Evaluating the health and economic impact of osteoarthritis pain in the workforce: results from the National Health and Wellness Survey
© DiBonaventura et al; licensee BioMed Central Ltd. 2011
Received: 27 October 2010
Accepted: 28 April 2011
Published: 28 April 2011
There has been increasing recognition that osteoarthritis (OA) affects younger individuals who are still participants in the workforce, but there are only limited data on the contribution of OA pain to work productivity and other outcomes in an employed population. This study evaluated the impact of OA pain on healthcare resource utilization, productivity and costs in employed individuals.
Data were derived from the 2009 National Health and Wellness Survey. Univariable and multivariable analyses were used to characterize employed individuals (full-time, part-time, or self-employed) ≥20 years of age who were diagnosed with OA and had arthritis pain in the past month relative to employed individuals not diagnosed with OA or not experiencing arthritis pain in the past month. Work productivity was assessed using the Work Productivity and Activity Impairment (WPAI) questionnaire; health status was assessed using the physical (PCS) and mental component summary (MCS) scores from the SF-12v2 Health Survey and SF-6D health utilities; and healthcare utilization was evaluated by type and number of resources within the past 6 months. Direct and indirect costs were estimated and compared between the two cohorts.
Individuals with OA pain were less likely to be employed. Relative to workers without OA pain (n = 37,599), the OA pain cohort (n = 2,173) was significantly older (mean age 52.1 ± 11.5 years vs 41.4 ± 13.2 years; P < 0.0001) and with a greater proportion of females (58.2% vs 45.9%; P < 0.0001). OA pain resulted in greater work impairment than among workers without OA pain (34.4% versus 17.8%; P < 0.0001), and was primarily due to presenteeism (impaired activity while at work). Health status, assessed both by the SF-12v2 and the SF-6D was significantly poorer among workers with OA pain (P < 0.0001), and healthcare resource utilization was significantly higher (P < 0.0001) than workers without OA pain. Total costs were higher in the OA pain cohort ($15,047 versus $8,175; P < 0.0001), driven by indirect costs that accounted for approximately 75% of total costs.
A substantial proportion of workers suffer from OA pain. After controlling for confounders, the impact of OA pain was significant, resulting in lower productivity and higher costs.
Osteoarthritis (OA) is a degenerative joint disease that affects almost 27 million adults in the United States (US) and is ranked among the top three causes of disability [1, 2]. Pathologic features of OA include loss of articular cartilage and concomitant development of osteophytes at the joint margins. In the clinical setting, pain is a major complaint among patients with OA that also contributes to patient report of reduced joint function. In line with this, management strategies of OA include reduction of pain and improvement of function as the main targets [3–7].
OA has been considered an age-related disease, and substantial functional impairment, decreased quality of life, and increased healthcare resource utilization have been reported among older patients with OA [8–12]. However, there is increasing recognition of the effects of OA on younger patients who are still participants in the workforce, and several studies have documented that OA is associated with substantial reductions in productivity among employed individuals [13–15].
The importance of lost productivity in arthritis has recently been highlighted by the endorsement by OMERACT (Outcome Measures in Rheumatology) of work as an outcome, although no particular measure was recommended for its evaluation . While it has also been suggested that indirect costs related to lost work productivity are the primary driver of the economic burden of OA [17–19], some studies reported indirect costs that were lower than direct costs [20–22]. Since there are no standardized methods for estimating indirect costs in OA , these contrasting results are likely due to differences in populations and methodologies, including inadequately accounting for the contribution of presenteeism (reduced productivity while at work) to indirect costs. In fact, presenteeism has been suggested to be the primary source of lost productive time and indirect costs among workers with chronic pain conditions including arthritis . This was recently demonstrated in a study reporting a considerably increased risk of presenteeism among workers with arthritis relative to individuals without chronic conditions (odds ratio: 8), whereas the risk of absenteeism was not increased .
In workers with OA, reductions in work productivity, including presenteeism, appear to be associated with increased patient-reported OA severity , yet data on the contribution of OA pain to work productivity and other outcomes in an employed population are limited. A study by White et al.  estimated the economic burden of patients with OA who were receiving pain pharmacotherapy, but the relative impact of pain on costs was not addressed. A more direct effect of OA pain was demonstrated in an analysis of data from the Longitudinal Examination of Arthritis Pain (LEAP) study . Results from LEAP suggested that weekly fluctuations in OA pain were associated with changes in levels of daily activities/functioning, work absenteeism, sleep interference, and healthcare resource use. In an analysis of four measures of presenteeism (the Health and Labor Questionnaire [HLQ]; the Work Limitations Questionnaire [WLQ]; the World Health Organization's Health and Work Performance Questionnaire [HPQ]; and the Work Productivity and Activity Impairment Questionnaire [WPAI]), Zhang et al.  observed a significant association between pain and the risk of presenteeism, but only weak associations between pain severity and hours lost. Another study implicated acute pain exacerbations as a factor in lost productivity in a population of employed adults with arthritis, however, the type of arthritis was not specified . In that study, the magnitude of lost productivity was mediated by the proportion of workers who lost work time rather than the amount of time lost. This use of proportions rather than amount of time was further considered in a combined OA and rheumatoid arthritis population as part of a validation study comparing responsiveness of five at-work productivity measures: the Workplace Activity Limitations Scale (WALS); the 6-item Stanford Presenteeism Scale [SPS-6]; the Endicott Work Productivity Scale [EWPS]; the Rheumatoid Arthritis Work Instability Scale [WIS]; and the Work Limitations Questionnaire [WLQ]) . As indicated by the mean score on each of the measures, only mild at-work productivity losses were reported, and the correlations between pain severity in the past week and scores on the five measures were only moderate.
To increase our knowledge of the consequences of OA pain in the workforce, the objective of this study was to use the National Health and Wellness Survey (NHWS) to evaluate the impact of OA pain on direct and indirect costs and health provider visits, as well as on measures of general health status in an employed population. The NHWS is a cross-sectional, self-administered, internet-based questionnaire administered annually to a nationwide sample of adults (aged 18 or older).
Data source and population
Data were derived from the 2009 National Health and Wellness Survey (NHWS) that included information on 75,000 individuals in the United States (US). To represent the demographic composition of the US adult population, the data are weighted by gender, age and race/ethnicity http://www.chsinternational.com/nhws.html.
This analysis was performed using data only for those respondents who were ≥ 20 years of age and were currently employed full-time, part-time, or self-employed. Subjects meeting these criteria were stratified into two cohorts. The first cohort was defined as workers who self-reported that they have been diagnosed with OA and were experiencing arthritis pain in the past month, and the comparator cohort consisted of workers who self-reported that they were either not diagnosed with osteoarthritis or not experiencing arthritis pain in the past month. Self-report of an OA diagnosis was based on two questions. The first question determined whether the subject had been diagnosed with arthritis by a physician (response of yes/no), and the second question elicited the type of arthritis that the subject has, with potential responses of osteoarthritis, rheumatoid arthritis, psoriatic arthritis, and not sure. No clinical information (e.g., X-ray findings) was asked of participants to define the presence of OA.
The demographic and health characteristics of the two cohorts were characterized and compared. These characteristics included age, gender, race/ethnicity, marital status, education, income, insurance status, employment type, body mass index (BMI), and Charlson Comorbidity Index (CCI) .
Work productivity was assessed using the Work Productivity and Activity Impairment (WPAI) questionnaire . The WPAI is a self-reported questionnaire consisting of four subscales that evaluate absenteeism, presenteeism, overall work impairment, and activity impairment during the previous seven days, generated in the form of percentages, with higher values indicating greater impairment. The WPAI used in the current analysis was not specific for OA.
Health-related quality of life was assessed using the physical (PCS) and mental component summary (MCS) scores from the self-reported SF-12v2 Health Survey . Scores for the PCS and MCS are normed to the US population (mean = 50, SD = 10) and vary from 0 to 100, with higher scores indicating better quality of life. Additionally, health utility scores for both cohorts were calculated using the SF-6D , which provides a preference-based single index measure for health status and varies from 0.29 to 1.
Healthcare utilization, regardless of cause, was evaluated by type and number of resources that the patients reported using within the past six months. These resources included number of prescriptions and provider visits for both traditional healthcare (physician, emergency room [ER], and hospitalizations) and non-traditional healthcare e.g., acupuncturist, herbalist, etc.
The direct medical costs evaluated in this analysis included only traditional provider visits (i.e. physician, ER, and hospitalizations). These costs were estimated by multiplying the units of resource categories for six months by the average cost of the resource derived from the Medical Expenditure Panel Survey database [34–36], and then multiplying by two to project annual costs. Indirect costs associated with lost productivity for any reason were calculated among both cohorts using the method of Lofland et al.  based on data from the WPAI and median annual income values obtained through the Bureau of Labor Statistics (BLS) . For each respondent, the percent overall work impairment (obtained from the WPAI) was multiplied by the annual income. Direct and indirect costs were summed to provide an estimate of total costs.
Univariable analysis was used to examine differences in demographic and clinical characteristics between the two groups. Analysis of quality of life and work productivity were performed using multivariable models with the following demographic and clinical characteristics as covariates: age range (coded as 20-39 vs. 40-64 and ≥ 65 years), gender, race/ethnicity (coded as non-Hispanic white, non-Hispanic black, Hispanic, or other), education (more than high school vs. high school equivalent degree or less), income (< $25 K, $25 K to < $50 K, $50 K to < $75 K, ≥ $75 K, or decline to answer), CCI (0 vs. ≥ 1), health insurance (yes vs. no), BMI (underweight, normal, overweight, obese, or decline to answer), employment (full-time, part-time, or self-employed), traditional healthcare visits (yes vs. no), non-traditional healthcare visits (yes vs. no), prescription drug use (yes vs. no), ER visits (yes vs. no), and hospitalization (yes vs. no).
Determination and analysis of costs were not adjusted for covariates. Generalized linear models (GLMs) were conducted to estimate work productivity and activity impairment using a negative binomial distribution to account for skewness and provide best fit. Significant differences between the two groups were examined using Wald chi-square tests for categorical outcomes and independent-samples t-tests for continuous outcomes. For all analyses, a P value < 0.05 was considered statistically significant.
Of the 39,772 workers who met the inclusion criteria, 2,173 were diagnosed with OA and experienced arthritis pain in the past month, and thus were included in the OA pain cohort. The peripheral joints (ankles, elbows, feet, fingers, hands, hips, knees, neck, shoulders, wrists, other) were affected in 98.1% of these patients, and the spine was affected in 43.7%. The comparator cohort consisted of workers not diagnosed with osteoarthritis or not experiencing arthritis pain in the past month (n = 37,599), with 10.7% and 2.5% reporting peripheral and spinal involvement, respectively.
Weighted univariable statistics (to reflect the US population) for demographic characteristics of workers with OA pain compared with workers without OA pain.
OA Pain (n = 2,173)
Without OA pain (n = 37,599)
Weighted percent (SE)
Weighted percent (SE)
14.5 ± 0.8
47.7 ± 0.3
71.8 ± 1.1
47.8 ± 0.3
≥ 65 years
13.7 ± 0.9
4.5 ± 0.1
41.8 ± 1.1
54.1 ± 0.3
58.2 ± 1.1
45.9 ± 0.3
78.0 ± 1.1
66.5 ± 0.3
8.4 ± 0.8
12.1 ± 0.2
8.3 ± 0.8
14.6 ± 0.2
5.3 ± 0.5
6.8 ± 0.1
High school graduate or less
17.9 ± 0.9
16.9 ± 0.2
More than high school
82.2 ± 0.9
83.1 ± 0.2
13.5 ± 0.8
11.6 ± 0.2
$25,000 to $49,999
30.4 ± 1.1
29.1 ± 0.3
$50,000 to $74,999
24.8 ± 1.0
24.2 ± 0.2
26.5 ± 1.1
30.9 ± 0.3
Decline to answer
4.8 ± 0.5
4.2 ± 0.1
57.3 ± 1.2
70.7 ± 0.3
23.9 ± 1.1
18.3 ± 0.2
18.8 ± 0.9
11.0 ± 0.2
85.4 ± 0.8
81.8 ± 0.2
14.6 ± 0.8
18.2 ± 0.2
0.8 ± 0.2
1.7 ± 0.1
20.1 ± 1.0
32.1 ± 0.3
30.0 ± 1.1
33.6 ± 0.3
47.5 ± 1.2
30.9 ± 0.3
Decline to answer
1.5 ± 0.3
1.8 ± 0.1
All presented costs represent actual costs unadjusted for covariates. Direct medical costs were significantly higher in the OA pain cohort across all provider categories (Figure 4A), resulting in total direct medical costs that were more than 1.5-times higher than for the comparator group, $3,702 vs $2,158 (P < 0.0001). In both cohorts, hospitalization costs accounted for slightly more than half of the direct costs, 51% and 55% for OA pain and the comparator, respectively. Total costs were almost twice as high among workers with OA pain cohort as in workers without OA pain, $15,047 and $8,175, respectively (P < 0.0001), and were primarily driven by indirect costs resulting from lost productivity.
This study not only confirms the substantial presence and economic impact of OA in the workforce that has been suggested by other studies [14, 15, 21], but supports other evidence that OA pain is a contributory factor to the economic and individual worker burden. Notably, among the employed population that served as the basis for this study, the prevalence of workers with OA who had arthritis pain during the past month was greater than 5%. Although pain is primary symptom of OA, it is likely that the comparator cohort contained a proportion of workers with OA who did not have pain in the past month, suggesting that the overall presence of OA in the workforce is likely to be higher.
While the demographics of the OA pain cohort relative to the comparator were generally consistent with what might be expected for OA, i.e. older and female, the mean age of the OA pain cohort (52 years) nevertheless demonstrates the presence of OA in a younger demographic having a potential for additional years of workforce participation.
Workers with OA pain reported significantly lower health status than the comparator cohort even after adjusting for relevant covariates. Not surprisingly, since OA and pain affects physical functioning, there was a greater effect on physical components of health status, although the difference in mental components was also significant. The health utility score was also significantly lower among the workers with OA pain relative to the comparators; health utility scores are important from the economic perspective since they are frequently incorporated into economic analyses. The adjusted difference between cohorts on the SF-12v2 PCS score (7.6 points) and the SF-6D health utility score (0.07 points) exceeded the values that are considered clinically meaningful; > 3 and 0.03 points, respectively [39, 40].
The data also show that workers with OA pain had more health provider visits across categories and were prescribed twice as many medications than the comparator cohort, although whether these visits or medications were specifically related to pain could not be ascertained. It is also interesting to note that non-traditional health resources were used by a greater proportion of individuals with OA pain, since these visits may not necessarily be covered by insurance plans.
Workers with OA pain were characterized by significantly greater work and activity impairment relative to comparators. In the OA pain cohort overall, approximately one-third (34%) of worker productivity was lost. Presenteeism has been a neglected component of assessing lost productivity, and is an outcome that can best be captured by studies that are based on patient report. As far as we can ascertain, this is the first study in OA that evaluated presenteeism in a complete context of worker impairment along with absenteeism. Consistent with the results suggested by the literature on the general arthritis population [13, 24, 25, 41], presenteeism was the primary source of work impairment, with almost 10 hours per week lost while at work; almost 4-fold greater than for absenteeism.
A number of measures of productivity are available that include assessment of presenteeism, and a recent study has shown variability in the ability of four of these measures, including the WPAI, to estimate presenteeism . However, among the four measures, the WPAI was the only one having a complete response rate, possibly related to its brevity and ease of use; several of the other measures are associated with an administration burden because of their length. It is for this reason that the WPAI is among the most commonly used productivity measures, and was considered appropriate for the current study. Additionally, the significant association between pain and presenteeism observed in that study further suggests that the high burden of lost productivity observed in our OA pain cohort is due at least in part to the pain component .
Mean annual unadjusted costs in the OA pain cohort, which were significantly higher than the comparator cohort, reflected the substantial impact of lost productivity, with estimated indirect costs of $11,345. These indirect costs account for approximately 75% of total costs, and are almost twice as high as the indirect costs of the comparator cohort ($6,017). Interestingly, among workers without OA pain, indirect costs accounted for a similar proportion of total costs, suggesting the general importance of lost productivity in economic evaluations of health and disease. For direct costs, although only 10% of the OA pain cohort reported hospitalizations, this resource category was the primary cost driver, most likely due to the high cost per event.
All outcomes, except for costs, were adjusted for relevant covariates. Since many factors (such as age, ethnicity, gender, socioeconomic status, and insurance) are likely to impact health care seeking behavior by patients and management strategies by providers, caution should be applied when interpreting the implications of the above cost analysis. Future cost analyses controlling for such covariates may yield slightly different estimates.
Although strengths of this study that may enhance its generalizability include a large sample size and population-level analysis based on a weighted assessment to reflect the demographic composition of the US population, there are certain limitations that need to be considered. An important limitation is that the data used in the analyses are based on patient self-report, without clinical verification of an OA diagnosis, and thus are subject to the biases that are inherent in this type of data presentation. It is possible that some patients reported that they were diagnosed with OA when, in fact, they were not. Conversely, some patients may have thought they were diagnosed with another condition when, in fact, it was OA. As a result, additional error could have been introduced into the analyses. Nevertheless, as previously noted, patient report provides an important source for evaluating outcomes, and is the primary means of determining presenteeism.
Since this was part of a large general health survey, the version of the WPAI that was used was not OA specific. Therefore, the observed relationships between OA pain and productivity should be considered associative rather than causal, since direct causality cannot be inferred regarding the OA pain as a source of lost productivity, especially given that workers with OA pain were characterized by a significantly greater comorbidity burden than workers without OA pain. Similarly, the higher resource utilization and costs cannot be ascribed specifically to the OA nor the pain, since there are no claims linking resource use with the disease and symptoms of interest. Nevertheless, lost productivity in the OA pain cohort was twice as high as the comparator cohort, with both total costs and indirect costs also almost twice as high, suggesting a substantial burden associated with OA pain that may be of special concern to employers.
Another limitation was that the questionnaire captured neither the type of employment nor the specific site of OA pain. Since these variables are likely to impact productivity as well as management strategies, their absence may reduce the generalizability of the results.
Because the source of our data was not a medical claims database, only the number of prescribed drugs by patient report was captured, and our inability to estimate the costs associated with pharmacotherapy for inclusion in direct costs is another limitation. However, extrapolating from a study that reported total pharmacotherapy costs of $2,941 among patients with OA receiving pain therapy , and adding these costs to the direct costs for provider visits estimated in the current study would result in total direct costs that are approximately half of the indirect costs. Our derivation of annual costs was based on extrapolation of 6 month data to 1 year. However, this method may not adequately reflect actual resource utilization over a 12-month period.
Results from this study highlight the fact that OA pain is not necessarily relegated to an older population, but is present in an under-recognized proportion of the workforce. Despite the above limitations, the data show that presence of OA pain has a profound impact on quality of life, work productivity, and healthcare resource use among workers. Even after controlling for confounding variables, workers with OA pain reported significantly reduced health status and significant work impairment. Notably, this study also demonstrated the importance of presenteeism as a contributing factor to lost productivity. These combined factors resulted in costs that were significantly higher than among workers without OA pain, and were driven by indirect costs, which appeared to primarily result from work impairment that occurred while at work (presenteeism) rather than absence from work. These results not only expand our knowledge of the burden of OA, but they can also inform employers and health care providers on the contribution of OA pain to patient productivity and quality of life. Such information may potentially be of use when considering how to evaluate management strategies for alleviating the worker and employer burdens associated with this condition in the general population.
This study was funded by Pfizer Inc. Marco DiBonaventura and Shaloo Gupta are employees of Kantar Health, and were paid consultants to Pfizer in the conduct of this study and the development of this manuscript. The authors would like to thank Jonathan Chapnick for his input in study design and execution, and E. Jay Bienen who provided editorial assistance, which was funded by Pfizer, Inc.
- Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, Gabriel S, Hirsch R, Hochberg MC, Hunder GG, Jordan JM, Katz JN, Kremers HM, Wolfe F, National Arthritis Data Workgroup: Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008, 58 (1): 26-35. 10.1002/art.23176.View ArticlePubMedPubMed CentralGoogle Scholar
- Centers for Disease Control and Prevention (CDC): Prevalence and most common causes of disability among adults--United States, 2005. MMWR Morb Mortal Wkly Rep. 2009, 58 (16): 421-426.Google Scholar
- Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, Bierma-Zeinstra S, Brandt KD, Croft P, Doherty M, Dougados M, Hochberg M, Hunter DJ, Kwoh K, Lohmander LS, Tugwell P: OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008, 16 (2): 137-162. 10.1016/j.joca.2007.12.013.View ArticlePubMedGoogle Scholar
- Zhang W, Doherty M, Arden N, Bannwarth B, Bijlsma J, Gunther KP, Hauselmann HJ, Herrero-Beaumont G, Jordan K, Kaklamanis P, Leeb B, Lequesne M, Lohmander S, Mazieres B, Martin-Mola E, Pavelka K, Pendleton A, Punzi L, Swoboda B, Varatojo R, Verbruggen G, Zimmermann-Gorska I, Dougados M: EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 2005, 64 (5): 669-681. 10.1136/ard.2004.028886.View ArticlePubMedGoogle Scholar
- Jordan KM, Arden NK, Doherty M, Bannwarth B, Bijlsma JW, Dieppe P, Gunther K, Hauselmann H, Herrero-Beaumont G, Kaklamanis P, Lohmander S, Leeb B, Lequesne M, Mazieres B, Martin-Mola E, Pavelka K, Pendleton A, Punzi L, Serni U, Swoboda B, Verbruggen G, Zimmerman-Gorska I, Dougados M: EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis. 2003, 62 (12): 1145-1155. 10.1136/ard.2003.011742.View ArticlePubMedPubMed CentralGoogle Scholar
- American College of Rheumatology: Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum. 2000, 43 (9): 1905-1915.View ArticleGoogle Scholar
- American College of Rheumatology Ad Hoc Group on Use of Selective and Nonselective Nonsteroidal Antiinflammatory Drugs: Recommendations for use of selective and nonselective nonsteroidal antiinflammatory drugs: an American College of Rheumatology white paper. Arthritis Rheum. 2008, 59 (8): 1058-1073. Erratum in: Arthritis Rheum. 2008;1058:1686. Dosage error in article text.View ArticleGoogle Scholar
- Briggs A, Scott E, Steele K: Impact of osteoarthritis and analgesic treatment on quality of life of an elderly population. Ann Pharmacother. 1999, 33 (11): 1154-1159. 10.1345/aph.18411.View ArticlePubMedGoogle Scholar
- Dominick KL, Ahern FM, Gold CH, Heller DA: Health-related quality of life among older adults with arthritis. Health Qual Life Outcomes. 2004, 2: 5-10.1186/1477-7525-2-5.View ArticlePubMedPubMed CentralGoogle Scholar
- Salaffi F, Carotti M, Stancati A, Grassi W: Health-related quality of life in older adults with symptomatic hip and knee osteoarthritis: a comparison with matched healthy controls. Aging Clin Exp Res. 2005, 17 (4): 255-263.View ArticlePubMedGoogle Scholar
- Jakobsson U, Hallberg IR: Quality of life among older adults with osteoarthritis: an explorative study. J Gerontol Nurs. 2006, 32 (8): 51-60.PubMedGoogle Scholar
- Cook C, Pietrobon R, Hegedus E: Osteoarthritis and the impact on quality of life health indicators. Rheumatol Int. 2007, 27 (4): 315-321. 10.1007/s00296-006-0269-2.View ArticlePubMedGoogle Scholar
- Ricci JA, Stewart WF, Chee E, Leotta C, Foley K, Hochberg MC: Pain exacerbation as a major source of lost productive time in US workers with arthritis. Arthritis Rheum. 2005, 53 (5): 673-681. 10.1002/art.21453.View ArticlePubMedGoogle Scholar
- Kotlarz H, Gunnarsson CL, Fang H, Rizzo JA: Osteoarthritis and absenteeism costs: evidence from US National Survey Data. J Occup Environ Med. 2010, 52 (3): 263-268. 10.1097/JOM.0b013e3181cf00aa.View ArticlePubMedGoogle Scholar
- Kleinman N, Harnett J, Melkonian A, Lynch W, Kaplan-Machlis B, Silverman S: Burden of Fibromyalgia and Comparisons With Osteoarthritis in the Workforce. J Occup Environ Med. 2009, 51 (12): 1384-1393. 10.1097/JOM.0b013e3181bb808b.View ArticlePubMedGoogle Scholar
- Beaton D, Bombardier C, Escorpizo R, Zhang W, Lacaille D, Boonen A, Osborne RH, Anis AH, Strand CV, Tugwell PS: Measuring worker productivity: frameworks and measures. J Rheumatol. 2009, 36 (9): 2100-2109. 10.3899/jrheum.090366.View ArticlePubMedGoogle Scholar
- Leardini G, Salaffi F, Caporali R, Canesi B, Rovati L, Montanelli R, Italian Group for Study of the Costs of Arthritis: Direct and indirect costs of osteoarthritis of the knee. Clin Exp Rheumatol. 2004, 22 (6): 699-706.PubMedGoogle Scholar
- Rabenda V, Manette C, Lemmens R, Mariani AM, Struvay N, Reginster JY: Direct and indirect costs attributable to osteoarthritis in active subjects. J Rheumatol. 2006, 33 (6): 1152-1158.PubMedGoogle Scholar
- Gupta S, Hawker GA, Laporte A, Croxford R, Coyte PC: The economic burden of disabling hip and knee osteoarthritis (OA) from the perspective of individuals living with this condition. Rheumatology (Oxford). 2005, 44 (12): 1531-1537. 10.1093/rheumatology/kei049.View ArticleGoogle Scholar
- Maetzel A, Li LC, Pencharz J, Tomlinson G, Bombardier C: The economic burden associated with osteoarthritis, rheumatoid arthritis, and hypertension: a comparative study. Ann Rheum Dis. 2004, 63 (4): 395-401. 10.1136/ard.2003.006031.View ArticlePubMedPubMed CentralGoogle Scholar
- White AG, Birnbaum HG, Janagap CC, Buteau L, Schein J: Direct and indirect costs of pain therapy for osteoarthritis in an insured population in the United States. J Occup Environ Med. 2008, 50 (9): 998-1005. 10.1097/JOM.0b013e3181715111.View ArticlePubMedGoogle Scholar
- White LA, Birnbaum HG, Kaltenboeck A, Tang J, Mallett D, Robinson RL: Employees with fibromyalgia: medical comorbidity, healthcare costs, and work loss. J Occup Environ Med. 2008, 50 (1): 13-24. 10.1097/JOM.0b013e31815cff4b.View ArticlePubMedGoogle Scholar
- Xie F: The need for standardization: a literature review of indirect costs of rheumatoid arthritis and osteoarthritis. Arthritis Rheum. 2008, 59 (7): 1027-1033. 10.1002/art.23825.View ArticlePubMedGoogle Scholar
- Stewart WF, Ricci JA, Chee E, Morganstein D, Lipton R: Lost productive time and cost due to common pain conditions in the US workforce. JAMA. 2003, 290 (18): 2443-2454. 10.1001/jama.290.18.2443.View ArticlePubMedGoogle Scholar
- Zhang W, Koehoorn M, Anis AH: Work Productivity Among Employed Canadians With Arthritis. J Occup Environ Med. 2010Google Scholar
- Sadosky A, Bushmakin A, Cappelleri JC, Lionberger DR: Relationship between patient-reported disease severity in osteoarthritis and self-reported pain, function, and work productivity. Arthritis Res Ther. 2010, 12: R162-10.1186/ar3121.View ArticlePubMedPubMed CentralGoogle Scholar
- Hutchings A, Calloway M, Choy E, Hooper M, Hunter DJ, Jordan JM, Zhang Y, Baser O, Long S, Palmer L: The Longitudinal Examination of Arthritis Pain (LEAP) study: relationships between weekly fluctuations in patient-rated joint pain and other health outcomes. J Rheumatol. 2007, 34 (11): 2291-2300.PubMedGoogle Scholar
- Zhang W, Gignac MA, Beaton D, Tang K, Anis AH: Productivity loss due to presenteeism among patients with arthritis: estimates from 4 instruments. J Rheumatol. 2010, 37 (9): 1805-1814. 10.3899/jrheum.100123.View ArticlePubMedGoogle Scholar
- Beaton DE, Tang K, Gignac MA, Lacaille D, Badley EM, Anis AH, Bombardier C: Reliability, validity, and responsiveness of five at-work productivity measures in patients with rheumatoid arthritis or osteoarthritis. Arthritis Care Res. 2010, 62 (1): 28-37. 10.1002/acr.20011.View ArticleGoogle Scholar
- Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987, 40 (5): 373-383. 10.1016/0021-9681(87)90171-8.View ArticlePubMedGoogle Scholar
- Reilly MCZ, A S, Dukes EM: The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics. 1993, 4: 353-365. 10.2165/00019053-199304050-00006.View ArticlePubMedGoogle Scholar
- Ware JE, Kosinski M, Turner-Bowker D, Gandek B: User's Manual for the SF-12v2™ Health Survey with a Supplement Documenting SF-12® Health Survey. 2002, Lincoln, RI: QualityMetric IncorporatedGoogle Scholar
- Brazier J, Roberts J, Deverill M: The estimation of a preference-based measure of health from the SF-36. J Health Econ. 2002, 21 (2): 271-292. 10.1016/S0167-6296(01)00130-8.View ArticlePubMedGoogle Scholar
- Machlin S: Expenses for a hospital emergency room visit 2003. MEPS Statistical Brief No. 111 (2006). [http://www.meps.ahrq.gov/data_files/publications/st111/stat111.pdf]
- Machlin S, Carper K: Expenses for Office-Based Physician Visits by Specialty, 2004. MEPS Statistical Brief No. 166 (2007). [http://www.meps.ahrq.gov/data_files/publications/st166/stat166.pdf]
- Machlin S, Carper K: Expenses for Hospital Inpatient Stays, 2004. MEPS Statistical Brief No. 164. [http://www.meps.ahrq.gov/data_files/publications/st164/stat164.pdf]
- Lofland JH, Pizzi L, Frick KD: A review of health-related workplace productivity loss instruments. Pharmacoeconomics. 2004, 22 (3): 165-184. 10.2165/00019053-200422030-00003.View ArticlePubMedGoogle Scholar
- United States Department of Labor. United States Bureau of Labor Statistics: Highlights of women's earnings in 2008. Report 1017. [http://www.bls.gov/cps/cpswom2008.pdf]
- Hays RD, Morales LS: The RAND-36 measure of health-related quality of life. Ann Med. 2001, 33 (5): 350-357. 10.3109/07853890109002089.View ArticlePubMedGoogle Scholar
- Walters SJ, Brazier JE: Comparison of the minimally important difference for two health state utility measures: EQ-5D and SF-6D. Qual Life Res. 2005, 14 (6): 1523-1532. 10.1007/s11136-004-7713-0.View ArticlePubMedGoogle Scholar
- Li X, Gignac MA, Anis AH: The indirect costs of arthritis resulting from unemployment, reduced performance, and occupational changes while at work. Med Care. 2006, 44 (4): 304-310. 10.1097/01.mlr.0000204257.25875.04.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2474/12/83/prepub
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