Fig. 6
From: Upregulating miR-181b promotes ferroptosis in osteoarthritic chondrocytes by inhibiting SLC7A11
Diagram of the mechanism by which mir-181b-5p induces ferroptosis through SLC7A11. p53 represses SLC7A11 transcription by binding to the promoter area of SLC7A11. In addition, miR-181b-5p can inhibit the mRNA expression of SLC7A11 by binding to the SLC7A11 3’UTR. The important combinatorial protein SLC7A11 of System Xc− can take extracellular cystine into the cell and convert it into reduced glutathione (GSH). GPX4 uses GSH as a substrate for lipid peroxidation repair and converts GSH into oxidized glutathione (GS-SH). Then, the occurrence of lipid peroxidation and ferroptosis is inhibited