Incidence and excess mortality of hip fracture in young adults: a nationwide population-based cohort study
BMC Musculoskeletal Disorders volume 17, Article number: 326 (2016)
This study assessed the incidence and excess mortality of hip fractures among inpatients aged 20–40 years in a nationwide population database in Taiwan.
Subjects were selected from Taiwan’s National Health Insurance Research Database for the period 2001–2008 and were followed up until the end of 2010. A total of 4,523 subjects were admitted for the first time with primary diagnosis of hip fracture and treated with operation.
The overall annual incidence, mortality, and standardized mortality ratio (SMR) decreased from 7.68 to 7.23 per 100,000, from 1.37 % to 0.94 %, and from 9.06 to 6.71, respectively, from 2001 to 2008. The 1-year, 2-year, 3-year, 5-year, and 10-year mortality rates were 1.28 %, 2.44 %, 3.54 %, 5.32 %, and 10.50 %, respectively for the whole cohort. The 1-year, 2-year, 3-year, 5-year, and 10-year SMRs were 8.33, 7.59, 7.28, 6.39, and 5.82, respectively, for the whole cohort. Risk factors for overall death were male gender, trochanteric fracture, hemiarthroplasty, and higher Charlson comorbidity index (CCI) scores.
The high SMRs found in the present study suggest that young adults with former hip fracture should be closely followed up to prevent early mortality.
Hip fractures in young adults are uncommon and often caused by high-energy trauma, whereas hip fractures in elderly adults are more common and are generally sustained in falls [1–11]. Previous studies estimated that less than 10 % of total hip fractures occurred among subjects aged under 50 to 60 years in North America [12, 13]. Studies likewise revealed that the one-year mortality after hip fractures among the elderly population was as high as 20 % to 30 % [7, 10, 12–18]. Several studies have reported mortality rates in hip fracture patients aged under 50 to 65 years old [1, 5, 7, 10, 11, 18]. However, there are relatively few studies on mortality rates after hip fractures among young adults aged under 40 years [1–11]. Studies from individual institutes generally did not use a large sample size and thus it was not possible to precisely assess the incidence of short-term and long-term mortalities after hip fractures. At present, no population studies have explored the incidence of hip fracture and mortality rates in a young Asian population. Therefore, this study assessed the incidence of hip fracture and excess post-hip fracture mortality using a sample of inpatients aged 20 to 40 years from a nationwide population database in Taiwan.
Data source and subjects
The National Health Insurance (NHI) program in Taiwan was launched in 1995. The program provides compulsory universal medical insurance for all Taiwanese residents. The NHI Research Database (NHIRD), which was established in 1997, is a repository of NHI claims data. As of 2010, the coverage rate in Taiwan’s population of more than 23 million was over 99 %. The completeness and accuracy of the NHI database is verified by Taiwan’s Ministry of Health and Welfare (formerly the Department of Health) and the Bureau of NHI. The data sources in the present study were the NHIRD and the National Register of Deaths Database maintained by Taiwan’s Ministry of Health and Welfare.
This study screened all subjects, aged between 20 and 40 years and admitted to hospitals between January 1, 2001 and December 31, 2008. All subjects were followed up to death, exit from the NHI program, or the end of 2010. All subjects were followed up for 2–10 years, depending on when the patients were entered into the study. The following two conditions represented the inclusion criteria for such subjects: (i) the first discharge diagnosis code was hip fracture [based on the International Classification of Disease, Ninth Revision, Clinical Modification (ICD-9-CM) codes 820, 820.0, 820.00, 820.01, 820.02, 820.09, 820.8, 820.03, 820.2, 820.20, and 820.21] and (ii) the medical code was surgery of internal fixation or hemiarthroplasty (based on ICD-9-CM codes 79.15, 79.35, and 81.52). The first admission date of hip fracture was defined as the index date. The exclusion criteria for the inpatients admitted to hospitals were pathological fractures (ICD-9-CM codes 733.14 and 733.15) or open hip fractures (ICD-9-CM codes 820.1, 820.10, 820.11, 820.12, 820.19, 820.9, 820.13, 820.22, 820.3, 820.30, 820.31, and 820.32). Patients who had surgery on the pelvis, femur, or hip regions before the index date were excluded to avoid confounding effects. More than 99 % of the hip fractures in these young adults were caused by high-energy trauma; i.e., most were due to motorbike accident. Multiple fractures and concomitant head and neck fractures were possible but the latter type was relatively rare.
This study analyzed several outcomes, namely, (a) annual incidence of hip fracture; (b) annual mortality; (c) annual standardized mortality ratio (SMR); (d) cumulative mortality; (e) follow-up SMR; and (f) risk factors of mortality, over ten years after hip fracture among young adults. Annual mortality and cumulative mortality are absolute rates indicating the occurrence proportion of death among these study subjects. Meanwhile, annual SMR and follow-up SMR are relative mortality rates indicating the relative risk of death of our study population compared to that in the corresponding general population. Overall survival time was defined as the duration from the index day to the death day. Subjects alive at the end of the study or lost to follow-up were treated as censored. The comorbidities of each subject were retrieved before or at the time of the index day based on the Charlson comorbidity index (CCI) .
For each cohort year, we calculated the annual incidence as the number of inpatients with hip fractures divided by the mid-population in that cohort year, and stratified patients by gender. We calculated the annual mortality as the number of deaths divided by the number of newly diagnosed cases in that cohort year, and stratified patients by gender. We calculated the annual standardized mortality ratio (SMR) from the date of diagnosis of hip fracture in that calendar year and then followed up the patient for one year. We estimated the overall cumulative mortality based on Kaplan–Meier (KM) method. We calculated the one- to ten-year follow-up SMRs of hip fracture based on the available data after the fracture, and stratified them by age and gender. The SMR estimation was based on the following definition: the number of deaths among inpatients with hip fractures divided by the expected number of death cases according to the age-, gender-, and calendar-year-specific death rates obtained from the National Register of Deaths Database of Taiwan. We assessed the excess mortality in incident hip fracture patients with that of the general population using annual and follow-up SMR. We explored the effects of risk factors, such as age, gender, type of hip fracture, and CCI score, on mortality using the log-rank test. All analyses were performed using the SAS System (version 9.2; SAS Institute, Cary, NC).
Between 2001 and 2008, 4,523 subjects were admitted for the first time with a primary diagnosis of hip fracture and then treated with surgery. Among these patients, 3439 (76.03 %) were male, 1084 (24.97 %) were female, 1931 (42.69 %) had trochanteric fracture, 2592 (57.31 %) had cervical fracture, 4363 (96.46 %) received internal fixation, and 160 (3.54 %) received hemiarthroplasty (Table 1). For the period 2001 to 2008, the annual incidence rates of hip fractures changed from 7.68 to 7.23 (P =0.6519), from 11.09 to 11.29 (P =0.9885), and from 4.15 to 3.07 (P =0.5415) per 100,000 for the overall population, males, and females, respectively (Table 2).
For the same period, the annual mortality rates of hip fractures decreased significantly from 1.37 % to 0.94 % (P =0.0464) and from 1.86 % to 0.95 % (P =0.0094) for the overall population and males, respectively (Table 2). The values in females were unstable due to the small number of newly diagnosed hip fracture cases which resulted in fewer death cases within one year after fracture. We used the annual SMR to indirectly compare the annual mortality of young adults after hip fracture with that of the general population in Taiwan. The overall annual SMR was 9.06 in 2001 which decreased to 6.71 in 2008 (P =0.0781) (Table 2).
For the entire cohort, the 1-year, 2-year, 3-year, 5-year, and 10-year follow-up mortality rates were 1.28 %, 2.44 %, 3.54 %, 5.32 %, and 10.50 %, respectively (Table 3). Males had higher mortalities than those of females within ten years after the occurrence of fracture (Table 3 and Fig. 1). The gender- and age-stratified follow-up mortalities indicated that all male age groups had higher death rates than those of females within ten years after the occurrence of fracture, except the 20–24 years group (Table 3). For the entire cohort, the 1-year, 2-year, 3-year, 5-year, and 10-year SMRs were 8.33, 7.59, 7.28, 6.39, and 5.82, respectively. Females had higher SMRs than those of males within ten years after the occurrence of fracture (Table 3). The gender- and age-stratified SMRs indicated that all female age groups had higher SMRs than those of males within ten years after the occurrence of fracture (Table 3). We compared the effects of the possible risk factors of mortality using a log-rank test (Fig. 1). The statistically significant risk factors for overall death were male gender, trochanteric fracture, hemiarthroplasty, and larger CCI scores.
The present investigation is the first population study to evaluate long-term excess mortality in young adults after hip fracture in Taiwan. The annual mortality and SMR of young adults after hip fracture increased gradually during 2001–2003 and decreased slightly after 2005. The launch of the national health insurance program in 1995 and the nationwide implementation of a case payment system in 2002–2003 provided better funding for hip fracture patients and allowed for the provision of more complete care. The decreasing trend of annual SMR may indicate that following the implementation of the NHI there was a decrease in mortality rates for young adults in the general population and also a decrease in mortality rates for young adults with hip fracture, but there was higher decreases in the mortality rate of young adult hip fracture patients compared with that of the general population of young adults. The general improvement in healthcare, as well as the year-on-year improvement in surgical techniques, the increased penality for drunk driving, and decreasing traffic accident death rates may explain, at least in part, the decrease in peri-operative mortality and short-term post-operative mortality after 2003.
The estimated 1-month, 3-month, 6-month, 1-year, 2-year, 3-year, 5-year, and 10-year follow-up mortality rates were 0.13 %, 0.48 %, 0.81 %, 1.28 %, 2.44 %, 3.54 %, 5.32 %, and 10.50 %, respectively (Table 3). Karantana et al. revealed that the cumulative mortality rates were 3.5 % and 13.3 % for 30 days and 1 year after hip fracture among women under 65 years . The differences observed might be attributed to the selection of a greater number of subjects aged over 40 years in the Karantana et al. report . The overall follow-up 1-year, 2-year, 5-year, and 10-year SMRs were 8.33, 7.59, 7.28, 6.39, and 5.82, respectively. Several studies demonstrated that hip fractures continuously affected the long-term mortality even one year after the occurrence of fracture among elderly adults [20–22]. Our results support the premise that hip fractures affected both short-term and long-term mortality rates. To our best knowledge, the present investigation is the first study of long-term excess mortality among young adults. Furthermore, we analyzed the causes of death stratified by year of death for up to ten years following the index day (Additional file 1: Table S1). We found that accident injury, cancer, and suicide were the major causes of death, each of which is highly correlated with the mortality rate of the young adult population. Though the proportion of each of these causes of death fluctuated slightly from year to year, overall the contribution of each major cause to the death rate remained stable.
We also determined that the long-term mortalities and SMRs varied by gender and age in Taiwan, as indicated in the literature on elderly adults [23–25]. We found that in the long-term mortalities stratified by gender and age, the young male group had a higher mortality than that of the young female group, while the result for SMRs was reversed within ten years after the occurrence of fracture (Table 3). One of the reasons for the higher risk of mortality in males might involve the greater prevalence of high-energy trauma with severe injury in males than in females, which might result from differences in behaviors such as vehicular speeding and lifestyle factors between the genders. Meanwhile, high-energy trauma causes the most hip fractures among young adults, and females might be less biomechanically resilient than male, resulting in worse outcomes following a traumatic impact for females when compared to those in their corresponding gender-specific subgroup in the general population. With increasing age, hip fractures tend to show a greater correlation with osteoporosis or osteopenia. Several studies reported that the prevalence of osteoporosis rapidly increased after the age of 40 to 45 years [26–29]. Other studies revealed that the incidence of osteoporotic hip fractures increased after 40 to 50 years of age [10, 28, 30, 31]. We postulate that the prevalence of osteopenia begins to increase even before the age of 40, and contributes to the increased mortality after hip fractures.
We found that the annual incidences of hip fracture among young adults decreased from 7.68 to 7.23, 10.18 to 11.84, and 3.07 to 4.20 per 100,000 persons per year for overall, males, and females, respectively, from 1999 to 2008. These incidence rates of hip fractures among young adults were lower than those of elderly adults [18, 30, 32–34]. Wang et al. reported that the incidence rates of hip fractures among elderly adults were 405 and 476 per 100,000 persons in 1998 and 2009, respectively . Only a few studies have reported population incidence rates of hip fractures among young adults [5, 7, 18, 30, 32, 35]. Previous studies reported that the annual incidence rates of hip fracture varied from 1.9 to 16.3 per 100,000 persons per year [5, 7, 18, 30, 32, 35]. These incidence rates of hip fractures among young adults were close to those reported in Germany  and Japan , but higher than those in England  and Spain . The incidence rates of hip fractures among young adults fluctuated in Taiwan, showing a similar pattern to that observed in England . However, Icks et al. revealed that the incidence rates of hip fractures gradually decreased from 1995 to 2004 . Possible factors that contributed to the differences among regions include different inclusion criteria, distributions of age and gender in the studied populations, trauma severity, and bone mineral density near middle age.
The statistically significant risk factors of overall death were male gender, older age, trochanteric fracture, hemiarthroplasty, and larger CCI scores. These risk factors for mortality after hip fractures among young adults in Taiwan were similar to those reported for the elderly population [10, 17, 34, 37]. Only a few studies analyzed the risk factors, including comorbidities and lifestyles, for the mortality among young adults [10, 11]. We found that among young adults, males had a higher risk for overall death than females. Moreover, males had a higher prevalence of multiple comorbidities, especially chronic pulmonary disease, than females, which might explain one of the reasons for the higher risk of mortality. Duckworth et al. revealed that excess alcohol consumption and pre-existing morbidities such as renal, liver, and respiratory diseases, were predictors of surgery failure among 122 adult fracture patients younger than 60 years . Karantana et al. investigated 315 hip fractures among younger women aged less than 65 years, and determined that smoking and alcohol abuse were important risk factors for mortality . In their meta-analysis, Hu et al. identified multiple comorbidities as risk factors of overall mortality among elderly adults . However, the comorbidities used in the multivariable analysis varied among these studies. There were no clinical measurements of individuals in our database that could be used to sufficiently evaluate these risk factors. We used CCI score to represent the combined severity of multiple comorbidities, which was demonstrated to play a key role in the mortality rate after hip fractures [38, 39]. Hip fractures among young adults are typically treated with internal fixation. We found that hemiarthroplasty had a higher mortality rate compared with that of internal fixation. However, only 160 subjects (3.54 %) received hemiarthroplasty in our database; the sample size was thus much too small to obtain a meaningful conclusion of the effect of surgery type.
Our study used a sample of young adults in Taiwan, particularly hospitalized patients who had hip fractures and subsequently underwent surgery. Selection biases may have existed and thus, our results should be interpreted with caution. Our database had incomplete clinical data for this population and therefore there may have been a number of potentially influential variables that changed or were not taken into consideration during the follow-up period, such as pre-operative joint functions/conditions, smoking status, body mass index, bone mineral density, lifestyle, severity of comorbidity, and quality of life. Furthermore, in contrast to other case–control and cohort studies, there was no control group in the present study. We did not directly compare the relative risk of death to that of a population without hip fractures or to a population with hip fractures but without surgery. We used the NHI database of inpatients in this study, which includes all subjects admitted to hospitals in Taiwan. Since many young adults were admitted to hospitals due to severe medical diseases, surgical diseases or major trauma, it was very difficult to find a well-defined matched control group that did not have a hip fracture nor any other major disease to achieve a balanced distribution in covariates/comorbidities between the two groups, with or without hip fracture. Instead, we calculated the SMRs from Taiwan’s National Register of Deaths Database to evaluate indirectly the relative risk of death compared to that of the general population.
The overall annual incidence rates of hip fracture for young adults aged 20 to 40 years in Taiwan were 7.68 and 7.23 per 100,000 in 2001 and 2008, respectively. The cumulative mortality rate was as high as 10.5 % during the ten-year follow-up. Although the one- to ten-year follow-up SMRs decreased, all values remained five-fold greater or more, which indicated that the relative impact on the mortality rate was quite high in young adults with hip fracture compared with the mortality rate in the general young adult population. We recommend that young adults that have been treated for hip fracture should be closely followed up to reduce the risk of mortality.
CCI, Charlson comorbidity index; ICD-9-CM, international classification of disease, ninth revision, clinical modification; IRB, institutional review board; NHI, The National Health Insurance; NHIRD, The NHI Research Database; SMR, standardized mortality ratio
Protzman RR, Burkhalter WE. Femoral-neck fractures in young adults. J Bone Joint Surg Am. 1976;58(5):689–95.
Askin SR, Bryan RS. Femoral neck fractures in young adults. Clin Orthop Relat Res. 1976;114:259–64.
Swiontkowski MF, Winquist RA, Hansen Jr ST. Fractures of the femoral neck in patients between the ages of twelve and forty-nine years. J Bone Joint Surg Am. 1984;66(6):837–46.
Boden SD, Labropoulos P, Saunders R. Hip fractures in young patients: is this early osteoporosis? Calcif Tissue Int. 1990;46(2):65–72.
Robinson CM, Court-Brown CM, McQueen MM, Christie J. Hip fractures in adults younger than 50 years of age. Epidemiology and results. Clin Orthop Relat Res. 1995;312:238–46.
Hwang LC, Lo WH, Chen WM, Lin CF, Huang CK, Chen CM. Intertrochanteric fractures in adults younger than 40 years of age. Arch Orthop Trauma Surg. 2001;121(3):123–6.
Verettas DA, Galanis B, Kazakos K, Hatziyiannakis A, Kotsios E. Fractures of the proximal part of the femur in patients under 50 years of age. Injury. 2002;33(1):41–5.
Lofthus CM, Osnes EK, Meyer HE, Kristiansen IS, Nordsletten L, Falch JA. Young patients with hip fracture: a population-based study of bone mass and risk factors for osteoporosis. Osteoporos Int. 2006;17(11):1666–72.
Platzer P, Thalhammer G, Wozasek GE, Vecsei V. Femoral shortening after surgical treatment of trochanteric fractures in nongeriatric patients. J Trauma. 2008;64(4):982–9.
Karantana A, Boulton C, Bouliotis G, Shu KS, Scammell BE, Moran CG. Epidemiology and outcome of fracture of the hip in women aged 65 years and under: a cohort study. J Bone Joint Surg. 2011;93(5):658–64.
Duckworth AD, Bennet SJ, Aderinto J, Keating JF. Fixation of intracapsular fractures of the femoral neck in young patients: risk factors for failure. J Bone Joint Surg. 2011;93(6):811–6.
Zuckerman JD. Hip fracture. N Engl J Med. 1996;334(23):1519–25.
Kim SH, Meehan JP, Blumenfeld T, Szabo RM. Hip fractures in the United States: 2008 nationwide emergency department sample. Arthritis Care Res. 2012;64(5):751–7.
Wolinsky FD, Fitzgerald JF, Stump TE. The effect of hip fracture on mortality, hospitalization, and functional status: a prospective study. Am J Public Health. 1997;87(3):398–403.
Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002;359(9319):1761–7.
Court-Brown CM, Caesar B. Epidemiology of adult fractures: A review. Injury. 2006;37(8):691–7.
Tosteson AN, Gottlieb DJ, Radley DC, Fisher ES, Melton 3rd LJ. Excess mortality following hip fracture: the role of underlying health status. Osteoporos Int. 2007;18(11):1463–72.
Wu TY, Jen MH, Bottle A, Liaw CK, Aylin P, Majeed A. Admission rates and in-hospital mortality for hip fractures in England 1998 to 2009: time trends study. J Public Health (Oxf). 2011;33(2):284–91.
Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83.
Kanis JA, Oden A, Johnell O, De Laet C, Jonsson B, Oglesby AK. The components of excess mortality after hip fracture. Bone. 2003;32(5):468–73.
Tsuboi M, Hasegawa Y, Suzuki S, Wingstrand H, Thorngren KG. Mortality and mobility after hip fracture in Japan: a ten-year follow-up. J Bone Joint Surg. 2007;89(4):461–6.
Vestergaard P, Rejnmark L, Mosekilde L. Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications. Osteoporos Int. 2007;18(12):1583–93.
Empana JP, Dargent-Molina P, Breart G. Effect of hip fracture on mortality in elderly women: the EPIDOS prospective study. J Am Geriatr Soc. 2004;52(5):685–90.
Yoon HK, Park C, Jang S, Lee YK, Ha YC. Incidence and mortality following hip fracture in Korea. J Korean Med Sci. 2011;26(8):1087–92.
Panula J, Pihlajamaki H, Mattila VM, Jaatinen P, Vahlberg T, Aarnio P, Kivela SL. Mortality and cause of death in hip fracture patients aged 65 or older: a population-based study. BMC Musculoskelet Disord. 2011;12:105.
Tenenhouse A, Joseph L, Kreiger N, Poliquin S, Murray TM, Blondeau L, Berger C, Hanley DA, Prior JC, CaMos Research Group. Canadian Multicentre Osteoporosis S: . Estimation of the prevalence of low bone density in Canadian women and men using a population-specific DXA reference standard: the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos Int. 2000;11(10):897–904.
Wang Y, Tao Y, Hyman ME, Li J, Chen Y. Osteoporosis in china. Osteoporos Int. 2009;20(10):1651–62.
Aggarwal N, Raveendran A, Khandelwal N, Sen RK, Thakur JS, Dhaliwal LK, Singla V, Manoharan SR. Prevalence and related risk factors of osteoporosis in peri- and postmenopausal Indian women. J Mid-life Health. 2011;2(2):81–5.
Mengmeng Z, Yagang L, Ying L, Xuena P, Binbin L, Liu Z. A study of bone mineral density and prevalence of osteoporosis in Chinese people of Han nationality from Changchun. Archives Osteoporosis. 2012;7(1–2):31–6.
Hagino H, Furukawa K, Fujiwara S, Okano T, Katagiri H, Yamamoto K, Teshima R. Recent trends in the incidence and lifetime risk of hip fracture in Tottori, Japan. Osteoporos Int. 2009;20(4):543–8.
Bjorgul K, Reikeras O. Incidence of hip fracture in southeastern Norway: a study of 1,730 cervical and trochanteric fractures. Int Orthop. 2007;31(5):665–9.
Icks A, Haastert B, Wildner M, Becker C, Meyer G. Trend of hip fracture incidence in Germany 1995–2004: a population-based study. Osteoporos Int. 2008;19(8):1139–45.
Maggi S, Kelsey JL, Litvak J, Heyse SP. Incidence of hip fractures in the elderly: a cross-national analysis. Osteoporos Int. 1991;1(4):232–41.
Wang CB, Lin CF, Liang WM, Cheng CF, Chang YJ, Wu HC, Wu TN, Leu TH. Excess mortality after hip fracture among the elderly in Taiwan: a nationwide population-based cohort study. Bone. 2013;56(1):147–53.
Lizaur-Utrilla A, Puchades Orts A, Sanchez del Campo F, Anta Barrio J, Gutierrez Carbonell P. Epidemiology of trochanteric fractures of the femur in Alicante, Spain, 1974–1982. Clin Orthop Relat Res. 1987;218:24–31.
Icks A, Haastert B, Meyer G. Remarkable decline in hip fracture incidence in younger age groups in Germany. Am J Public Health. 2007;97(10):1733–4.
Hu F, Jiang C, Shen J, Tang P, Wang Y. Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis. Injury. 2012;43(6):676–85.
Radley DC, Gottlieb DJ, Fisher ES, Tosteson AN. Comorbidity risk-adjustment strategies are comparable among persons with hip fracture. J Clin Epidemiol. 2008;61(6):580–7.
Kirkland LL, Kashiwagi DT, Burton MC, Cha S, Varkey P. The Charlson Comorbidity Index Score as a predictor of 30-day mortality after hip fracture surgery. Am J Med Qual. 2011;26(6):461–7.
We are grateful for the data provided by the Ministry of Health and Welfare, Taiwan. We would like to thank Mr. Peter Wilds for his assistance in providing professional writing services.
No resource of funding.
Availability of data and materials
The website of the Taiwan National Health Insurance Research Database is found at http://www.mohw.gov.tw/.
JCFL and CL planned the study design. THL and WCC drafted the manuscript. WML, YJC, DPS, CCW, CFC and SJW participated in the study and data analysis. JCFL WML and CFC performed the statistical analysis. CL coordination and helped to draft the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
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Ethics approval and consent to participate
The NHIRD is composed of anonymous secondary data released to the public for research purposes. All patients’ data were encrypted using the same encryption algorithm to cross-link the data while protecting the privacy of the patients. This study was exempted from a full review by the local ethics review committee, but the protocol was approved by the Institutional Review Board (IRB) of China Medical University Hospital (protocol # CMUH102-REC2-012).
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Leu, TH., Chang, WC., Lin, J.CF. et al. Incidence and excess mortality of hip fracture in young adults: a nationwide population-based cohort study. BMC Musculoskelet Disord 17, 326 (2016). https://doi.org/10.1186/s12891-016-1166-9
- Hip fracture
- Standardized mortality ratio
- Young adults
- Nationwide population-based study