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Table 1 General characteristics of the included studies

From: Effects of manual lymphatic drainage on total knee replacement: a systematic review and meta-analysis of randomized controlled trials

First Author, Year

Country of study

Intervention group(Sample Size)

Control group(Sample Size)

Intervention group

Control group

Intervention time

Follow up time

Outcomes measures

Vergili et al., 2022 [12]

Turkey

8

8

MLD + physical therapy

NO MLD + physical therapy

30 min/day on the second and fourth day after surgery

D2, D4 and D6 after surgery

ROM; pain:VAS; edema: knee volume; function: FIM

CiHAN et al., 2021 [17]

Turkey

11

11

MLD + physical therapy

NO MLD + physical therapy

No technical details

D3 and 6 weeks after surgery

pain:VAS; function:NHP; fear:TKS

Guney-Deniz et al., 2022 [18]

Turkey

13

15

MLD + exercises

NO MLD + exercises

30 min/day, 2–4 days after surgery

D2, D3, D4, 2 weeks and 6 weeks after surgery

ROM; pain:VAS; function:KOOS; edema:knee circumference

Pichonnaz et al., 2016 [20]

Switzerland

29

27

MLD + physical therapy

NO MLD + physical therapy

30 min/day, 2–7 days after surgery

D2, D7, and 3 months after surgery

ROM; pain:VAS; function:KSS,WOMAC; edema:BIS limb volume

Ebert et al., 2013 [29]

Australia

24

26

MLD + physical therapy

NO MLD + physical therapy

30 min/day, 2–4 days after surgery

D2, D3, D4, and 6 weeks after surgery

ROM; pain:NRS; function:KOOS; edema:knee girths

Fujiura et al., 2020 [30]

Japan

20

20

MLD + physical therapy

NO MLD + physical therapy

20 min/day, 2–6 days after surgery

Immediately and the fifth MLD application after surgery

ROM; pain:VAS; edema:knee circumference

Tornatore et al., 2020 [31]

Italy

33

33

MLD + education

Kinesio tape + education

30 min/day on the second and fourth day after surgery

D4, D6 after surgery

ROM; pain:NRS; edema:knee circumference

  1. Note: MLD: Manual lymphatic drainage; VAS: Visual Analogue Scale; NRS: Numeric Rating Scale; FIM: Functional independence measurement; TKS: Tampa Kinesiophobia Scale; KOOS: Knee Injury and Osteoarthritis Outcome Score; NHP: Nottingham Health Profile; BIS: Bioimpedance Spectroscopy; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index; KSS: Knee Society Score; D: Day