Managing chronic widespread pain in primary care: a qualitative study of patient perspectives and implications for treatment delivery
© The Author(s). 2016
Received: 1 June 2016
Accepted: 29 July 2016
Published: 22 August 2016
Clinical guidelines recommend a combination of physical, pharmacological and psychological treatments for chronic widespread pain, but published accounts of treatment acceptability are lacking.
Semi-structured interviews (n = 44) nested within a randomised controlled trial comparing the clinical and cost effectiveness of prescribed exercise, cognitive behavioural therapy (CBT), and combined exercise and CBT to treatment as usual for adults with chronic widespread pain.
Three main themes emerged from the data: i) the illness context (how people experience chronic pain and associated health services); ii) the identity context (how people react to their symptoms and accommodate these within themselves) and iii) the intervention context (the extent and manner by which the trial interventions models aligned with these responses).
Referral to a prescribed exercise programme resonated most closely with participants’ tendency to attribute pain to a structural or mechanical defect. Psychological therapy brought with it connotations of social judgement, deviance and stigma. Experience of psychological therapy often exceeded expectation. Participants who engaged in cognitive reflection and behavioural adaptation reported an upward identity shift independent of increased physical exercise behaviour.
A logical rationale for a health intervention is in itself insufficient to ensure uptake and participation. Potential differences in treatment meaning emphasise the importance of acknowledging different phases of illness acceptance and of providing the most appropriate treatment option for the stage of reconciliation. Health service providers must not only understand people’s own perceptions of chronic widespread pain but also the broader spheres of influence in which this pain is experienced.
KeywordsChronic widespread pain Treatment acceptability Patient perspectives Qualitative
Chronic widespread pain has an estimated population prevalence of 11–15 % [1–3] and the associated personal and societal burdens are high. CWP is a disorder characterised by diffuse body pain that has persisted for at least three months. It is the cardinal feature of fibromyalgia syndrome, a disorder diagnosed when CWP co-occurs with a high number of tender points .
Chronic widespread pain is associated with lost work productivity , mental ill health  and reduced quality of life . UK data suggest that newly diagnosed patients receive almost double the number of primary care visits and prescribed medicines to those without the condition . In the US, mean per-patient costs in the first 6 months following diagnosis are estimated at $3481; costs that include pain and non–pain-related medications, medical tests and procedures and emergency department consultations .
The development of clinically-effective and cost-effective pain management strategies for chronic widespread pain is challenged by syndrome complexity and equivocal causal mechanisms. International, evidence-based guidelines recommend a combination of physical, pharmacological and psychological treatments [10, 11]; although the relative contribution of each and the magnitude of gain that may be conferred through a multi-component approach remain ill-defined. Systematic reviews [12–14] suggest that physical exercise and cognitive behavioral therapy (CBT) both hold promise as discrete treatment options.
Current models of chronic pain propose that the somatic symptoms arise from a complex interplay of biological, sociological and psychological determinants . The relative roles that these different variables may play in mediating pain symptoms have thus been the focus of much research attention. Uncertainty regarding the diagnostic underpinnings of CWP has precipitated a range of studies examining the influence of affective responses and/or self-efficacy for pain control on functional capacity and quality of life . These studies provide valuable insights into potential mediators of chronic pain, but are unable to shed light on patients’ treatment preferences or intervention experience. Published accounts of patients perspectives on treatment acceptability are lacking.
This paper reports the findings of a qualitative study nested within a large, randomised controlled trial. The MUSICIAN trial, which allocated 442 primary care participants to one of four arms, compared the clinical and cost effectiveness of three psychosocial interventions (Prescribed exercise, CBT and exercise-CBT combined) with treatment as usual for chronic pain. Trial results have been published previously .
This qualitative study, conducted with a sub-sample of trial participants aimed to explore participants’ illness and treatment experiences, with a view to understanding their potential influences on intervention acceptability. To our knowledge, it is the first study seeking to understand how the perspectives of primary care CWP patients may underpin treatment uptake, engagement and delivery.
Trial groups consisted of i) telephone-based Cognitive Behavioural Therapy (T-CBT); ii) prescribed exercise (PE); iii) combined T-CBT & PE (T-CBT/PE) and iv) usual GP care (UC). Trial participants were recruited from 8 general practices in North-West England & Scotland. Trial inclusion criteria comprised of adults with i) an American College of Rheumatology (ACR) definition of CWP in fibromyalgia , ii) impaired physical function as assessed by the Chronic Pain Grade Questionnaire , iii) a GP consultation for pain within the last 12 months and iv) access to a landline or mobile phone for the purposes of intervention delivery. All participants had to meet the ACR criteria for CWP but were not required to undergo the tender point examination necessary to confirm a fibromyalgia diagnosis. Participants were excluded from the trial if their GP highlighted contraindications to participation in any of the proposed interventions.
All participants received usual GP care. Those in the T-CBT intervention also received an initial 1 h telephone assessment followed by seven weekly T-CBT sessions of between 30 and 45 min duration. Two follow-up therapy sessions occurred at 3 and 6 months post assessment. T-CBT participants received a self-management workbook which included agreed collaborative goals for the therapist and patient to work towards, activity diaries and a range of monitoring sheets. CBT was delivered by experienced and accredited therapists who received 5 days additional training incorporating contextual CWP information and telephone skills practice. Clinical supervision was provided to therapists on a fortnightly basis.
Participants assigned to the PE arm were prescribed an exercise programme consistent with the American College of Sport Medicine (ACSM) guidelines for improving cardiorespiratory fitness . Participants were advised to attend a designated local leisure facility at least twice per week for 20–60mins duration, where personal trainers would be available to guide them through an individually tailored programme. The specific mode of exercise reflected the personal preference of the participant. Initial exercise intensity was low to moderate and gradually increased until patients are exercising at a level consistent with the ACSM guidelines. Participants were free to engage in other modes of exercise, such as strength and flexibility training, as they wished and were also advised to engage in ‘everyday’ activities designed to enhance cardio-respiratory fitness (e.g. brisk walking) on those days that they did not attend. Fitness instructors received 1 day of additional training focusing on exercise prescription for individuals with chronic widespread pain. Thereafter they were encouraged to view participants in the same way that they would view clients without chronic widespread pain. Participants randomised to the combined arm received both of the interventions detailed above, with two-way information exchange encouraged between the CBT and PE facilitators.
Participation in the qualitative study was voluntary and not a pre-requisite to trial participation. Participants were invited into the qualitative study after the trial’s primary end point (6-month post-randomization) to avoid any reporting bias arising from interview participation. The first 100 people recruited to the trial and returning 9-month follow-up data were invited to take part. Sampling was purposeful in that it targeted participants with direct experience of the trial interventions. Maximum variation in geographical location was achieved by sampling across trial recruitment regions and sites. There was no minimum eligibility criterion for treatment engagement; only participants who had formally withdrawn from the trial were ineligible to take part.
All invited participants who expressed an interest in the qualitative study (n = 46) were telephoned by a researcher (PB) and provided with additional information regarding study procedures.
Following the receipt of written informed consent, interviews were conducted using open-ended, inductive questioning organised around broad topics identified and piloted among the research team. These included patients’ physical and emotional reactions to pain, their rationalisation of chronic or unexplained symptoms, their treatment preferences and the perceived fit between the trial interventions and patient need. Due to the geographical spread of study participants, all interviews were conducted on the telephone via a scheduled call to participants’ homes. Interviews were conducted by a health services researcher with over 10 years’ experience of conducting qualitative interviews (PB). The interviewer was not known to participants, had no prior experience of CWP, and introduced herself as a non-clinical researcher independent from the trial team.
Interviews were digitally recorded and transcribed verbatim. No field notes were taken during the telephone interviews as priority was given to establishing rapport with participants. Each interview was reviewed immediately after completion to confirm that all salient information had been picked up by the digital recordings. Interview duration was flexible and determined by the research participant. Interviews ranged from 30 to 60 min; mean (SD) 50.3 (8.0) minutes.
Participants were sent copies of their transcripts for editing and correction purposes; no changes to transcripts were made and no repeat interviews were conducted. Questionnaires administered as part of the trial provided baseline demographic, psychological and clinical data for the sample.
Resulting data were analysed by the framework method . Data were coded inductively by PB using the method of constant comparison . Codes were initially developed within each intervention group and then collectively applied across all four trial arms. A provisional analytical framework was built up by grouping into codes into clusters and then into emergent themes. During the constant comparison of new data, the framework was amended to allow for the introduction of new codes, and/or the removal of provisional codes that became superfluous during the course of analysis. Data coding and development of the analytical framework was managed in Microsoft Word. Data interpretation was facilitated by entering the indexed data into Microsoft Excel. A matrix was constructed in which participant was represented as rows and codes were represented as columns to facilitate data interpretation within and across cases. Analysis occurred in parallel to data collection and sampling continued until no new themes or sub-themes emerged. Verification of the analysis was provided by two other members of the research team who independently reviewed excerpts of the coding framework and agreed data interpretations and themes. All researchers were blinded to the trial’s quantitative results. Due to the geographical spread of the sample, participants’ were not asked to review the final analytical framework or its associated data trail.
Study methods are reported according to COREQ guidelines. Within the text that follows, participants (P) have been assigned a code number rather than a name or pseudonym. Participant gender (M/F) and trial allocation (TCBT, PE, COMBINED, UC) are provided.
Sample demographics for the nested qualitative study and trial samples
Nested sample (n = 44)
Trial Sample (n = 442)
Mean (SD) age
% fair-good health (self-report)
Mean (SD) GHQ scorea
% CPG Grade 1–2b
Three main themes emerged from the data. These themes were labelled: i) the illness context i.e. how people experience chronic pain & associated health services; ii) the identity context, referring to how people react to their symptoms and accommodate these within themselves and iii) the intervention context, denoting the extent and manner by which the different trial interventions aligned with these illness and identity responses.
The illness context
“It’s not consistent. You’ll have a while when it’s bad and then, whether you get used to it or not, I dunno, and then it just flares up again, it’s not a constant thing.” (41, F, COMBINED)
“But you go to the doctor and it’s…well, you don’t seem to get any help at all. They never asked me how I was getting on or anything. There was just nothing, which I thought was quite amazing really!” (12, F, COMBINED)
“I mean you can go a week or two weeks and you’ve not got pain, and you just do something and you try to think, what did I do?.. You try to figure out, now what did I do? And you can’t think. How have I managed that? I mean I try, when I sit in a chair, I try to sit up as straight as I can, not lunge in the chair…” (39, M, UC)
“I mean I did go for, and I paid it myself, to a chiropractor, something like that but I didn’t find that helped- just that it was very expensive.” (33, F, UC)
“Oh, I’ve had endless pills, things that confused me. I think everybody has problems with pain killers.” (41, F, COMBINED)
The identity context
The second emergent theme, the identity context, encompassed three main sub-themes pertaining to participants’ behavioural responses to pain, the interplay between participants self and illness identities and their emotional reactions to symptom progression.
“What I packed into a week, you can’t keep going at that rate and not expect some fallout at the end of it, which normally was the bam or bust, I was either wham bam or I was absolutely knackered and bust.” (40, F, COMBINED)
“Now to me I just say at times, mind over matter. I don’t have chronic pain. You can be in agony but you just try to shut off to it.” (Denial & Distraction, 39, M, UC)
“I’d be like, sod it, I’ll do it myself, I’ll manage, fine. It was if I permanently had to prove myself.” (Resistance, 40, F, COMBINED)
“I do bits, clear up a bit, then have a sit down. I usually get it done, just in a different way. I mean, it sometimes takes me longer and I’ve changed a bit what I do, but I still keep things clean and tidy, at least I hope I do!” (Tolerance, 41 F, COMBINED).
“I was very busy, I would go here there and everywhere, I was one of those people who looked after people, and then……I was going through a sort of process of having all sorts of things that seemed to be going wrong with me and restrictive movement and I was getting really quite depressed about it. I mean I’ve never had any treatment for depression but I was beginning to feel very down because you think “God, is this what it’s going to be like for the rest of my life?” (12, F, COMBINED)
“People can’t see it, and it’s hard to explain. Doing something one day and not the next, sometimes I’d worry, you know, that asking for help, well, that it sounds like an excuse…” (40, F, COMBINED)
The intervention context
The third and final theme, intervention context, comprised of two key sub-themes: Intervention preferences and intervention experiences. For clarity, data pertaining to this theme are presented separately for each trial intervention.
Acceptability of PE
As described previously, the MUSICIAN trial comprised four arms: i) telephone-based Cognitive Behavioural Therapy (T-CBT); ii) prescribed exercise (PE); iii) combined T-CBT & PE (T-CBT/PE) and iv) usual GP care (UC). All participants who were allocated to an intervention and who participated in post-intervention interviews (n = 35) expressed a pre-treatment preference for the PE arm. Qualitative data suggested that this preference was underpinned by three discrete but interacting biases.
“It made some sense to me, yeah, I was an engineer, so that’s I see it you know. If it’s a problem with your joints, then that’s where you need a solution. Similar to physio in a way.. moving about, building up your muscles.. if you make the framework stronger, then yeah, that’s gonna help, I could see how that could work.” (31, M, UC)
“I mean I’m not lying in bed, I’ve never done that since I was in my twenties, you know, I just keep going, and I think exercise is going to be the answer.” (36, F, COMBINED)
“I wouldn’t have believed that I could actually do them but then I found I actually could, so my expectations were…it gave me more confidence because I could actually do it and also feel comfortable doing it. I was really quite pleased with myself because I thought, well, I have actually done it.” (12, F, COMBINED)
“It wasn’t fair to keep going to the gym and making myself -- because I was worse, so much worse when I’d been. So I thought, well,.. I’m not going to carry on doing it to make myself worse and suffer.” (16, M, COMBINED)
“It wasn’t easy and a couple of times, when I had lots on, I didn’t go. It seemed to take up a lot more time than you expected, getting there and changing. It did take up quite a lot of time. It needs a lot of planning really, because for me, well, I found it changes your routine.” (41, F, COMBINED)
“I told him I was having trouble with the bike, so he said right, okay, and the next time I went I realised that he’d written an extra lot of bikes on my sheet, like, woah! It didn’t make sense to me, somehow. After that, that’s when it all started to go downhill, really.” (9, M, PE)
Regular facilitation with timely and appropriate responses to spontaneous pain events significantly elevated the acceptability of the PE intervention and emerged as a critical factor in patient engagement.
Acceptability of CBT
“And I was a bit -- I wasn’t flippant about it, I don’t mean in that way, but I was, like, I’m not quite sure what this is going to do for me, love, you’re really going to have to prove your point here.” (40, F, COMBINED)
“Therapy, I mean, it’s one of those words, isn’t it. People think it’s for people who can’t cope, who aren’t strong enough to cope. I wasn’t sure what they were getting at I suppose, that I wasn’t in pain, that I had imagined that?” (39, M, UC)
“If I say to my husband, ‘I’m not going out, I really don’t want to,’ I don’t feel guilty now. Before I would never admit that, so from that perspective, things have changed, because I will say what I think and I will say no, I’m not doing it or I can’t do it. So the way I cope with my pain has changed.” (40, F, COMBINED)
“It was fine, actually. And I think in some ways maybe it’s easier than face-to-face. I think if you had to make the appointment of somebody coming to the house it would be so much more difficult. And to be sat face-to-face with somebody might not necessarily be as easy as over the phone. Well, I suppose it’s like you, I can say anything, you don’t know whether I’m embarrassed or not. I can just say it..I can tell the truth, and it doesn’t matter.” (11, F, TCBT)
“None of them, none of them related to anybody like me. The majority of people were people that were frightened of moving and frightened of doing things. They weren’t like me, I mean, I’ve got the opposite problem.” (36, F, COMBINED)
Acceptability of combined PE and CBT
“No, they’re two totally different things. On some occasions she’d say, oh, how are you today? And I was like: oh, I went to the bloody gym last night, and I know it today. But no, the two together for me were absolutely fine, they were totally different aspects, really, I had no problem having two of them.” (40, F, COMBINED)
“You could tell her how things had worked in the gym and she could offer advice. It was helpful to have the two I would say have both if they got the chance. Yes I think that the talking did help. One goes along with the other, they work together.” (41, F, COMBINED)
Chronic widespread pain (CWP) is associated with lost work productivity , mental ill health , and reduced quality of life . Developing effective treatments is challenging. The present study sought to explore patient experiences of chronic widespread pain in an attempt to identify influences on treatment acceptability. Qualitative data were obtained from research trial participants allocated to a prescribed exercise programme and/or a psychological intervention (CBT).
There existed, at the start of the trial, a substantial tension between participants’ desires to maintain their daily routines and the extent to which pain symptoms and pain management strategies constrained these activities. Multiple role fulfilment was common in our sample. Although this could in part be justified by economic or domestic necessity, a shared patient narrative also emerged to confirm a social dimension to participants’ behaviour. Descriptions of habitual activities were typically framed in terms of their relevance to an individual, suggesting that substantial personal meaning was derived from their enactment. Lack of symptom visibility and casual attribution also heightened the risk that behavioural modification would be perceived negatively by others. Sociological theory, based on the Illness narratives of people living with other chronic conditions, confirms that physical impairment can intrude on a person’s life to the extent that it can undermine valued aspects of self-identity [23–25]. All modes of living are embedded in social context, and by implication, most individuals will take account of social attitudes when defining acceptable and non-acceptable behaviours. . Our study thus suggests that health service providers must seek not only to understand people’s illness perceptions per se but the broader spheres of influence in which this illness is experienced.
Prior research has attended to the links between pain, the self and society [26–28] with specific attention directed towards the relationships between symptom disclosure, stigma and social exclusion [25, 29]. Successful adaptation to chronic illness is argued to depend upon an individual’s readiness to a) acknowledge their impairment and b) alter their life and self-identity in personally and socially acceptable ways [23, 28]. Varying levels of resistance were identified in our study, each tending towards a different level of symptom denial, dismissal or tolerance. Such behaviour is reminiscent of other categorisations of chronic illness responses, in which individuals are proposed to ignore, minimise or struggle against a burgeoning symptom profile . Personal acceptance of CWP and its illness trajectory was rare among our sample, suggesting that effective self-management may not be an intuitive behaviour for primary care populations.
The novel contribution of our study lies in the exploration of patient perspectives as a key driver of uptake and engagement in internationally recommended CWP treatments . Although intervention acceptability will inevitably be judged at the individual level, trends in our data suggest there may be some key differences between modes of intervention. Our study revealed that participants’ baseline preferences appeared to favour physical rather than psychological intervention. Qualitative analysis was undertaken blind to trial datasets; nevertheless these findings remain broadly consistent with quantitative data collected at the start of the MUSICIAN trial. Quantitative data reveal that 78 % of trial participants (n = 442) expressed a preference for physical exercise either alone (33 %) or in combination with CBT (45 %), 18 % expressed no preference and only 5 % preferred CBT as their sole intervention approach. Greater effort may thus be required to understand and overcome prejudices to psychological CWP intervention.
The parallels that have already been drawn between our data and the existing sociological literature provide one potential framework through which participants’ treatment preferences can be viewed. Referral to a prescribed exercise programme resonated most closely with participants’ tendency to attribute pain to a structural or mechanical defect. In doing so, it is also possible that it appealed sub-consciously or consciously, to their need to separate somatic symptoms from the self. Arguably, by objectifying pain and encouraging engagement in a socially-desirable health behaviour, the physical exercise intervention held considerable promise for personal and social identities threatened by ill-health. Psychological therapy in contrast, weakened this perspective. Among therapy-naïve individuals, CBT was perceived to denigrate pain, bringing with it connotations of social judgement, deviance and stigma. Potential differences in treatment meaning emphasise the importance of acknowledging different phases of illness acceptance and of providing relevant treatment options appropriate to each patient’s stage of reconciliation.
From a behavior change perspective, a logical rationale for a health intervention is rarely sufficient to ensure adequate uptake and participation [30–32]. A range of logistical, behavioral and psychosocial determinants of exercise behavior identified in the current study, many of which (e.g. competing lifestyle responsibilities and subjective perceptions of behavioural norms) resemble components of behavioural change theories developed for the general population . Of particular interest to primary care CWP services however, may be the disproportionate influences that negative emotional reactions and/or a perceived lack of behavior control appear to exert on exercise participation. Our study participants tended towards concepts of CWP as a health state that could both affect, and be affected by, physical activity and functioning. In this sense, physical exercise was perceived as a high gain but high risk strategy, and fear of exacerbating pain symptoms was common. This finding resonates closely with previous work postulating relationships between pain-related fear, fear-avoidance and physical functioning in adults with chronic musculoskeletal pain . Future applications of structured exercise programmes should acknowledge the context in which these interventions will be delivered, and ensure that all feasible opportunities to minimise risk and maximise motivation are taken. The need for exercise facilitators to be equipped with a minimum level of CWP knowledge and competency emerged as a critical element determining the acceptability of the prescribed exercise programme in the MUSICIAN trial, and has important implications for its resourcing and longer term integration.
Cognitive behavioural therapy, by definition does not pose equivalent physical risk. Our data suggest that the experiential gains of psychological therapy may ultimately exceed patient expectations. Through cognitive reflection and behavioural adaptation, participants may ultimately have experienced an upward identity shift independently of the need to increase physical exercise behaviour. Due consideration must nonetheless be given to the chosen delivery mechanism of any psychological therapies targeting chronic pain. Telephone delivery conferred substantial benefits for participants in the current study, both in terms of enhancing access and enabling ‘in situ’ intervention, delivering therapy directly into the context where behavioural change and/or pain management needed to occur. Among CWP populations, the use of a remote communication technology may ultimately help to overcome stigma and patient reticence for psychological therapy by reframing the therapeutic relationship as a non-clinical intervention providing socially-orientated support. Further study comparing patients’ views of the acceptability of different delivery models for CBT is recommended.
Our study suggests that the acceptability of primary care CWP interventions may be maximised when physical and psychological intervention are provided simultaneously, particularly where there is a pathway facilitating information exchange between the two. Nevertheless, uncertainty remains regarding the magnitude of acceptability gain, or the strength and nature of the relationship between treatment acceptability and effect. The MUSICAN trial10 has demonstrated that, when compared to treatment as usual (standard GP care), active intervention (PE, CBT and PE plus CBT) leads to clinically meaningful improvements in self-rated global health. Receiving the combined intervention (PE plus CBT) was associated with only a slightly better outcome than T-CBT alone and was considerably more expensive. Exploring patients’ treatment expectations at the point of assessment and referral, and ensuring that patients are informed and appropriately orientated to the premise and purpose of psychological intervention may ultimately be sufficient to ensure treatment uptake and engagement with a clinically and cost effective treatment.
This qualitative study has extended current understanding of CWP and pain management interventions by elucidating the likely acceptability of evidence-based treatments cited in interdisciplinary guidelines [11, 12]. Nesting a qualitative study within a randomised controlled raises the possibility of selection bias. Patients were initially recruited to the trial via self-report questionnaire, rather than during or immediately following primary care appointments. Assessing the accuracy of self-report consultation is challenging. Moreover, all interviewees had initially consented to participate in a randomised trial of CWP interventions and thus may be argued to display a level of openness towards the evaluated treatments atypical of a broader service population.
Trial process and outcome data were independently managed by a regulated clinical trials unit, prohibiting the early release of intervention outcome data. This ruled out the opportunity for maximum variation sampling based on treatment engagement or effect. Consent to participate in the nested qualitative study may have been motivated by a drive to report negative or positive treatment experiences.
Through our use of in-depth, semi-structured interviews, we allowed participants to raise issues that were important to them and which may not have arisen during a quantitative, questionnaire based study. All interviews were conducted on the telephone which reduced the researcher’s opportunity to draw on participants’ facial expressions and non-verbal cues. The impact of this on data depth and quality is not clear. The interviewer was experienced in conducting telephone interviews and in establishing telephone rapport. Telephone exchanges, when evaluated in the context of healthcare delivery, have been shown to overcome multiple access barriers including stigma [35, 36]. Non-face-to-face- communication can enhance a patient’s sense of anonymity, which may have particularly benefitted the current study given the potential impact of CWP on individuals’ self and social identities. When eligible participants are spread over a broad geographical area, telephone interviews can enhance recruitment and facilitate sampling across multiple recruitment sites. Due to access and ethical constraints, the views of participants who withdrew from the MUSCIAN trial, or who chose not to return their 9 month follow-up data, could not be explored.
The acceptability of clinically recommended, evidence-based treatments for chronic widespread pain is influenced by a complex interplay of illness, social and self-identities. Patients’ pre-treatment preferences are likely to favour physical rather than psychological intervention but the experiential gains of psychological therapy typically exceed patient expectations. Potential differences in treatment meaning emphasise the importance of acknowledging different phases of illness acceptance and of providing the most appropriate treatment option for the stage of reconciliation. To maximise treatment adherence, health service providers should seek to understand individual perceptions of chronic widespread pain as well as the personal and social contexts in which this pain is experienced.
The MUSICIAN study team are: Professor Gary J Macfarlane (chief investigator), Professor Phil Hannaford, Dr Philip Keeley, Professor Karina Lovell, Dr John McBeth, Dr Paul McNamee, Professor Deborah Symmons and Dr Steve Woby (investigators), Marcus Beasley (research assistant), Chrysa Gkazinou (trial manager), Dr Elizabeth Jones (PhD student), Dr Gordon Prescott (statistician) and Dr Graham Scotland (health economist).
We are grateful to the following GP practices and their patients for participating in the study in Aberdeen: Carden Medical Centre, Elmbank Medical Practice, Great Western Medical Practice, Garthdee Medical Group; and in Macclesfield: Readesmoor Medical Group Practice, Lawton House Surgery, Bollington Medical Centre, and Park Lane Surgery. The Scottish Primary Care Research Network facilitated access to patient information at the practices in Aberdeen city. At the University of Aberdeen John Norrie (while director of CHaRT) and Ashraf El-Metwally, PhD (while Lecturer in Epidemiology) were originally investigators on the MUSICIAN study. Alison MacDonald and Gladys McPherson of the Health Services Research Unit (HSRU) at the University of Aberdeen provided input regarding the conduct of the study. Dev Acharya, Jennifer Banister, Gertrude Chikwekwe, Rowan Jasper, Flora Joyce, Karen Kane and Michelle Rein, were project assistants on the study. Alison Littlewood performed the study management at the Manchester site and Charlie Stockton was the study manager during the setting up and part of study conduct. Research nurses Daniel Barlow, Roslyn Campbell and Vivien Vaughan conducted the pre-randomisation clinic assessments. Wesley Bramley, Julie Carney and Richard Paxton delivered the exercise intervention, and Jayne Fox, Nicola McConnell, Marie Pope and Lindsay Rigby delivered the CBT.
In addition, we are grateful to the independent members of the Trial Steering Committee: Professor Matthew Hotopf, Professor Tracey Howe, and Professor Martin Underwood; and the Data Monitoring Committee: Dr Marwan Bukhari, Professor Hazel Inskip and Dr Chris Edwards.
The MUSICIAN trial was supported by an award from Arthritis Research UK, Chesterfield, UK. Grant number: 17292. The funding body approved the design of the study. They played no role in the collection, analysis, and interpretation of data or the writing of the manuscript.
Availability of data and materials
Due to ethical restrictions, data are not available in a public repository. Data are from the ARC-funded MUSICIAN trial whose investigators may be contacted at the University of Aberdeen, UK. Any questions or enquiries regarding the present study can be directed to Dr. Penny Bee, PhD as corresponding author, and Professor Gary Macfarlane, PhD, as lead investigator on the trial.
PB: participant consent, data collection, data analysis, drafting of manuscript. JB: Study conception and design, verification of themes, approval of final manuscript. GM: Study conception and design, verification of themes, approval of final manuscript. KL: Study design, intervention development (T-CBT), verification of themes, approval of final manuscript.
PB has no competing interested to declare. GM was PI on the MUSICAN trial. JB and KL were MUSICAN trial co-applicants.
Consent to publish
Ethics approval and consent to participate
Ethical approval for the study was granted by Cheshire NHS Research Ethics Committee; reference number: 07/Q1506/61. All participants provided written consent.
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