Fig. 5
From: Circ_0027885 sponges miR-203-3p to regulate RUNX2 expression and alleviates osteoporosis progression
Circ_0027885 regulated hBMSCs osteogenic differentiation via the miR-203‐3p/RUNX2 axis. (A-B) Relative protein expression of RUNX2 in LV-circ_0027885 + NC mimic or LV-circ_0027885 + miR‐203‐3p mimic treated hBMSCs, measured by western blot. **P < 0.05, as comparison to the LV-NC + NC mimic group; **P < 0.01, as comparison to the LV-circ_0027885 + NC mimic group. (C) Relative ALP activity was examined in LV-circ_0027885 + NC mimic or LV-circ_0027885 + miR‐203‐3p mimic treated hBMSCs. **P < 0.01, as comparison to the LV-NC + NC mimic group; *P < 0.05, as comparison to the LV-circ_0027885 + NC mimic group. (D) The mineralization levels in LV-circ_0027885 + NC mimic or LV-circ_0027885 + miR‐203‐3p mimic treated hBMSCs, as determined by Alizarin red staining