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  • Research article
  • Open Access
  • Open Peer Review

The impact of sarcopenic obesity on knee and hip osteoarthritis: a scoping review

BMC Musculoskeletal Disorders201819:271

https://doi.org/10.1186/s12891-018-2175-7

  • Received: 8 March 2018
  • Accepted: 10 July 2018
  • Published:
Open Peer Review reports

Abstract

Background

The progressive, debilitating nature of knee and hip osteoarthritis can result in severe, persistent pain and disability, potentially leading to a need for total joint arthroplasty (TJA) in end-stage osteoarthritis. TJA in adults with obesity is associated with increased surgical risk and prolonged recovery, yet classifying obesity only using body mass index (BMI) precludes distinction of obesity phenotypes and their impact on surgical risk and recovery. The sarcopenic obesity phenotype, characterized by high adiposity and low skeletal muscle mass, is associated with higher infection rates, poorer function, and slower recovery after surgery in other clinical populations, but not thoroughly investigated in osteoarthritis. The rising prevalence and impact of this phenotype demands further attention in osteoarthritis treatment models of care, particularly as osteoarthritis-related pain, disability, and current treatment practices may inadvertently be influencing its development.

Methods

A scoping review was used to examine the extent of evidence of sarcopenic obesity in adults with hip or knee osteoarthritis. Medline, CINAHL, Web of Science and EMBASE were systematically searched from inception to December 2017 with keywords and subject headings related to obesity, sarcopenia and osteoarthritis.

Results

Eleven studies met inclusion criteria, with indications that muscle weakness, low skeletal muscle mass or sarcopenia are present alongside obesity in this population, potentially impacting therapeutic outcomes, and TJA surgical risk and recovery.

Conclusions

Consideration of sarcopenic obesity should be included in osteoarthritis patient assessments.

Keywords

  • Sarcopenic obesity
  • Body composition
  • BMI
  • Osteoarthritis
  • Arthroplasty

Background

Osteoarthritis is a chronic, progressive joint disease and leading cause of pain and mobility disability for over 27 million Americans [1] and 4 million Canadians [2]. Age, sex, genetics, joint trauma, and obesity all influence the development of this disease [3], and its progressive nature means advanced treatment options may be required in later stages to reduce pain, improve function and maintain quality of life. Surgical replacement of articular joint components, called a total joint arthroplasty (TJA), is currently the most effective treatment for severe pain and disability associated with end-stage knee or hip osteoarthritis that ceases to respond to other therapeutic interventions.

There has been a rapid and sustained increase in demand for TJA surgery around the world over the past two decades. TJA rates in the USA doubled from 336,000 patients in 1993 to 735,000 patients in 2005 [4], and are projected to top 4 million patients by 2030 [5]. In Canada, volumes are lower but the accrual rate tripled from 42,000 patients in 2000 [6] to 117,000 patients in 2016 [7], and similar persistent growth is apparent throughout Europe [8]. This increased demand is outpacing the supply of TJA, leading to longer wait times and pressure on health care systems to reduce delays in accessing care. To ensure timely and appropriate TJA access, optimization and prioritization of patient selection is critical. Clear, evidence-based guidelines for surgical appropriateness are lacking, resulting in a reliance on clinical judgement [9]. This has led to subjectivity in risk stratification, conflicting approaches and barriers or delays in treatment access for patients with obesity due to evidence of increased surgical risk.

Two meta-analyses have found increased risk of superficial infections (OR 1.7–2.2) [10, 11] and deep infections (OR 2.4) [10] after total knee arthroplasty (TKA) in patients with obesity (defined as a body mass index/BMI ≥ 30 kg/m2) compared to patients without obesity (BMI < 30 kg/m2). Those with severe obesity (BMI ≥ 40 kg/m2) appear to be at even higher risk, with four times the rate of infection after TKA compared to those without obesity [11, 12]. Increased infection after total hip arthroplasty (THA) is less clear [13]. Yet controversy exists around evidence of increased risk related to excess body weight. Methodological concerns regarding quality and comparability of studies have been raised, with underpowered sample sizes, BMI categorization/dichotomization, and absence of sub-classification by comorbidity status limitations in current evidence [14, 15].

Suggestions for establishing a BMI threshold for withholding TJA surgery have been made [11, 14, 16], while others argue against using BMI as an outright contraindication for TJA [17, 18]. Without clear guidelines, orthopaedic surgeons may decide to deny or delay surgery based on their interpretation of evidence of surgical risk. Of greater concern, many surgeons recommend that patients lose weight to reduce their BMI before returning for re-assessment of surgical eligibility [12, 14, 19]. This recommendation is in contrast to current evidence that suggests weight loss does not improve perioperative TJA risk. Lui et al. [20] found weight loss of ≥5% of body weight in the year prior to TJA resulted in either no difference or an increased risk of deep infection (OR 3.8). Weight loss may inadvertently increase perioperative infection, as muscle lost concomitantly with fat may lower lean muscle reserves, which are critical to the wound healing process [21].

Reliance on BMI may result in misclassification bias and denial of surgery for patients with obesity. BMI is a poor indicator of individual health as it cannot discern individual body composition of muscle, bone or fat [22]. Significant deviations in body composition within BMI categories have been reported [2224], including twofold differences in adiposity [25] and 30 kg differences in lean soft tissue [26] between patients who have the same BMI [27]. Relying on BMI as a screening tool for TJA ignores the influence body composition has on surgical risk, particularly in relation to the amount of skeletal muscle mass as shown in other clinical scenarios [28, 29]. A high BMI could disguise important skeletal muscle mass depletion, as in the condition of sarcopenic obesity [26, 30].

What is sarcopenic obesity?

Sarcopenic obesity is defined as the co-occurrence of high adiposity and sarcopenia, a term coined to describe low skeletal muscle mass, strength and physical function originally diagnosed in the elderly [31], but present across the age spectrum [32, 33]. Sarcopenia is associated with physical disability, falls, extended hospital stays, infection and non-infection related complications, and increased overall mortality [3436]. Importantly, sarcopenia is not restricted to people who appear thin or underweight. Aging is often paralleled by increased rates of muscle loss and concomitant gains in adiposity (both subcutaneous and intramuscular), which can culminate in sarcopenic obesity [37].

Compounding the effects of both sarcopenia and obesity, sarcopenic obesity is associated with poorer quality of life and greater disability, morbidity and mortality when compared with either obesity or sarcopenia alone [3739]. Although the majority of studies to date have been conducted in elderly individuals, sarcopenia and sarcopenic obesity are not limited to this population. There are several clinical disorders where individuals are prone to muscle loss (with or without concurrent obesity), including diabetes, cancer, chronic obstructive pulmonary disease, HIV, cirrhosis, and arthritis [40]. The presence of sarcopenic obesity may be particularly important to consider when surgery is indicated. In addition to increased length of hospital stay and increased mortality associated with this condition [40], there is convincing evidence of its relationship with increased infection rates [28, 29, 41].

With obesity present in 26 to 38% of adults in Canada and the USA respectively [42], and an aging population with a longer life span, sarcopenic obesity may be a new epidemiological trend of current times [43]. Importantly, it cannot be identified by simply measuring body weight or calculating BMI [44].

Is sarcopenic obesity a concern in osteoarthritis?

Individuals with osteoarthritis may be at particular risk for sarcopenic obesity. The prevalence of osteoarthritis rises with age and obesity, and osteoarthritis-related pain can lead to inactivity and a decline in physical function. These factors in combination create a vicious cycle of inflammation, inactivity and aging-related muscle loss accompanied by aging-related gains in adiposity, giving rise and perpetuating the sarcopenic obesity phenotype [4547] (Fig. 1). Chronic diseases associated with osteoarthritis [48], such as diabetes, metabolic syndrome, and hypertension, along with weight loss and subsequent re-gain (weight cycling), could exacerbate skeletal muscle loss, increase adiposity and contribute to the development of sarcopenic obesity [49]. Further, the development and progression of sarcopenia and osteoarthritis may occur through interrelated pathways [50, 51].
Fig. 1
Fig. 1

Relationship between aging, obesity and osteoarthritis and the development of sarcopenic obesity

Body composition phenotypes of low skeletal muscle and high adiposity have been reported in patients with knee and hip osteoarthritis by Karlsson [5254], Purcell [55] and Visser [56], although sarcopenia or obesity were not specifically identified. Nevertheless, this is compelling evidence and may indicate that this condition is present in osteoarthritis but not recognized or identified as sarcopenic obesity.

To provide a more complete understanding of sarcopenic obesity in lower extremity osteoarthritis, a scoping review was conducted to determine the extent of reported prevalence and impact of low muscle mass, muscle weakness or sarcopenia in adults with obesity and knee or hip osteoarthritis. Scoping reviews enable a comprehensive and encompassing review of emerging literature on a topic [57], and can be preferable to systematic reviews when the research question is examining the breadth of evidence on a topic, as in this case. Scoping reviews utilize transparent processes and systematic search strategies much like systematic reviews, and while they don’t typically include a grading system or formal quality assessment of included studies, a description of study limitations can be incorporated into the results.

Methods

This scoping review was conducted following the methodology of Arksey and O’Malley [58], including a systematic search of the published literature. Medline, CINAHL, Web of Science and Embase databases were searched from inception to December 2017 using MeSH terms and keywords related to osteoarthritis, obesity, and sarcopenia (including dynapenia, muscle weakness, muscle atrophy, low muscle mass, muscle loss, body composition, body compartment, lean soft tissue, lean body mass, lean mass, fat free mass, muscle size or muscle mass). Inclusion criteria was determined by the authors prior to search initiation. Studies were to be included if they were primary or secondary analyses, and subjects had knee or hip osteoarthritis. Additionally, studies must have conducted group/subgroup analysis by obesity (identified using body mass index/BMI, waist circumference, fat mass or percent body fat), and examined muscle mass, muscle strength/weakness or sarcopenia. Studies on animal models and children were excluded, along with studies where participants did not have knee or hip osteoarthritis, or obesity, or if the study was an editorial, protocol or review article. Reference lists of relevant articles were hand searched to identify articles missed in the primary investigation. From each included study we extracted the author, publication year, study design, sample population, methodologies for assessing obesity and sarcopenia, study limitations and relevant findings. A summary of extracted information was tabulated and a descriptive analysis was conducted.

Results

A total of 796 articles were identified in the original search and 118 full text articles were screened for potential relevance (Fig. 2). Eleven studies met inclusion criteria [5969], and a summary of study characteristics and key findings are presented in Table 1.
Fig. 2
Fig. 2

Systematic search strategy and results

Table 1

Studies reporting low skeletal muscle mass and/or muscle weakness in adults with obesity and knee or hip osteoarthritis

Author, Year

Study purpose

Study design

Population

Definition of obesity

Body composition methodology

Definition of low muscle massa,b or muscle weakness

Study limitations

Relevant findings

Batsis et al. [59], 2015

To describe the impact of dynapenic obesity on physical function in knee OA

Longi-tudinal,

North American population from OsteoArthritis Initiative (OAI), age ≥ 60 years, n = 526 in subgroup with knee OA (rKOA),

BMI ≥30 kg/m2

NI

Lowest sex-specific tertile of knee extensor strength (dynapenia)

Secondary analysis of prospective data from longitudinal cohort. Excluded severe knee OA. No assessment of muscle mass or body composition

Prevalence of dynapenic obesity was 16%.

Clemence et al. [69], 2017

To analyze the association between low lean mass and clinical symptoms in knee and hip OA

Cross-sectional

French adults with hip and knee OA (KL grade ≥ 2) from KHOALA study, n = 358, age 63.4 ± 8.4 years

BMI ≥30 kg/m2, or sex specific FM or WC cut-offs

DXA

ASM/BMI < 0.789 for men and < 0.512 for women (FNIH cutoffs)

Secondary analysis of prospective data from longitudinal cohort. No information on exclusion criteria. No assessment of muscle strength or function

SO prevalence was 16.2%. Low lean mass was associated with pain and impaired function in subjects with normal BMI, but not with obesity (no significant differences between NSO and SO groups).

Ji et al. [60], 2016

To identify the prevalence of SO in knee and hip orthopedic surgery (OS) patients

Cross-sectional

Korean orthopedic surgery patients (hip or knee TJA or femoral fracture repair) (OS, n = 222) compared to control non-surgical outpatients (non-OS, n = 364)

BMI > 25 kg/m2

DXA

ASM/height2, ASM/weight, and ASM/height and fat mass (residuals)

Retrospective analysis of data. No assessment of muscle strength or function

SO prevalence ranged from 1.3–35.4% in TKA and 0–18.4% in THA patients depending on definition used. SO rates were higher in OS patients compared to non-OS patients.

Jin et al. [61], 2017

To examine the associations between obesity, sarcopenia and OA in elderly

Cross-sectional

Korean population (KNHANES) age ≥ 65 years group with knee OA (K/L grade ≥ 2) (n = 1865) compared to lumbar spondylosis group (n = 1709)

BMI ≥25 kg/m2

DXA

ASM/weight, 2SDs below average of sex-matched young reference group

Secondary analysis of population survey data. No assessment of muscle strength or function

Results indicate correlation between SO and NSO with knee OA, but no relationship with lumbar spondylosis. Females with SO had increased OR for knee OA when adjusted for age and waist circumference (OR 1.80, CI 1.03–3.12).

Knoop et al. [62], 2011

To identify distinct clinical phenotypes and their impact in knee OA

Cross-sectional

North American population with knee OA (K/L grade 0–4) from OsteoArthritis Initiative (n = 842, age 63.2 ± 9.1)

BMI ≥30 kg/m2

NI

Low mean score of quadriceps and hamstring isometric strength

Secondary analysis of prospective data from longitudinal cohort. No assessment of muscle mass or body composition. No clear cut-off for defining weakness

Dynapenic obesity group (“obese and weak” phenotype) had higher pain and poorer physical function compared to “minimal joint disease”, “strong muscle”, and “non-obese and weak” phenotypes.

Lee et al. [63], 2016

To investigate association between lower limb muscle mass and knee OA

Cross-sectional

Korean population (KNHANES) age ≥ 50 years, n = 821 with knee OA (K/L grade ≥ 2), (n = 821), and control group without knee OA (n = 4103)

BMI ≥27.5 kg/m2

DXA

ASM/weight, 2SD below the mean in sex-matched young reference group (< 29.5% in men, < 23.2% in women)

Secondary analysis of population survey data. No assessment of muscle strength or function

SO prevalence was 5.2% in knee OA group compared to 1.8% in control group.

Lee et al. [64], 2012

To analyze the association between knee OA, sarcopenia and obesity

Cross-sectional

Korean population (KNHANES) with bilateral knee OA (K/L grade ≥ 2) age ≥ 50 years, n = 2893

BMI ≥27.5 kg/m2

DXA

ASM/weight, 2SD below the mean in sex-matched young reference group (< 26.8% in men, < 21% in women)

Secondary analysis of population survey data. No assessment of muscle strength or function

SO prevalence was 3% overall. When adjusted for age and sex, SO had stronger association with knee OA (OR 3.51, CI 2.15–5.75) compared to NSO (OR 2.38, CI 1.80–3.15).

Manoy et al. [65], 2017

To assess association between leptin, vitamin D, muscle strength and physical performance in knee OA

Cross-sectional

Thailand knee OA patients (K/L grade < 3) (n = 208), age 65 ± 7 years

BMI > 25 kg/m2

BIA

ASM/weight < 30.4% in men and < 25.8% in women, and EWGSOP gait speed and grip strength cutoffs

Unclear if data collected retrospectively or prospectively. No description of sampling methods. Excluded severe knee OA

SO prevalence was 13.9%. Patients with SO had poorer performance on the timed up and go (TUG), sit to stand (STS) and 6 min walk tests (6MWT) compared to those with NSO or NO.

Oosting et al. [66], 2016

To determine the association of obesity and recovery after THA when stratified by muscle strength

Cross-sectional

Netherlands THA patients (n = 297), age 69 ± 11 years

BMI > 30 kg/m2

NI

Maximal handgrip strength (< 20 kg for woman and < 30 kg for men)

Secondary analysis of prospective cohort. No assessment of muscle mass or body composition

Obesity and muscle weakness (dynapenic obesity) was associated with prolonged length of stay > 4 days (OR 3.59, CI 1.09–11.89) and delayed inpatient recovery (> 2 days to walk with gait aid) (OR 6.21, CI 1.64–23.65), but not in those with obesity alone.

Segal et al. [67], 2005

To analyze the impact of low limb lean mass in knee OA distinct from body weight

Cross-sectional

Japanese female orthopedic knee OA (K/L grade ≥ 2) patients age ≥ 45 years (n = 341), compared to control group with fracture, sprains or back pain (n = 604)

BMI > 24.9 kg/m2

BIA

Lower limb LST

Unclear if data collected retrospectively or prospectively. No clear cut-off for defining low LST. No assessment of muscle strength or function

Females with knee OA had 5–15% less lower limb LST compared to control groups across BMI categories, with significant 1.8 kg and 1.5 kg differences in overweight and obesity groups, respectively.

Suh et al. [68], 2016

To analyze the association between obesity, sex, and lower extremity lean mass in knee OA

Cross-sectional

Korean population (KNHANES) age ≥ 50 years with unilateral knee OA (K/L grade ≥ 2) (n = 4246; 1829 men and 2417 women)

BMI ≥27.5 kg/m2

DXA

Lower extremity LST/weight, in lowest quartile

Secondary analysis of population survey data. No assessment of muscle strength or function

In females, obesity and low muscle mass was strongly association with knee OA (OR 2.31, CI 1.35–3.93) compared to obesity and normal muscle mass (OR 1.03, CI 0.26–4.02).

ASM appendicular skeletal mass, ASMI ASM/height2, BIA bioelectrical impedance analysis, BMI body mass index, CI confidence interval, DXA dual-energy x-ray absorptiometry, EWGSOP European Working Group on Sarcopenia in Older People, FM fat mass, FFM fat free mass, FNIH Foundation for the National Institute of Health, KNHANES Korean National Health and Nutrition Examination Survey, K/L Kellgren/Lawrence radiographic osteoarthritis score, LST lean soft tissue, LSTI LST/height2, NI not included in study design, NO normal body composition, NSO non-sarcopenic obesity, OA osteoarthritis, OR odds ratio, rKOA radiographic evidence of knee osteoarthritis, SD standard deviation, SO sarcopenic obesity, THA total hip arthroplasty, TJA total joint arthroplasty, TKA total knee arthroplasty, VAS visual analog scale, WC waist circumference, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index

aVaried indices for identifying low muscle mass: LSTI, LST/weight, ASM, ASMI, ASM/weight, ASM/BMI, ASM relative to height and FM (residuals), and FM:FFM ratio [26]. Indices that consider LST or ASM relative to weight, BMI or FM may be most appropriate in adults with obesity [26], and relevant to identify clinically relevant weakness [76]

bTerms from included studies were adjusted for consistency and accurate representation of body composition compartment, and may differ from original reports

Publication dates ranged from 2005 to 2017, with the majority (n = 8, 73%) published in the last three years, potentially indicating a growing awareness and understanding of sarcopenic obesity. Ten of the eleven studies were cross-sectional [6069], and one longitudinal [59]. Four studies (36.4%) were secondary analyses of the Korea National Health and Nutrition Examination Survey (KNHANES) population cohort [61, 63, 64, 68], two (18.2%) were secondary analyses of the North American Osteoarthritis Initiative (OAI) population cohort [59, 62], one (9%) was a secondary analysis of the French Knee and Hip OsteoArthritis Long-term Assessment (KHOALA) cohort [69], and the remaining four (36.4%) were independent studies with cohorts from Korea [60], Thailand [65], Japan [67] and the Netherlands [66]. Eight studies focused on osteoarthritis of the knee joint [59, 6165, 67, 68], with two additional studies examining both knee and hip [60, 69], and one solely on hip osteoarthritis [66].

Discussion

This scoping review identified eleven studies with clear indications that muscle weakness, low skeletal muscle mass, or sarcopenia occur in conjunction with obesity in lower extremity osteoarthritis. The majority of included studies examined prevalence and association of the sarcopenic obesity phenotype with the presence of knee or hip osteoarthritis [60, 61, 63, 64, 67, 68], however others investigated the impact on pain, physical function, and quality of life [59, 62, 65, 69] or arthroplasty outcomes [66].

The prevalence of the sarcopenic obesity phenotype in adults with knee osteoarthritis may be as high as 35.4% [60], although a wide range was reported across included studies (prevalence of 3% [64], 13.9% [65], 16.2% [69], and up to 35.4% [60]). Differences in prevalence are likely related to varied obesity and sarcopenia classification criteria utilized in each study, a problem previously addressed elsewhere [26]. Obesity was classified by BMI (in kg/m2) in all studies, but different cut-offs were used in Asian populations (either BMI ≥ 25 [60, 61, 65, 67] or ≥ 27.5 [63, 68]), and North American and European populations (BMI ≥ 30 [59, 62, 66, 69]), making it difficult to compare across study groups and populations. Prevalence also varied depending on the sarcopenia assessment method used in the study. Ji et al. [60] examined differences in sarcopenic obesity rates in hip and knee arthroplasty patients comparing low muscle mass (assessed with dual-energy x-ray absorptiometry/DXA) using three approaches: appendicular skeletal mass (ASM)/height2, ASM/weight, and ASM relative to height and total fat mass, called the residual method [70]). They found prevalence of sarcopenic obesity differed between 1.3–35.4% in TKA patients and 0–18.4% in THA patients depending on the approach. Whether distinctions exist between low muscle mass present only in the lower extremities versus the whole body remains unclear [63, 67, 68]. Emerging evidence suggests that in patients with a larger body mass, the ratio between fat and muscle compartments (a metabolic load-capacity model) may be most relevant for identifying clinically important sarcopenic obesity [26].

There is currently no definitive diagnostic criteria established to identify sarcopenic obesity [7173]. Several consensus papers on defining sarcopenia in the elderly have been published, including the European Working Group on Sarcopenia in Older Persons (EWGSOP) [31], the European Society for Clinical Nutrition and Metabolism Special Interest Groups (ESPEN-SIG) [74], the International Working Group on Sarcopenia (IWGS) [75], and the Foundation for the National Institute of Health (FNIH) [76]. There is general agreement that the presence or absence of sarcopenia in the elderly should be based on a combined assessment of physical function (measurement of gait speed), muscular strength (measurement of handgrip or lower body strength), and body composition (to determine low skeletal muscle mass). However whether these measures are equally applicable to patients with concurrent chronic degenerative conditions remains to be explored.

Of the studies in this scoping review, seven used only body composition/low muscle mass for sarcopenia identification [60, 61, 63, 64, 6769], three used only an assessment of muscle weakness (testing handgrip [66] or quadriceps strength [59, 62]), and only one study utilized a combined approach following EWGSOP consensus criteria [65] including assessment of physical function with gait speed in addition to muscle strength and body composition. Using gait speed as an assessment of physical function may create challenges in the osteoarthritis population. Osteoarthritis-related joint pain and stiffness may impact testing methods or may require alterations or alternatives to currently used criteria thresholds [77] or modifications to gait speed parameters. Additionally, risk of falls is high in those with moderate to severe osteoarthritis [78], which may increase the challenge of assessing physical function in this population.

The relationship between the sarcopenic obesity phenotype and knee osteoarthritis may be unique compared to other orthopedic and musculoskeletal conditions. In the included studies, no association was found between sarcopenic obesity and lumbar spondylosis [61], or in patients with fractures, sprains and back pain [67], or non-orthopedic hospital outpatients [60]. The development and progression of sarcopenic obesity may be interrelated with osteoarthritis development and progression. Lee et al. [63] found sarcopenic obesity was more prevalent in Korean adults with knee osteoarthritis compared to those without knee osteoarthritis (5.2% vs 1.8%, respectively). Batsis et al. [59] found rates of muscle weakness with obesity were higher in adults with clinically diagnosed knee osteoarthritis compared to those at risk for knee osteoarthritis (16% vs 6%, respectively). Sex specific differences may exist in this relationship. Suh et al. [68] found increased odds of knee osteoarthritis when low lower-extremity muscle mass was present in women with obesity (OR 2.31, CI 1.35–3.93), but not in men. Another study reported similar associations only in women over age 65 [61].

The findings of this scoping review support the theoretical impact of sarcopenic obesity on therapeutic outcomes for osteoarthritis, and surgical risk and recovery after joint arthroplasty. To date, only one study has investigated outcomes after TJA, with results showing obesity with muscle weakness was related to delayed independent walking (more than 2 days) and prolonged hospital stays (more than 4 days) compared to obesity alone [66].

It is reasonable to infer that reduced muscle strength or skeletal muscle mass would influence short and long-term recovery after arthroplasty and rehabilitation requirements to return to daily life. Muscle depletion is indicative of a reduction in physiologic protein reserves, which can contribute to impaired wound healing, increased risk of infections and longer recuperation after surgery [79]. A study by Kumar et al. [80] found that handgrip strength < 15 kg was associated with longer hospital stay after TJA, highlighting this potential relationship. Further, a study by Mau-Moller et al. [81] reported that low thigh muscle mass was a better predictor than BMI for loss of bone mineral density after TKA. This is important as loss of bone mineral density can lead to early prosthetic loosening after TKA and a need for revision surgery, suggesting that muscle mass may be more relevant than BMI for long term TKA outcomes.

Identifying sarcopenic obesity early in the continuum of care for osteoarthritis is critical to avoid inappropriate treatment recommendations. The current practice of recommending weight loss prior to TJA based on assessment of body weight or BMI [64] may need further consideration as weight loss attempts may also result in loss of skeletal muscle mass [40, 49], potentially exacerbating the sarcopenic obesity phenotype. Body composition measurement may be a critical assessment tool to distinguish between normal versus abnormal amounts of skeletal muscle mass and provide a more accurate assessment of adiposity [82], as anthropometric measures of obesity (using waist circumference, height, weight and BMI) may not differentiate between muscle and adipose tissue compartments. As previously discussed, body weight loss ≥5% in year preceding TJA was associated with increased surgical risk and higher readmission rates [20]. This may be a result of individuals with sarcopenic obesity losing weight, further reducing their already low muscle reserve, in turn impacting healing rates and perpetuating the vicious cycle of sarcopenia and obesity. Alternatively, it could suggest individuals with obesity and normal skeletal muscle mass (non-sarcopenic obesity) became sarcopenic post weight-loss (by losing more skeletal muscle mass without a substantial decrease in body weight to be considered non-obese) [40].

Study limitations

Every effort was made to comprehensively search and include all relevant studies in the literature, however there is a possibility that some were inadvertently missed. Further, while a limitation of scoping reviews is the lack of a formal risk of bias or study quality assessment, we have included a descriptive analysis of study design and limitations in Table 1 of the results section to enable assessment of level of evidence.

Conclusion

Sarcopenic obesity may be impacting therapeutic and surgical outcomes in osteoarthritis treatment approaches, yet this cannot be discerned until assessments for sarcopenic obesity are explored and regularly applied. There is a need to move beyond BMI and simple obesity diagnosis in osteoarthritis models of care, possibly including more sophisticated assessments of body composition. As gait speed and handgrip strength assessments to identify patients at risk for sarcopenic obesity have not been well-tested in the osteoarthritis population, further research is required to clarify the effectiveness of these screening approaches in populations with physical function limitations. In the interim, incorporating clinical assessments for sarcopenic obesity through body composition may be essential to prevent misclassification bias and provide clarity on TJA surgical risk and recovery in adults with obesity.

Abbreviations

BMI: 

body mass index

CINAHL: 

Cumulative Index of Nursing and Allied Health Literature

DXA: 

dual-energy x-ray absorptiometry

EMBASE: 

Excerpta Medica dataBASE

MeSH: 

medical subject heading

THA: 

total hip arthroplasty

TJA: 

total joint arthroplasty

TKA: 

total knee arthroplasty

Declarations

Funding

KG is supported by a Mitacs Accelerate internship in partnership with the Alberta Bone and Joint Health Institute. CMP is supported by a Canadian Institutes of Health Research (CIHR) New Investigator Salary Award and the Campus Alberta Innovation Program.

Availability of data and materials

All articles included in the review are listed in the references. Articles were identified in Medline, CINAHL, Web of Science and EMBASE databases, and access to full text is dependent on journal and institutional constraints.

Authors’ contributions

KG, CMP, LJW and MF contributed to the conception and design of the review. KG prepared the first draft, and KG, CMP, LJW and MF contributed to the manuscript revision and approval of the final version.

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

All authors declare they have no competing interests that would create a conflict of interest in connection with this manuscript. KG, CMP and MF have no disclosures; LJW has received funding from the Research Advisory Board of Focus on Therapeutic Outcomes Inc. (FOTO) and the American Physical Therapy Association Outcome Measures Registry.

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Authors’ Affiliations

(1)
Faculty of Rehabilitation Medicine, University of Alberta, 8205 – 114 Street, 2-64 Corbett Hall, Edmonton, AB, T6G 2G4, Canada
(2)
Division of Human Nutrition, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, AB, Canada
(3)
Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada
(4)
Department of Occupational Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada

References

  1. Lawrence RC, Felson DT, Helmick CG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States, part II for the National Arthritis Data Workgroup. Arthritis Rheum. 2008;58(1):26–35.View ArticlePubMedPubMed CentralGoogle Scholar
  2. Bombardier C, Hawker G, Mosher D. The impact of arthritis in Canada : today and over the next 30 years. Arthritis Alliance of Canada. 2011;Google Scholar
  3. Bastick A, Runhaar J, Belo J, Bierma-Zeinstra S. Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies. Arthritis Res Ther. 2015;17(152):1–13.Google Scholar
  4. Tian W, DeJong G, Brown M, Hsieh CH, Zamfirov ZP, Horn SD. Looking upstream: factors shaping the demand for postacute joint replacement rehabilitation. Arch Phys Med Rehabil. 2009;90(8):1260–8.View ArticlePubMedGoogle Scholar
  5. Bumpass DB, Nunley RM. Assessing the value of a total joint replacement. Curr Rev Musculoskelet Med. 2012;5(4):274–82.View ArticlePubMedPubMed CentralGoogle Scholar
  6. Canadian Joint Replacement Registry. 2002 Report Total Hip and Total Knee Replacements in Canada.; 2002.Google Scholar
  7. Canadian Institute for Health Information (CIHI). Hip and Knee Replacements in Canada: Canadian Joint Replacement Registry 2015–2016 Quick Stats.; 2017.Google Scholar
  8. OECD/EU. Health at a Glance: Europe 2016 – State of Health in the EU Cycle. Paris; 2016.Google Scholar
  9. Dowsey MM, Gunn J, Choong PFM. Selecting those to refer for joint replacement: who will likely benefit and who will not? Best Pract Res Clin Rheumatol. 2014;28(1):157–71.View ArticlePubMedGoogle Scholar
  10. Kerkhoffs GMMJ, Servien E, Dunn W, Dahm D, Bramer JAM, Haverkamp D. The influence of obesity on the complication rate and outcome of total knee arthroplasty. J Bone Jt Surg. 2012;94(20):1839–44.View ArticleGoogle Scholar
  11. Si H, Zeng Y, Shen B, et al. The influence of body mass index on the outcomes of primary total knee arthroplasty. Knee surgery, Sport Traumatol Arthrosc. 2015;23(6):1824–32.View ArticleGoogle Scholar
  12. Samson AJ, Mercer GE, Campbell DG. Total knee replacement in the morbidly obese: a literature review. ANZ J Surg. 2010;80(9):595–9.View ArticlePubMedGoogle Scholar
  13. American Academy of Orthopaedic Surgeons. Management of Osteoarthritis of the Hip: Evidence-Based Clinical Practice Guideline.; 2017.Google Scholar
  14. Springer B, Parvizi J, Austin M, et al. Obesity and total joint arthroplasty. A literature based review. J Arthroplast. 2013;28(5):714–21.View ArticleGoogle Scholar
  15. Vaishya R, Vijay V, Wamae D, Agarwal AK. Is total knee replacement justified in the morbidly obese? A systematic review. Cureus. 2016;8(9):e804.PubMedGoogle Scholar
  16. Springer BD, Carter JT, McLawhorn AS, et al. Obesity and the role of bariatric surgery in the surgical management of osteoarthritis of the hip and knee: a review of the literature. Surg Obes Relat Dis. 2016:1–8.Google Scholar
  17. Kulkarni K, Karssiens T, Kumar V, Pandit H. Obesity and osteoarthritis. Maturitas. 2016;89:22–8.View ArticlePubMedGoogle Scholar
  18. Vasarhelyi EM, MacDonald SJ. The influence of obesity on total joint arthroplasty. J Bone Joint Surg Br. 2012;94(11 Suppl A):100–102.Google Scholar
  19. Roth KC, Bessems G. Sorry, but you will have to lose weight before receiving your knee replacement. Erasmus J Med. 2013;3(2):54–7.Google Scholar
  20. Lui M, Jones CA, Westby MD. Effect of non-surgical, non-pharmacological weight loss interventions in patients who are obese prior to hip and knee arthroplasty surgery: a rapid review. Syst Rev. 2015;4(1):121.View ArticlePubMedPubMed CentralGoogle Scholar
  21. Demling RH. Nutrition, anabolism, and the wound healing process: an overview. Eplasty. 1954;9:65–94.Google Scholar
  22. Prado CM, Gonzalez MC, Heymsfield SB. Body composition phenotypes and obesity paradox. Curr Opin Clin Nutr Metab Care. 2015;18(6):535–51.View ArticlePubMedGoogle Scholar
  23. Kuk JL, Lee S, Heymsfield SB, Ross R. Waist circumference and abdominal adipose tissue distribution: influence of age and sex. Am J Clin Nutr. 2005;81(6):1330–4.View ArticlePubMedGoogle Scholar
  24. Romero-Corral A, Somers VK, Sierra-Johnson J, et al. Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality. Eur Heart J. 2010;31(6):737–46.View ArticlePubMedGoogle Scholar
  25. Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr. 2000;72(3):694–701.View ArticlePubMedGoogle Scholar
  26. Johnson Stoklossa C, Sharma A, Forhan M, Siervo M, Padwal R, Prado C. Prevalence of sarcopenic obesity in adults with class II/III obesity using different diagnostic criteria. J Nutr Metab. 2017;Google Scholar
  27. Gonzalez MC, Correia MITD, Heymsfield SB. A requiem for BMI in the clinical setting. Curr Opin Clin Nutr Metab Care. 2017;20(5):1.View ArticleGoogle Scholar
  28. Nishigori T, Tsunoda S, Okabe H, et al. Impact of sarcopenic obesity on surgical site infection after laparoscopic total gastrectomy. Ann Surg Oncol. 2016:524–31.Google Scholar
  29. Visser M, van Venrooij LMW, Vulperhorst L, et al. Sarcopenic obesity is associated with adverse clinical outcome after cardiac surgery. Nutr Metab Cardiovasc Dis. 2013;23(6):511–8.View ArticlePubMedGoogle Scholar
  30. Prado CM, Lieffers JR, McCargar LJ, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol. 2008;9(7):629–35.View ArticlePubMedGoogle Scholar
  31. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis. Age Ageing. 2010;39(4):412–23.View ArticlePubMedPubMed CentralGoogle Scholar
  32. Prado CM, Siervo M, Mire E, et al. A population-based approach to define body-composition. Am J Clin Nutr. 2014:1369–78.Google Scholar
  33. Cherin P, Voronska E, Fraoucene N, De Jaeger C. Prevalence of sarcopenia among healthy ambulatory subjects: the sarcopenia begins from 45 years. Aging Clin Exp Res. 2014;26(2):137–46.View ArticlePubMedGoogle Scholar
  34. Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr. 2002;50:889–96.View ArticleGoogle Scholar
  35. Santilli V, Bernetti A, Mangone M, Paoloni M. Clinical definition of sarcopenia. Clin Cases Miner Bone Metab. 2014;11(3):177–80.PubMedPubMed CentralGoogle Scholar
  36. Metter EJ, Talbot LA, Schrager M, Conwit R. Skeletal muscle strength as a predictor of all-cause mortality in healthy men. J Gerontol: Biol Sci. 2002;57:B359–B365.Google Scholar
  37. Roubenoff R. Sarcopenic obesity: the confluence of two epidemics. Obes Res. 2004;12(6):887–8.View ArticlePubMedGoogle Scholar
  38. Baumgartner RN, Wayne SJ, Waters DL, Janssen I, Gallagher D, Morley JE. Sarcopenic obesity predicts instrumental activities of daily living disability in the elderly. Obes Res. 2004;12(12):1995–2004.View ArticlePubMedGoogle Scholar
  39. Tian S, Xu Y. Association of sarcopenic obesity with the risk of all-cause mortality: a meta-analysis of prospective cohort studies. Geriatr Gerontol Int. 2016;16:155–66.View ArticlePubMedGoogle Scholar
  40. Prado CM, Wells JCK, Smith SR, Stephan BCM, Siervo M. Sarcopenic obesity: a critical appraisal of the current evidence. Clin Nutr. 2012;31(5):583–601.View ArticlePubMedGoogle Scholar
  41. Kallwitz ER. Sarcopenia and liver transplant: the relevance of too little muscle mass. World J Gastroenterol. 2015;21(39):10982–93.View ArticlePubMedPubMed CentralGoogle Scholar
  42. Organization for Economic Cooperation and Development. Obesity Update, 2017.Google Scholar
  43. Roubenoff R. Sarcopenic obesity: does muscle loss cause fat gain? Lessons from rheumatoid arthritis and osteoarthritis. Ann N Y Acad Sci. 2000;904:553–7.View ArticlePubMedGoogle Scholar
  44. Juby AG. A healthy body habitus is more than just a normal BMI: implications of sarcopenia and sarcopenic obesity. Maturitas. 2014;78(4):243–4.View ArticlePubMedGoogle Scholar
  45. Thijssen E, van Caam A, van der Kraan PM. Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis. Rheumatology. 2015;54(4):588–600.View ArticlePubMedGoogle Scholar
  46. Zamboni M, Mazzali G, Fantin F, Rossi A, Di Francesco V. Sarcopenic obesity: a new category of obesity in the elderly. Nutr Metab Cardiovasc Dis. 2008;18(5):388–95.View ArticlePubMedGoogle Scholar
  47. Lee D, Drenowatz C, Blair SN. Physical activity and sarcopenic obesity: definition, assessment, prevalence and mechanism. Futur Sci. 2016;Google Scholar
  48. Griffin TM, Huffman KM. Insulin resistance: releasing the brakes on synovial inflammation and osteoarthritis? Arthritis Rheumatol. 2016;68(6):1–30.View ArticleGoogle Scholar
  49. Cauley JA. An overview of sarcopenic obesity. J Clin Densitom. 2015;18(4):499–505.View ArticlePubMedGoogle Scholar
  50. De Ceuninck F, Fradin A, Pastoureau P. Bearing arms against osteoarthritis and sarcopenia: when cartilage and skeletal muscle find common interest in talking together. Drug Discov Today. 2014;19(3):305–11.View ArticlePubMedGoogle Scholar
  51. Papalia R, Zampogna B, Torre G, et al. Sarcopenia and its relationship with osteoarthritis: risk factor or direct consequence? Musculoskelet Surg. 2014;98(1):9–14.View ArticlePubMedGoogle Scholar
  52. Karlsson MK, Magnusson H, Coster M, Karlsson C, Rosengren BE. Patients with knee osteoarthritis have a phenotype with higher bone mass, higher fat mass, and lower lean body mass. Clin Orthop Relat Res. 2015;473(1):258–64.View ArticlePubMedGoogle Scholar
  53. Karlsson MK, Magnusson H, Coster MC, Vonschewelov T, Karlsson C, Rosengren BE. Patients with hip osteoarthritis have a phenotype with high bone mass and low lean body mass. Clin Orthop Relat Res. 2014;472(4):1224–9.View ArticlePubMedGoogle Scholar
  54. Karlsson MK, Karlsson C, Magnusson H, et al. Individuals with primary osteoarthritis have different phenotypes depending on the affected joint - a case control study from southern Sweden including 514 participants. Open Orthop J. 2014;8:450–6.View ArticlePubMedPubMed CentralGoogle Scholar
  55. Purcell S, Thornberry R, Elliott SA, et al. Body composition, strength, and dietary intake of patients with hip or knee osteoarthritis. Can J Diet Pract Res. 2016;77:1–5.View ArticleGoogle Scholar
  56. Visser AW, de Mutsert R, Loef M, et al. The role of fat mass and skeletal muscle mass in knee osteoarthritis is different for men and women: the NEO study. Osteoarthr Cartil. 2014;22(2):197–202.View ArticlePubMedGoogle Scholar
  57. Levac D, Colquhoun H, O’Brien KK. Scoping studies: advancing the methodology. Implement Sci. 2010;5:69.View ArticlePubMedPubMed CentralGoogle Scholar
  58. Arksey H, O’Malley L. Scoping studies: towards a methodological framework. Int J Soc Res Methodol. 2005;8(1):19–32.View ArticleGoogle Scholar
  59. Batsis JA, Zbehlik AJ, Pidgeon D, Bartels SJ. Dynapenic obesity and the effect on long-term physical function and quality of life: data from the osteoarthritis initiative. BMC Geriatr. 2015;15(1):118.View ArticlePubMedPubMed CentralGoogle Scholar
  60. Ji HM, Han J, Jin DS, Suh H, Chung YS, Won YY. Sarcopenia and sarcopenic obesity in patients undergoing orthopedic surgery. Clin Orthop Surg. 2016;8(2):194–202.View ArticlePubMedPubMed CentralGoogle Scholar
  61. Jin WS, Choi EJ, Lee SY, Bae EJ, Lee T, Park J. Relationships among obesity, sarcopenia, and osteoarthritis in the elderly. J Obes Metab Syndr. 2017:36–44.Google Scholar
  62. Knoop J, Van Der Leeden M, Thorstensson CA, et al. Identification of phenotypes with different clinical outcomes in knee osteoarthritis: data from the osteoarthritis initiative. Arthritis Care Res. 2011;63(11):1535–42.View ArticleGoogle Scholar
  63. Lee SY, Ro HJ, Chung SG, Kang SH, Seo KM, Kim DK. Low skeletal muscle mass in the lower limbs is independently associated to knee osteoarthritis. PLoS One. 2016;11(11):1–11.Google Scholar
  64. Lee S, Kim TN, Kim SH. Sarcopenic obesity is more closely associated with knee osteoarthritis than is nonsarcopenic obesity: a cross-sectional study. Arthritis Rheum. 2012;64(12):3947–54.View ArticlePubMedGoogle Scholar
  65. Manoy P, Anomasiri W, Yuktanandana P, et al. Elevated serum leptin levels are associated with low vitamin D, sarcopenic obesity, poor muscle strength, and physical performance in knee osteoarthritis. Biomarkers. 2017:1–22.Google Scholar
  66. Oosting E, Hoogeboom TJ, Dronkers JJ, Visser M, Akkermans RP, NLU VM. The influence of muscle weakness on the association between obesity and inpatient recovery from total hip arthroplasty. J Arthroplasty. 2016;Google Scholar
  67. Segal NA, Toda Y. Absolute reduction in lower limb lean body mass in Japanese women with knee osteoarthritis. J Clin Rheumatol. 2005;11(5):245–9.View ArticlePubMedGoogle Scholar
  68. Suh DH, Han KD, Hong JY, et al. Body composition is more closely related to the development of knee osteoarthritis in women than men: a cross-sectional study using the fifth Korea National Health and nutrition examination survey (KNHANES V-1, 2). Osteoarthr Cartil. 2016;24(4):605–11.View ArticlePubMedGoogle Scholar
  69. Clémence J, Bernard M, Lorraine B, Francis G, Anne-Christine R. Body composition and clinical symptoms in patients with hip or knee osteoarthritis: results from the KHOALA cohort. Semin Arthritis Rheum. 2017;Google Scholar
  70. Newman AB, Kupelian V, Visser M, et al. Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc. 2003;51(11):1602–9.View ArticlePubMedGoogle Scholar
  71. Bosy-Westphal A, Müller MJ. Identification of skeletal muscle mass depletion across age and BMI groups in health and disease - there is need for a unified definition. Int J Obes. 2015;39(3):379–86.View ArticleGoogle Scholar
  72. Donini LM, Poggiogalle E, Migliaccio S, Aversa A, Pinto A. Body composition in sarcopenic obesity: systematic review of the literature. Med J Nutrition Metab. 2013;6(3):191–8.View ArticleGoogle Scholar
  73. Batsis JA, Barre LK, Mackenzie TA, Pratt SI, Lopez-Jimenez F, Bartels SJ. Variation in the prevalence of sarcopenia and sarcopenic obesity in older adults associated with different research definitions: dual-energy X-ray absorptiometry data from the National Health and nutrition examination survey 1999-2004. J Am Geriatr Soc. 2013;61(6):974–80.View ArticlePubMedGoogle Scholar
  74. Muscaritoli M, Anker SD, Argilés J, et al. Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) “ cachexia-anorexia in chronic wasting diseases” and “ nutrition in geriatrics.”. Clin Nutr. 2010;29(2):154–9.View ArticlePubMedGoogle Scholar
  75. Fielding RA, Vellas B, Evans WJ, et al. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc. 2011;12(4):249–56.View ArticlePubMedGoogle Scholar
  76. Studenski SA, Peters KW, Alley DE, et al. The FNIH sarcopenia project: Rationale, study description, conference recommendations, and final estimates. Journals Gerontol - Ser A Biol Sci Med Sci. 2014;69 A(5):547–558.Google Scholar
  77. Ilich JZ, Kelly OJ, Inglis JE. Osteosarcopenic obesity syndrome: what is it and how can it be identified and diagnosed? Curr Gerontol Geriatr Res. 2016;Google Scholar
  78. Tsonga T, Michalopoulou M, Malliou P, et al. Analyzing the history of falls in patients with severe knee osteoarthritis. Clin Orthop Surg. 2015;7(4):449–56.View ArticlePubMedPubMed CentralGoogle Scholar
  79. Chernoff R. Protein and older adults. J Am Coll Nutr. 2004;23(6 Suppl):627S–30S.View ArticlePubMedGoogle Scholar
  80. Shyam Kumar AJ, Beresford-Cleary N, Kumar P, et al. Preoperative grip strength measurement and duration of hospital stay in patients undergoing total hip and knee arthroplasty. Eur J Orthop Surg Traumatol. 2013;23:553–6.View ArticlePubMedGoogle Scholar
  81. Mau-Moeller A, Behrens M, Felser S, et al. Modulation and predictors of periprosthetic bone mineral density following total knee arthroplasty. Biomed Res Int. 2015.Google Scholar
  82. Prado CM, Heymsfield SB. Lean tissue imaging: a new era for nutritional assessment and intervention. J Parenter Enter Nutr. 2014;38(8):940–53.View ArticleGoogle Scholar

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