Table 1 Primary and selected secondary outcomes at baseline, one- and four-year follow-up

BPI Severity - BL

(0 to 10, best to worst)

110

5.1 (1.6)

227

5.3 (1.7)

BPI Severity − 1Y

(0 to 10, best to worst)

100

3.7 (2.5)

212

3.1 (2.4)

-0.65

(-1.17, -0.13)

0.014

BPI Severity − 4Y

(0 to 10, best to worst)

67

3.1 (2.4)

159

2.8 (2.6)

-0.42

(-1.07, 0.23)

0.202

BPI Interference - BL

(0 to 10, best to worst)

110

6.2 (2.0)

227

6.3 (1.9)

BPI Interference − 1Y

(0 to 10, best to worst)

100

4.1 (2.9)

213

3.5 (2.8)

-0.68

(-1.28, -0.08)

0.026

BPI Interference − 4Y

(0 to 10, best to worst)

65

3.7 (3.0)

158

3.2 (3.0)

-0.64

(-1.41, 0.12)

0.099

Oxford Knee Score - BL

(0 to 48, worst to best)

110

18.9 (5.3)

227

18.0 (6.0)

Oxford Knee Score − 1Y

(0 to 48, worst to best)

93

27.2 (9.7)

201

28.4 (10.2)

2.10

(-0.13, 4.33)

0.064

Oxford Knee Score − 4Y

(0 to 48, worst to best)

64

27.7 (11.8)

158

29.9 (11.3)

2.93

(-0.02, 5.89)

0.052

PainDETECT - BL

(–1 to 38, best to worst)

110

17.2 (6.9)

227

18.6 (6.7)

PainDETECT − 1Y

(–1 to 38, best to worst)

94

12.7 (7.5)

198

12.9 (7.7)

-0.31

(-2.07, 1.44)

0.725

PainDETECT − 4Y

(–1 to 38, best to worst)

66

11.1 (7.7)

159

11.5 (8.5)

-0.43

(-2.51, 1.65)

0.686

HADS

Anxiety - BL

(0 to 21, best to worst)

110

7.1 (4.6)

227

7.8 (4.5)

HADS Anxiety − 1Y

(0 to 21, best to worst)

92

6.0 (4.7)

198

6.0 (4.4)

-0.04

(-1.10, 1.02)

0.941

HADS Anxiety − 4Y

(0 to 21, best to worst)

66

6.6 (4.6)

156

6.6 (5.1)

-0.66

(-1.76, 0.44)

0.238

HADS Depression - BL

(0 to 21, best to worst)

110

7.3 (3.9)

227

7.9 (4.1)

HADS Depression − 1Y

(0 to 21, best to worst)

90

6.1 (4.3)

197

6.0 (3.8)

-0.31

(-1.23, 0.61)

0.511

HADS Depression − 4Y

(0 to 21, best to worst)

66

6.5 (4.6)

156

6.3 (4.2)

-0.45

(-1.44, 0.54)

0.373