Fig. 5
From: FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation
FTH1 suppress OA progression through inhibition of the MAPK pathway. Immunoblotting show that MAPK signal-related proteins p-P38/P38, p-JNK/JNK and p-ERK/ERK expression after knock down FTH1. A-C Gray scale analysis of p-P38/P38, p-JNK/JNK and p-ERK/ERK. n = 3 per group, *P < 0.05;**P < 0.01. D-F G Immunofluorescence images of FTH1 in primary chondrocytes, stimulated with IL-1β, vehicle and adenovirus- expressing FTH1. Scale bars: 100 µm. H Immunofluorescence images of phospho-ERK in primary chondrocytes, stimulated with IL-1β, vehicle and adenovirus- expressing FTH1. Scale bars: 100 µm