Association of type 2 Diabetes Mellitus and bone mineral density: a two-sample Mendelian randomization study

Table 1 Mendelian randomization (MR) analysis of DM2 and BMD.

	Method	TB-BMD			FN-BMD			UF-BMD			H-BMD			LS-BMD
	Method	SNP (n)	OR (95%CI)	P Value	SNP (n)	OR (95%CI)	p Value	SNP (n)	OR (95%CI)	p Value	SNP (n)	OR (95%CI)	p Value	SNP (n)	OR (95%CI)	p Value
DM2	IVW	118	1.03 (1.01,1.06)	0.002	82	1.04 (1.01,1.07)	0.001	115	1.05 (1.01,1.09)	7e^− 4	118	1.03 (1.01,1.06)	4.3e^− 4	82	1.05 (1.01,1.09)	0.003
	MR Egger	118	1.02 (0.97,1.08)	0.33	82	1.05 (0.98,1.11)	0.12	115	1.03 (0.95,1.13)	0.38	118	1.01 (0.97,1.06)	0.48	82	0.98 (0.92,1.06)	0.73
	Weighted median	118	1.05 (1.02,1.09)	0.0004	82	1.04 (0.99,1.09)	0.08	115	1.06 (0.99,1.12)	0.06	118	1.03 (1.01,1.05)	9.48e^− 10	82	1.00 (0.95,1.05)	0.97
	Weighted mode	118	1.05 (1.01,1.09)	0.01	82	1.05 (1,1.1)	0.03	115	1.06 (0.99,1.14)	0.08	118	1.03 (1.02,1.04)	7.29e^− 6	82	0.98 (0.92,1.04)	0.51

Note: DM2 Type 2 Diabetes Mellitus, MR Mendelian randomization, SNP single nucleotide polymorphism, TB Total body, FN, Femoral neck, UF, Ultradistal forearm, LS, Lumbar spine, BMD Bone mineral density, IVW inverse variance weighting, OR odds ratio, CI confidence interval

ISSN: 1471-2474