Fig. 5
From: Upregulating miR-181b promotes ferroptosis in osteoarthritic chondrocytes by inhibiting SLC7A11
The miR-181b/SLC7A11 axis regulates MIA-induced rat osteoarticular ferroptosis. (A-B) IHC was used to detect the distribution and expression of SLC7A11 protein in bone tissue, and IPP6.0 was used for quantitative analysis. (C-D) qPCR was used to detect the expression levels of mir-181b and SLC7A11 genes. (E-J) The protein expression levels of TFR1, FTH1, p53, SLC7A11 and GPX4 in bone tissue were detected by Western blotting, and the optical density values of the protein bands were quantified. **P < 0.01, *P < 0.05, the model group was significantly different from the sham group. ##P < 0.01, #P < 0.05, the two groups of the line were compared, and the difference was statistically significant