Skip to main content

Cost-effectiveness of exercise therapy versus general practitioner care for osteoarthritis of the hip: design of a randomised clinical trial



Osteoarthritis (OA) is the most common joint disease, causing pain and functional impairments. According to international guidelines, exercise therapy has a short-term effect in reducing pain/functional impairments in knee OA and is therefore also generally recommended for hip OA. Because of its high prevalence and clinical implications, OA is associated with considerable (healthcare) costs. However, studies evaluating cost-effectiveness of common exercise therapy in hip OA are lacking. Therefore, this randomised controlled trial is designed to investigate the cost-effectiveness of exercise therapy in conjunction with the general practitioner's (GP) care, compared to GP care alone, for patients with hip OA.


Patients aged ≥ 45 years with OA of the hip, who consulted the GP during the past year for hip complaints and who comply with the American College of Rheumatology criteria, are included. Patients are randomly assigned to either exercise therapy in addition to GP care, or to GP care alone. Exercise therapy consists of (maximally) 12 treatment sessions with a physiotherapist, and home exercises. These are followed by three additional treatment sessions in the 5th, 7th and 9th month after the first treatment session. GP care consists of usual care for hip OA, such as general advice or prescribing pain medication. Primary outcomes are hip pain and hip-related activity limitations (measured with the Hip disability Osteoarthritis Outcome Score [HOOS]), direct costs, and productivity costs (measured with the PROductivity and DISease Questionnaire). These parameters are measured at baseline, at 6 weeks, and at 3, 6, 9 and 12 months follow-up. To detect a 25% clinical difference in the HOOS pain score, with a power of 80% and an alpha 5%, 210 patients are required. Data are analysed according to the intention-to-treat principle. Effectiveness is evaluated using linear regression models with repeated measurements. An incremental cost-effectiveness analysis and an incremental cost-utility analysis will also be performed.


The results of this trial will provide insight into the cost-effectiveness of adding exercise therapy to GPs' care in the treatment of OA of the hip. This trial is registered in the Dutch trial registry trial number NTR1462.

Peer Review reports


Osteoarthritis (OA) is the most common joint disease. It is a chronic condition causing pain and disability of especially hip and knee joints [1, 2]. On January 1 2007 about 238, 000 persons were registered in a general practitioner's (GP) database in the Netherlands because of symptoms of hip OA [3]. Incidence and prevalence will increase in the coming years due to ageing of the population. The rapid increase in persons aged ≥ 55 years in Western countries implies that OA is becoming a public healthcare problem with increasing healthcare costs [1, 4].

In addition to the societal influence, OA affects daily activities and quality of life. The GP is the initial caregiver involved, in many cases providing the patient with advice and medication over many years. The GP may also refer to exercise therapy. International guidelines recommend exercise therapy as part of the treatment of OA [57]. The Osteoarthritis Research Society International (OARSI) [7] reviewed 51 treatment modalities that were investigated in studies published 2006-2009, in which exercise therapy was shown to reduce pain and improve physical functioning in patients with knee OA [8]. Studies investigating OA have often recruited both hip OA and knee OA patients [2, 9]. However, because few hip patients were recruited and no joint-specific data were reported, recommendations for the treatment of hip and/or knee OA are mainly based on knee OA studies; less evidence for the effectiveness of exercise therapy on hip OA symptoms is available. This underlines the importance of obtaining more data on the effects of exercise therapy in hip OA.

Hip OA is associated with markedly reduced lower limb muscle strength [10]. Hernandez-Molina et al. reported that the most effective therapeutic exercise involves regular aerobic activity and/or a strengthening program [11]. Their meta-analysis combining 8 trials with similar exercise strategies for hip OA, demonstrated exercise benefit with an effect size of -0.46 (95% CI -0.64, -0.28; P < 0.0001) [11]; in that meta-analysis, most exercise programs lasted maximally 12 weeks. The beneficial effects of exercise therapy seem to decline and eventually disappear [12, 13]. Although it is suggested that adding booster exercise sessions to the intervention may induce long-term effects [12], few studies include such booster sessions [2, 9, 14].

In a comparison of three studies investigating the cost-effectiveness of exercise therapy, the reported costs per quality-adjusted life year (QALY) ranged from -$503 (cost saving) to $11.530 [7]. To gain insight into the cost-effectiveness of exercise therapy added to GP care, compared to GP care alone, additional economic evaluations alongside randomised controlled trials are needed.

Although evidence was found for the effectiveness of exercise therapy on pain and activity limitations associated with hip OA, more insight into short-term and long-term effects is needed. Because studies on the cost-effectiveness in this area of research are lacking, an economic evaluation of exercise therapy in OA is also needed.

Therefore, the present research questions are:

  1. 1)

    What is the cost-effectiveness of exercise therapy added to GP care, compared to GP care alone, in patients with OA of the hip?

  2. 2)

    What is the effectiveness of exercise therapy added to GP care, compared to GP care alone, in patients with OA of the hip?


Study design

This study is a multi-centre randomised controlled trial with a parallel group design. Follow-up lasts for 12 months. Figure 1 presents the flowchart of the study. This study is approved by the Erasmus MC Medical Ethical committee.

Figure 1
figure 1

Flowchart of the study.


The target population consists of patients suffering from hip OA, 45 years and older, who have consulted their GP during the past year regarding hip complaints. Patients are identified via searches in the patient registries of the participating GPs.

Patient recruitment

Participating GPs in the area of Rotterdam will invite patients with hip OA who visited them during the past year for hip complaints and who comply with the clinical American College of Rheumatology (ACR) criteria [15] for hip OA (Figure 2). After receiving a positive patient's response, researchers screen for eligibility. If eligible and patients' written informed consent is obtained, the baseline measurement is conducted (Figure 1).

Figure 2
figure 2

Clinical ACR criteria Hip.

Inclusion/exclusion criteria

Patients are eligible if they consulted the GP for a new episode of non-traumatic hip complaints during the past year, are 45 years or older, comply with the clinical ACR criteria for hip OA, and complete the informed consent procedure. Researchers determine whether the patient complies with the ACR criteria by conducting a physical examination at baseline.

Patients are excluded if they meet one of six exclusion criteria: 1) has received exercise therapy in the past 3 months; 2) hip pain score < 2 on an 11-point numeric rating scale (NRS) (0 means no pain); 3) hip surgery in the past or on the waiting list for hip surgery; 4) severe disabling co-morbidity that disallows receiving exercise therapy; 5) insufficient comprehension of the Dutch language; and/or 6) mentally incapable of participation.


The randomisation procedure is based on a computer-generated randomisation list provided by a person independent to the randomisation procedure. Based on this list, opaque, sealed, sequentially numbered, non-reusable envelopes are prepared for the researchers to open after the baseline measurement. To prevent unequal group sizes, block randomisation is used with random blocks of 4, 6 and 8 patients.

Randomisation is performed by the researcher who conducts the baseline measurement. After performing all baseline measurements, the researcher opens a sealed envelope in the presence of the patient. The contents of the envelope are revealed to both the researcher and the patient.

The randomisation procedure assigns patients to a group receiving exercise therapy in conjunction with GP care, or to a group receiving GP care alone.


Due to the study design and the use of questionnaires, GPs, patients and therapists cannot be blinded to the intervention.


Patients are randomised to a group receiving exercise therapy in conjunction with GP care (intervention group), or to a group receiving GP care alone (control group). Patients in the intervention group are referred to a physiotherapist who is trained to administer exercise therapy according to the study protocol.


The exercise therapy supervised by physiotherapists consists of (maximally) 12 evenly spread treatment sessions during 3 months. If treatment goals are reached before the 12th treatment session, physiotherapists are allowed to stop the treatment before the 12th treatment session. Nevertheless, the first block of treatment sessions is followed by three treatment sessions in the 5th, 7th and 9th month. One treatment session lasts 25-30 minutes.

A consensus meeting was organised for the participating physiotherapists. During this meeting, the exercise therapy protocol based on the Dutch guideline for physiotherapy [16] was discussed and trained in detail. A booklet with exercises was created to stimulate treatment adherence regarding home exercises. A selection of these exercises is shown in Additional file 1.

Physiotherapists are instructed to administer exercise therapy as they usually do in patients with hip OA, taking into account the limitations set by the study protocol. The protocol states that passive treatment forms (such as manual therapy, massage and joint traction) are not allowed. A treatment session should always include giving advice to the patient about OA and lifestyle adaptations. Furthermore, the instruction and evaluation of home exercises are considered to be key elements. Physiotherapists are allowed to administer exercises and home exercises of their choice. As physiotherapists mainly follow their own approach, treatments may differ slightly between therapists. Some patients will receive individual therapy, while others will exercise in groups. Methods, treatment goals, intensity and frequency are tailored to the patient's needs. Using standardised forms, physiotherapists register the duration of treatment sessions, number of treatment sessions, individual treatment goals, adherence to home exercises, and any possible violation of the protocol.

The general aims of exercise therapy are to improve functioning, increase levels of activity, and to encourage an adequate way of dealing with the complaints. Individual aims may consist of reducing pain, improving muscle strength, active joint stability, coordination, joint mobility, endurance and/or the performance of activities.

GP care

GP care is provided as usual in daily practice by the patient's own GP. Patients in either group are allowed unrestricted visits to their GP for hip complaints as required. The GP may provide education and counselling and/or prescribe pain medication. Furthermore, the GP may refer the patient to an orthopaedic surgeon or request additional diagnostic tests or examinations.

After admission to the study, patients in both groups receive an identical brochure with general information and advice. The topics covered include the diagnosis and prognosis of hip OA, as well as advice on daily activities, the use of (walking) aids, medical treatment and exercise. The information in the brochure was developed by the Dutch College of General Practitioners [17].

Study parameters

The measurements at baseline and at 12 months follow-up consist of a physical examination in conjunction with questionnaires. All other measurements consist of questionnaires only. At baseline a pelvic X-ray (anteroposterior) is taken.

Main study parameters are hip pain and hip-related activity limitations (measured with the Hip disability Osteoarthritis Outcome Score (HOOS) [18, 19]), direct costs and productivity costs (measured with the PROductivity and DISease Questionnaire (PRODISQ) [20]). These outcomes are obtained at baseline, at 6 weeks, and at 3, 6, 9 and 12 months follow-up (Table 1). The HOOS questionnaire is an extension of the Western Ontario McMaster Universities (WOMAC) Osteoarthritis Index [21]); WOMAC pain and function scores are calculated based on HOOS scores.

Table 1 Outcome measures

The following secondary study parameters are measured with questionnaires at baseline, at 6 weeks, and at 3, 6, 9 and 12 months follow-up:

  • Hip pain, measured with an NRS score (0-10 scale) [22]

  • Hip pain, measured with the Intermittent and Constant Osteoarthritis Pain (ICOAP) questionnaire [23, 24]

  • Perceived Recovery, measured on a 7-point Likert scale [25]

  • Quality of life, measured with the EuroQol, EQ-5D [26].

In addition, activity limitations are measured with the Timed Up and Go test [27]. Range of motion of both hips is also obtained. These tests are performed at baseline and at 12 months follow-up.

In this study, the following demographic data are collected:

  • Age, gender, height, weight, education, duration of complaints, previous hip pain, co-morbidity.

  • Radiographic OA parameters, obtained with X-ray (anteroposterior pelvic).

  • Active and passive activity limitations, and range of motion of the hip (obtained by the physical examination at baseline and at 12 months follow-up).

  • Compliance to assigned treatment.

  • Co-interventions, including referral of patients in the control group to physiotherapy.

Sample size calculation

It is expected that 25% of patients assigned to the group that receives GP care only will be referred to physiotherapy (cross-over). Also, a 10% loss to follow-up is expected. To detect a 25% clinical difference in the WOMAC pain score (mean 4.83, SD 2.25) after 12 months with two-tailed testing, a power of 80% and an alpha 5%, 210 patients are required [28].

Statistical analysis


Success of randomisation and distribution of outcome measures is assessed before actual analyses are performed. Data collected during 12 months follow-up are analysed according to the intention-to-treat principle using linear regression models with repeated measurements. Risk differences are calculated for HOOS outcome scores of the intervention and the control group. Risk differences are adjusted for possible differences between groups concerning prognostic factors.

In addition, risk differences are analysed per protocol. In the intervention group, patients receiving < 60% (≈ 12) of the maximum number of exercise therapy sessions are not considered. In the control group, crossovers are not considered.

Subgroup analyses are planned for the following variables: age (45-65 years vs. > 65 years), pain intensity (NRS score ≥ 3), education, radiographic severity and co-morbidity (low-back pain or knee pain). Because of insufficient power the subgroups are analysed for explorative purpose only.

Economic evaluation

In an incremental cost-effectiveness analysis, societal costs during the first year are compared with the primary outcome measure (HOOS and WOMAC, averaged over the first year) and perceived recovery (7-point Likert scale). For comparison with a wider range of interventions an incremental cost-utility analysis is conducted, comparing the incremental societal costs of the intervention per patient during the first year and the incremental quality of life in years/days, as obtained from the EuroQol (QALY during the first year). Utility values of the Dutch public for EuroQol health states are applied [29]. The costs per unit of medical consumption and the costs per hour productivity lost are estimated using updated information from the Dutch Manual for economic evaluation of health care [30]. The friction cost method is used to calculate the productivity costs according to the Dutch guidelines. Costs are reported for the year 2009. Using non-parametric bootstrapping (randomly drawing 2500 observations with replacement from the patient sample), the degree of uncertainty for costs and health effects, and the cost-utility ratio, is depicted in a so-called cost-effectiveness plane.

In addition an acceptability curve is drawn, which indicates the probability that the intervention has lower incremental costs per QALY gained than various thresholds for the maximum willingness to pay for an extra QALY. An attempt is made to model differences in effectiveness and costs beyond the time horizon of the study itself, by extrapolating the success rates of exercise therapy, GP consultations, required surgery due to hip OA, and absenteeism. Here, time horizons of 2 and 5 years are used with discounting of costs by 4% per year and health effects by 1.5% per year, according to the pharmacoeconomic guidelines of the Dutch Health Care Insurance Board [31].


Patient recruitment is expected to be finished by end 2011. Based on a 12-month follow-up, the results are expected early 2013. The results of this trial will provide insight into the cost-effectiveness of adding exercise therapy to GPs' care in the treatment of OA of the hip.


  1. Fransen M, McConnell S, Bell M: Exercise for osteoarthritis of the hip or knee. Cochrane Database Syst Rev. 2003, CD004286-

    Google Scholar 

  2. Pisters MF, Veenhof C, Schellevis FG, De Bakker DH, Dekker J: Long-term effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: a randomized controlled trial comparing two different physical therapy interventions. Osteoarthritis and Cartilage. 2010, 18: 1019-1026. 10.1016/j.joca.2010.05.008.

    Article  CAS  PubMed  Google Scholar 

  3. RIVM: Nationaal Kompas Volksgezondheid. Versie 3.16. 2008, Bilthoven: RIVM

    Google Scholar 

  4. Tak E, Staats P, Van Hespen A, Hopman-Rock M: The effects of an exercise program for older adults with osteoarthritis of the hip. J Rheumatol. 2005, 32: 1106-1113.

    PubMed  Google Scholar 

  5. Jordan KM, Arden NK, Doherty M, Bannwarth B, Bijlsma JW, Dieppe P, Gunther K, Hauselmann H, Herrero-Beaumont G, Kaklamanis P: EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis. 2003, 62: 1145-1155. 10.1136/ard.2003.011742.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Roddy E, Zhang W, Doherty M, Arden NK, Barlow J, Birrell F, Carr A, Chakravarty K, Dickson J, Hay E: Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee--the MOVE consensus. Rheumatology (Oxford). 2005, 44: 67-73. 10.1093/rheumatology/keh399.

    Article  CAS  Google Scholar 

  7. Zhang W, Nuki G, Moskowitz RW, Abramson S, Altman RD, Arden NK, Bierma-Zeinstra S, Brandt KD, Croft P, Doherty M: OARSI recommendations for the management of hip and knee osteoarthritis Part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage. 2010, 18: 476-499. 10.1016/j.joca.2010.01.013.

    Article  CAS  PubMed  Google Scholar 

  8. Health Council of the Netherlands: Therapeutic exercise. The Hague 2003:publication no. 2003/2022.

  9. Veenhof C, Koke AJ, Dekker J, Oostendorp RA, Bijlsma JW, van Tulder MW, van den Ende CH: Effectiveness of behavioral graded activity in patients with osteoarthritis of the hip and/or knee: A randomized clinical trial. Arthritis Rheum. 2006, 55: 925-934. 10.1002/art.22341.

    Article  PubMed  Google Scholar 

  10. Fransen M, McConnell S, Hernandez-Molina G, Reichenbach S: Exercise for osteoarthritis of the hip. Cochrane Database Syst Rev. 2009, CD007912-

    Google Scholar 

  11. Hernandez-Molina G, Reichenbach S, Zhang B, Lavalley M, Felson DT: Effect of therapeutic exercise for hip osteoarthritis pain: results of a meta-analysis. Arthritis Rheum. 2008, 59: 1221-1228. 10.1002/art.24010.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Pisters MF, Veenhof C, van Meeteren NL, Ostelo RW, de Bakker DH, Schellevis FG, Dekker J: Long-term effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: a systematic review. Arthritis Rheum. 2007, 57: 1245-1253. 10.1002/art.23009.

    Article  PubMed  Google Scholar 

  13. van Baar ME, Dekker J, Oostendorp RA, Bijl D, Voorn TB, Bijlsma JW: Effectiveness of exercise in patients with osteoarthritis of hip or knee: nine months' follow up. Ann Rheum Dis. 2001, 60: 1123-1130. 10.1136/ard.60.12.1123.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Coupé VM, Veenhof C, van Tulder MW, Dekker J, Bijlsma JW, Van den Ende CH: The cost effectiveness of behavioural graded activity in patients with osteoarthritis of hip and/or knee. Ann Rheum Dis. 2007, 66: 215-221.

    Article  PubMed  Google Scholar 

  15. Altman R, Alarcon G, Appelrouth D, Bloch D, Borenstein D, Brandt K, Brown C, Cooke TD, Daniel W, Feldman D: The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis Rheum. 1991, 34: 505-514. 10.1002/art.1780340502.

    Article  CAS  PubMed  Google Scholar 

  16. Peter WFH, Jansen MJ, Bloo H, Dekker-Bakker LMM, Dilling RG, Kersten-Smit C, de Rooij M, Veenhof C, Vermeulen HM, de Vos I: Revision of the KNGF guideline osteoarthritis of the hip and knee [Dutch]. Nederlands Tijdschrift Voor Fysiotherapie. 2010, 120: 2-15.

    Google Scholar 

  17. Nederlands Huisartsen Genootschap. []

  18. Klässbo M, Larsson E, Mannevik E: Hip disability and osteoarthritis outcome score. An extension of the Western Ontario and McMaster Universities Osteoarthritis Index. Scand J Rheumatol. 2003, 32: 46-51. 10.1080/03009740310000409.

    Article  PubMed  Google Scholar 

  19. de Groot IB, Reijman M, Terwee CB, Bierma-Zeinstra SM, Favejee M, Roos EM, Verhaar JA: Validation of the Dutch version of the Hip disability and Osteoarthritis Outcome Score. Osteoarthritis Cartilage. 2007, 15: 104-109. 10.1016/j.joca.2006.06.014.

    Article  CAS  PubMed  Google Scholar 

  20. Koopmanschap M: PRODISQ: a modular questionnaire on productivity and disease for economic evaluation studies. Expert Rev Pharmacoeconomics Outcomes Res. 2005, 5: 23-28. 10.1586/14737167.5.1.23.

    Article  Google Scholar 

  21. Bellamy N: WOMAC Osteoarthritis Index. A user's guide. 1995, London, Ontario, Canada: University of Western Ontario

    Google Scholar 

  22. Scott J, Huskisson EC: Graphic representation of pain. Pain. 1976, 2: 175-184. 10.1016/0304-3959(76)90113-5.

    Article  CAS  PubMed  Google Scholar 

  23. Hawker GA, Davis AM, French MR, Cibere J, Jordan JM, March L, Suarez-Almazor M, Katz JN, Dieppe P: Development and preliminary psychometric testing of a new OA pain measure - an OARSI/OMERACT initiative. Osteoarthritis and Cartilage. 2008, 16: 409-414. 10.1016/j.joca.2007.12.015.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Maillefert JF, Kloppenburg M, Fernandes L, Punzi L, Gunther KP, Martin Mola E, Lohmander LS, Pavelka K, Lopez-Olivo MA, Dougados M, Hawker GA: Multi-language translation and cross-cultural adaptation of the OARSI/OMERACT measure of intermittent and constant osteoarthritis pain (ICOAP). Osteoarthritis Cartilage. 2009, 17: 1293-1296. 10.1016/j.joca.2009.04.003.

    Article  CAS  PubMed  Google Scholar 

  25. Bombardier C, Tugwell P, Sinclair A, Dok C, Anderson G, Buchanan WW: Preference for endpoint measures in clinical trials: results of structured workshops. J Rheumatol. 1982, 9: 798-801.

    CAS  PubMed  Google Scholar 

  26. Euroqol Group: EuroQol--a new facility for the measurement of health-related quality of life. The EuroQol Group. Health Policy. 1990, 16: 199-208.

    Article  Google Scholar 

  27. Podsiadlo D, Richardson S: The timed "Up & Go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991, 39: 142-148.

    Article  CAS  PubMed  Google Scholar 

  28. Angst F, Aeschlimann A, Steiner W, Stucki G: Responsiveness of the WOMAC osteoarthritis index as compared with the SF-36 in patients with osteoarthritis of the legs undergoing a comprehensive rehabilitation intervention. Ann Rheum Dis. 2001, 60: 834-840.

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Lamers LM, Stalmeier PF, McDonnell J, Krabbe PF, van Busschbach JJ: Measuring the quality of life in economic evaluations: the Dutch EQ-5D tariff [Dutch]. Ned Tijdschr Geneeskd. 2005, 149: 1574-1578.

    CAS  PubMed  Google Scholar 

  30. Hakkaart-van Roijen L, Tan S, Bouwmans C: Manual for Costing: Methods and Standard Costs for Economic Evaluations in Healthcare [Dutch]. 2010, Institute for Medical Technology Assessment, Erasmus University Rotterdam. Health Care Insurance Board

    Google Scholar 

  31. Health Care Insurance Board: Guidelines for pharmacoeconomic research, updated version. 2006

    Google Scholar 

Pre-publication history

Download references


ZonMw provided funding for this study.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Pauline P van Es.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

PAJL, JD, MAK, JANV, BWK and SMABZ conceived the study, developed the trial design and contributed to writing the article. AMB contributed to writing the article. PPVE participated in completing the study design, drafted the article and will conduct the research. All authors have read and approved the final version of the article.

Electronic supplementary material


Additional file 1:Selection of home exercises. A selection of home exercises in the booklet that is given to patients in the exercise therapy group. (PDF 18 MB)

Authors’ original submitted files for images

Below are the links to the authors’ original submitted files for images.

Authors’ original file for figure 1

Authors’ original file for figure 2

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

van Es, P.P., Luijsterburg, P.A., Dekker, J. et al. Cost-effectiveness of exercise therapy versus general practitioner care for osteoarthritis of the hip: design of a randomised clinical trial. BMC Musculoskelet Disord 12, 232 (2011).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI:


  • Treatment Session
  • Exercise Therapy
  • Home Exercise
  • Numeric Rating Scale Score
  • General Practitioner Care