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Figure 3 | BMC Musculoskeletal Disorders

Figure 3

From: Effects of hypoxia on anabolic and catabolic gene expression and DNA methylation in OA chondrocytes

Figure 3

Methylation status of MMP13 proximal promoter in articular OA chondrocytes under normoxic versus hypoxic conditions analysed by pyrosequencing (A); methylation of specific CpG sites correlates with lower levels of gene expression (B). Primary OA chondrocytes were cultured with or without IL-1β + OSM and 5-aza-dC for 5 weeks. Values are the mean ± SD (n = 5; *p < 0.1; **p < 0.05).

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