Fig. 2
From: FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation
FTH1 deficiency leads to chondrocytes senescence and ECM degradation. A Relative mRNA expression level of FTH1 in primary murine chondrocytes which treated with FTH1 siRNA for 48 h; Relative mRNA expression level of aggrecan (B), collagen type II (C), P16 (D) and P21 (E) in primary murine chondrocytes which treated with FTH1 siRNA for 48 h; n = 5,*P < 0.05, **P < 0.01, ***P < 0.001,****P < 0.0001; (F) Immunoblotting of FTH1, SOX9 and P21 in primary murine chondrocytes which treated with FTH1 siRNA for 48 h; (G) ROS level of chondrocytes, after transfection with FTH1 siRNA or si-NC. Scale bar: 400 µm