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Fig. 8 | BMC Musculoskeletal Disorders

Fig. 8

From: Bone marrow mesenchymal stem cell-derived exosomes promote osteoblast proliferation, migration and inhibit apoptosis by regulating KLF3-AS1/miR-338-3p

Fig. 8

PTEN is a target gene of miR-338-3p. (A) Complementary sites of miR-338-3p and PTEN. (B) luciferase reporter gene assay. ***p < 0.001 vs. Control group (n = 5, one-way ANOVA). The expression level of PTEN in serum was down-regulated in patients with (C) hand fracture and (D) intraarticular fracture (Healthy individuals = 65, Hand fracture = 35, Intra-articular fracture = 30). ***p < 0.001 vs. Healthy individuals (Independent sample t test). (E) The content of PTEN was increased in BMSCs-Exo incubated cells. ***p < 0.001 vs. control group; ###p < 0.001 vs. BMSCs-Exo + si-NC group; &&&p < 0.001 vs. BMSCs-Exo + si-KLF3-AS1 + inhibitor-NC group (n = 5, one-way ANOVA).

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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