Ischial tuberosity, GM: Gluteus maximus, SN: Sciatic nerve (arrows))

The IBM SPSS software (version 16.0; IBM Corporation, New York, USA) was used for the statistics analyses. All data are reported as mean ± standard deviation (SD). The normal distribution of the variables was examined using visual (histogram and probability plots) and analytical methods (Kolmogorov–Smirnov tests). Between-group comparisons were made using the Student’s t Test. The statistical significance was set at P < 0.05.


Demographic and clinical characteristics of each subject were shown on the Table 1. Mean symptom duration ± SD was 66.6 ± 32.0 (range, 0.25–90) months. Mean VAS scores ± SD was 6.6 ± 2.1 (range, 1–9). No significant difference was observed between the groups in terms of age (P = 0.779)、BMI (P = 0.388)、and diameter of the sciatic nerve (all P > 0.05).

Table 1 demographic and clinical characteristics

US measurements were summarized on the Table 2. The affected side comprised 20 patients with mean value of 20.4 ± 4.6 kPa, and the mean value of unaffected side was 12.9 ± 2.2 kPa (Fig. 3). The control group involved 27 subjects with mean value of 12.7 ± 2.1 kPa (left) and 13.5 ± 1.9 kPa (right) (Fig. 4). The sciatic nerve stiffness measurement was found to be significantly higher on the affected side than the unaffected side (P < 0.05) and the control group (all P < 0.05). However, the difference was not statistically significantly in respect of the sciatic nerve diameter on the affected side between the unaffected side and the control group.

Table 2 Diameter of the sciatic nerve and shear wave elastography findings of the groups
Fig. 3
figure 3

A 30-year-old male patient with complaints of sciatalgia for 12 months and VAS scores was 6. The shear wave elasticity value is measured as 22.3 kPa in the affected side (a), and 15.1 kPa in the unaffected side (b)

Fig. 4
figure 4

A 47-year-old female healthy subjects. Shear wave elasticity value is measured as 13.7 kPa in the right (a) and 13.1 kPa in the left (b)

Moreover, the stiffness measurements of the affected side were found to correlate to symptom duration (r = 0.60, p = 0.006). Although the symptom duration and VAS scores were correlated (r = 0.52, p = 0.019), the sciatic nerve diameters were not correlated either with VAS scores or symptom duration (P > 0.05). The r value means correlation coefficient which is a non-dimensional index for measuring the linearity between two variables; the p value is the test value, which is to test whether the two variables have the same correlation with the sample in the population from which the sample is derived Table 3.

Table 3 Relationship between SWE measurements data and clinical features


There have been some studies in literature evaluating the sciatic nerve with elastography. In 2013, Santos claimed that sciatic nerve can be visualized and evaluated by US elastography [9]. After that, Andrade assessed the elasticity of sciatic nerve during passive movements, using SWE. It was demonstrated that the sciatic nerve stiffness can be assessed accurately using elastography, and the stiffness of the sciatic nerve can be affected by the lower limb movements [10].

This study was performed to observe the relationship of the SWE findings and clinical characteristics in patients with unilateral LDH. To the best of our knowledge, this is the first time that the correlation of the stiffness measurements and symptom duration was explored. Our study demonstrated that the longer the unilateral LDH duration, the higher the stiffness of the sciatic nerve. In addition, we also investigated the relationship of VAS scores and symptom duration. We observed that longer history of the unilateral LDH are significantly associated with more serious pain. These findings showed that the importance of early detection of LDH.

LDH, which is manifested by low back pain or sciatica, is one of the common causes of disability in the community [11]. In LDH, nucleus pulposus (NP) material exits the disk space area through the annulus fibrosus (AF), causing mild compression on the spinal nerves and resulting in neurological dysfunction including pain, sensory deficits, and weakness in the low back and leg [12]. There are several changes in the biology of the intervertebral disc which is thought to contribute to LDH. These include increased percent of type I collagen within the NP and inner AF [13], reduced water retention in the NP [14,15,16], degradation of collagen and extracellular matrix materials (ECM) [17], and upregulation of systems of degradation such as apoptosis, matrix metalloproteinase (MMP) expression, and inflammatory pathways [18]. Increased expression of chemokines are associated to clinical severity of sciatic pain in lumbar disk herniation patients [19] .Mechanical compression and accompanying chemical stimulation may cause severe nerve root damage, which in turn affects the axonal transport, affecting the circulation of nerve roots and the metabolism of neurotransmitters [20]. Thereby causes neurilemma edema, fibroblast infiltration, and nerve fiber deformation. These changes can lead to demyelination of the nerve and can alter the nerve connective tissue [21], causing the proliferation of scar tissue and the acceleration of the transverse wave in the nerve. SWE is an imaging technique that emits transverse waves to tissue through a transducer. According to E = 3ρc2 (E is the Young’s modulus, c is the shear wave propagation velocity, and ρ is the tissue density), the machine displays the E value, The faster the shear wave propagation speed, the higher the E value. SWE can quantitatively calculate the E value according to the shear wave propagation velocity in the region of interest, and evaluate the elastic properties of tissues qualitatively by the E value. The tissue stiffness is displayed by color coding. The harder the tissue, the faster the shear wave travels, the higher the E value, and the image appears red. Conversely, the smaller the E value, the softer the tissue and the blue color of the image. In this study, the sciatic nerve of affected appeared blue-green, while the normal one appeared blue. In addition, axonal injury and demyelination occur in parallel with the severity of the injury. Increased expression of chemokines is closely related to the clinical severity of sciatica in patients with LDH [19].


There are a couple of tissues that have to be mentioned and discussed in this study. First, the sample size is small, and the method is not suitable for thick gluteal subcutaneous fat tissue. Second, demographic data such as body mass index、walking habit should be considered. Third, a study, which evaluated the cross-sectional area of the sciatic nerves with tracing method, observed the sciatic nerve enlargement in patients with unilateral sciatica [3]. In contrast, this study showed no significant difference between the affected and unaffected sides in respect of the sciatic nerve diameter. The difference in this measurement method can be attributed ed. as a limitation. The tracing method is more sensitive and accurate than other methods to measure nerve size. Fourth, Andrade demonstrated that the stiffness of the sciatic nerve can be affected by the lower limb movements [10]. This study observed the sciatic nerve in prone position during plantar flexion for the knee 180° condition. Therefore, other position and lower limb movements should be considered.


In summary, we showed that the stiffness measurements of the sciatic nerve were significantly higher in patients with LDH than in healthy subjects. In addition, this study demonstrates that the shear wave elastography of the sciatic nerve in patients with LDH is influenced by symptom duration. Moreover, VAS scores is positively correlated with symptom duration. Although this preliminary study show that shear wave elastography can detect the relationship of the sciatic nerve stiffness、symptom duration and VAS scores, further investigations are required to determine the clinical utility of this technique.

Availability of data and materials

The datasets used and/or analyzed during the current study are stored in our hospital and are available from the corresponding author on reasonable resquest.



Annulus fibrosus


Body mass index


Extracellular matrix materials


Low back pain


Lumbar disc herniation


Matrix metalloproteinase


Magnetic resonance imaging


Nucleus pulposus


Strain Elastography


Straight Leg Raise


Shear wave elastography


Visual analog scale


  1. Epidemiological features of chronic low-back pain. Lancet. 1999;354:581–5.

    Article  Google Scholar 

  2. Amin RM, Andrade NS. Lumbar disc herniation. Curr Rev Musculoskelet Med. 2017;10:507–16.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kara M, Özçakar L, Tiftik T, et al. Sonographic evaluation of sciatic nerves in patients with unilateral sciatica. Arch Phys Med Rehabil. 2012;93:1598–602.

    Article  PubMed  Google Scholar 

  4. Martin BI, Deyo RA, Mirza SK, et al. Expenditures and health status among adults with back and neck problems. JAMA. 2008;299:656–64.

    Article  CAS  PubMed  Google Scholar 

  5. Castera L, Friedrich-Rust M. Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease. Gastroenterology. 2019;156:1264–1281.e4.

    Article  PubMed  Google Scholar 

  6. Inal M, Tan S, Yumusak EM, MH S¸a, Alpua M, Ornek K. Evaluation of the optic nerve using strain and shear wave elastography in patients with multiple sclerosis and healthy subjects. Med Ultrason. 2017;19:39–44.

    Article  Google Scholar 

  7. Jedrzejewski G, Osemlak P, Wieczorek AP. Prognostic values of shear wave elastography in adolescent boys with varicocele. J Pediatr Urol. 2019.

    Article  Google Scholar 

  8. Zardi EM, Franceschetti E, Giorgi C, et al. Reliability of quantitative point shear-wave ultrasound elastography on vastus medialis muscle and quadriceps and patellar tendons. Med Ultrason. 2019;21:50–5.

    Article  PubMed  Google Scholar 

  9. Santos R, Armada P. Sciatic nerve hardness measurement by using ultrasound elastography. Ultrasound Med Biol. 2013;39(5):S57.

    Google Scholar 

  10. Andrade RJ, Nordez A, Hug F, et al. Non-invasive assessment of sciatic nerve stiffness during human ankle motion using ultrasound shear wave elastography. J Biomech. 2016;49(3):326–31.

    Article  Google Scholar 

  11. Frymoyer JW, Pope MH, Clements JH, Wilder DG, MacPherson B, Ashikaga T. Risk factors in low-back pain. An epidemiological survey. J Bone Joint Surg. 1983;65:213–8.

    Article  CAS  Google Scholar 

  12. Chan WC, Sze KL, Samartzis D, Leung VY, Chan D. Structure and biology of the intervertebral disk in health and disease. Orthop Clin North Am. 2011;42:447–64.

    Article  Google Scholar 

  13. Adams MA. Intervertebral disc tissues. In: Mechanical properties of aging soft tissues; 2015. p. 7–35.

    Google Scholar 

  14. Kalb S, Martirosyan NL, Kalani MYS, Broc GG, Theodore N. Genetics of the degenerated intervertebral disc. World Neurosurg. 2012;77(3–4):491–501

    Article  Google Scholar 

  15. Brayda-Bruno M, Tibiletti M, Ito K, et al. Advances in the diagnosis of degenerated lumbar discs and their possible clinical application. Eur Spine J 2014;23(SUPPL. 3):315–323. https://doi. org/10.1007/s00586-013-2960-9.

    Article  Google Scholar 

  16. Colombier P, Clouet J, Hamel O, Lescaudron L, Guicheux J. The lumbar intervertebral disc: from embryonic development to degeneration. Jt Bone Spine. 2014;81(2):125–9

    Article  Google Scholar 

  17. Mayer JE, Iatridis JC, Chan D, Qureshi SA, Gottesman O, Hecht AC. Genetic polymorphisms associated with intervertebral disc degeneration. Spine J. 2013;13(3):299–317

    Article  Google Scholar 

  18. Martirosyan NL, Patel AA, Carotenuto A, et al. Genetic alterations in intervertebral disc disease. Front Surg. 2016;3(November):1–15

    Google Scholar 

  19. Peng ZY, Chen R, Fang ZZ, et al. Increased local expressions of CX3CL1 and CCL2 are related to clinical severity in lumbar disk herniation patients with sciatic pain. J Pain Res. 2017;10:157–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Kantarci F, Ustabasioglu FE, Delil S, Olgun DC, Korkmazer B, Dikici AS, et al. Median nerve stiffness measurement by shear wave elastography: a potential sonographic method in the diagnosis of carpal tunnel syndrome. Eur Radiol. 2014;24(2):434–40.

    Article  Google Scholar 

  21. Dahlin LB, Lundborg G. The neurone and its response to peripheral nerve compression. J Hand Surg (Br). 1990;15:5–10.

    Article  CAS  Google Scholar 

Download references


My sincere appreciation also goes to the Department of Spine Surgery from the First Affiliated Hospital of Anhui Medical University, who participated this study with great cooperation.


The authors declare that they have no funding for the research.

Author information

Authors and Affiliations



QYW, data processing and write the paper. HAZ, revised the paper. HUZ, provide experimental guidance in every stage. JXZ, image acquisition, experimental operation. HQZ, assist in specimen collection, provide necessary materials, give advice of great value and inspiration of new idea. All authors have read and approved the manuscript.

Corresponding author

Correspondence to Hui Zheng.

Ethics declarations

Ethics approval and consent to participate

This research involving human data have been performed in accordance with the Declaration of Helsinki and have been approved by an appropriate ethics committee. Written, informed consent to participate was obtained from participants (or their parent or legal guardian in the case of children under 16).

The name of the ethics committee: The Ethics Committee of Clinical Medicine Research, the First Affiliated Hospital of Anhui Medical University.

The reference number: YJ2019-05-07.

Consent for publication

Written, informed consent was obtained for participants (or their legal guardian if they were under the age of 16), for the publication of identifying images or other personal or clinical details of participants that compromise anonymity.

Competing interests

The authors declare that they have non-financial competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, Q., Zhang, H., Zhang, J. et al. The relationship of the shear wave elastography findings of patients with unilateral lumbar disc herniation and clinical characteristics. BMC Musculoskelet Disord 20, 438 (2019).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: