Physical activity practiced at a young age is associated with a less severe subsequent clinical presentation in facioscapulohumeral muscular dystrophy

Table 3 Association of organized or at medium-high cardiovascular commitment physical activities and FSHD severity

Subcategory	FSHD score		MR (95% CI)	p-value	aMR (95% CI)	p-value
Subcategory	n	mean ± SD	MR (95% CI)	p-value	aMR (95% CI)	p-value
Organized PAs
Classical phenotype
No organized PAs	108	6.13 ± 3.09	Reference	-	Reference	-
Organized Pas	49	5.20 ± 2.73	0.85 (0.73; 0.98)	0.025 *	0.85 (0.74; 0.99)	0.031 *
Incomplete phenotype
No organized PAs	28	2.14 ± 1.88	Reference	-	Reference	-
Organized Pas	18	2.22 ± 1.40	1.04 (0.70; 1.55)	0.859	0.83 (0.55; 1.26)	0.374
Asymptomatic carriers
No organized PAs	81	0.00 ± 0.00	Reference	-	Reference	-
Organized Pas	23	0.13 ± 0.34	NA	NA	NA	NA
Complex phenotype
No organized PAs	52	6.98 ± 3.77	Reference	-	Reference	-
Organized Pas	9	3.89 ± 3.30	0.56 (0.39; 0.79)	0.001 *	0.58 (0.41; 0.83)	0.002 *
Medium-high cardiovascular commitment PAs
Classical phenotype
No MHCC Pas	106	6.17 ± 3.08	Reference	-	Reference	-
MHCC Pas	51	5.18 ± 2.75	0.84 (0.73; 0.97)	0.016 *	0.87 (0.75; 1.01)	0.061
Incomplete phenotype
No MHCC Pas	27	1.93 ± 1.52	Reference	-	Reference	-
MHCC Pas	19	2.53 ± 1.90	1.31 (0.89; 1.94)	0.175	0.99 (0.64; 1.52)	0.952
Asymptomatic carriers
No MHCC Pas	78	0.00 ± 0.00	Reference	-	Reference	-
MHCC Pas	26	0.12 ± 0.33	NA	NA	NA	NA
Complex phenotype
No MHCC Pas	49	7.10 ± 3.84	Reference	-	Reference	-
MHCC Pas	12	4.17 ± 2.95	0.59 (0.44; 0.79)	0.000 *	0.61 (0.45; 0.83)	0.002 *

Notes: MHCC = medium-high cardiovascular commitment; SD = standard deviation; MR = mean ratio; aMR = MR adjusted for gender, disease duration and DRA dimension; CI = confidence interval; * = p-value < 0.05

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