Physical activity practiced at a young age is associated with a less severe subsequent clinical presentation in facioscapulohumeral muscular dystrophy

Table 2 Association of physical activities and FSHD severity

Subcategory	FSHD score		MR (95% CI)	p-value	aMR (95% CI)	p-value
Subcategory	n	mean ± SD	MR (95% CI)	p-value	aMR (95% CI)	p-value
Classical phenotype
No PAs	91	6.29 ± 3.01	Reference	-	Reference	-
PAs	66	5.24 ± 2.90	0.83 (0.73; 0.95)	0.008 *	0.83 (0.73; 0.95)	0.007 *
Incomplete phenotype
No PAs	22	2.00 ± 1.63	Reference	-	Reference	-
PAs	24	2.33 ± 1.76	1.17 (0.79; 1.73)	0.444	0.87 (0.56; 1.34)	0.524
Asymptomatic carriers
No PAs	74	0.00 ± 0.00	Reference	-	Reference	-
PAs	30	0.10 ± 0.31	NA	NA	NA	NA
Complex phenotype
No PAs	47	7.06 ± 3.87	Reference	-	Reference	-
PAs	14	4.71 ± 3.27	0.67 (0.51; 0.87)	0.003 *	0.67 (0.51; 0.89)	0.006 *

Notes. PA = physical activity; SD = standard deviation; MR = mean ratio; aMR = MR adjusted for gender, disease duration and DRA dimension; CI = confidence interval; * = p-value < 0.05

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