Fig. 3
From: FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation
Down-regulation of FTH1 results in articular cartilage loss and the sensitive of ferroptosis increased. A Safranin O and Fast Green staining of cartilage explants from 3-week-old c57 mice which treated with si-NC and si-FTH1 for 72 h. Scale bar: 400 µm; Immunohistochemical staining and quantification of FTH1 (B, C) and GPX4 (D, E)and SLC7A11 (F, G) in cartilage explants from 3-week-old c57 mice which treated with si-NC and si-FTH1 for 72 h. n = 5 per group; Immunohistochemical staining and quantification of aggrecan(H,I) and SOX9(J, K) and ADAMTS5(L,M) and MMP13(N,O) in cartilage explants from 3-week-old c57 mice which treated with si-NC and si-FTH1 for 72 h. n = 5 per group *P < 0.05; Scale bar: 200 µm;